PubHawk
Cancer June 2025 PMID 40518804

Long-term benefits of single-dose psilocybin in depressed patients with cancer.

Manish Agrawal, Kim Roddy, Betsy Jenkins, Celia Leeks, Ezekiel Emanuel

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Mentions

216
Peak: 36 in Jun 2025
across 7 sources since Jun 2025

Extended reach

641,693
potential audience

Total likes

248

Video views

1,916

Mentions per month

Jun 2025 – Aug 2025

Where it's discussed

  • News130 articles
  • X / Twitter69 posts
  • Blogs9 articles
  • Bluesky2 posts
  • YouTube2 videos
  • Facebook2 posts
  • Reddit2 posts

AI synopsis

What people are saying

Overall, the digital discussions praise the study for revealing long-lasting relief from depression and anxiety with a single dose of psilocybin, with words like 'promising' and 'game-changing' illustrating excitement and perceived importance. The tone and context suggest both strong agreement and high perceived impact of the research, supported by mentions of specific results such as 'lasting 2 years' and 'robust antidepressive activity.'

AgreementStrong agreement

Most discussions express strong support and positivity towards the findings, citing the promising effects of psilocybin and its potential to treat depression in cancer patients.

InterestHigh interest

The discussions demonstrate high curiosity and enthusiasm, with many posts emphasizing the significance of the long-term benefits and innovative treatment approach.

EngagementModerate engagement

While the majority mention the study and its results directly, some posts reflect personal opinions or questions, indicating a moderate level of deep engagement.

ImpactHigh impact

The posts highlight that the publication could be transformative for mental health treatment in oncology, with phrases like 'paradigm-changing' and 'significant' underscoring its potential influence.

Abstract in brief

  • A phase 2 trial found that a single dose of psilocybin, combined with psychological support, is safe, feasible, and effective for reducing depression and anxiety in cancer patients, with benefits lasting up to 2 years.
  • In the study, approximately half of the patients experienced significant and sustained reductions in depression, while around 43% saw similar improvements in anxiety.
  • These results suggest that psilocybin could be a promising new treatment for depression and anxiety in cancer patients, potentially offering an alternative to traditional antidepressants, though more research is needed.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Julie Holland, MD
@BellevueDoc · X

Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin delivers two years of depression relief for cancer patients https://t.co/JrYsS4Z1ol

Jul 6, 2025 · 83 likes · 25 shares · 14,469 followers View post →
Beckley Foundation | Psychedelic Research
@BeckleyResearch · X

A paper published this week explores the lasting benefits of psychedelic-assisted therapy for depression in cancer patients. The study outlines antidepressive effects persisting 2 years after a 25mg psilocybin dose combined with psychotherapy. Article: https://t.co/XiFVR9Bgrs https://t.co/ZpyyZ6o2Eq

Jun 19, 2025 · 56 likes · 11 shares · 60,141 followers View post →
Psychedelic Vantage
@PsychedVantage · X

Long-term benefits of single-dose psilocybin in depressed patients with cancer https://t.co/CgFF4HydKe

Jun 16, 2025 · 17 likes · 3 shares · 1,520 followers View post →
Dr. Rick Barnett, PsyD
@drrickbarnett · X

https://t.co/bNkulzedWq

Jun 18, 2025 · 13 likes · 3 shares · 17,461 followers View post →
Kevin McKernan
@Kevin_McKernan · X

https://t.co/76XpDW5QDc https://t.co/4kgOObOrYT

Jul 8, 2025 · 10 likes · 3 shares · 118,600 followers View post →
Grinspoon -- Grinspoon on Drugs
@Peter_Grinspoon · X

Psilocybin in depressed cancer patients: 'robust antidepressive activity from a single 25 mg dose of psilocybin combined with psychotherapy and suggest a potentially paradigm-changing alternative to traditional antidepressants' benefit lasted 2 years https://t.co/RDsFsBX0Op

Jun 19, 2025 · 6 likes · 35,220 followers View post →

All mentions

Fufu
@fouadity · X

@bryan_johnson https://t.co/Pa0h52RTo0

Aug 28, 2025 · 1,385 followers View post →
jd
@JD_Socab · X

Long‐term benefits of single‐dose psilocybin in depressed patients with cancer - Agrawal - 2025 - Cancer - Wiley Online Library https://t.co/MSNAvfzOPE

Aug 28, 2025 · 147 followers View post →
PennMedCSO
@pennmedcso.bsky.social · Bluesky

New research from @zekeemanuel.bsky.social (@pennmehp.bsky.social) out in @JournalCancer finds long-term benefits of single-dose psilocybin in depressed patients with cancer acsjournals.onlinelibrary.wiley.com/doi/10.1002/...

