N Engl J Med September 2025 PMID 40513024

Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation.

Karen J Bosma, Karen E A Burns, Claudio M Martin, Yoanna Skrobik, Jordi Mancebo Cortés, Sorcha Mulligan, Myriam Lafreniere-Roula, Kevin E Thorpe, Juan Carlos Suárez Montero, Indalecio Morán Chorro, Núria Rodríguez-Farré, Ron Butler, Tracey Bentall, Gaëtan Beduneau, Pauline Enguerrand

Mentions

69
Peak: 33 in Jun 2025
across 5 sources since Apr 2023

Extended reach

2,239,519
potential audience

Total likes

208

Video views

342

Mentions per month

Apr 2023 – Sep 2025

Where it's discussed

  • X / Twitter53 posts
  • News9 articles
  • Blogs3 articles
  • Bluesky2 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions contain various reflections on the PROMIZING trial, where users highlight outcomes like 'no significant difference in the duration of mechanical ventilation' between PAV+ and PSV. Phrases such as 'silly study' indicate skepticism, while others express appreciation for the rigorous design of the trial by mentioning the variety of clinical settings involved. This mix of humor, skepticism, and detailed breakdown of results showcases the participants' varying levels of engagement with the study.

AgreementNeither agree nor disagree

The discussions reflect a mix of opinions, with some expressing skepticism towards the study's significance while others support its findings.

InterestModerate interest

There is moderate interest as many users share details from the study and its implications for clinical practice.

EngagementModerate engagement

Participants engage with the content by referencing methods and discussing their experiences, although few show deep personal reflections.

ImpactNeutral impact

Impact perception is low as the consensus suggests that the study did not demonstrate clear advantages for one method over the other.

Abstract in brief

  • In critically ill patients, a study compared two ventilation methods: proportional-assist ventilation with load-adjustable gain factors (PAV+) and pressure-support ventilation (PSV) to see which one leads to a quicker recovery from mechanical ventilation.
  • The trial involved 573 patients across 23 centers in seven countries, finding a median liberation time of 7.3 days for PAV+ compared to 6.8 days for PSV, indicating no significant difference.
  • Both groups showed similar rates of ventilator-free days, reintubation, and death by day 90, suggesting that neither method offered a clear advantage in long-term outcomes.

Top posts

Most liked on X and Bluesky
NEJM
@NEJM · X

Original Article: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING trial) https://t.co/NC0ESS19iy #CCR25 | @CritCareReviews https://t.co/S11ksT9YEm

Jun 14, 2025 · 53 likes · 8 shares · 935,634 followers View post →
NEJM
@NEJM · X

Original Article: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING trial) https://t.co/NC0ESS19iy #Pulmonology #CriticalCare https://t.co/gzBMDMjcok

Sep 21, 2025 · 41 likes · 9 shares · 935,634 followers View post →
大木谷 直樹|ER x ICU
@Cafe_Dogtor · X

PAV+がPSVと比較して呼吸器離脱期間を短縮できるかという多施設RCT。Primary Outcomeは7日以上再挿管なし。結果有意差はなし。90日死亡率/再挿管/気切の割合も同様。鎮静薬使用量や呼吸筋活動指標ではPAV+群が優勢かも。PAV+使い慣れる必要があるしやりたいかと言われると... https://t.co/YqItxEwbDH

Jun 14, 2025 · 17 likes · 6 shares · 1,232 followers View post →
Critical Care Reviews
@criticalcarereviews.com · Bluesky

The sixth trial result for #CCR25 in Titanic Belfast in June is PROMIZING Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation Register at criticalcarereviews.com/meetings/ccr25

Jan 16, 2025 · 13 likes · 7 shares View post →
あっきー
@moto_moto_moto · X

まさかのPROMIZING studyはNEJMからのpublish PAV+ vs PSVの23施設, n=733 RCT 今後はpost hoc analysisで様々な生理学的評価が明らかになることでしょう https://t.co/wNjYHORCwu

Jun 13, 2025 · 10 likes · 3 shares · 1,199 followers View post →
小谷祐樹 Yuki Kotani|ICU × 臨床研究 × Podcast
@YukiKotani5 · X

