Nat Aging July 2025 PMID 40437307

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan.

Lisonia Gkioni, Tobias Nespital, Maarouf Baghdadi, Carolina Monzó, Jitin Bali, Taim Nassr, Anna Lena Cremer, Andreas Beyer, Joris Deelen, Heiko Backes, Sebastian Grönke, Linda Partridge

Mentions

177
Peak: 37 in May 2025
across 7 sources since May 2025

Extended reach

419,359
potential audience

Total likes

214

Video views

507

Mentions per month

May 2025 – Oct 2025

Where it's discussed

  • News78 articles
  • X / Twitter75 posts
  • Blogs9 articles
  • Bluesky7 posts
  • Facebook3 posts
  • Reddit3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone conveys strong support and fascination, exemplified by comments like 'New 30% mouse lifespan extension paper just dropped!' and references to the additive effects of the drugs. Words such as 'stronger effects,' 'significant lifespan extension,' and 'breakdown of the paper' reflect high engagement and perceived impact, indicating that these discussions recognize the research as a potentially transformative step in aging science.

AgreementStrong agreement

Most discussions strongly support the study’s findings, emphasizing the significance of combining these drugs for lifespan extension.

InterestModerate interest

Interest is moderate, with many posts showing curiosity and excitement about the research, but some focus mainly on reporting rather than deep analysis.

EngagementModerate engagement

Posts tend to mention the methodology and implications, indicating an active engagement, though mostly in sharing and summarizing information.

ImpactHigh impact

Participants believe this research could have high influence on anti-aging strategies, as reflected in phrases like 'game changer' and mentions of significant lifespan increases.

Top posts

Most liked on X and Bluesky
Aging Science News
@AgingBiology · X

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/J65NACABn4

May 30, 2025 · 73 likes · 18 shares · 30,998 followers View post →
Ruslan Rust
@rust_ruslan · X

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging https://t.co/bTnipBAwhv

Jun 2, 2025 · 26 likes · 1 share · 2,132 followers View post →
Gilles Gouspillou
@GGouspillou · X

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging https://t.co/RKt2DDkm5A

Jun 1, 2025 · 19 likes · 9 shares · 1,853 followers View post →
Agingdoc
@agingdoc1 · X

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/Ko5j6IiYgy https://t.co/0gWL9AY0Cl

Jun 6, 2025 · 16 likes · 4 shares · 42,377 followers View post →
OpenRead
@OpenRead_HQ · X

@kimmonismus Breakdown of the paper behind it: Title: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan The study is about how certain tiny things inside living things, like animals, work together to help them grow and stay healthy. When https://t.co/jpsVnomb69

May 29, 2025 · 13 likes · 4 shares · 2,147 followers View post →
Longevity
@LongevityTao · X

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging https://t.co/RYbp0sbfUb

May 28, 2025 · 11 likes · 3 shares · 331 followers View post →

All mentions

darkmodebiohacking
@darkmodebio · X

Rapamycin was discovered in dirt from Easter Island. It ended up being one of the most reliable lifespan-extending drugs in mammals, by literally slowing down aging. What we know (and don’t know) about rapamycin → https://t.co/m0xC90JB99 https://t.co/zcgXfyYdke

Oct 29, 2025 · 82 followers View post →
Aubrai
@Aubrai_ · X

@rajikousik awda(https://t.co/YagfuGT8Oy)

Oct 28, 2025 · 1 like · 10,650 followers View post →
Aubrai
@Aubrai_ · X

@rajikousik awdal

Oct 28, 2025 · 10,650 followers View post →
Aubrai
@Aubrai_ · X

@rajikousik

Oct 28, 2025 · 10,650 followers View post →
Aubrai
@Aubrai_ · X

@rajikousik

Oct 28, 2025 · 10,650 followers View post →
Aubrai
@Aubrai_ · X

@rajikousik

Oct 27, 2025 · 10,650 followers View post →
Aubrai
@Aubrai_ · X

@rajikousik

Oct 27, 2025 · 10,650 followers View post →
Alex Feigl
@alexjfeigl · X

@dicortona Rapamycin + Trametinib extended mouse lifespans by ~30% https://t.co/LtMyi2q3K1 70% of AI-identified anti-aging drugs significantly extended microscopic worm lifespans https://t.co/aiC02r7tSV

Aug 26, 2025 · 1 like · 1,156 followers View post →
Jacques Touchon
@jacques_touchon · X