Jul 15, 2025 View post →
Nicole Tenev
@NicoleTenev · X

RT @Kevin_McKernan: https://t.co/76XpDW5QDc https://t.co/4kgOObOrYT

Jul 13, 2025 · 3 shares · 4,649 followers View post →
ZeitgeistBuster
@Earl_R_Robinson · X

RT @Kevin_McKernan: https://t.co/76XpDW5QDc https://t.co/4kgOObOrYT

Jul 11, 2025 · 3 shares · 1,722 followers View post →
Farshad ❤️
@FarshadHere · X

مطالعه‌ای بسیار جدید: یک دوز ۲۵ میلی‌گرم سیلوسایبین همراه با روان‌درمانی در بیماران مبتلا به افسردگی و سرطان، اثرات ضدافسردگی و ضداضطراب پایداری تا ۲ سال داشته! حدود ۵۳٫۶٪ کاهش افسردگی، ۵۰٪ بهبود ماندگار و ۴۶٪ کاهش اضطراب. https://t.co/o9M4KmoIiU

Jul 10, 2025 · 838 followers View post →
Foreplay
@Foreplay8521875 · X

Long‐term benefits of single‐dose psilocybin in depressed patients with cancer - Agrawal - 2025 - Cancer - Wiley Online Library https://t.co/mqnbmoxRGM

Jul 9, 2025 · 22 followers View post →
Hope Larkin-Begley
@HopeBegley · X

RT @Kevin_McKernan: https://t.co/76XpDW5QDc https://t.co/4kgOObOrYT

Jul 9, 2025 · 3 shares · 2,809 followers View post →
Kevin McKernan
@Kevin_McKernan · X

https://t.co/76XpDW5QDc https://t.co/4kgOObOrYT

Jul 8, 2025 · 10 likes · 3 shares · 118,600 followers View post →
Kevin McKernan
@Kevin_McKernan · X

https://t.co/76XpDW5QDc https://t.co/ruTXPD3Nni

Jul 8, 2025 · 3 likes · 118,600 followers View post →
Groot Jedi
@GrootJedi · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 7, 2025 · 25 shares · 991 followers View post →
Sybylla
@EntelechyInc · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 7, 2025 · 25 shares · 2,474 followers View post →
Sunflower Blue
@UnintendedBlue · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 7, 2025 · 25 shares · 70 followers View post →
Jose Chavez Martinez
@matracaelcan · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 155 followers View post →
MzDi
@DiChills · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 140 followers View post →
Gleb Kretinin |
@GKretinin · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 356 followers View post →
Greg Ransom
@GregRansom · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 607 followers View post →
AllColdInside
@allcoldinside · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 8,521 followers View post →
Michael Ostrolenk, MA, MFT
@mostrolenk · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 7,065 followers View post →
IEET
@IEET · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 9,817 followers View post →
Interfaith Mormon Bahaii Vegan Scarlett Caquimbo ❄
@soulhealinglife · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 479 followers View post →
LongCovidPNW
@longcovidpnw · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 1,636 followers View post →
wqx0T2d9
@Wqx0T23264 · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 819 followers View post →
Mind Escape Podcast
@MikeEscape · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 4,069 followers View post →
Psychonaut
@WakingLifeDream · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 20,614 followers View post →
Steven Glass, Psy.D./ Beyond the Journey
@StevenG41417579 · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 440 followers View post →
ShamansGlobalVillage
@ShamansGV · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 1,455 followers View post →
EA
@LisAustin_X · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 179 followers View post →
Plastic Shaman
@Entheogenist · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 394 followers View post →
Ward Wyatt
@wardwyatt_ · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 10,093 followers View post →
Gopalkumar Rakesh
@landoltwithpsy · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 95 followers View post →
Seretoninen
@JTFS84 · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 991 followers View post →
Nauseous_Vent
@NauseousVent · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 80 followers View post →
PsychedelicsASL
@PharmacopeiaE · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 132 followers View post →
Mackenzie P
@mpadvisorshares · X

RT @BellevueDoc: Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin…

Jul 6, 2025 · 25 shares · 898 followers View post →
Julie Holland, MD
@BellevueDoc · X

Long‐term benefits of single‐dose psilocybin in depressed patients with cancer Phase 2 trial single dose of psilocybin delivers two years of depression relief for cancer patients https://t.co/JrYsS4Z1ol

