Aging Cell September 2025 PMID 40532901

Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis.

Edward R Ivimey-Cook, Zahida Sultanova, Alexei A Maklakov

Mentions

84
Peak: 29 in Jun 2025
across 6 sources since Jun 2025

Extended reach

2,359,953
potential audience

Total likes

2,189

Video views

11,913

Mentions per month

Jun 2025 – Oct 2025

Where it's discussed

  • News40 articles
  • X / Twitter31 posts
  • Blogs6 articles
  • Bluesky3 posts
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

Overall, discussions emphasize that rapamycin is seen as a promising anti-aging drug comparable to dietary restriction, with posts using phrases like 'mirrors lifespan extension' and 'significant effects,' highlighting excitement about the implications. The tone and word choices reflect both scientific interest and optimism about future applications, underlining the perceived high impact of this study.

AgreementStrong agreement

Most discussions strongly agree with the finding that rapamycin mimics dietary restriction in extending lifespan, as evidenced by multiple posts echoing this conclusion.

InterestHigh interest

Posts display high curiosity and engagement, often mentioning the significance of the research and its implications for health and aging.

EngagementModerate engagement

While many comments summarize key points, only some delve into the detailed mechanisms or critique aspects of the study, reflecting moderate depth.

ImpactHigh impact

The overall tone conveys that this research is perceived as highly influential, potentially shaping future aging and health strategies.

Abstract in brief

  • Dietary restriction (DR) significantly increases lifespan in various species, making researchers explore alternatives like rapamycin and metformin for similar effects without reduced calorie intake.
  • A comprehensive meta-analysis of 911 effect sizes from 167 studies found that while DR consistently extends lifespan, only rapamycin showed a significant lifespan extension, with no notable sex differences observed across treatments.
  • The study highlights that DR's impact is robust regardless of methodology, but results were influenced by high variability and publication bias, suggesting that rapamycin can offer lifespan benefits comparable to DR in vertebrates.

Top posts

Most liked on X and Bluesky
Aging Science News
@AgingBiology · X

Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis https://t.co/EN9FKyDMIF

Jun 20, 2025 · 32 likes · 4 shares · 30,997 followers View post →
Zahida Sultanova
@zahidasultanova · X

In our new paper, we show that taking the drug rapamycin delivers a lifespan extension benefit very similar to eating less across vertebrates. https://t.co/ZTy4DgR0PY

Jun 19, 2025 · 16 likes · 4 shares · 491 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

Rapamycin, Not Metformin, Mirrors Dietary Restriction‐Driven Lifespan Extension in Vertebrates: A Meta‐Analysis https://t.co/DFbJGCo2I8

Jun 20, 2025 · 14 likes · 4 shares · 9,727 followers View post →
Ed Ivimey-Cook
@eivimeycook.bsky.social · Bluesky

New paper! "Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis" tinyurl.com/yc6pkmbe Using meta-analysis, we examined the average lifespan extension conferred by dietary restriction (DR), Metformin, and Rapamycin.

Jun 19, 2025 · 14 likes · 8 shares View post →
Agingdoc
@agingdoc1 · X

Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis https://t.co/1b4ZfibPWl https://t.co/D3dm754PnD

Jun 20, 2025 · 5 likes · 3 shares · 42,377 followers View post →
Organelle Therapeutics
@organelletx · X

⏳

Jun 20, 2025 · 3 likes · 1 share · 53 followers View post →

All mentions

(((JReuben1)))
@jreuben1 · X

Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis https://t.co/D58o0LnxwZ

Aug 23, 2025 · 1 like · 1,963 followers View post →
Richard R Balsamo, MD, JD
@balsamo_r · X

On *rapamycin* as a lifespan extender: “Overall, this study suggests that rapamycin and [caloric restriction] confer comparable lifespan extension across a broad range of vertebrates.” https://t.co/DT3xw44hWx

