N Engl J Med September 2025 PMID 40544435

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes.

Julio Rosenstock, Stanley Hsia, Luis Nevarez Ruiz, Sarah Eyde, David Cox, Wen-Shuo Wu, Rong Liu, Jianghao Li, Laura Fernández Landó, Max Denning, Lisa Ludwig, Yanyun Chen, ACHIEVE-1 Trial Investigators

Mentions

301
Peak: 66 in Jun 2025
across 9 sources since Jun 2025

Extended reach

2,761,543
potential audience

Total likes

4,496

Video views

219,138

Mentions per month

Jun 2025 – Oct 2026

Where it's discussed

  • X / Twitter107 posts
  • Facebook52 posts
  • News50 articles
  • Instagram36 posts
  • YouTube16 videos
  • Bluesky15 posts
  • LinkedIn12 posts
  • Reddit9 posts
  • TikTok4 posts

AI synopsis

What people are saying

Several mentions, such as the posts describing Orforglipron as a 'game-changing' oral GLP-1 receptor agonist, demonstrate high interest and engagement through detailed discussion of trial data and treatment implications. The tone is optimistic, emphasizing the drug's efficacy (HbA1c reductions up to -1.48%), safety profile, and ease of use, indicating a strong belief in its high impact for diabetes management.

AgreementModerate agreement

Most mentions acknowledge the positive findings of the phase 3 trial, highlighting its significance.

InterestModerate interest

Mentions use enthusiastic language like 'promising results' and emphasize the potential of a new oral medication, indicating high interest.

EngagementModerate engagement

Many mentions discuss detailed trial results, safety, and implications, showing deep engagement.

ImpactModerate impact

Mentions consistently highlight the potential for major advances in diabetes treatment and medication accessibility, indicating significant impact.

Abstract in brief

  • Orforglipron, a novel oral small-molecule GLP-1 receptor agonist, was tested over 40 weeks in a phase 3 trial involving 559 participants with type 2 diabetes, showing significant reductions in glycated hemoglobin levels compared to placebo, with mean decreases of -1.24% to -1.48% for doses of 3 mg, 12 mg, and 36 mg.
  • All three doses significantly outperformed placebo in lowering HbA1c, achieving mean differences from placebo of approximately -0.83 to -1.07 percentage points, indicating strong efficacy.
  • The study also assessed changes in body weight, although detailed results for weight reduction are not provided in the excerpt, emphasizing the need for further data on safety and secondary outcomes.]

Top posts

Most liked on X and Bluesky
Dr.U@内科医
@dr_ukio · X

★2025年糖尿病領域キー論文まとめ★ 今年発表された糖尿病関連論文のうち、知っていてほしい27本についてまとめました!(糖尿病メモ新着論文集の★3つ論文です) ① チルゼパチド、CVD抑制でデュラグルチドに優越性示せず SURPASS-CVOT試験。 2型DM・心血管疾患既往例13,165人を対象とした国際共同第3相RCT。 チルゼパチド(最大15mg/週)とデュラグルチド(1.5mg/週)を比較し、MACEはHR 0.92(0.83–1.01)。 非劣性は示されたが、優越性は示されなかった(P=0.09)。 Nicholls SJ, et al. Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes. N Engl J Med. 2025;393(24):2409–2420. ② 経口セマグルチドが心血管イベント抑制 SOUL試験。 CVDまたはCKD合併2型DM 9,650人、約4年間のRCT。 経口セマグルチド14mgで複合CVDはHR 0.86(0.77–0.96)。 心筋梗塞HR 0.73、全死亡HR 0.91、消化器系有害事象は5.0% vs 4.4%。 McGuire DK, et al. Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes. N Engl J Med. 2025. ③ 経口GLP-1オルフォルグリプロン、早期2型糖尿病への効果 ACHIEVE-1試験。 食事運動療法のみの2型DM 559人、40週間。 HbA1cは−0.83〜−1.07%、体重は−4.5〜−7.6%。 主な副作用は軽度〜中等度の消化器症状。 Rosenstock J, et al. Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes. N E

Dec 28, 2025 · 152 likes · 19 shares · 10,523 followers View post →
NEJM
@NEJM · X

Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial) https://t.co/qKRfQon3fN Editorial: Mimicking Complex Receptor Actions with Small(ish) Molecules https://t.co/551PZYPm9D #Endocrinology https://t.co/bMCdIt6jS6

Sep 18, 2025 · 114 likes · 33 shares · 1,041,724 followers View post →
Melina Manolas, MD, MPH
@melina_manolas · X

? New in @NEJM : Orforglipron, a once-daily oral GLP‑1, led to ~2% A1c drop & ~16 lb weight loss in T2D (ACHIEVE-1 trial). A non-peptide, no-injection option with classic GLP-1 GI profile. Big step for access & adherence! ?https://t.co/aIb2CShopY

