Eur J Appl Physiol November 2025 PMID 40500534

Individual muscle hypertrophy response is affected by the overload progression model and is associated with changes in satellite cell content.

Maíra C Scarpelli, João G A Bergamasco, Joshua S Godwin, Paulo H C Mesquita, Talisson S Chaves, Deivid G Silva, Diego Bittencourt, Nathalia F Dias, Ricardo A Medalha Junior, Paulo C Carello Filho, Vitor Angleri, Luiz A R Costa, Andreas N Kavazis, Carlos Ugrinowitsch, Michael D Roberts

Mentions

25
Peak: 12 in Jun 2025
across 5 sources since Jun 2025

Extended reach

31,271
potential audience

Total likes

79

Video views

725

Mentions per month

Jun 2025 – Dec 2025

Where it's discussed

  • X / Twitter11 posts
  • Instagram8 posts
  • Facebook3 posts
  • YouTube2 videos
  • Reddit1 posts

AI synopsis

What people are saying

The overall tone demonstrates moderate engagement with the publication, with users referencing its core points such as the importance of the overload progression model and satellite cell responses, using words like 'affected' and 'associated' to highlight key findings; however, there is limited critical analysis or application beyond the basic acknowledgment of its significance.

AgreementModerate agreement

Most discussions acknowledge the findings, especially regarding the influence of overload progression on muscle growth and satellite cells.

InterestModerate interest

Posts indicate moderate curiosity, as some share the publication's title and express general approval, but few delve into deeper analysis.

EngagementModerate engagement

Comments reflect some engagement with the study's methodology and implications, such as noting the relevance of satellite cells and training models.

ImpactModerate impact

The discussions suggest that the research could influence training approaches and understanding of muscle hypertrophy, though not with widespread or immediate application.

Abstract in brief

  • The study found that individual responses to resistance training vary, with some people gaining more muscle size when overload is increased by adding weight (LOADProg), and others by increasing repetitions (REPSProg), and these responses are linked to satellite cell changes.
  • Participants who responded better to the repetition increase showed more satellite cell growth, but there were no significant differences in long-term changes in myonuclei, proteolysis, or extracellular matrix biomarkers across different groups.
  • Overall, the way overload is progressed during training (by load or repetitions) may influence how much muscle growth an individual experiences, and increasing repetitions appears to promote satellite cell addition, though it doesn't seem to affect myonuclei long-term.]

Top posts

Most liked on X and Bluesky
Cleiton Libardi
@cleiton_libardi · X

Jun 12, 2025 · 21 likes · 7 shares · 532 followers View post →
Lorenzo S.Wayne
@LorenzoSWayne · X

Individual muscle hypertrophy response is affected by the overload progression model and is associated with changes in satellite cell content

Jun 15, 2025 · 5 likes · 1 share · 51 followers View post →
Marcelo A. S. Carneiro, PhD
@carneiromas · X

"Individual muscle hypertrophy response is affected by the overload progression model and is associated with changes in satellite cell content" — Read it on @ResearchGate: https://t.co/5drVhp6hON

Jun 15, 2025 · 1 like · 109 followers View post →
Nick Krontiris
@nick_krontiris · X

Individual muscle hypertrophy response is affected by the overload progression model and is associated with changes in satellite cell content https://t.co/QnOuRM1Vin

Jun 13, 2025 · 19,481 followers View post →
Martino V. Franchi
@MVFranchi · X

RT @cleiton_libardi:

Jun 14, 2025 · 7 shares · 6,016 followers View post →
Mike Roberts
@DrMikeRoberts · X

RT @cleiton_libardi:

Jun 12, 2025 · 7 shares · 2,512 followers View post →

All mentions

Marcelo A. S. Carneiro, PhD
@carneiromas · X

"Individual muscle hypertrophy response is affected by the overload progression model and is associated with changes in satellite cell content" — Read it on @ResearchGate: https://t.co/5drVhp6hON

Jun 15, 2025 · 1 like · 109 followers View post →
ALVARO ESPINOZA
@alvarosur · X

RT @LorenzoSWayne: Individual muscle hypertrophy response is affected by the overload progression model and is associated with changes in s…

Jun 15, 2025 · 1 share · 112 followers View post →
Alex
@AlexViKu · X

RT @cleiton_libardi:

Jun 15, 2025 · 7 shares · 96 followers View post →
Lorenzo S.Wayne
@LorenzoSWayne · X

Individual muscle hypertrophy response is affected by the overload progression model and is associated with changes in satellite cell content

Jun 15, 2025 · 5 likes · 1 share · 51 followers View post →
Martino V. Franchi
@MVFranchi · X

RT @cleiton_libardi:

Jun 14, 2025 · 7 shares · 6,016 followers View post →
Nick Krontiris
@nick_krontiris · X

Individual muscle hypertrophy response is affected by the overload progression model and is associated with changes in satellite cell content https://t.co/QnOuRM1Vin

Jun 13, 2025 · 19,481 followers View post →
Paulo Azevedo PhD
@paulohsmazevedo · X

RT @cleiton_libardi:

Jun 12, 2025 · 7 shares · 1,125 followers View post →
Matthew Stratton PhD
@MTSstrength89 · X

RT @cleiton_libardi:

Jun 12, 2025 · 7 shares · 165 followers View post →
Mike Roberts
@DrMikeRoberts · X

RT @cleiton_libardi:

Jun 12, 2025 · 7 shares · 2,512 followers View post →
Msc Rodrigo Volga
@RodrigoVolga · X

RT @cleiton_libardi:

Jun 12, 2025 · 7 shares · 126 followers View post →
Cleiton Libardi
@cleiton_libardi · X

Jun 12, 2025 · 21 likes · 7 shares · 532 followers View post →
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