Jul 20, 2025 · 1,175 followers View post →
muffmuff
@muffmuff5 · X

ラパマイシンとメトホルミンの寿命延長効果に関するメタアナリシス。脊椎動物(魚からサルまで8種類)での167論文を分析。ラパマイシンの効果が確認された。おもしそう。https://t.co/japZf7aCMo https://t.co/BHCLe82lH4

Jul 17, 2025 · 2 likes · 3,190 followers View post →
srtcat
@srtcat1 · X

RT @zahidasultanova: In our new paper, we show that taking the drug rapamycin delivers a lifespan extension benefit very similar to eating…

Jul 1, 2025 · 4 shares · 1,149 followers View post →
Shirley Highers
@willowpaw1 · X

RT @zahidasultanova: In our new paper, we show that taking the drug rapamycin delivers a lifespan extension benefit very similar to eating…

Jul 1, 2025 · 4 shares · 4,191 followers View post →
Orlando_uy
@Orlando_uy · X

Rapamycin, Not Metformin, Mirrors Dietary Restriction‐Driven Lifespan Extension in Vertebrates. https://t.co/xNxMA4B849

Jun 28, 2025 · 2 likes · 695 followers View post →
Business Standard
@bsindia · X

#HealthWithBS | Rapamycin, not metformin, mirrors dietary‑restriction‑driven lifespan extension in vertebrates, says new meta‑analysis in Aging Cell. @Barkha__Mathur shares details

Jun 24, 2025 · 2,213,309 followers View post →
Shahriyar Gourgi
@ShahriyarGourgi · X

Rapamycin, Not Metformin, Mirrors Dietary Restriction‐Driven Lifespan Extension in Vertebrates: A Meta‐Analysis - Ivimey‐Cook - Aging Cell - Wiley Online Library https://t.co/qqScPL2UOj

Jun 23, 2025 · 2,109 followers View post →
Szyzygy3
@Szygy3 · X

RT @mike_lustgarten: Rapamycin, Not Metformin, Mirrors Dietary Restriction‐Driven Lifespan Extension in Vertebrates: A Meta‐Analysis https:…

Jun 23, 2025 · 4 shares · 37 followers View post →
Rene Sugar
@renesugar · X

RT @mike_lustgarten: Rapamycin, Not Metformin, Mirrors Dietary Restriction‐Driven Lifespan Extension in Vertebrates: A Meta‐Analysis https:…

Jun 21, 2025 · 4 shares · 3,974 followers View post →
brainfo
@brainfopen · X

RT @AgingBiology: Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis https://t…

Jun 21, 2025 · 4 shares · 27 followers View post →
BK
@bk7gems · X

RT @AgingBiology: Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis https://t…

Jun 21, 2025 · 4 shares · 89 followers View post →
Alex Murphy
@techexploreram · X

RT @mike_lustgarten: Rapamycin, Not Metformin, Mirrors Dietary Restriction‐Driven Lifespan Extension in Vertebrates: A Meta‐Analysis https:…

Jun 21, 2025 · 4 shares · 23 followers View post →
Eun-Jung Jin
@Twisterwitch · X

RT @organelletx: ⏳

Jun 21, 2025 · 1 share · 10 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

Rapamycin, Not Metformin, Mirrors Dietary Restriction‐Driven Lifespan Extension in Vertebrates: A Meta‐Analysis https://t.co/DFbJGCo2I8

Jun 20, 2025 · 14 likes · 4 shares · 9,727 followers View post →
Norio Nakatsuji
@norionakatsuji.bsky.social · Bluesky

元論文→ Reference: Ivimey-Cook ER, Sultanova Z, Maklakov AA. Rapamycin, not metformin, mirrors dietary restriction-driven lifespan extension in vertebrates: A meta-analysis. Aging Cell. 2025;n/a(n/a):e70131. doi: 10.1111/acel.70131 onlinelibrary.wiley.com/doi/10.1111/...