Jun 21, 2025 · 72 likes · 10 shares · 10,684 followers View post →
NEJM
@NEJM · X

Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial) https://t.co/qKRfQon3fN @ADA_DiabetesPro | #ADASciSessions https://t.co/TlSPkixnBI

Jun 22, 2025 · 69 likes · 22 shares · 1,041,724 followers View post →
Katalin Susztak
@KSusztak · X

The oral GLP !! Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | ⁦@NEJM⁩ https://t.co/9XuyCeT6ew

Jun 22, 2025 · 27 likes · 4 shares · 7,610 followers View post →
Robert Kalyesubula,MD, FISN(USA), PhD-FRCP(London)
@rkalyes1 · X

✍️ Here comes Orforglipron- the Oral GLP-1 Receptor Agonist for Type 2 Diabetes ✍️ I hope it also works like Ozempic for weight loss ✍️Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New England Journal of Medicine https://t.co/ClMHeBhcrX?

Sep 28, 2025 · 18 likes · 3 shares · 22,972 followers View post →

All mentions

HilmyHealth
@HilmyHealth · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New England Journal of Medicine https://t.co/2TksocbB58 The therapies are getting better and better. Small molecule drugs are coming. I expect to see similar medications for obesity soon!

Jun 4, 2026 · 7 followers View post →
GLP-1 LIFE!
@GLP1_LIFE · X

#foundayo #glp1 #orforglipron #elilly https://t.co/OQciSLnopa

Apr 3, 2026 · 26 followers View post →
NEJM.org
@nejm.org · Bluesky

In the phase 3 ACHIEVE-1 trial, published in June 2025, the oral small-molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with early type 2 diabetes. Download the Notable Articles of 2025: nej.md/49td1Lq

Jan 12, 2026 · 7 likes · 3 shares View post →
Dr.U@内科医
@dr_ukio · X

★2025年糖尿病領域キー論文まとめ★ 今年発表された糖尿病関連論文のうち、知っていてほしい27本についてまとめました!(糖尿病メモ新着論文集の★3つ論文です) ① チルゼパチド、CVD抑制でデュラグルチドに優越性示せず SURPASS-CVOT試験。 2型DM・心血管疾患既往例13,165人を対象とした国際共同第3相RCT。 チルゼパチド(最大15mg/週)とデュラグルチド(1.5mg/週)を比較し、MACEはHR 0.92(0.83–1.01)。 非劣性は示されたが、優越性は示されなかった(P=0.09)。 Nicholls SJ, et al. Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes. N Engl J Med. 2025;393(24):2409–2420. ② 経口セマグルチドが心血管イベント抑制 SOUL試験。 CVDまたはCKD合併2型DM 9,650人、約4年間のRCT。 経口セマグルチド14mgで複合CVDはHR 0.86(0.77–0.96)。 心筋梗塞HR 0.73、全死亡HR 0.91、消化器系有害事象は5.0% vs 4.4%。 McGuire DK, et al. Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes. N Engl J Med. 2025. ③ 経口GLP-1オルフォルグリプロン、早期2型糖尿病への効果 ACHIEVE-1試験。 食事運動療法のみの2型DM 559人、40週間。 HbA1cは−0.83〜−1.07%、体重は−4.5〜−7.6%。 主な副作用は軽度〜中等度の消化器症状。 Rosenstock J, et al. Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes. N E

Dec 28, 2025 · 152 likes · 19 shares · 10,523 followers View post →
Editörün Gözünden
@editorgozunden · X

2026'da sağlık teknolojilerinde neler değişecek dersiniz? Videonun tamamı YouTube kanalımızda. Gelin birlikte 2026'da sağlıkta neler değişecek göz atalım. https://t.co/vgpzJ9Ffao #saglik #saglikteknolojileri #sağlıkhaberleri https://t.co/ESBOAf2ZT8

Dec 23, 2025 · 1 share · 62 followers View post →
Editörün Gözünden
@editorgozunden · X

2026 sağlık dünyası nasıl olacak? Yapay zekâ kişisel sağlık koçuna mı dönüşüyor? Zayıflama iğneleri yerini haplara mı bırakacak? Obezite cerrahisi azalacak mı? Kanser aşıları gerçekten yakın mı? Longevity neden yükselişte? https://t.co/4KPS9kyDkk #saglik #saglikhaberleri https://t.co/iS0u3qlZ45

Dec 10, 2025 · 62 followers View post →
内科医 J
@9DlWzHLxml8t2ZA · X

https://t.co/4BkvzpcDxm

Nov 13, 2025 · 1 like · 120 followers View post →
SAEDYN
@SAEDYN_ · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Nov 8, 2025 · 22 shares · 3,934 followers View post →
LongevityLab
@SciFit_ · X