Jul 6, 2025 · 83 likes · 25 shares · 14,469 followers View post →
Penn Medicine CSO
@PennMedCSO · X

New research from @ZekeEmanuel (@PennMEHP) out in @JournalCancer finds long-term benefits of single-dose psilocybin in depressed patients with cancer https://t.co/QkIGtGQ1RW https://t.co/h7KTHMka9a

Jul 3, 2025 · 1 like · 5,885 followers View post →
ForensicPsyMD
@ForensicPsyMD · X

Long‐term benefits of single‐dose psilocybin in depressed patients with cancer - Agrawal - 2025 - Cancer - Wiley Online Library https://t.co/bnPbs32oaW

Jun 23, 2025 · 358 followers View post →
Deshmani Kewat
@KickassLucky · X

RT @SunstoneHeals: We’re pleased to announce the publication of our Long-term Benefits of Single-Dose Psilocybin in Depressed Patients with…

Jun 23, 2025 · 2 shares · 35 followers View post →
Luke Nakaji/中島 振一郎@バルサと島巡りと猫と精神医療
@Luke_629 · X

RT @BeckleyResearch: A paper published this week explores the lasting benefits of psychedelic-assisted therapy for depression in cancer pat…

Jun 21, 2025 · 11 shares · 2,289 followers View post →
♧
@GTBBduzzit · X

RT @BeckleyResearch: A paper published this week explores the lasting benefits of psychedelic-assisted therapy for depression in cancer pat…

Jun 20, 2025 · 11 shares · 1,496 followers View post →
Seretoninen
@JTFS84 · X

RT @BeckleyResearch: A paper published this week explores the lasting benefits of psychedelic-assisted therapy for depression in cancer pat…

Jun 20, 2025 · 11 shares · 991 followers View post →
GET SOME
@keldog125 · X

RT @BeckleyResearch: A paper published this week explores the lasting benefits of psychedelic-assisted therapy for depression in cancer pat…

Jun 20, 2025 · 11 shares · 249 followers View post →
Jim Baskin
@jameskbaskin · X

RT @BeckleyResearch: A paper published this week explores the lasting benefits of psychedelic-assisted therapy for depression in cancer pat…

Jun 19, 2025 · 11 shares · 196 followers View post →
AW
@AWW1989 · X

RT @BeckleyResearch: A paper published this week explores the lasting benefits of psychedelic-assisted therapy for depression in cancer pat…

Jun 19, 2025 · 11 shares · 59 followers View post →
ShamansGlobalVillage
@ShamansGV · X

RT @BeckleyResearch: A paper published this week explores the lasting benefits of psychedelic-assisted therapy for depression in cancer pat…

Jun 19, 2025 · 11 shares · 1,455 followers View post →
Pink Elephant
@PinkElephantHQ · X

Full clinical trial: https://t.co/NmNPDQCPPD

Jun 19, 2025 · 2 likes · 23 followers View post →
Interzone
@Quad4vr · X

RT @BeckleyResearch: A paper published this week explores the lasting benefits of psychedelic-assisted therapy for depression in cancer pat…

Jun 19, 2025 · 11 shares · 1,081 followers View post →
vanni santoni
@vannisantoni · X

RT @BeckleyResearch: A paper published this week explores the lasting benefits of psychedelic-assisted therapy for depression in cancer pat…

Jun 19, 2025 · 11 shares · 15,997 followers View post →
Beckley Foundation | Psychedelic Research
@BeckleyResearch · X

A paper published this week explores the lasting benefits of psychedelic-assisted therapy for depression in cancer patients. The study outlines antidepressive effects persisting 2 years after a 25mg psilocybin dose combined with psychotherapy. Article: https://t.co/XiFVR9Bgrs https://t.co/ZpyyZ6o2Eq

Jun 19, 2025 · 56 likes · 11 shares · 60,141 followers View post →
Philip Sharp,MD
@AtomicCityDoc · X

Long‐term benefits of single‐dose psilocybin in depressed patients with cancer - Agrawal - 2025 - Cancer - Wiley Online Library https://t.co/rLivoWArTi

Jun 19, 2025 · 1 like · 872 followers View post →
Grinspoon -- Grinspoon on Drugs
@Peter_Grinspoon · X

Psilocybin in depressed cancer patients: 'robust antidepressive activity from a single 25 mg dose of psilocybin combined with psychotherapy and suggest a potentially paradigm-changing alternative to traditional antidepressants' benefit lasted 2 years https://t.co/RDsFsBX0Op

Jun 19, 2025 · 6 likes · 35,220 followers View post →
Muhammad Aadil, MD
@m_aadil · X

