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Aging Cell August 2025 PMID 40424097

Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange.

Matias Fuentealba, Dobri Kiprov, Kevin Schneider, Wei-Chieh Mu, Prasanna Ashok Kumaar, Herbert Kasler, Jordan B Burton, Mark Watson, Heather Halaweh, Christina D King, Zehra Stara Yüksel, Chelo Roska-Pamaong, Birgit Schilling, Eric Verdin, David Furman

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Mentions

101
Peak: 28 in Jun 2025
across 6 sources since Aug 2024

Extended reach

737,839
potential audience

Total likes

246

Video views

1,016

Mentions per month

Aug 2024 – Sep 2025

Where it's discussed

  • X / Twitter50 posts
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  • Blogs6 articles
  • Bluesky3 posts
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  • Facebook2 posts

AI synopsis

What people are saying

Several discussions highlight specific findings, such as how therapeutic plasma exchange (TPE) therapy can reduce biological age by an average of 2.61 years and its potential to remove harmful substances associated with aging. Phrases like 'breakthrough results' and 'game changer' reflect the tone of excitement and urgency among participants, emphasizing the transformative potential of these findings on health and wellness.

AgreementModerate agreement

The majority of discussions present a positive response to the findings, leaning towards agreement with the benefits noted in the publication.

InterestHigh interest

A significant number of posts express enthusiasm and curiosity about the implications of the research for aging and health.

EngagementHigh engagement

Many posts not only reference the publication but delve into specific details about the study, indicating a strong engagement with the content.

ImpactHigh impact

Posts suggest that the findings are seen as having a significant influence on future research and potential therapeutic approaches.

Abstract in brief

  • A randomized, placebo-controlled trial investigated the safety and biological age effects of various therapeutic plasma exchange (TPE) regimens in healthy adults over 50, with bi-weekly TPE and IVIG showing promising results.
  • Participants saw improvements in biological age markers, specifically 15 epigenetic clocks showed rejuvenation compared to placebo, signifying potential age-reversal benefits.
  • The study highlights TPE-IVIG as the most effective regimen, reversing age-related immune decline and indicating that initial health status may predict positive outcomes, making it the first multi-omics research of its kind.
Read the full abstract

Top posts

Most liked on X and Bluesky
Aging Science News
@AgingBiology · X

Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange https://t.co/JZmoqs56sN

Jun 1, 2025 · 52 likes · 12 shares · 30,998 followers View post →
Aging Science News
@AgingBiology · X

Multi-omics Analysis Reveals Biomarkers that Contribute to Biological Age Rejuvenation in Response to Therapeutic Plasma Exchange https://t.co/njHQoEKmmv

Aug 12, 2024 · 35 likes · 10 shares · 30,998 followers View post →
Agingdoc
@agingdoc1 · X

Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange https://t.co/FM7wgRMqcA

Jun 6, 2025 · 8 likes · 42,377 followers View post →
Agingdoc
@agingdoc1 · X

Multi-omics Analysis Reveals Biomarkers that Contribute to Biological Age Rejuvenation in Response to Therapeutic Plasma Exchange Matias Fuentealba @birgits61642917 @EricVerdin

Aug 12, 2024 · 3 likes · 42,377 followers View post →
エイジング若手研究者連盟-SAKRA-
@SAKRA_Aging · X

血漿交換によるエピジェネティック時計の若返りの検証 50歳以上の健康の成人を対象とした、無作為化プラセボ対照試験を実施したところ、血漿交換は15のエピジェネティック時計の若返りを示唆する結果となった。 https://t.co/SBIQGSznFp