②PROMIZING trial|NEJM 人工呼吸からの離脱段階で、PAV+ vs PSV(n=573) 離脱までの時間に差なし(7.3日 vs 6.8日)

Jul 3, 2025 · 8 likes · 7,807 followers View post →

All mentions

Mark
@headass_deadass · X

RT @NEJM: Original Article: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING trial) https:/…

Sep 27, 2025 · 9 shares · 770 followers View post →
NEJM.org
@nejm.org · Bluesky

In the PROMIZING trial, proportional-assist ventilation with load-adjustable gain factors did not differ significantly from pressure-support ventilation with respect to the time to liberation from mechanical ventilation. Full trial results and Research Summary: nej.md/4kC2a67 #MedSky #PulmSky

Sep 23, 2025 · 4 likes View post →
Dr. Ahmad Raza Khan
@AhmadRa12080260 · X

RT @NEJM: Original Article: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING trial) https:/…

Sep 22, 2025 · 9 shares · 2,051 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @NEJM: Original Article: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING trial) https:/…

Sep 21, 2025 · 9 shares · 32,536 followers View post →
Irving
@s98121058 · X

RT @NEJM: Original Article: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING trial) https:/…

Sep 21, 2025 · 9 shares View post →
Syed Shahrul Naz
@drshahrul80 · X

RT @NEJM: Original Article: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING trial) https:/…

Sep 21, 2025 · 9 shares · 6,925 followers View post →
Alberto García-Salido
@Nopanaden · X

RT @NEJM: Original Article: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING trial) https:/…

Sep 21, 2025 · 9 shares · 125,657 followers View post →
Hari Krishnan
@Dr_Hari_Krishna · X

RT @NEJM: Original Article: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING trial) https:/…

Sep 21, 2025 · 9 shares · 3,019 followers View post →
ricardo nassar b
@rnassarmd · X

RT @NEJM: Original Article: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING trial) https:/…

Sep 21, 2025 · 9 shares · 561 followers View post →
NEJM
@NEJM · X

Original Article: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING trial) https://t.co/NC0ESS19iy #Pulmonology #CriticalCare https://t.co/gzBMDMjcok

Sep 21, 2025 · 41 likes · 9 shares · 935,634 followers View post →
通りすがりの麻酔科医
@torisugari_anes · X

https://t.co/EYmi8lsnMg 重症患者においてPAV+がPSVに比べて人工呼吸離脱までの時間を短縮するかを調べたRCT 結果は離脱までの時間は両群間で差はなかった(7.3vs6.8d)、また人工呼吸フリー日数、再挿管、気管切開率、90日死亡率、重篤な合併症も差がなかった #当麻_呼吸

Sep 17, 2025 · 1 like · 2,035 followers View post →
Cyrus Askin, MD, FACP
@Askins_Razor · X

https://t.co/ofBGv34MFx Silly study, we already have SIMV - the ULTIMATE in vent weaning

Sep 17, 2025 · 1 like · 1,695 followers View post →
ICUEdandToddCast
@IcuCast · X

Episode 69! We talk about the articles from the #CCR25 conference with RESCUE-3 published in @ATSBlueEditor by Dres et al and PROMIZING by Bosma et al in @NEJM RESCUE-3: https://t.co/Xfldl0gEuz PROMIZING: https://t.co/4Tw8tEMdVx Listen: https://t.co/qPyhTM3p2C

Jul 15, 2025 · 1 like · 1,249 followers View post →
音速
@SSCG2024 · X

PAV+はPSVと比較し人工呼吸器離脱までの期間を短縮せず。 PSVの離脱プロトコルと比較したところで、やってることは本質的に同じである気もするが...。この辺も個別化が必要なのかなと。 https://t.co/kLWp33SKbD

Jul 7, 2025 · 2 likes · 2,502 followers View post →
小谷祐樹 Yuki Kotani|ICU × 臨床研究 × Podcast
@YukiKotani5 · X

② PROMIZING trial|NEJM PAV+ vs PSV during weaning from mechanical ventilation (n=573) No difference in time to liberation (7.3 vs 6.8 days)

Jul 3, 2025 · 6 likes · 7,807 followers View post →
小谷祐樹 Yuki Kotani|ICU × 臨床研究 × Podcast
@YukiKotani5 · X

