Am J Clin Nutr July 2025 PMID 40409468

Vitamin D and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial.

Haidong Zhu, JoAnn E Manson, Nancy R Cook, Bayu B Bekele, Li Chen, Kevin J Kane, Ying Huang, Wenjun Li, William Christen, I-Min Lee, Yanbin Dong

Mentions

396
Peak: 44 in May 2025
across 7 sources since May 2025

Extended reach

690,524
potential audience

Total likes

1,312

Video views

19,497

Mentions per month

May 2025 – Sep 2025

Where it's discussed

  • News286 articles
  • X / Twitter72 posts
  • Blogs22 articles
  • YouTube9 videos
  • Facebook3 posts
  • Reddit3 posts
  • Bluesky1 posts

AI synopsis

What people are saying

Many discussions center around specific details of the study, such as the mention of '2,000 IU of vitamin D3 over four years' and its link to telomere preservation. Phrases like 'may slow biological aging' and 'first large RCT showing' indicate a sense of excitement and seriousness regarding the findings. The language used, including words like 'transformative' and 'potential,' amplifies the perceived importance of the publication.

AgreementStrong agreement

The majority of posts display strong support for the findings, highlighting the benefits of vitamin D3 supplementation.

InterestHigh interest

There is evident curiosity about the implications of the study, especially regarding its potential for healthy aging.

EngagementModerate engagement

Posts generally reflect a moderate level of engagement, with some users referencing specific details of the trial.

ImpactHigh impact

Many users perceive the findings as significant, suggesting a potential shift in dietary recommendations.

Abstract in brief

  • Limited studies indicate potential benefits of vitamin D and omega-3 fatty acids for maintaining telomere length, but large clinical trial evidence is sparse.
  • The VITAL trial investigated the effects of vitamin D3 and omega-3 fatty acids on leukocyte telomere length in a diverse group of participants over five years.
  • Results showed that vitamin D3 supplementation significantly reduced telomere length attrition compared to placebo, while omega-3 supplementation did not have a significant effect.

Top posts

Most liked on X and Bluesky
William A. Wallace, Ph.D.
@drwilliamwallac · X

This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID: 10.1016/j.ajcnut.2025.05.003) from the VITAL randomized controlled trial found that daily supplementation with 2,000 IU of vitamin D3 over four years https://t.co/pW9NoXSmOR

May 23, 2025 · 96 likes · 23 shares · 8,359 followers View post →
Travis Smith, D.O. FAAEM
@RosenelliEM · X

https://t.co/NJhPlFc66r https://t.co/XfGbJ7imKQ

Jun 19, 2025 · 76 likes · 18 shares · 5,107 followers View post →
William A. Wallace, Ph.D.
@drwilliamwallac · X

This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID: 10.1016/j.ajcnut.2025.05.003) from the VITAL randomized controlled trial found that daily supplementation with 2,000 IU of vitamin D3 over four years https://t.co/vaoIF2eHk9

Jun 29, 2025 · 47 likes · 9 shares · 8,359 followers View post →
Cristina Dragani
@CristinaDragani · X

May 22, 2025 · 33 likes · 9 shares · 10,816 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation and Leukocyte Telomere Length: 4-Year Findings from the VITAL Randomized Controlled Trial” by JoAnn Manson et al. American Journal of Clinical Nutrition https://t.co/Tlw6SyMd8e

May 21, 2025 · 10 likes · 2 shares · 505,360 followers View post →
Tom Coughlin
@tecoughlin · X

Reference: https://t.co/MdTt5Vk7nh

Jun 10, 2025 · 4 likes · 4,150 followers View post →

All mentions

Impact of Vitamin D on Telomere Length Over Four Years

A recent substudy of the VITAL trial published in The American Journal of Clinical Nutrition reveals that daily supplementation with 2000 IU of vitamin D3 significantly reduced telomere shortening compared to placebo…

VHFILM · May 30, 2025 215 views
qr4tt.bsky.social
@qr4tt.bsky.social · Bluesky

pubmed.ncbi.nlm.nih.gov/40409468/ news.harvard.edu/gazette/stor...