Another “miracle” weight-loss drug is in the pipeline: Orforglipron. ? In 10 months, it lowered glycated hemoglobin HbA1c from ~8% → 6.5–6.7%. ⚠️ Reminder: anything >6.4% is still diabetes! ❌ Adverse events forced discontinuation in 4.4–7.8% of patients. Meanwhile, a ketogenic diet + fasting can push HbA1c below 6% in just 3-6 months — without new side-effect labels. DOI: 10.1056/NEJMoa2505669

Oct 24, 2025 · 3 likes · 942 followers View post →
Robert Kalyesubula,MD, FISN(USA), PhD-FRCP(London)
@rkalyes1 · X

✍️ Here comes Orforglipron- the Oral GLP-1 Receptor Agonist for Type 2 Diabetes ✍️ I hope it also works like Ozempic for weight loss ✍️Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New England Journal of Medicine https://t.co/ClMHeBhcrX?

Sep 28, 2025 · 18 likes · 3 shares · 22,972 followers View post →
Prof. Wasim Hanif OBE
@docwas · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes https://t.co/2WSEGDw625

Sep 22, 2025 · 4 likes · 1 share · 5,175 followers View post →
NEJM.org
@nejm.org · Bluesky

In the ACHIEVE-1 phase 3 trial, the oral small-molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with early type 2 diabetes. Full trial results and Research Summary: nej.md/4ngEZ36 #MedSky #EndoSky

Sep 22, 2025 · 5 likes · 3 shares View post →
naija prince ??
@NiyiMk · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 21, 2025 · 33 shares · 2,121 followers View post →
Medicine Pods
@MedicinePods · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 21, 2025 · 33 shares · 591 followers View post →
Nitin Gandhi, M Pharm
@NitinGa35829582 · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 20, 2025 · 33 shares · 341 followers View post →
Dr Benil
@hafeeq_benil · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 20, 2025 · 33 shares · 396 followers View post →
drianmusyoki
@muendo_ian · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 357 followers View post →
??Luck InHeels??
@LuckInHeels147 · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 363 followers View post →
Dr. Hugo Corrales - Endocrinología.
@hugoendocrino · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 6,556 followers View post →
Truly Blessed
@Loretta63354723 · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 6,588 followers View post →
José Adrián
@elchepesaurio · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 99 followers View post →
Dr Vinod Veerapalli
@mightymedico · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 97 followers View post →
HUMBLE
@XPEACEEY · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 690 followers View post →
Shima Aziz
@AzizShima1990 · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 13 followers View post →
Aaron Scott
@FuturePH_Scott · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 33 followers View post →
Khushboo Agarwal
@DrKhushboo_Endo · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 261 followers View post →
Bohabib2466
@bohabib2466 · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 67 followers View post →
Eric Adler
@DrEricAdler · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 73 followers View post →
Eve Fain, BSN MPH RN CDE, CHES
@espacetimeNOT · X

RT @DrKarlNadolsky: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Obesity + Early Type 2 Diabetes | NEJM -1.5% HbA1c redu…

Sep 19, 2025 · 1 share · 1,138 followers View post →
JORGE FERNANDEZ
@drjorfer · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 1,106 followers View post →
María Ballesteros #yoelijoEndocrino
@mdballesteros · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 4,919 followers View post →
Dr Ashish Kumar
@DrAshish_Kumar · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 19,113 followers View post →
SmritiG97????
@youngendo2023 · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 23 followers View post →
Iradukunda Jean Marie
@JeanIraduk88335 · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 21 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 33,355 followers View post →
Joseph KAMTCHUM TATUENE
@JTatuene · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 583 followers View post →
Elena Shcherbakova
@Ohlalena · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 481 followers View post →
Lilia
@Cookie_2025521 · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 19, 2025 · 33 shares · 92 followers View post →
Min Seo Kim, MD, MSDH
@MinSeoKim_MD · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 18, 2025 · 33 shares · 2,603 followers View post →
Marko
@Markotelomerase · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 18, 2025 · 33 shares · 74 followers View post →
Joshuan J. Barboza
@joshuanbarbozam · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 18, 2025 · 33 shares · 10,533 followers View post →
Herbs and Havoc
@HerbsAndHavoc · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 18, 2025 · 33 shares · 287 followers View post →
Andres Felipe Florez
@Andresffmed · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Sep 18, 2025 · 33 shares · 144 followers View post →
NEJM
@NEJM · X

Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial) https://t.co/qKRfQon3fN Editorial: Mimicking Complex Receptor Actions with Small(ish) Molecules https://t.co/551PZYPm9D #Endocrinology https://t.co/bMCdIt6jS6