RT @brunovellas: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging http…

Jul 11, 2025 · 2 shares · 660 followers View post →
Geroscience Pre-Clinical and Clinical Trials
@GeroscienceCT · X

RT @brunovellas: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging http…

Jul 11, 2025 · 2 shares · 532 followers View post →
Bruno Vellas
@brunovellas · X

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging https://t.co/1k2PFUKCNL

Jul 10, 2025 · 1 like · 2 shares · 2,559 followers View post →
Nsprdwmn
@BrinkleyJu35643 · X

RT @LongevityTao: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging htt…

Jul 10, 2025 · 3 shares · 1,020 followers View post →
CTAD
@CTADconference · X

RT @INSPIREPlatfor1: A combination of treatment in "The geroprotectors trametinib and rapamycin combine additively to extend mouse healthsp…

Jul 10, 2025 · 1 share · 3,236 followers View post →
INSPIRE Platform - IHU HealthAge
@INSPIREPlatfor1 · X

A combination of treatment in "The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan." https://t.co/THFmKFCAgA @brunovellas @InfinityTLS @I2mcT @RollandYves2

Jul 8, 2025 · 1 like · 1 share · 674 followers View post →
EARA Polska
@EARA_PL · X

RT @animalresearch: The combination of two drugs, rapamycin and trametinib, currently used in cancer therapy extended the #lifespan of #mic…

Jun 9, 2025 · 4 shares · 187 followers View post →
Pon|食と健康
@PonNutr · X

相乗効果ではなく、相加効果でしたが、薬を組み合わせて投与すると、メカニズムが重複している場合には負の交互作用が認められることも多いので、それぞれの効果を邪魔することなく機能しているというのは実は珍しいのでは?と思っています https://t.co/L9fu1exrf6

Jun 7, 2025 · 5 likes · 2,749 followers View post →
EARA Eesti
@eara_ee · X

RT @animalresearch: The combination of two drugs, rapamycin and trametinib, currently used in cancer therapy extended the #lifespan of #mic…

Jun 6, 2025 · 4 shares · 173 followers View post →
EARA Česká republika
@EARA_CZ · X

RT @animalresearch: The combination of two drugs, rapamycin and trametinib, currently used in cancer therapy extended the #lifespan of #mic…

Jun 6, 2025 · 4 shares · 220 followers View post →
Understanding Animal Research
@animalresearch · X

The combination of two drugs, rapamycin and trametinib, currently used in cancer therapy extended the #lifespan of #mice by 30% in a study published in Nature Aging. #AnimalResearch #AnimalTesting https://t.co/HqsDe06Mg7 https://t.co/Ju3ZMZMJkB

Jun 6, 2025 · 6 likes · 4 shares · 8,037 followers View post →
Amy Lamotte
@amylamotte88 · X

RT @agingdoc1: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/Ko5j6Ii…

Jun 6, 2025 · 4 shares · 256 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @agingdoc1: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/Ko5j6Ii…

Jun 6, 2025 · 4 shares · 32,581 followers View post →
Mark Patterson
@MarkGPatterson · X

RT @agingdoc1: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/Ko5j6Ii…

Jun 6, 2025 · 4 shares · 3,373 followers View post →
Well Done
@welldone00 · X

RT @agingdoc1: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/Ko5j6Ii…

Jun 6, 2025 · 4 shares · 1,065 followers View post →
Agingdoc
@agingdoc1 · X

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/Ko5j6IiYgy https://t.co/0gWL9AY0Cl

Jun 6, 2025 · 16 likes · 4 shares · 42,377 followers View post →
Dimon Lers
@Dimon_Lers · X

RT @OpenRead_HQ: @kimmonismus Breakdown of the paper behind it: Title: The geroprotectors trametinib and rapamycin combine additively to e…

Jun 3, 2025 · 4 shares · 848 followers View post →
Ben-Sahra Lab
@bensahralab · X

RT @GGouspillou: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging http…

Jun 2, 2025 · 9 shares · 2,586 followers View post →
Joe Gordon
@josephwgordon · X

RT @GGouspillou: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging http…

Jun 2, 2025 · 9 shares · 2,110 followers View post →
Chris Carter
@fintechcyb · X

RT @rust_ruslan: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging http…

Jun 2, 2025 · 1 share · 21 followers View post →
Ruslan Rust
@rust_ruslan · X

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging https://t.co/bTnipBAwhv

Jun 2, 2025 · 26 likes · 1 share · 2,132 followers View post →
Ivana Bjedov
@Ivana75154822 · X