Jun 4, 2025 · 3 likes · 158 followers View post →
Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)
@biogerontology · X

https://t.co/YAxehLTGef

Jun 3, 2025 · 2 likes · 2 shares · 32,495 followers View post →

All mentions

Brad Younggren
@Younggren · X

@AcebedoErichMD @liveliferevive https://t.co/dmRbxg56GS

Sep 10, 2025 · 926 followers View post →
Brad Younggren
@Younggren · X

@liveliferevive https://t.co/dmRbxg56GS

Sep 10, 2025 · 926 followers View post →
Longevity Decoded
@Longevity0S · X

Buck Institute just published breakthrough results: 44 adults over 50 got plasma exchange therapy

Aug 22, 2025 · 1 like · 207 followers View post →
Diego
@ucedilla · X

8/ Fuente original: https://t.co/iuo8OFlNmY

Aug 17, 2025 · 509 followers View post →
Mike Petegorsky
@mikeroplastics · X

5/ What’s the upside? TPE can remove inflammatory mediators, cholesterol, senescent proteins, and other molecules that cause aging and disease. TPE has even been shown to slow down your biological clock! https://t.co/Lv9PzuXDBB https://t.co/icWtgx8E9T

Jul 29, 2025 · 292 followers View post →
Mike Petegorsky
@mikeroplastics · X

5/ What’s the upside? TPE can remove inflammatory mediators, cholesterol, senescent proteins, and other molecules that cause aging and disease. TPE has even been shown to slow down your biological clock! https://t.co/Lv9PzuXDBB https://t.co/jEz5y3t2GI

Jul 29, 2025 · 292 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @gglinskii: Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomi…

Jul 8, 2025 · 1 share · 575 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange. https://t.co/z0OLetwYEl

Jul 7, 2025 · 1 share · 2,062 followers View post →
Francisco Garcia
@Guardian_PPA · X

Multi‐Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single‐Blinded Randomized Placebo‐Controlled Therapeutic Plasma Exchange - Fuentealba - Aging Cell - Wiley Online Library https://t.co/kXuGp6qJtD

Jun 27, 2025 · 1 like · 3 followers View post →
Hotte
@hottekoeln.bsky.social · Bluesky

Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange onlinelibrary.wiley.com/doi/10.1111/...

Jun 25, 2025 View post →
manuel macia heras
@mmacia25 · X

Multi‐Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single‐Blinded Randomized Placebo‐Controlled Therapeutic Plasma Exchange - Fuentealba - Aging Cell - Wiley Online Library https://t.co/L17R4M1YZ6

Jun 25, 2025 · 2 likes · 823 followers View post →
Raghav "RV" Sehgal
@rv_sehgal · X

Can plasma exchange slow aging at the cellular level? Yes, especially when combined with IVIG.

Jun 19, 2025 · 2 likes · 582 followers View post →
Dr. Willie Girald-Rosa
@DrGirald_Rosa · X

https://t.co/ym8LYN9bHV

Jun 10, 2025 · 155 followers View post →
101stmonk3y ◼️
@101stmonk3y · X

Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange https://t.co/v5ehQ0DwoM

Jun 9, 2025 · 1 like · 947 followers View post →
Carl Lumma
@clumma · X

2025 May Biological Age Rejuvenation in Response to TPE https://t.co/xJGMp5KdOr

Jun 8, 2025 · 516 followers View post →
Agingdoc
@agingdoc1 · X

Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange https://t.co/FM7wgRMqcA

Jun 6, 2025 · 8 likes · 42,377 followers View post →
John Greene
@Greene_Thoughts · X

RT @biogerontology: https://t.co/YAxehLTGef

Jun 5, 2025 · 2 shares · 1,709 followers View post →
AlfredoPietracatella
@alfredopietraca · X

RT @biogerontology: https://t.co/YAxehLTGef

Jun 5, 2025 · 2 shares · 241 followers View post →
Orlando_uy
@Orlando_uy · X

This is the first multi-omics study to examine various therapeutic plasma exchange modalities to slow epigenetic biologic clocks, which demonstrate biological age rejuvenation and the molecular features associated with this rejuvenation. https://t.co/1xPuM8cmow