Sep 29, 2025 · 2 likes View post →
Margo
@recodelongevity · X

Daily vitamin D3 isn’t just for bones – a 2025 study finds it may slow biological aging and potentially keep cells “younger” longer. A very simple step for supporting healthy aging. Source: https://t.co/wdyK7MmnRB

Sep 5, 2025 · 31 followers View post →
Isao Uno(宇野勲)/リハ栄養指導士/栄養嚥下理学療法
@isao_reha_nutri · X

一般中高年者では、ビタミンD3サプリメントを2,000 IU/日の摂取は、白血球テロメア長の減少を抑制する効果があったそうです。 https://t.co/9cbu6SAI7C

Aug 5, 2025 · 1 like · 1,837 followers View post →
Dr NAGA SHASHIKANTH P
@NagaShashikanth · X

RT @DrAkhilX: https://t.co/bK5h9SprcY

Jul 23, 2025 · 1 share · 74 followers View post →
Dr. Akhil
@DrAkhilX · X

https://t.co/bK5h9SprcY

Jul 23, 2025 · 1 share · 38,991 followers View post →
Lino C M
@lcm69e · X

Vitamin D3 and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial. Am J Clin Nutr. (2025). doi:10.1016/j.ajcnut.2025.05.003 https://t.co/mRvnCftNm1

Jul 18, 2025 · 861 followers View post →
Argón
@metilargon · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

Jun 29, 2025 · 9 shares · 350 followers View post →
Dino
@mrblues67 · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

Jun 29, 2025 · 9 shares · 334 followers View post →
Dino
@dino3355 · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

Jun 29, 2025 · 9 shares · 127 followers View post →
⎊RendyAksa⍟
@RendyAksa__ · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

Jun 29, 2025 · 9 shares · 298 followers View post →
Zack
@keychupkicap · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

Jun 29, 2025 · 9 shares · 384 followers View post →
Paul Williams
@PaulWillBirds · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

Jun 29, 2025 · 9 shares · 867 followers View post →
William A. Wallace, Ph.D.
@drwilliamwallac · X

This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID: 10.1016/j.ajcnut.2025.05.003) from the VITAL randomized controlled trial found that daily supplementation with 2,000 IU of vitamin D3 over four years https://t.co/vaoIF2eHk9

Jun 29, 2025 · 47 likes · 9 shares · 8,359 followers View post →
Paulo Farber, MD, PhD.
@paulofarber · X

Zhu H et al. Vitamin D3 and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial. Am J Clin Nutr. 2025 May 21:S0002-9165(25)00255-2. doi: 10.1016/j.ajcnut.2025.05.003. +

Jun 20, 2025 · 335 followers View post →
Alper Aydın (Dietitian )
@aydinnalper · X

RT @RosenelliEM: https://t.co/NJhPlFc66r https://t.co/XfGbJ7imKQ

Jun 19, 2025 · 18 shares · 1,427 followers View post →
Agathokakological
@aaish_muhammad · X

RT @RosenelliEM: https://t.co/NJhPlFc66r https://t.co/XfGbJ7imKQ

Jun 19, 2025 · 18 shares · 57 followers View post →
Dr.Ezhil Mugunthan
@Ezhil_mugunthan · X

RT @RosenelliEM: https://t.co/NJhPlFc66r https://t.co/XfGbJ7imKQ

Jun 19, 2025 · 18 shares · 60 followers View post →
scrummaster
@HimuraBattosaj · X

RT @RosenelliEM: https://t.co/NJhPlFc66r https://t.co/XfGbJ7imKQ

Jun 19, 2025 · 18 shares · 35 followers View post →
José Nelson Suárez
@josensuarez · X

RT @RosenelliEM: https://t.co/NJhPlFc66r https://t.co/XfGbJ7imKQ

Jun 19, 2025 · 18 shares · 504 followers View post →
Sandeep Palakodeti, MD MPH
@DrDeepMD · X

RT @RosenelliEM: https://t.co/NJhPlFc66r https://t.co/XfGbJ7imKQ

Jun 19, 2025 · 18 shares · 4,813 followers View post →
Lorenzo Gutiérrez
@Lojoga · X

RT @RosenelliEM: https://t.co/NJhPlFc66r https://t.co/XfGbJ7imKQ

Jun 19, 2025 · 18 shares · 579 followers View post →
Swaminathan Sendhil
@theswami · X

RT @RosenelliEM: https://t.co/NJhPlFc66r https://t.co/XfGbJ7imKQ

Jun 19, 2025 · 18 shares · 534 followers View post →
suburban radiologist
@dryogi909 · X

