Several mentions, such as the posts describing Orforglipron as a 'game-changing' oral GLP-1 receptor agonist, demonstrate high interest and engagement through detailed discussion of trial data and treatment implications. The tone is optimistic, emphasizing the drug's efficacy (HbA1c reductions up to -1.48%), safety profile, and ease of use, indicating a strong belief in its high impact for diabetes management.
AgreementModerate agreement
Most mentions acknowledge the positive findings of the phase 3 trial, highlighting its significance.
InterestModerate interest
Mentions use enthusiastic language like 'promising results' and emphasize the potential of a new oral medication, indicating high interest.
EngagementModerate engagement
Many mentions discuss detailed trial results, safety, and implications, showing deep engagement.
ImpactModerate impact
Mentions consistently highlight the potential for major advances in diabetes treatment and medication accessibility, indicating significant impact.
Abstract in brief
Orforglipron, a novel oral small-molecule GLP-1 receptor agonist, was tested over 40 weeks in a phase 3 trial involving 559 participants with type 2 diabetes, showing significant reductions in glycated hemoglobin levels compared to placebo, with mean decreases of -1.24% to -1.48% for doses of 3 mg, 12 mg, and 36 mg.
All three doses significantly outperformed placebo in lowering HbA1c, achieving mean differences from placebo of approximately -0.83 to -1.07 percentage points, indicating strong efficacy.
The study also assessed changes in body weight, although detailed results for weight reduction are not provided in the excerpt, emphasizing the need for further data on safety and secondary outcomes.]
★2025年糖尿病領域キー論文まとめ★
今年発表された糖尿病関連論文のうち、知っていてほしい27本についてまとめました!(糖尿病メモ新着論文集の★3つ論文です)
① チルゼパチド、CVD抑制でデュラグルチドに優越性示せず
SURPASS-CVOT試験。
2型DM・心血管疾患既往例13,165人を対象とした国際共同第3相RCT。
チルゼパチド(最大15mg/週)とデュラグルチド(1.5mg/週)を比較し、MACEはHR 0.92(0.83–1.01)。
非劣性は示されたが、優越性は示されなかった(P=0.09)。
Nicholls SJ, et al. Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes. N Engl J Med. 2025;393(24):2409–2420.
② 経口セマグルチドが心血管イベント抑制
SOUL試験。
CVDまたはCKD合併2型DM 9,650人、約4年間のRCT。
経口セマグルチド14mgで複合CVDはHR 0.86(0.77–0.96)。
心筋梗塞HR 0.73、全死亡HR 0.91、消化器系有害事象は5.0% vs 4.4%。
McGuire DK, et al. Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes. N Engl J Med. 2025.
③ 経口GLP-1オルフォルグリプロン、早期2型糖尿病への効果
ACHIEVE-1試験。
食事運動療法のみの2型DM 559人、40週間。
HbA1cは−0.83〜−1.07%、体重は−4.5〜−7.6%。
主な副作用は軽度〜中等度の消化器症状。
Rosenstock J, et al. Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes. N E
Dec 28, 2025 · 152 likes · 19 shares · 10,523 followersView post →
N
NEJM
@NEJM · X
Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial) https://t.co/qKRfQon3fN
Editorial: Mimicking Complex Receptor Actions with Small(ish) Molecules https://t.co/551PZYPm9D
#Endocrinology https://t.co/bMCdIt6jS6
? New in @NEJM : Orforglipron, a once-daily oral GLP‑1, led to ~2% A1c drop & ~16 lb weight loss in T2D (ACHIEVE-1 trial). A non-peptide, no-injection option with classic GLP-1 GI profile.
Big step for access & adherence!
?https://t.co/aIb2CShopY
Jun 21, 2025 · 72 likes · 10 shares · 10,684 followersView post →
N
NEJM
@NEJM · X
Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial) https://t.co/qKRfQon3fN
@ADA_DiabetesPro | #ADASciSessions https://t.co/TlSPkixnBI
Jun 22, 2025 · 69 likes · 22 shares · 1,041,724 followersView post →
KS
Katalin Susztak
@KSusztak · X
The oral GLP !! Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | @NEJM https://t.co/9XuyCeT6ew
Jun 22, 2025 · 27 likes · 4 shares · 7,610 followersView post →
RL
Robert Kalyesubula,MD, FISN(USA), PhD-FRCP(London)
@rkalyes1 · X
✍️ Here comes Orforglipron- the Oral GLP-1 Receptor Agonist for Type 2 Diabetes
✍️ I hope it also works like Ozempic for weight loss
✍️Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New England Journal of Medicine https://t.co/ClMHeBhcrX?