RT @AgingBiology: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/J65NA…

Jun 1, 2025 · 18 shares · 324 followers View post →
Agingdoc
@agingdoc1 · X

RT @agingdoc1: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan [ Finalized, in prin…

Jun 1, 2025 · 1 share · 42,377 followers View post →
Agingdoc
@agingdoc1 · X

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan [ Finalized, in print ]

Jun 1, 2025 · 5 likes · 1 share · 42,377 followers View post →
Matías Monsalves-Álvarez
@profemonsalves · X

RT @GGouspillou: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging http…

Jun 1, 2025 · 9 shares · 1,501 followers View post →
Shima Taherkhani
@ShimaTaherkhani · X

RT @GGouspillou: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging http…

Jun 1, 2025 · 9 shares · 353 followers View post →
André Katayama Yamada
@KatayamaYamada · X

RT @GGouspillou: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging http…

Jun 1, 2025 · 9 shares · 402 followers View post →
Alex Hruska
@alex_hruska · X

RT @weldeiry: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/zqxPt4YG…

Jun 1, 2025 · 2 shares · 287 followers View post →
Vincent Marcangeli
@VMarcangeli · X

RT @GGouspillou: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging http…

Jun 1, 2025 · 9 shares · 270 followers View post →
tsutaki.a
@ATsutaki2011 · X

RT @GGouspillou: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging http…

Jun 1, 2025 · 9 shares · 8 followers View post →
Dana Parish
@danaparish · X

RT @weldeiry: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/zqxPt4YG…

Jun 1, 2025 · 2 shares · 41,226 followers View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry.bsky.social · Bluesky

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan www.nature.com/articles/s43...

Jun 1, 2025 View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/zqxPt4YGf2

Jun 1, 2025 · 10 likes · 2 shares · 18,503 followers View post →
Edward Robinson
@edwardlabs · X

RT @AgingBiology: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/J65NA…

Jun 1, 2025 · 18 shares · 32 followers View post →
ラーマべとサカナ
@marewoaisu · X

RP メラノーマ治療薬のトラメチニブとラパマイシンかぁ。 ラパマイシン面白いな。 The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/d4C0xOItIC

Jun 1, 2025 · 71 followers View post →
Cefis Marina
@CefisM · X

RT @GGouspillou: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging http…

Jun 1, 2025 · 9 shares · 20 followers View post →
Gilles Gouspillou
@GGouspillou · X

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging https://t.co/RKt2DDkm5A

Jun 1, 2025 · 19 likes · 9 shares · 1,853 followers View post →
tsutaki.a
@ATsutaki2011 · X

RT @HornbergerLab: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/NbBA…

May 31, 2025 · 1 share · 8 followers View post →
Olivia lewis
@LewisOlivi78695 · X

RT @AgingBiology: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/J65NA…

May 31, 2025 · 18 shares · 23 followers View post →
Elmira Khabusheva
@sciencyelmira · X

RT @AgingBiology: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/J65NA…

May 31, 2025 · 18 shares · 749 followers View post →
iArmandoVBaneado
@iArmandoVBanned · X

RT @AgingBiology: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/J65NA…

May 31, 2025 · 18 shares · 69 followers View post →
Jessica Lancaster
@jnlancast · X

RT @AgingBiology: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/J65NA…

May 31, 2025 · 18 shares · 673 followers View post →
The Hornberger Lab
@HornbergerLab · X

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/NbBAN1GnJV

May 31, 2025 · 6 likes · 1 share · 2,399 followers View post →
Boris Carikeo
@BCarikeo · X

RT @AgingBiology: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/J65NA…

May 31, 2025 · 18 shares · 686 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @AgingBiology: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/J65NA…

May 31, 2025 · 18 shares · 200 followers View post →
Jay Patrick
@JoeKilpatrick15 · X

RT @AgingBiology: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/J65NA…

May 31, 2025 · 18 shares · 5,797 followers View post →
Fox
@FoxRiverC · X

RT @AgingBiology: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/J65NA…

May 31, 2025 · 18 shares · 715 followers View post →
Jorge I. Castillo-Quan, MD, PhD
@CastilloQuan_JI · X

RT @AgingBiology: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/J65NA…

May 30, 2025 · 18 shares · 2,053 followers View post →
Lt. Ice Eagle #USARMY
@PsyopLogician · X

RT @AgingBiology: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/J65NA…

May 30, 2025 · 18 shares · 6,646 followers View post →
CraftmeatI
@CraftmeatI · X