@theliverdr sir, please comment https://t.co/yQvBWgmGN4

Jun 19, 2025 · 51 followers View post →
Dracunculus Medinensis
@mediniensis · X

RT @RosenelliEM: https://t.co/NJhPlFc66r https://t.co/XfGbJ7imKQ

Jun 19, 2025 · 18 shares · 19 followers View post →
HumaNxy
@pp_huma · X

RT @RosenelliEM: https://t.co/NJhPlFc66r https://t.co/XfGbJ7imKQ

Jun 19, 2025 · 18 shares · 8,997 followers View post →
Norma Moore
@Mousehole1 · X

RT @RosenelliEM: https://t.co/NJhPlFc66r https://t.co/XfGbJ7imKQ

Jun 19, 2025 · 18 shares · 3,193 followers View post →
(ᓀ‸ᓂ)AF
@astxyzzz · X

RT @RosenelliEM: https://t.co/NJhPlFc66r https://t.co/XfGbJ7imKQ

Jun 19, 2025 · 18 shares · 1,023 followers View post →
Travis Smith, D.O. FAAEM
@RosenelliEM · X

https://t.co/NJhPlFc66r https://t.co/XfGbJ7imKQ

Jun 19, 2025 · 76 likes · 18 shares · 5,107 followers View post →
Tom Coughlin
@tecoughlin · X

Reference: https://t.co/MdTt5Vk7nh

Jun 10, 2025 · 4 likes · 4,150 followers View post →
籠入猫
@trashcantiglets · X

RT @PonNutr: Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation and Leukocyte Telomere Length: 4-Year Findings from the VITAL Random…

May 31, 2025 · 1 share · 498 followers View post →
Pon|食と健康
@PonNutr · X

Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation and Leukocyte Telomere Length: 4-Year Findings from the VITAL Randomized Controlled Trial. The American journal of clinical nutrition, S0002-9165(25)00255-2. https://t.co/56Wif3v59P

May 31, 2025 · 4 likes · 1 share · 2,614 followers View post →
John Siracusa
@john_siracusa · X

RT @CristinaDragani:

May 28, 2025 · 9 shares · 19,746 followers View post →
Beth S. Sanford, DNP
@DNP4VitaminD · X

@BrandonLuuMD I would add sun exposure and robust vitamin D serum concentrations to your list—https://t.co/c4jcESmPFe

May 28, 2025 · 1 like · 200 followers View post →
th1976
@th_1976 · X

Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation and Leukocyte Telomere Length: 4-Year Findings from the V… https://t.co/BFo0yvKIuQ

May 27, 2025 · 22 followers View post →
CHSeaton
@COSseaton · X

RT @CristinaDragani:

May 27, 2025 · 9 shares · 5,924 followers View post →
Weldon
@Rocker75W · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

May 25, 2025 · 23 shares · 330 followers View post →
Robert Sapolsky's Burner
@sapolskysburner · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

May 24, 2025 · 23 shares · 901 followers View post →
Luis Eduardo Celi C.
@luchitoceli · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

May 24, 2025 · 23 shares · 162 followers View post →
Kwame
@Mixx92 · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

May 24, 2025 · 23 shares · 191 followers View post →
Kocour
@Rehbergus · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

May 24, 2025 · 23 shares · 1,882 followers View post →
z Boží vůle frajer
@JiriBogdan · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

May 24, 2025 · 23 shares · 1,603 followers View post →
Dino
@dino3355 · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

May 24, 2025 · 23 shares · 127 followers View post →
Mind Your Science!
@MindYourSci · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

May 24, 2025 · 23 shares · 133 followers View post →
Pattibe
@pattiber1 · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

May 24, 2025 · 23 shares · 768 followers View post →
Johnatan Braz
@BrazJohnatan · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

May 24, 2025 · 23 shares · 28 followers View post →
panchanok
@lYCKrRWxCkzuP3a · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

May 24, 2025 · 23 shares · 32 followers View post →
علي الجهر المعاوي
@ocnhjM9nhcWnTYI · X

فيتامين د3 قد يساعد في الحفاظ على علامات الشيخوخة البيولوجية الأبحاث الحديثة (PMID: 10.1016/j.ajcnut.2025.05.003) من تجربة VITAL العشوائية الخاضعة للرقابة أن تناول مكملات يومية تحتوي على 2000 وحدة دولية من فيتامين D3 على مدى أربع سنوات أدى إلى إبطاء التيلومير في الكريات البيضاء https://t.co/MESUJsGRHc