②PROMIZING trial|NEJM 人工呼吸からの離脱段階で、PAV+ vs PSV(n=573) 離脱までの時間に差なし(7.3日 vs 6.8日)

Jul 3, 2025 · 8 likes · 7,807 followers View post →
North York General
@NYGH_News · X

Congratulations to all NYG team members who participated in the PROMIZING international trial that was recently published in the @NEJM. Your commitment underscores NYG’s dedication to impactful, high-quality clinical research on a global scale! https://t.co/82nERvaKt7 #NYGProud https://t.co/kxB3VWlnVt

Jun 26, 2025 · 15,568 followers View post →
SEAMO: Southeastern Ontario Academic Medical Org.
@SEAMOKingston · X

Jun 25, 2025 · 3 likes · 1,429 followers View post →
中島聡志
@SNakajima1990 · X

【PROMIZING試験(NEJM, 2025)】 人工呼吸器からの早期離脱にPAV+とPSVのどちらが有用か? →primary outcome(離脱までの期間)に有意差なし。死亡率や再挿管率も同等。 https://t.co/8pnKCatW6X

Jun 23, 2025 · 16 followers View post →
STITCHES Medicine - the Best of Medical Research
@STITCHESMed · X

Proportional-assist ventilation did not significantly shorten mechanical ventilation duration compared to pressure-support ventilation in critically ill patients. by Bosma KJ, Burns KEA (...) Brochard L et 44 al. in N Engl J Med https://t.co/raazRNFMbO #MedX #MedResearch

Jun 22, 2025 · 83 followers View post →
Ala Eddin Sagar
@AlaEddinSagar · X

New episode of “This Week in Pulmonary and Critical Care” ✅ Switching from Controlled to Assisted Ventilation ✅ PROMIZING: PAV+ vs. PSV ✅ High-Flow O2 for Bronch in COPD ✅ Biopsy of lung Nodules: Inside-Out vs. Outside-In ✅ Pleural Fluid Analysis https://t.co/oqbLQfzDPM

Jun 21, 2025 · 2 likes · 1,008 followers View post →
Bryan Cotton
@bryanacotton1 · X

Sticking w/ pressure support. No benefit of PAV+ for duration of mech vent. While, Vent-free days, reintubation, & tracheostomy less w/ PSV (p<0.20, but>0.05) Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation | NEJM https://t.co/Lj1eOK1SgM

Jun 18, 2025 · 6 likes · 5,033 followers View post →
MK
@MK150307 · X

PAV+は人工呼吸器離脱(抜管)を早めるか? @NEJM PAV+群 vs PSV群 →7.3日 (95% CI, 6.2-9.7) vs 6.8日 (95% CI, 5.4-8.8) 副次的評価項目も有意差なし https://t.co/EcXjTYwujP

Jun 17, 2025 · 1 like · 469 followers View post →
Coleg Neumología Pue
@colegneumopueb · X

RT @tipssovetorax: De 20 millones de personas en el mundo con ventilación mecánica invasiva VMI al año, 35 % tendrá retiro gradual del resp…

Jun 16, 2025 · 3 shares · 141 followers View post →
Caesar De Melniboné
@CesarDMelnibone · X

RT @tipssovetorax: De 20 millones de personas en el mundo con ventilación mecánica invasiva VMI al año, 35 % tendrá retiro gradual del resp…

Jun 16, 2025 · 3 shares · 123 followers View post →
Sovetorax Tips
@tipssovetorax · X

De 20 millones de personas en el mundo con ventilación mecánica invasiva VMI al año, 35 % tendrá retiro gradual del respirador difícil o largo, o fallecerá. VMI prolongada se asocia a mas riesgo de complicacion, muerte y secuelas a largo plazo y mayor costo 10.1056/NEJMoa2505708

Jun 16, 2025 · 5 likes · 3 shares · 3,247 followers View post →
ISICEM
@ISICEM · X

@ISICEM Critical Care Input Proportional-Assist Ventilation for Minimizing the Duration of #MechanicalVentilation #ISICEMelearning #MedED @NEJM

Jun 16, 2025 · 4 likes · 10,903 followers View post →
Daniel Polo
@pulmonologist01 · X