Sep 18, 2025 · 114 likes · 33 shares · 1,041,724 followers View post →
Tom Hsiung ???????‍⚕️ですね??!? ?
@TomHsiung · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New England Journal of Medicine https://t.co/mziedF67IE

Sep 18, 2025 · 473 followers View post →
Karl Nadolsky
@DrKarlNadolsky · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Obesity + Early Type 2 Diabetes | NEJM -1.5% HbA1c reduction & 6-7.6% weight loss vs -0.4% and -1.7% resp for placebo https://t.co/SCPOVNMJZf

Sep 18, 2025 · 4 likes · 1 share · 5,902 followers View post →
BaladoCritique : club de lecture médical
@baladocritique.bsky.social · Bluesky

“Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes.”” Publié ce jour dans le @nejm.org. #MedSky #EndoSky www.nejm.org/doi/full/10....

Sep 18, 2025 · 1 like View post →
caloriesproper.bsky.social
@caloriesproper.bsky.social · Bluesky

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes www.nejm.org/doi/full/10....

Aug 25, 2025 · 1 like View post →
William Lagakos
@caloriesproper2 · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes https://t.co/rhAtIy1FZL

Aug 25, 2025 · 3 likes · 4,405 followers View post →
Vědou Ke Zdraví
@VedouKeZdravi · X

? "Ozempic" v pilulce? Nový lék bez jehel pomáhá s cukrovkou i hubnutím. Podle ?? studie publikované v časopise @NEJM lék orforglipron ukazuje slibné výsledky již po 40 týdnech léčby. Více v našem článku: https://t.co/GuoLHWCutX Zdroj: Rosenstock, J., Hsia, S., Ruiz, L. N., Eyde, S., Cox, D., Wu, W., Liu, R., Li, J., Landó, L. F., Denning, M., Ludwig, L., & Chen, Y. (2025). Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes. New England Journal of Medicine.

Aug 21, 2025 · 5 likes · 971 followers View post →
CardioNova
@AppCardioNova · X

? Ya disponibles los datos de Fase 3 sobre hemoglobina glicosilada de #Orforglipron ?¿Qué es? Un agonista del receptor GLP-1 oral en desarrollo clínico para la diabetes tipo 2 y el control del peso. ?Resultados tras 40 semanas: • Reducción de HbA1c de hasta –1.48% • Pérdida de peso de hasta –7.6% • Sin hipoglucemias graves • Perfil de seguridad favorable DOI: 10.1056/NEJMoa2505669

Aug 1, 2025 · 5 likes · 17,066 followers View post →
Pierre Gholam MD
@livermd.bsky.social · Bluesky

The second @nejm.org #orforpligron paper is out. There is no doubt that Oral GLP-1s are coming. For #MASH, discontinuation rates will matter. 4-8% in T2DM (44w) vs. 10-17% in obesity (36w) which always seems higher. How might our patients fare? #liversky

Jul 29, 2025 View post →
Pierre Gholam
@pgholam · X

The second ⁦⁦@NEJM⁩ #orforpligron paper is out. There is no doubt that Oral GLP-1s are coming. For #MASH, discontinuation rates will matter. 4-8% in T2DM (44w) vs. 10-17% in obesity (36w) How might our patients fare? #livertwitter https://t.co/1aUMBnZk6n

Jul 29, 2025 · 11 likes · 3 shares · 1,634 followers View post →
CardioNova
@AppCardioNova · X

? Ya disponibles los datos de Fase 3 sobre hemoglobina glicosilada de #Orforglipron ?¿Qué es? Un agonista del receptor GLP-1 oral en desarrollo clínico para la diabetes tipo 2 y el control del peso. ?Resultados tras 40 semanas: • Reducción de HbA1c de hasta –1.48% • Pérdida de peso de hasta –7.6% • Sin hipoglucemias graves • Perfil de seguridad favorable DOI: 10.1056/NEJMoa2505669

Jul 2, 2025 · 5 likes · 1 share · 17,066 followers View post →
Pon|食と健康
@PonNutr · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes. The New England journal of medicine, 10.1056/NEJMoa2505669. https://t.co/hNLokpG2gU

Jul 2, 2025 · 2 likes · 3,145 followers View post →
Dr Celestino Gutiérrez González MD ?????
@CelestinoGutirr · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes Orforglipron is a small-molecule,…

Jul 1, 2025 · 4 shares · 11,506 followers View post →
உன்னைப்போல் ஒருவன்
@vinopan007 · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes Orforglipron is a small-molecule,…

Jul 1, 2025 · 4 shares · 230 followers View post →
Huda Saleh
@HistHumorDoc · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes Orforglipron is a small-molecule,…