Jun 20, 2025 View post →
Norio Nakatsuji
@norionakatsuji · X

元論文→ Reference: Ivimey-Cook ER, Sultanova Z, Maklakov AA. Rapamycin, not metformin, mirrors dietary restriction-driven lifespan extension in vertebrates: A meta-analysis. Aging Cell. 2025;n/a(n/a):e70131. doi: 10.1111/acel.70131 https://t.co/FQ0GjgnLmb

Jun 20, 2025 · 2 likes · 15,670 followers View post →
Organelle Therapeutics
@organelletx · X

⏳

Jun 20, 2025 · 3 likes · 1 share · 53 followers View post →
Fox
@FoxRiverC · X

RT @AgingBiology: Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis https://t…

Jun 20, 2025 · 4 shares · 715 followers View post →
Nathalia Le Hen
@NathaliaLeHen · X

RT @AgingBiology: Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis https://t…

Jun 20, 2025 · 4 shares · 2,816 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis https://t.c…

Jun 20, 2025 · 3 shares · 132 followers View post →
DeScAI agent
@longevity_agent · X

RT @agingdoc1: Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis https://t.c…

Jun 20, 2025 · 3 shares · 754 followers View post →
Charlie
@begoodthyself · X

RT @agingdoc1: Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis https://t.c…

Jun 20, 2025 · 3 shares · 694 followers View post →
Agingdoc
@agingdoc1 · X

Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis https://t.co/1b4ZfibPWl https://t.co/D3dm754PnD

Jun 20, 2025 · 5 likes · 3 shares · 42,377 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

The anti-aging drug #Rapamycin has the same life-extending effect as eating less, according to new research from the University of East Anglia @uniofeastanglia & University of Glasgow @UofGlasgow. By @AlexeiMaklakov, Edward R. Ivimey-Cook,et al. https://t.co/vE8P3earF7 https://t.co/LOsAORwYnE

Jun 20, 2025 · 1 like · 738 followers View post →
Aging Science News
@agingbiology.bsky.social · Bluesky

Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis onlinelibrary.wiley.com/doi/10.1111/...

Jun 20, 2025 · 1 like View post →
Aging Science News
@AgingBiology · X

Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis https://t.co/EN9FKyDMIF

Jun 20, 2025 · 32 likes · 4 shares · 30,997 followers View post →
Quentin Corbel
@QuentinCorbel1 · X

RT @zahidasultanova: In our new paper, we show that taking the drug rapamycin delivers a lifespan extension benefit very similar to eating…

Jun 20, 2025 · 4 shares · 87 followers View post →
Hotte
@Hotte11184211 · X

Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis https://t.co/SYuXAAejw7

Jun 19, 2025 · 1 like · 47 followers View post →
Alexei Maklakov
@AlexeiMaklakov · X

RT @zahidasultanova: In our new paper, we show that taking the drug rapamycin delivers a lifespan extension benefit very similar to eating…

Jun 19, 2025 · 4 shares · 1,496 followers View post →
Zahida Sultanova
@zahidasultanova · X

In our new paper, we show that taking the drug rapamycin delivers a lifespan extension benefit very similar to eating less across vertebrates. https://t.co/ZTy4DgR0PY

Jun 19, 2025 · 16 likes · 4 shares · 491 followers View post →
Ed Ivimey-Cook
@eivimeycook.bsky.social · Bluesky

New paper! "Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis" tinyurl.com/yc6pkmbe Using meta-analysis, we examined the average lifespan extension conferred by dietary restriction (DR), Metformin, and Rapamycin.

Jun 19, 2025 · 14 likes · 8 shares View post →
Professor Erwin Loh
@erwinloh · X

Source: https://t.co/HdLYuwdcda

Jun 19, 2025 · 8,223 followers View post →
サイエンスあれこれ
@sarekore · X

根拠を明らかにしました。一方、こちらも抗老化薬として期待されていた2型糖尿病治療薬のメトホルミンではその効果がないこともわかりました。ラパマイシンとメトホルミンは現在、ともに臨床試験が継続中ですが、結果はまだ出ていません。https://t.co/YCB2kPQ8Ih

Jun 19, 2025 · 2 likes · 927 followers View post →