Cell Genom June 2025 PMID 40403731

An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis.

Yufeng Zhang, Jie Wang, Chuanyou Yi, Yue Su, Zi Yin, Shuxian Zhang, Li Jin, Mark Stoneking, Jian Yang, Ke Wang, He Huang, Jin Li, Shaohua Fan

Mentions

37
Peak: 11 in May 2025
across 7 sources since May 2025

Extended reach

163,188
potential audience

Total likes

1,699

Video views

44,714

Mentions per month

May 2025 – Aug 2025

Where it's discussed

  • News16 articles
  • X / Twitter9 posts
  • Bluesky4 posts
  • YouTube2 videos
  • Facebook2 posts
  • Reddit2 posts
  • Blogs2 articles

AI synopsis

What people are saying

The discussions revolve around personal and ancestral connections to the research, exemplified by statements like 'I'm Natufian, I'm 1.90m' and comparisons to historical populations like Yamnayas. The tone is casual and reflective, with some participants emphasizing personal relevance and others briefly mentioning the scientific focus, indicating moderate interest and engagement without deep analysis or critique.

AgreementNeither agree nor disagree

Most discussions show curiosity but not explicit agreement or disagreement with the findings, with some individuals expressing personal relevance or skepticism.

InterestModerate interest

Participants demonstrate moderate interest, as they reference the study and relate it to personal ancestry or traits, but there is limited deep discussion.

EngagementModerate engagement

Comments include personal anecdotes, references to other populations, or brief mentions of the study's implications, indicating some level of active engagement.

ImpactModerate impact

The discussions suggest that the publication influences thoughts on human evolution and genetics, but they do not highlight widespread or profound societal impact.

Abstract in brief

  • Anatomically modern humans have higher basal metabolic rates and greater height than non-human apes, which this study examines for genetic underpinnings.
  • A specific regulatory mutation, rs34590044-A, is linked to increased height and metabolic rates by enhancing the expression of the ACSF3 gene.
  • This mutation has undergone positive selection in the British population over the last 20,000 years, particularly in the last 5,000 years, indicating its association with adaptation to a meat-rich diet.

Top posts

Most liked on X and Bluesky
Nrken19
@nrken19 · X

An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis https://t.co/hoJ7FWqJFT

May 21, 2025 · 20 likes · 1 share · 74,954 followers View post →
Cell Genomics
@CellGenomics · X

An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis https://t.co/R7nNzXpTlX

Jun 12, 2025 · 8 likes · 7,916 followers View post →
Cell Genomics
@CellGenomics · X

An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis https://t.co/5WZtOVdzYz

May 21, 2025 · 7 likes · 2 shares · 7,916 followers View post →
Chris Stringer
@chrisbstringer.bsky.social · Bluesky

An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis www.cell.com/cell-genomic...

May 22, 2025 · 7 likes · 2 shares View post →
Chris Stringer
@chrisbstringer.bsky.social · Bluesky

An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis: Cell Genomics www.cell.com/cell-genomic...

May 30, 2025 · 4 likes · 1 share View post →
hbd chick
@hbdchick · X

An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis: Cell Genomics https://t.co/xJf9bbjBEU

May 30, 2025 · 3 likes · 15,600 followers View post →

All mentions

José Pinto ✝️ Cristão Novo
@2dedostesta5 · X

@damasiousc @PJudiciaria An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis. I’m Natufian, I’m 1,90m, with the same lineages of Einstein, wouldn’t trade them for increased height/BMI from Yamnayas (dark triads). https://t.co/ncvQpYi4a5 https://t.co/KzfplaeVMu

Aug 5, 2025 · 16 followers View post →
MEATrition.com
@MEATritionCom · X

An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis: Cell Genomics https://t.co/LaeG9Yrg9i

Jun 22, 2025 · 1 like · 6,352 followers View post →
Cell Genomics
@CellGenomics · X

An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis https://t.co/R7nNzXpTlX

Jun 12, 2025 · 8 likes · 7,916 followers View post →
hbd chick
@hbdchick · X

An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis: Cell Genomics https://t.co/xJf9bbjBEU

May 30, 2025 · 3 likes · 15,600 followers View post →
Chris Stringer
@chrisbstringer.bsky.social · Bluesky

An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis: Cell Genomics www.cell.com/cell-genomic...

May 30, 2025 · 4 likes · 1 share View post →
cottonjenny.bsky.social
@cottonjenny.bsky.social · Bluesky

An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis: Cell Genomics www.cell.com/cell-genomic...

May 29, 2025 View post →
priya joseph
@ayirpelle · X

RT @CellGenomics: An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via…

May 22, 2025 · 2 shares · 4,887 followers View post →
Chris Stringer
@chrisbstringer.bsky.social · Bluesky

An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis www.cell.com/cell-genomic...

May 22, 2025 · 7 likes · 2 shares View post →
Charleston Chiang
@charleston.bsky.social · Bluesky

An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis: Cell Genomics www.cell.com/cell-genomic...

May 22, 2025 · 3 likes View post →
Daniel Tabin
@DanTabin · X

RT @nrken19: An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metab…

May 21, 2025 · 1 share · 791 followers View post →
Nrken19
@nrken19 · X

An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis https://t.co/hoJ7FWqJFT

May 21, 2025 · 20 likes · 1 share · 74,954 followers View post →
Quanyu Chen
@yezus_chen · X

RT @CellGenomics: An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via…

May 21, 2025 · 2 shares · 21 followers View post →
Cell Genomics
@CellGenomics · X

An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis https://t.co/5WZtOVdzYz

May 21, 2025 · 7 likes · 2 shares · 7,916 followers View post →