Jun 4, 2025 · 695 followers View post →
エイジング若手研究者連盟-SAKRA-
@SAKRA_Aging · X

血漿交換によるエピジェネティック時計の若返りの検証 50歳以上の健康の成人を対象とした、無作為化プラセボ対照試験を実施したところ、血漿交換は15のエピジェネティック時計の若返りを示唆する結果となった。 https://t.co/SBIQGSznFp

Jun 4, 2025 · 3 likes · 158 followers View post →
Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)
@biogerontology · X

https://t.co/YAxehLTGef

Jun 3, 2025 · 2 likes · 2 shares · 32,495 followers View post →
Ronnie Cutler
@cutleraging · X

RT @AgingBiology: Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Ra…

Jun 3, 2025 · 12 shares · 462 followers View post →
Lt. Ice Eagle #USARMY
@PsyopLogician · X

RT @AgingBiology: Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Ra…

Jun 2, 2025 · 12 shares · 6,646 followers View post →
Alfred Morales
@GodTemur · X

RT @AgingBiology: Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Ra…

Jun 2, 2025 · 12 shares · 37 followers View post →
Anirbanius Mitros
@anirbanius · X

RT @AgingBiology: Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Ra…

Jun 1, 2025 · 12 shares · 171 followers View post →
Longevity
@LongevityTao · X

Multi‐Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single‐Blinded Randomized Placebo‐Controlled Therapeutic Plasma Exchange - Fuentealba - Aging Cell - Wiley Online Library https://t.co/nujctDoG78

Jun 1, 2025 · 331 followers View post →
Rene Sugar
@renesugar · X

RT @AgingBiology: Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Ra…

Jun 1, 2025 · 12 shares · 3,973 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @AgingBiology: Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Ra…

Jun 1, 2025 · 12 shares · 200 followers View post →
friendly ghost
@ghostobs3126991 · X

RT @AgingBiology: Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Ra…

Jun 1, 2025 · 12 shares · 179 followers View post →
Lisa Vlad
@LisaVlad2 · X

RT @AgingBiology: Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Ra…

Jun 1, 2025 · 12 shares · 105 followers View post →
The Longevist
@Dr_coachbear · X

RT @AgingBiology: Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Ra…

Jun 1, 2025 · 12 shares · 508,654 followers View post →
Frank Paul Mora
@InTime_49 · X

RT @AgingBiology: Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Ra…

Jun 1, 2025 · 12 shares · 413 followers View post →
備忘録
@bibourokuabc · X

RT @AgingBiology: Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Ra…

Jun 1, 2025 · 12 shares · 227 followers View post →
Aging Science News
@agingbiology.bsky.social · Bluesky

Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange onlinelibrary.wiley.com/doi/full/10....

Jun 1, 2025 View post →
Aging Science News
@AgingBiology · X

Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange https://t.co/JZmoqs56sN

Jun 1, 2025 · 52 likes · 12 shares · 30,998 followers View post →
Canadian Longevity Association
@canlongevity · X

3/3 https://t.co/l2HnQGc6dm

May 30, 2025 · 121 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

The first interventional multi-omics study to examine the effectiveness of therapeutic plasma exchange modalities: Patients with TPE-IVIG treatment showed an average biological age reduction of 2.61 years By Eric Verdin, David Furman... @BuckInstitute https://t.co/7Nm3MJmyGd https://t.co/cpkosvASmQ

May 29, 2025 · 1 like · 738 followers View post →
Hannah Went
@EverythingEpi · X

Sep 1, 2024 · 2 likes · 555 followers View post →
André Katayama Yamada
@KatayamaYamada · X

RT @AgingBiology: Multi-omics Analysis Reveals Biomarkers that Contribute to Biological Age Rejuvenation in Response to Therapeutic Plasm…

Aug 12, 2024 · 10 shares · 402 followers View post →
Ronnie Cutler
@cutleraging · X