RT @NEJM: Original Article: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING trial) https:/…

Jun 15, 2025 · 8 shares · 278 followers View post →
Abstream
@abstreamme · X

Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation #science #publication #research #publications https://t.co/fJbQrOHzsC

Jun 15, 2025 · 787 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @NEJM: Original Article: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING trial) https:/…

Jun 14, 2025 · 8 shares · 32,536 followers View post →
Dedi Aji
@DediiAjii · X

RT @NEJM: Original Article: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING trial) https:/…

Jun 14, 2025 · 8 shares · 872 followers View post →
Caesar De Melniboné
@CesarDMelnibone · X

RT @NEJM: Original Article: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING trial) https:/…

Jun 14, 2025 · 8 shares · 123 followers View post →
Rebecca Hay
@RebeccaEHay · X

RT @NEJM: Original Article: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING trial) https:/…

Jun 14, 2025 · 8 shares · 389 followers View post →
Syed Shahrul Naz
@drshahrul80 · X

RT @NEJM: Original Article: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING trial) https:/…

Jun 14, 2025 · 8 shares · 6,925 followers View post →
Dr.Anand Tiwari
@DrAnandTiwari · X

Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation | New England Journal of Medicine Neutral study

Jun 14, 2025 · 8 followers View post →
Fabio Varon MD. MsC. PhD.
@FABIOVARON · X

RT @NEJM: Original Article: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING trial) https:/…

Jun 14, 2025 · 8 shares · 3,052 followers View post →
NEJM
@NEJM · X

Original Article: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING trial) https://t.co/NC0ESS19iy #CCR25 | @CritCareReviews https://t.co/S11ksT9YEm

Jun 14, 2025 · 53 likes · 8 shares · 935,634 followers View post →
t-peds
@peds_t · X

RT @Cafe_Dogtor: PAV+がPSVと比較して呼吸器離脱期間を短縮できるかという多施設RCT。Primary Outcomeは7日以上再挿管なし。結果有意差はなし。90日死亡率/再挿管/気切の割合も同様。鎮静薬使用量や呼吸筋活動指標ではPAV+群が優勢かも。PAV…

Jun 14, 2025 · 6 shares · 20 followers View post →
でぃ
@LasalleKodama · X

RT @Cafe_Dogtor: PAV+がPSVと比較して呼吸器離脱期間を短縮できるかという多施設RCT。Primary Outcomeは7日以上再挿管なし。結果有意差はなし。90日死亡率/再挿管/気切の割合も同様。鎮静薬使用量や呼吸筋活動指標ではPAV+群が優勢かも。PAV…

Jun 14, 2025 · 6 shares · 1,509 followers View post →
happy anesth
@kmyk08315265 · X

RT @Cafe_Dogtor: PAV+がPSVと比較して呼吸器離脱期間を短縮できるかという多施設RCT。Primary Outcomeは7日以上再挿管なし。結果有意差はなし。90日死亡率/再挿管/気切の割合も同様。鎮静薬使用量や呼吸筋活動指標ではPAV+群が優勢かも。PAV…

Jun 14, 2025 · 6 shares · 544 followers View post →
あっきー
@moto_moto_moto · X

RT @Cafe_Dogtor: PAV+がPSVと比較して呼吸器離脱期間を短縮できるかという多施設RCT。Primary Outcomeは7日以上再挿管なし。結果有意差はなし。90日死亡率/再挿管/気切の割合も同様。鎮静薬使用量や呼吸筋活動指標ではPAV+群が優勢かも。PAV…

Jun 14, 2025 · 6 shares · 1,199 followers View post →
moleskine
@moleskine8 · X

RT @Cafe_Dogtor: PAV+がPSVと比較して呼吸器離脱期間を短縮できるかという多施設RCT。Primary Outcomeは7日以上再挿管なし。結果有意差はなし。90日死亡率/再挿管/気切の割合も同様。鎮静薬使用量や呼吸筋活動指標ではPAV+群が優勢かも。PAV…

Jun 14, 2025 · 6 shares · 514 followers View post →
大木谷 直樹|ER x ICU
@Cafe_Dogtor · X