RT @AgingBiology: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/J65NA…

May 30, 2025 · 18 shares · 987 followers View post →
Eduardo Silva-Pavez
@EduSilvaPavez · X

RT @AgingBiology: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/J65NA…

May 30, 2025 · 18 shares · 134 followers View post →
Matias Hartman
@HartmanMatias_ · X

RT @AgingBiology: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/J65NA…

May 30, 2025 · 18 shares · 574 followers View post →
Julian Mutz
@julianmutz · X

RT @AgingBiology: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/J65NA…

May 30, 2025 · 18 shares · 518 followers View post →
VTV
@HabaneroDiabloC · X

RT @AgingBiology: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/J65NA…

May 30, 2025 · 18 shares · 387 followers View post →
Aging Science News
@AgingBiology · X

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/J65NACABn4

May 30, 2025 · 73 likes · 18 shares · 30,998 followers View post →
Aging Science News
@agingbiology.bsky.social · Bluesky

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan www.nature.com/articles/s43...

May 30, 2025 · 1 like · 1 share View post →
Andrew Steele
@statto.bsky.social · Bluesky

New 30% mouse lifespan extension paper just dropped!

May 30, 2025 · 8 likes · 8 shares View post →
Hotte
@Hotte11184211 · X

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/sthoM5dMFz

May 29, 2025 · 47 followers View post →
Hotte
@hottekoeln.bsky.social · Bluesky

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan www.nature.com/articles/s43...

May 29, 2025 View post →
Scott Amyx
@ScottSAmyx · X

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/V4B2GCiDx5

May 29, 2025 · 24,177 followers View post →
Scott Amyx
@scottamyx.bsky.social · Bluesky

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan www.nature.com/articles/s43...

May 29, 2025 View post →
Science_updates
@Scienceupdates6 · X

https://t.co/AGIa6y67gG https://t.co/7984bThMgf

May 29, 2025 · 14 followers View post →
Zoe Wang
@zoewangai · X

RT @OpenRead_HQ: @kimmonismus Breakdown of the paper behind it: Title: The geroprotectors trametinib and rapamycin combine additively to e…

May 29, 2025 · 4 shares · 1,459 followers View post →
BensenHsu
@BensenHsu · X

RT @OpenRead_HQ: @kimmonismus Breakdown of the paper behind it: Title: The geroprotectors trametinib and rapamycin combine additively to e…

May 29, 2025 · 4 shares · 3,160 followers View post →
OpenRead
@OpenRead_HQ · X

@kimmonismus Breakdown of the paper behind it: Title: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan The study is about how certain tiny things inside living things, like animals, work together to help them grow and stay healthy. When https://t.co/jpsVnomb69

May 29, 2025 · 13 likes · 4 shares · 2,147 followers View post →
Dan Jagger
@auditorynerves.bsky.social · Bluesky

Link to open access

May 29, 2025 · 2 likes · 2 shares View post →
Sun5
@55Sun5 · X

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/YQXnsuGJbo

May 29, 2025 · 295 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

The geroprotectors #trametinib and #rapamycin combine additively to extend mouse #healthspan and #lifespan. It has stronger effects than either drug alone in both female and male mice. By Lisonia Gkioni, Sebastian Grönke, Linda Partridge,et al. @MPIAGE https://t.co/uuapIVVXy2 https://t.co/r9ES6LXZDe

May 29, 2025 · 3 likes · 738 followers View post →
Ryan Marshall, PhD
@RNMarshallPhD · X

RT @LongevityTao: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging htt…

May 29, 2025 · 3 shares · 1,232 followers View post →
Rapamycin News
@RapaNews · X

RT @LongevityTao: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging htt…

May 29, 2025 · 3 shares · 5,336 followers View post →
Longevity
@LongevityTao · X

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging https://t.co/RYbp0sbfUb

May 28, 2025 · 11 likes · 3 shares · 331 followers View post →
darcy darnoc
@darcydarnoc · X

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan | Nature Aging https://t.co/y4xHwXYS34

May 28, 2025 · 3,121 followers View post →
Lasse Damgaard Harreskov
@LasseHarreskov · X

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan https://t.co/KjFqBdJNtl

May 28, 2025 · 42 followers View post →
Climate, Ecology, War & More by Dr. Glen Barry, BigEarthData.ai
@bigearthdata.bsky.social · Bluesky

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan ->Nature | More info from EcoSearch

May 28, 2025 View post →