Jun 30, 2025 · 4 shares · 8 followers View post →
Ahmed Bennis MD ?
@drbennisahmed · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes Orforglipron is a small-molecule, nonpeptide glucagon-like peptide-1 (GLP-1) receptor agonist in clinical development for type 2 diabetes and weight management. Additional data on the efficacy and safety of orforglipron are needed. In adults with early type 2 diabetes, orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks https://t.co/nM7ohohS28

Jun 30, 2025 · 16 likes · 4 shares · 5,878 followers View post →
pinacol
@pinacol · X

【RCT】HbA1c7.0%-9.5%でBMIが23以上の食事療法と運動療法のみの2型糖尿病患者へのOrforglipronの投与は、プラセボの投与と比較して、HbA1cを減少させた。 #ペ読 https://t.co/JH7g0ONKuJ

Jun 29, 2025 · 1 like · 1,759 followers View post →
YG研究会
@ogatakiya · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Jun 26, 2025 · 22 shares · 6,169 followers View post →
Vinod Mishra
@vinodmishra1960.bsky.social · Bluesky

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New England Journal of Medicine www.nejm.org/doi/full/10....

Jun 25, 2025 View post →
Vinod Mishra, PhD
@VinodMishr11338 · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New England Journal of Medicine https://t.co/roQkCN3p7y

Jun 25, 2025 · 99 followers View post →
Research Bites
@Research_Bites · X

A clinical trial found that orforglipron, a new medication for type 2 diabetes, significantly lowered blood sugar levels and helped participants lose weight over 40 weeks, with mild digestive side effects being common. - Read more: https://t.co/IbxS28KsJy

Jun 25, 2025 · 1 like · 1,067 followers View post →
Research Bites
@Research_Bites · X

A 40-week study found that orforglipron, a new medication for type 2 diabetes, significantly lowered blood sugar levels and aided weight loss in participants compared to a placebo, with manageable side effects. - Read more: https://t.co/IbxS28KsJy

Jun 25, 2025 · 1 like · 1,067 followers View post →
Esteban Jódar Gimeno
@estebanjodar · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Jun 25, 2025 · 22 shares · 4,538 followers View post →
redGDPS Diabetes
@redGDPS · X

Acceso artículo en @PubMedOnline https://t.co/RmgV8bfdJv

Jun 24, 2025 · 1 like · 16,014 followers View post →
RedGDPS
@redgdps.bsky.social · Bluesky

Acceso en #pubmed pubmed.ncbi.nlm.nih.gov/40544435/

Jun 24, 2025 · 1 like · 1 share View post →
RedGDPS
@redgdps.bsky.social · Bluesky

Full text links www.nejm.org/doi/10.1056/...

Jun 24, 2025 · 1 like View post →
Benjamin Vipler, MD, MEd
@vipsmdmed.bsky.social · Bluesky

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New England Journal of Medicine www.nejm.org/doi/full/10....

Jun 24, 2025 · 1 share View post →
Benjamin Vipler, MD, MEd
@VipsMDMEd · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New England Journal of Medicine https://t.co/Rjju295cKZ

Jun 24, 2025 · 6,527 followers View post →
Jessica Pan 潘尚敏, MPH
@calhunii · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New England Journal of Medicine https://t.co/TWxcEXu3mi

Jun 24, 2025 · 352 followers View post →
Henrik Ekenberg
@hekenberg.bsky.social · Bluesky

@annakrook.bsky.social I found this www.nejm.org/doi/full/10....

Jun 24, 2025 · 1 like View post →
Life Science Journal Content
@lsn_jc · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes #science #publication #research #journal https://t.co/vtK9OdIsA7

Jun 24, 2025 · 197 followers View post →
la máscara de gato:猫の仮面
@tymsshphd · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New England Journal of Medicine https://t.co/BDibuWZ1Y5

Jun 24, 2025 · 342 followers View post →
N
@NCKAR1999 · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Jun 24, 2025 · 22 shares · 15 followers View post →
Basem Mishriky, MD, FACP, ABOM Diplomate
@BasemMishriky · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Jun 24, 2025 · 22 shares · 269 followers View post →
Pancreatic Cell News
@PancreaticCell · X

Introducing Orforglipron, an oral small-molecule GLP-1 receptor agonist, in early #T2D! ? ACHIEVE-1 trial investigators report that in adults with early T2D, orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks. @NEJM | https://t.co/dBfeGZ97c8

Jun 24, 2025 · 2,766 followers View post →
Rexford S. Ahima, MD, PhD
@rex_ahima · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New England Journal of Medicine https://t.co/np3ThAVRtP

Jun 24, 2025 · 631 followers View post →
Yan Leyfman, MD
@yleyfman.bsky.social · Bluesky

This could mark a major step forward in oral GLP-1 therapies for type 2 diabetes. manuscript: www.nejm.org/doi/full/10.... #Diabetes #GLP1 #Orforglipron #WeightManagement #Endocrinology #ClinicalTrials

Jun 23, 2025 · 1 like View post →
Yan Leyfman, MD
@yleyfman.bsky.social · Bluesky

? Latest in Type 2 Diabetes & Weight Management ? New data from the phase 3 ACHIEVE-1 trial shows promising results for Orforglipron, a once-daily, oral, nonpeptide GLP-1 receptor agonist.