Foundayo (orforglipron) is the first truly convenient GLP-1 weight loss pill — once daily, no food or water rules, and no injections. Dr. Zaid Fadul explains how it works, real results, side effects, dosing, cost, and…
Un medicamento tipo GLP-1 en una pastilla y sin necesidad de inyecciones? Orforgliprón is an oral GLP-1 receptor agonist studied in a phase 3 trial with 559 adults. Results show significant HbA1c and weight reductions…
How will health care evolve by 2026? This video explores advancements such as AI-driven personal health coaching, oral GLP-1 pills for weight loss, developments in cancer vaccines, and the rise of longevity science…
Orforglipron, an oral small-molecule GLP-1 receptor agonist, was tested over 40 weeks in a phase 3 trial involving 559 participants with type 2 diabetes, showing significant reductions in glycated hemoglobin levels…
Orforglipron: A Diabetes Game Changer Hidden in Plain Sight. Unpack the latest data on this once-daily oral GLP-1 receptor agonist from the ACHIEVE-1 trial, which demonstrated significant HbA1c reductions of up to 1.5%…
¿El fin de las inyecciones de GLP-1? Análisis a fondo del ensayo ACHIEVE-1 (Orforgliprón) que evalúa el primer agonista oral del receptor GLP-1 de molécula pequeña. Este estudio muestra la eficacia en reducir HbA1c y…
Orforglipron, Eli Lilly’s new oral, non-peptide GLP-1 receptor agonist, was tested over 40 weeks in a phase 3 trial involving 559 participants with type 2 diabetes, showing significant reductions in glycated hemoglobin…
Diabetes Core Update discusses the latest research, including a phase 3 trial of Orforglipron, an oral GLP-1 receptor agonist. Results show significant HbA1c reductions over 40 weeks, highlighting its potential for…
Orforglipron, an oral small-molecule GLP-1 receptor agonist, was tested over 40 weeks in a phase 3 trial involving 559 participants with type 2 diabetes. The study showed significant reductions in glycated hemoglobin…
ACHIEVE-1: Phase 3 Trial of Orforglipron for Type 2 Diabetes details the efficacy and safety of this oral, once-daily GLP-1 receptor agonist. Involving 559 participants over 40 weeks, the drug significantly reduced…
Since 2025, diabetes medications have evolved from solely lowering blood glucose to protecting organs. This overview covers key clinical trials on oral GLP-1 receptor agonists, weekly insulins, and disease-modifying…
Orforglipron, a novel oral small-molecule GLP-1 receptor agonist, was tested over 40 weeks in a phase 3 trial involving 559 participants with type 2 diabetes, showing significant reductions in glycated hemoglobin levels…
Orforglipron, an oral small-molecule GLP-1 receptor agonist, was tested over 40 weeks in a phase 3 trial involving 559 participants with type 2 diabetes, showing significant reductions in glycated hemoglobin levels…
Orforglipron—an oral small-molecule GLP-1 receptor agonist in trials—shows promising results in reducing HbA1c in type 2 diabetes patients. This PubMed-cited review discusses current research findings, emphasizing…
Orforglipron (Foundayo) is an oral, non-peptide small-molecule partial agonist at the GLP-1 receptor, enabling easy daily dosing without injections. In phase 3 trials, it significantly reduced body weight and improved…
Orforglipron, a novel oral small-molecule GLP-1 receptor agonist, was tested over 40 weeks in a phase 3 trial involving 559 participants with type 2 diabetes. It demonstrated significant reductions in glycated…
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New England Journal of Medicine https://t.co/2TksocbB58
The therapies are getting better and better. Small molecule drugs are coming. I expect to see similar medications for obesity soon!
In the phase 3 ACHIEVE-1 trial, published in June 2025, the oral small-molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with early type 2 diabetes. Download the Notable Articles of 2025: nej.md/49td1Lq
★2025年糖尿病領域キー論文まとめ★
今年発表された糖尿病関連論文のうち、知っていてほしい27本についてまとめました!(糖尿病メモ新着論文集の★3つ論文です)
① チルゼパチド、CVD抑制でデュラグルチドに優越性示せず
SURPASS-CVOT試験。
2型DM・心血管疾患既往例13,165人を対象とした国際共同第3相RCT。
チルゼパチド(最大15mg/週)とデュラグルチド(1.5mg/週)を比較し、MACEはHR 0.92(0.83–1.01)。
非劣性は示されたが、優越性は示されなかった(P=0.09)。
Nicholls SJ, et al. Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes. N Engl J Med. 2025;393(24):2409–2420.
② 経口セマグルチドが心血管イベント抑制
SOUL試験。
CVDまたはCKD合併2型DM 9,650人、約4年間のRCT。
経口セマグルチド14mgで複合CVDはHR 0.86(0.77–0.96)。
心筋梗塞HR 0.73、全死亡HR 0.91、消化器系有害事象は5.0% vs 4.4%。
McGuire DK, et al. Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes. N Engl J Med. 2025.