PAV+がPSVと比較して呼吸器離脱期間を短縮できるかという多施設RCT。Primary Outcomeは7日以上再挿管なし。結果有意差はなし。90日死亡率/再挿管/気切の割合も同様。鎮静薬使用量や呼吸筋活動指標ではPAV+群が優勢かも。PAV+使い慣れる必要があるしやりたいかと言われると... https://t.co/YqItxEwbDH

Jun 14, 2025 · 17 likes · 6 shares · 1,232 followers View post →
happy anesth
@kmyk08315265 · X

RT @moto_moto_moto: まさかのPROMIZING studyはNEJMからのpublish PAV+ vs PSVの23施設, n=733 RCT 今後はpost hoc analysisで様々な生理学的評価が明らかになることでしょう https://t.…

Jun 14, 2025 · 3 shares · 544 followers View post →
moleskine
@moleskine8 · X

RT @moto_moto_moto: まさかのPROMIZING studyはNEJMからのpublish PAV+ vs PSVの23施設, n=733 RCT 今後はpost hoc analysisで様々な生理学的評価が明らかになることでしょう https://t.…

Jun 13, 2025 · 3 shares · 514 followers View post →
ryuchi11
@ray1111philo · X

RT @moto_moto_moto: まさかのPROMIZING studyはNEJMからのpublish PAV+ vs PSVの23施設, n=733 RCT 今後はpost hoc analysisで様々な生理学的評価が明らかになることでしょう https://t.…

Jun 13, 2025 · 3 shares · 115 followers View post →
nagare-Intensivist
@nagare_anes · X

Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation | New England Journal of Medicine https://t.co/TcyuCiYxxf

Jun 13, 2025 · 2 likes · 880 followers View post →
あっきー
@moto_moto_moto · X

まさかのPROMIZING studyはNEJMからのpublish PAV+ vs PSVの23施設, n=733 RCT 今後はpost hoc analysisで様々な生理学的評価が明らかになることでしょう https://t.co/wNjYHORCwu

Jun 13, 2025 · 10 likes · 3 shares · 1,199 followers View post →
Giovanni Landoni, MD
@giovannilandoni · X

RT @CritCareReviews: The sixth trial result for #CCR25 in @TitanicBelfast in June is PROMIZING from @CCCTG_ Proportional Assist Ventilati…

Jan 24, 2025 · 4 shares · 4,668 followers View post →
CCCTG
@CCCTG_ · X

RT @CritCareReviews: The sixth trial result for #CCR25 in @TitanicBelfast in June is PROMIZING from @CCCTG_ Proportional Assist Ventilati…

Jan 18, 2025 · 4 shares · 1,718 followers View post →
Dale Needham, MD, PhD
@DrDaleNeedham · X

RT @CritCareReviews: The sixth trial result for #CCR25 in @TitanicBelfast in June is PROMIZING from @CCCTG_ Proportional Assist Ventilati…

Jan 16, 2025 · 4 shares · 11,593 followers View post →
israel maia
@israelmaia16 · X

RT @CritCareReviews: The sixth trial result for #CCR25 in @TitanicBelfast in June is PROMIZING from @CCCTG_ Proportional Assist Ventilati…

Jan 16, 2025 · 4 shares · 202 followers View post →
Critical Care Reviews
@criticalcarereviews.com · Bluesky

The sixth trial result for #CCR25 in Titanic Belfast in June is PROMIZING Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation Register at criticalcarereviews.com/meetings/ccr25

Jan 16, 2025 · 13 likes · 7 shares View post →
Critical Care Reviews
@CritCareReviews · X

The sixth trial result for #CCR25 in @TitanicBelfast in June is PROMIZING from @CCCTG_ Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation #CCR25 - The Best Critical Care Trials in the World Register via the QR code or on the CCR website https://t.co/fgiTrQNFhA

Jan 16, 2025 · 7 likes · 4 shares · 61,500 followers View post →
ATS BSHSR
@ATS_BSHSR · X

#Study #protocol for a #randomized #controlled #trial of Proportional Assist #Ventilation for Minimizing the Duration of #Mechanical Ventilation: the PROMIZING study https://t.co/ekBeF2URiW https://t.co/Ewf6ICQ9pE

Apr 1, 2023 · 1,897 followers View post →