Jun 23, 2025 · 1 share View post →
Prof Derek Connolly
@DrDerekConnolly · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Jun 23, 2025 · 22 shares · 4,169 followers View post →
JoseM Garcia Almeida
@jgarciaalmeida · X

RT @CristobMorales: https://t.co/YwCnsjilp4 Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New Eng…

Jun 23, 2025 · 3 shares · 3,948 followers View post →
Joe Gordon
@josephwgordon · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Jun 23, 2025 · 22 shares · 2,091 followers View post →
Abstream
@abstreamme · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes #science #publication #research #publications https://t.co/XWlEm6VyMP

Jun 23, 2025 · 553 followers View post →
Julia Evans
@julicaretech · X

RT @KSusztak: The oral GLP !! Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | ⁦@NEJM⁩ https://t.co…

Jun 23, 2025 · 4 shares · 21 followers View post →
Tim Kambič
@TimKambic · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Jun 23, 2025 · 22 shares · 253 followers View post →
Mohammad Aleidi
@aleidimed · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes In adults with early type 2 diabe…

Jun 23, 2025 · 2 shares · 699 followers View post →
Ahmed Bennis MD ?
@drbennisahmed · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes In adults with early type 2 diabetes, orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks https://t.co/EjiiorKHAX https://t.co/2qDK3nulnZ

Jun 23, 2025 · 16 likes · 2 shares · 5,878 followers View post →
Ahmed Bennis MD ?
@drbennisahmed · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes In adults with early type 2 diabetes, orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks https://t.co/EjiiorLfqv https://t.co/5zitcyAKOj

Jun 23, 2025 · 6 likes · 5,878 followers View post →
Naeem ul Hassan
@naeemulhassan_ · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Jun 23, 2025 · 22 shares · 320 followers View post →
Arshad Rashid
@arshadkema · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Jun 23, 2025 · 22 shares · 997 followers View post →
mocchi
@mocchi_ym · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Jun 22, 2025 · 22 shares · 195 followers View post →
Erol Demir
@eroldemir83 · X

RT @KSusztak: The oral GLP !! Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | ⁦@NEJM⁩ https://t.co…

Jun 22, 2025 · 4 shares · 279 followers View post →
xxy
@xxy07255392 · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Jun 22, 2025 · 22 shares · 202 followers View post →
Servicio de Geriatría del INCMNSZ
@INCMNSZ_Geria · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Jun 22, 2025 · 22 shares · 16,941 followers View post →
Frank Paul Mora
@InTime_49 · X

RT @KSusztak: The oral GLP !! Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | ⁦@NEJM⁩ https://t.co…

Jun 22, 2025 · 4 shares · 493 followers View post →
Layla Omar
@hlaylaomar · X

RT @KSusztak: The oral GLP !! Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | ⁦@NEJM⁩ https://t.co…

Jun 22, 2025 · 4 shares · 15 followers View post →
María Ballesteros #yoelijoEndocrino
@mdballesteros · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Jun 22, 2025 · 22 shares · 4,919 followers View post →
Gibran Bello
@gibranbello · X

RT @CristobMorales: https://t.co/YwCnsjilp4 Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New Eng…

Jun 22, 2025 · 3 shares · 135 followers View post →
Juan Luis Alonso
@jalojer · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Jun 22, 2025 · 22 shares · 1,418 followers View post →
Laura Pérez ??‍⚕️
@tatana2007 · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Jun 22, 2025 · 22 shares · 240 followers View post →
Alexis A.
@Alexis_arbra · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Jun 22, 2025 · 22 shares · 223 followers View post →
Dr Ashok Dalal
@DrAshokGastro · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Jun 22, 2025 · 22 shares · 1,685 followers View post →
Alexia Espiño
@Alexia_EAlvarez · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Jun 22, 2025 · 22 shares · 49 followers View post →
José Mª Gª Quintana
@jose_g_quintana · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Jun 22, 2025 · 22 shares · 860 followers View post →
Cristobal Morales
@CristobMorales · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…

Jun 22, 2025 · 22 shares · 17,797 followers View post →
NEJM
@NEJM · X

Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial) https://t.co/qKRfQon3fN @ADA_DiabetesPro | #ADASciSessions https://t.co/TlSPkixnBI

Jun 22, 2025 · 69 likes · 22 shares · 1,041,724 followers View post →
Katalin Susztak
@KSusztak · X

The oral GLP !! Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | ⁦@NEJM⁩ https://t.co/9XuyCeT6ew

Jun 22, 2025 · 27 likes · 4 shares · 7,610 followers View post →
Adhithya Sankar
@adhithyasankar.bsky.social · Bluesky

www.nejm.org/doi/full/10....