May 24, 2025 · 1 like · 3,079 followers View post →
emonda70
@KMEmonda · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

May 24, 2025 · 23 shares · 3,051 followers View post →
Kejt
@katpaw97 · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

May 24, 2025 · 23 shares · 51 followers View post →
Marc Vilanova Marsà
@mvilanova87 · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

May 24, 2025 · 23 shares · 890 followers View post →
サイエンスあれこれ
@sarekore · X

約3年分の老化を予防しました。オメガ3脂肪酸サプリメントは、追跡期間を通じてテロメア長に有意な影響を与えませんでした。https://t.co/t5LDkX5CZt

May 24, 2025 · 922 followers View post →
Yourcryptofriend
@ucryptofrnd · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

May 24, 2025 · 23 shares · 235 followers View post →
Tom Englezos
@tomenglezos · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

May 24, 2025 · 23 shares · 1,261 followers View post →
Dr. Ibtisam (Ibby)
@ibtisam_ibby · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

May 24, 2025 · 23 shares · 264 followers View post →
Danilo Amorim
@danilonutripers · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

May 23, 2025 · 23 shares · 101 followers View post →
Lauren Jacobsen
@formulabylauren · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

May 23, 2025 · 23 shares · 5,769 followers View post →
Taylor Thompson
@TJThomps · X

Long live long telomeres!

May 23, 2025 · 3 likes · 255 followers View post →
Diana
@Diana79929170 · X

RT @drwilliamwallac: This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID…

May 23, 2025 · 23 shares · 856 followers View post →
William A. Wallace, Ph.D.
@drwilliamwallac · X

This is the first large RCT showing that vitamin D3 may help preserve biological aging markers. Recent research (PMID: 10.1016/j.ajcnut.2025.05.003) from the VITAL randomized controlled trial found that daily supplementation with 2,000 IU of vitamin D3 over four years https://t.co/pW9NoXSmOR

May 23, 2025 · 96 likes · 23 shares · 8,359 followers View post →
Cure Naturally LLC
@CureNaturally · X

RT @CristinaDragani:

May 23, 2025 · 9 shares · 1,021 followers View post →
Orlando Uguzzoni
@o_uguzzoni · X

RT @CristinaDragani:

May 23, 2025 · 9 shares · 383 followers View post →
Steven Mathern
@StevenMathern · X

delay telomere shortening, affecting biological age, vitamin d3 and omega 3 fatty acids . weird if true . https://t.co/Us2ilTlxNM https://t.co/DwTCCAD6Ex

May 22, 2025 · 455 followers View post →
Marco
@gatasch · X

RT @CristinaDragani:

May 22, 2025 · 9 shares · 1,188 followers View post →
It was never ‘bout a virus
@donotcomply70 · X

RT @CristinaDragani:

May 22, 2025 · 9 shares · 1,050 followers View post →
erdem direniştedir
@SimonLite · X

RT @CristinaDragani:

May 22, 2025 · 9 shares · 1,247 followers View post →
John Greene
@Greene_Thoughts · X

RT @CristinaDragani:

May 22, 2025 · 9 shares · 1,669 followers View post →
Cristina Dragani
@CristinaDragani · X

May 22, 2025 · 33 likes · 9 shares · 10,816 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

Vitamin D supplements may help prevent the loss of #telomeres and cell #aging, but fish oil had no significant effect, a large 4-year study shows. "4-years of supplementation with 2000 IU/day vitamin D3 reduced telomere attrition by 140 bp," https://t.co/HBbWNfLVSQ https://t.co/v063wW9Ujl

May 22, 2025 · 691 followers View post →
John Greene
@Greene_Thoughts · X

RT @NeuroscienceNew: “Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation and Leukocyte Telomere Length: 4-Year Findings from the VIT…

May 21, 2025 · 2 shares · 1,669 followers View post →
Jon Snow
@IqraAliPsy · X

RT @NeuroscienceNew: “Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation and Leukocyte Telomere Length: 4-Year Findings from the VIT…

May 21, 2025 · 2 shares · 89 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation and Leukocyte Telomere Length: 4-Year Findings from the VITAL Randomized Controlled Trial” by JoAnn Manson et al. American Journal of Clinical Nutrition https://t.co/Tlw6SyMd8e

May 21, 2025 · 10 likes · 2 shares · 505,360 followers View post →