RT @AgingBiology: Multi-omics Analysis Reveals Biomarkers that Contribute to Biological Age Rejuvenation in Response to Therapeutic Plasm…

Aug 12, 2024 · 10 shares · 462 followers View post →
kipling_r
@kipling___r · X

RT @AgingBiology: Multi-omics Analysis Reveals Biomarkers that Contribute to Biological Age Rejuvenation in Response to Therapeutic Plasm…

Aug 12, 2024 · 10 shares · 113 followers View post →
Agingdoc
@agingdoc1 · X

Multi-omics Analysis Reveals Biomarkers that Contribute to Biological Age Rejuvenation in Response to Therapeutic Plasma Exchange Matias Fuentealba @birgits61642917 @EricVerdin

Aug 12, 2024 · 3 likes · 42,377 followers View post →
nike
@wot_mikey · X

RT @AgingBiology: Multi-omics Analysis Reveals Biomarkers that Contribute to Biological Age Rejuvenation in Response to Therapeutic Plasm…

Aug 12, 2024 · 10 shares · 510 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @AgingBiology: Multi-omics Analysis Reveals Biomarkers that Contribute to Biological Age Rejuvenation in Response to Therapeutic Plasm…

Aug 12, 2024 · 10 shares · 575 followers View post →
qicy
@qicy11 · X

RT @AgingBiology: Multi-omics Analysis Reveals Biomarkers that Contribute to Biological Age Rejuvenation in Response to Therapeutic Plasm…

Aug 12, 2024 · 10 shares · 382 followers View post →
Charles Jourdan Reyes, Ph.D.
@reyes_jourdan · X

RT @AgingBiology: Multi-omics Analysis Reveals Biomarkers that Contribute to Biological Age Rejuvenation in Response to Therapeutic Plasm…

Aug 12, 2024 · 10 shares · 625 followers View post →
Fay
@fay90028966 · X

RT @AgingBiology: Multi-omics Analysis Reveals Biomarkers that Contribute to Biological Age Rejuvenation in Response to Therapeutic Plasm…

Aug 12, 2024 · 10 shares · 142 followers View post →
Nacho
@nachirulo21 · X

RT @AgingBiology: Multi-omics Analysis Reveals Biomarkers that Contribute to Biological Age Rejuvenation in Response to Therapeutic Plasm…

Aug 12, 2024 · 10 shares · 430 followers View post →
Laurie Green
@LaurieGreen36 · X

RT @AgingBiology: Multi-omics Analysis Reveals Biomarkers that Contribute to Biological Age Rejuvenation in Response to Therapeutic Plasm…

Aug 12, 2024 · 10 shares · 1,170 followers View post →
Aging Science News
@AgingBiology · X

Multi-omics Analysis Reveals Biomarkers that Contribute to Biological Age Rejuvenation in Response to Therapeutic Plasma Exchange https://t.co/njHQoEKmmv

Aug 12, 2024 · 35 likes · 10 shares · 30,998 followers View post →
SciencesNetwork
@SciencesNetwork · X

Multi-omics Analysis Reveals Biomarkers that Contribute to Biological Age Rejuvenation in Response to Therapeutic Plasma Exchange https://t.co/UZXQtWTU5j

Aug 8, 2024 · 354 followers View post →
medRxivpreprint
@medrxivpreprint.bsky.social · Bluesky

Multi-omics Analysis Reveals Biomarkers that Contribute to Biological Age Rejuvenation in Response to Therapeutic Plasma Exchange https://www.medrxiv.org/content/10.1101/2024.08.02.24310303v1

Aug 8, 2024 View post →
medRxiv
@medrxivpreprint · X

Multi-omics Analysis Reveals Biomarkers that Contribute to Biological Age Rejuvenation in Response to Therapeutic Plasma Exchange https://t.co/fPGFIWy2ao #medRxiv

Aug 8, 2024 · 17,460 followers View post →