Jun 22, 2025 · 2 likes View post →
Khushboo Agarwal
@DrKhushboo_Endo · X

RT @CMEINDIA1: Key clinical pearls from the ACHIEVE-1 trial on Orforglipron (NEJM 2025; DOI:10.1056/NEJMoa2505669): ? ORFORGLIPRON – Oral…

Jun 22, 2025 · 2 shares · 261 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @CMEINDIA1: Key clinical pearls from the ACHIEVE-1 trial on Orforglipron (NEJM 2025; DOI:10.1056/NEJMoa2505669): ? ORFORGLIPRON – Oral…

Jun 22, 2025 · 2 shares · 33,355 followers View post →
CME INDIA
@CMEINDIA1 · X

Key clinical pearls from the ACHIEVE-1 trial on Orforglipron (NEJM 2025; DOI:10.1056/NEJMoa2505669): ? ORFORGLIPRON – Oral Nonpeptide GLP-1 RA ? Once-daily oral GLP-1 agonist (non-peptide) ? First-in-class, no fasting or water restrictions ? ACHIEVE-1 Trial Highlights (40 Weeks) ? 559 adults with early T2DM (HbA1c 7–9.5%, BMI ≥23) ? Orforglipron 3/12/36 mg vs placebo ✅ HbA1c Reduction • −1.24% (3 mg) • −1.47% (12 mg) • −1.48% (36 mg) • Placebo: −0.41% ✅ Weight Loss • −4.5% (3 mg) • −5.8% (12 mg) • −7.6% (36 mg) • Placebo: −1.7% ⚠️ Safety Profile ? GI AEs (mild-moderate): nausea, diarrhea ? No severe hypoglycemia ? Discontinuation: 4–8% (vs 1.4% placebo) ? CME INDIA Pearls ? Oral GLP-1RA = injectable-like efficacy with better convenience ? HbA1c <6.5% achieved in majority at 36 mg ? Excellent weight loss (~7–8%) without plateau at 40 weeks ? Ideal for early T2DM, obese, needle-a

Jun 22, 2025 · 8 likes · 2 shares · 7,460 followers View post →
Dr. Karl Nadolsky
@drkarlnadolsky.bsky.social · Bluesky

Orforglipron, small molecule GLP-1ra in type 2 #diabetes. ➡️mean HbA1c at baseline was 8.0%. At week 40, it dropped −1.24% with 3-mg, −1.47 % with 12-mg, −1.48 % with 36-mg dose, and −0.41 % with placebo. www.nejm.org/doi/full/10.... #ADA2025

Jun 22, 2025 · 6 likes · 2 shares View post →
Fernando Moya-Méndez E.
@DrMoyaMendezE · X

RT @CristobMorales: https://t.co/YwCnsjilp4 Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New Eng…

Jun 22, 2025 · 3 shares · 115 followers View post →
la máscara de gato:猫の仮面
@tymsshphd · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New England Journal of Medicine https://t.co/BDibuWZ1Y5

Jun 21, 2025 · 342 followers View post →
Christian Assad, MD
@ChristianAssad · X

¿Un GLP-1 oral, sin restricciones ni aguja, con eficacia comparable a inyectables? Orforglipron es el primer agonista del receptor GLP-1 no peptídico aprobado en estudios fase 3 para la diabetes tipo 2. Su principal ventaja: se administra en cápsula diaria, sin restricciones de comida, agua o ayuno. Publicado en NEJM el 21 de junio de 2025 (DOI: 10.1056/NEJMoa2505669), el estudio ACHIEVE-1 evaluó su eficacia y seguridad en 559 adultos con diabetes tipo 2 temprana manejada solo con dieta y ejercicio. – Diseño doble ciego, controlado con placebo – Tres dosis (3, 12 y 36 mg/día) por 40 semanas – Sin uso previo de fármacos antidiabéticos Resultados clave: – Reducción de HbA1c hasta –1.48 % – Reducción de peso corporal de hasta –7.9 % – HbA1c < 7 % en 76.2 % – HbA1c ≤ 6.5 % en 66.0 % – HbA1c < 5.7 % (valor normal) en 25.8 % – Efecto sostenido desde semana 4 Ventajas farmacológicas: – Vida

Jun 21, 2025 · 2 likes · 1 share · 24,380 followers View post →
Melina Manolas, MD, MPH
@melina_manolas · X