RT @drrickbarnett: https://t.co/bNkulzedWq

Jun 18, 2025 · 3 shares · 1,645 followers View post →
Seretoninen
@JTFS84 · X

RT @drrickbarnett: https://t.co/bNkulzedWq

Jun 18, 2025 · 3 shares · 991 followers View post →
Wayne Kepner, PhD, MPH
@wkepner · X

RT @drrickbarnett: https://t.co/bNkulzedWq

Jun 18, 2025 · 3 shares · 1,019 followers View post →
Dr. Rick Barnett, PsyD
@drrickbarnett · X

https://t.co/bNkulzedWq

Jun 18, 2025 · 13 likes · 3 shares · 17,461 followers View post →
Teens get cancer too
@trials4now · X

RT @JournalCancer: Can a psychedelic compound from mushrooms benefit people with cancer and major depression?

Jun 17, 2025 · 3 shares · 10,310 followers View post →
BryanRoth
@zenbrainest · X

Long-term benefits of single-dose psilocybin in depressed patients with cancer #psychedelics https://t.co/54bvE892pV

Jun 17, 2025 · 17,042 followers View post →
Wiley Oncology & Hematology
@WileyOnc_Hem · X

RT @JournalCancer: Can a psychedelic compound from mushrooms benefit people with cancer and major depression?

Jun 17, 2025 · 3 shares · 2,180 followers View post →
F. Perry Wilson, MD MSCE
@fperrywilson · X

@Medscape So the study of interest is this one, appearing in CANCER. (Note the final author and, if you have a chance, read the disclosures...). https://t.co/cSvZRvwUuC https://t.co/fcbiT3svZv

Jun 17, 2025 · 1 like · 16,617 followers View post →
Biohack Yourself Media
@biohackyourself · X

A single guided psilocybin session may offer over two years of depression and anxiety relief for people with cancer. According to a new phase 2 clinical trial published in CANCER called Long-term benefits of single-dose psilocybin in depressed patients with cancer, 28 cancer https://t.co/MM7soAh0u3

Jun 17, 2025 · 332 followers View post →
Psychedelic Vantage
@PsychedVantage · X

RT @SunstoneHeals: We’re pleased to announce the publication of our Long-term Benefits of Single-Dose Psilocybin in Depressed Patients with…

Jun 17, 2025 · 2 shares · 1,520 followers View post →
Nauseous_Vent
@NauseousVent · X

RT @PsychedVantage: Long-term benefits of single-dose psilocybin in depressed patients with cancer https://t.co/CgFF4HydKe

Jun 16, 2025 · 3 shares · 80 followers View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry.bsky.social · Bluesky

Long-term benefits of single-dose psilocybin in depressed patients with cancer acsjournals.onlinelibrary.wiley.com/doi/10.1002/...

Jun 16, 2025 · 1 like View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

Long-term benefits of single-dose psilocybin in depressed patients with cancer https://t.co/SwbdOhElaW

Jun 16, 2025 · 18,502 followers View post →
PsychedStocks
@PsychedStocks · X

RT @PsychedVantage: Long-term benefits of single-dose psilocybin in depressed patients with cancer https://t.co/CgFF4HydKe

Jun 16, 2025 · 3 shares · 951 followers View post →
Julie Holland, MD
@BellevueDoc · X

RT @PsychedVantage: Long-term benefits of single-dose psilocybin in depressed patients with cancer https://t.co/CgFF4HydKe

Jun 16, 2025 · 3 shares · 14,469 followers View post →
Sunstone Therapies
@SunstoneHeals · X

We’re pleased to announce the publication of our Long-term Benefits of Single-Dose Psilocybin in Depressed Patients with Cancer Study in @JournalCancer, the Journal of the American Cancer Society! Led by our CEO and Principal Investigator, Dr. Manish Agrawal, this study https://t.co/GiP3XDOHqy

Jun 16, 2025 · 6 likes · 2 shares · 292 followers View post →
Psychedelic Vantage
@PsychedVantage · X

Long-term benefits of single-dose psilocybin in depressed patients with cancer https://t.co/CgFF4HydKe

Jun 16, 2025 · 17 likes · 3 shares · 1,520 followers View post →
OncoAlert
@OncoAlert · X

RT @JournalCancer: Can a psychedelic compound from mushrooms benefit people with cancer and major depression?

Jun 16, 2025 · 3 shares · 40,103 followers View post →
ACS Journal Cancer
@JournalCancer · X

Can a psychedelic compound from mushrooms benefit people with cancer and major depression?

Jun 16, 2025 · 3 likes · 3 shares · 30,958 followers View post →