? New in @NEJM : Orforglipron, a once-daily oral GLP‑1, led to ~2% A1c drop & ~16 lb weight loss in T2D (ACHIEVE-1 trial). A non-peptide, no-injection option with classic GLP-1 GI profile. Big step for access & adherence! ?https://t.co/aIb2CShopY

Jun 21, 2025 · 72 likes · 10 shares · 10,684 followers View post →
Prof. Dr. Sanjeev Bagai
@BagaiDr · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early T2DM | New England Journal of Medicine. phase 3, double-blind, placebo-controlled trial, randomly assigned in a 1:1:1:1 ratio to receive orforglipron at 1 of 3 doses (3 mg, 12 mg, 36 mg) https://t.co/yXChehuZpu

Jun 21, 2025 · 34,445 followers View post →
Basem Mishriky, MD, FACP, ABOM Diplomate
@BasemMishriky · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New England Journal of Medicine https://t.co/e4V0UJkOfW

Jun 21, 2025 · 1 like · 269 followers View post →
Cristobal Morales
@CristobMorales · X

https://t.co/YwCnsjilp4 Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New England Journal of Medicine @NEJM #ADA2025

Jun 21, 2025 · 14 likes · 3 shares · 17,797 followers View post →
Daniel Drucker
@danieljdrucker.bsky.social · Bluesky

A detailed P3 look at the leading small molecule oral GLP-1 RA orforglipron studied at a range of doses for moderate #T2D Good tolerability, solid efficacy on glucose and #weightloss no serious off target SAEs www.nejm.org/doi/full/10....

Jun 21, 2025 · 18 likes · 7 shares View post →
Orforglipron: A Comprehensive Review of an Oral Small-Molecule ...
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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes. N. Engl. J. Med.; 2025; 393, pp. 1065-1076. [DOI: https://dx.doi.org ...

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Orforglipron, an oral small-molecule GLP-1 receptor agonist, in adults with obesity. N Engl J Med. 2025;393:1796–1806. doi:10.1056/NEJMoa2511774. Aljazeeri ...

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"Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes". New England Journal of Medicine. 393 (11). doi:10.1056 ...

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Source Citation. Rosenstock J, Hsia S, Nevarez Ruiz L, et al; ACHIEVE-1 Trial Investigators. Orforglipron, an oral small-molecule GLP-1 receptor agonist, in ...

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes 2. Weekly Fixed-Dose Insulin Efsitora in Type 2 Diabetes without ...

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DOI: 10.1056/NEJMoa2505669. original sound - kivxr · Para Que Sirve Gestrygen · Texapon Para Que Sirve · Para Que Sirve Exicort Etoricoxib · Indigon Para Que ...

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes. N Engl J Med. 2025; 393:1065-1076. doi:10.1056/NEJMoa2505669. 1 ...

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Orforglipron, an oral small-molecule GLP-1 receptor agonist, in early type 2 diabetes. N Engl J Med. 2025; 393(11):1065-1076. doi:10.1056/NEJMoa2505669 ℹ️ ...

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Rosenstock, J ∙ Hsia, S ∙ Ruiz, LN ∙ et al. Orforglipron, an oral small-molecule GLP-1 receptor agonist, in early type 2 diabetes. N Engl ...

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จากการศึกษา phase 3 ล่าสุด ใน new england journal "Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes" .

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DOI: 10.1056/NEJMoa2505669. American Diabetes Association. Standards of Care in Diabetes—2020 Abridged for Primary Care Providers ...

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Orforglipron, an oral small-molecule glp-1 receptor agonist in early type 2 diabetes. Abstract presented at: American Diabetes Association's ...

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes. New England Journal of Medicine. June 21, 2025 ...

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes. N Engl J Med. 2025;393:1065-1076. doi:10.1056 ...

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林嘉俊醫師| 家醫•減重•糖尿病•疫苗(@drlimkc). 628 Views. https://www.nejm.org/doi/full/10.1056/NEJMoa2505669.

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ตัวนี้กำลังจะตามมานะครับ เบื้องหลังยาลดอ้วนสุดฮิตอย่าง Zepbound (ของ Eli Lilly) และ Wegovy (ของ Novo Nordisk) คือกลุ่มยา GLP-1 Agonist ...

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DOI: 10.1056/NEJMoa2505669 • Aronne LJ, et al. ATTAIN‑MAINTAIN. Nature Medicine, 2026. DOI: 10.1038/s41591-026-04386-7. 1 hour ago · dr ...

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Orforglipron, an oral small-molecule GLP-1 receptor agonist, in early type 2 diabetes. N Engl J Med. 2025;393(11):1065-1076. doi: 10.1056 ...

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... Orforglipron, an oral small-molecule GLP-1 receptor agonist, in early type 2 diabetes. N Engl J Med. 2025, 393:1065-76. 10.1056 ...

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