③ 経口GLP-1オルフォルグリプロン、早期2型糖尿病への効果
ACHIEVE-1試験。
食事運動療法のみの2型DM 559人、40週間。
HbA1cは−0.83〜−1.07%、体重は−4.5〜−7.6%。
主な副作用は軽度〜中等度の消化器症状。
Rosenstock J, et al. Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes. N E
Dec 28, 2025 · 152 likes · 19 shares · 10,523 followersView post →
EG
Editörün Gözünden
@editorgozunden · X
2026'da sağlık teknolojilerinde neler değişecek dersiniz?
Videonun tamamı YouTube kanalımızda. Gelin birlikte 2026'da sağlıkta neler değişecek göz atalım.
https://t.co/vgpzJ9Ffao
#saglik #saglikteknolojileri #sağlıkhaberleri https://t.co/ESBOAf2ZT8
2026 sağlık dünyası nasıl olacak?
Yapay zekâ kişisel sağlık koçuna mı dönüşüyor?
Zayıflama iğneleri yerini haplara mı bırakacak?
Obezite cerrahisi azalacak mı?
Kanser aşıları gerçekten yakın mı?
Longevity neden yükselişte?
https://t.co/4KPS9kyDkk
#saglik #saglikhaberleri https://t.co/iS0u3qlZ45
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…
Nov 8, 2025 · 22 shares · 3,934 followersView post →
L
LongevityLab
@SciFit_ · X
Another “miracle” weight-loss drug is in the pipeline: Orforglipron.
? In 10 months, it lowered glycated hemoglobin HbA1c from ~8% → 6.5–6.7%.
⚠️ Reminder: anything >6.4% is still diabetes!
❌ Adverse events forced discontinuation in 4.4–7.8% of patients.
Meanwhile, a ketogenic diet + fasting can push HbA1c below 6% in just 3-6 months — without new side-effect labels.
DOI: 10.1056/NEJMoa2505669
Robert Kalyesubula,MD, FISN(USA), PhD-FRCP(London)
@rkalyes1 · X
✍️ Here comes Orforglipron- the Oral GLP-1 Receptor Agonist for Type 2 Diabetes
✍️ I hope it also works like Ozempic for weight loss
✍️Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New England Journal of Medicine https://t.co/ClMHeBhcrX?
In the ACHIEVE-1 phase 3 trial, the oral small-molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with early type 2 diabetes. Full trial results and Research Summary: nej.md/4ngEZ36
#MedSky #EndoSky
Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial) https://t.co/qKRfQon3fN
Editorial: Mimicking Complex Receptor Actions with Small(ish) Molecules https://t.co/551PZYPm9D
#Endocrinology https://t.co/bMCdIt6jS6
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Obesity + Early Type 2 Diabetes | NEJM -1.5% HbA1c reduction & 6-7.6% weight loss vs -0.4% and -1.7% resp for placebo https://t.co/SCPOVNMJZf
“Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes.””
Publié ce jour dans le @nejm.org.
#MedSky #EndoSky
www.nejm.org/doi/full/10....
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes https://t.co/rhAtIy1FZL
Aug 25, 2025 · 3 likes · 4,405 followersView post →
VZ
Vědou Ke Zdraví
@VedouKeZdravi · X
? "Ozempic" v pilulce? Nový lék bez jehel pomáhá s cukrovkou i hubnutím. Podle ?? studie publikované v časopise @NEJM lék orforglipron ukazuje slibné výsledky již po 40 týdnech léčby. Více v našem článku: https://t.co/GuoLHWCutX
Zdroj:
Rosenstock, J., Hsia, S., Ruiz, L. N., Eyde, S., Cox, D., Wu, W., Liu, R., Li, J., Landó, L. F., Denning, M., Ludwig, L., & Chen, Y. (2025). Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes. New England Journal of Medicine.
? Ya disponibles los datos de Fase 3 sobre hemoglobina glicosilada de #Orforglipron
?¿Qué es?
Un agonista del receptor GLP-1 oral en desarrollo clínico para la diabetes tipo 2 y el control del peso.
?Resultados tras 40 semanas:
• Reducción de HbA1c de hasta –1.48%
• Pérdida de peso de hasta –7.6%
• Sin hipoglucemias graves
• Perfil de seguridad favorable
DOI: 10.1056/NEJMoa2505669
Aug 1, 2025 · 5 likes · 17,066 followersView post →
PM
Pierre Gholam MD
@livermd.bsky.social · Bluesky
The second @nejm.org #orforpligron paper is out.
There is no doubt that Oral GLP-1s are coming.
For #MASH, discontinuation rates will matter. 4-8% in T2DM (44w) vs. 10-17% in obesity (36w) which always seems higher.
How might our patients fare?
#liversky
The second @NEJM #orforpligron paper is out.
There is no doubt that Oral GLP-1s are coming.
For #MASH, discontinuation rates will matter. 4-8% in T2DM (44w) vs. 10-17% in obesity (36w)
How might our patients fare?
#livertwitter
https://t.co/1aUMBnZk6n
? Ya disponibles los datos de Fase 3 sobre hemoglobina glicosilada de #Orforglipron
?¿Qué es?
Un agonista del receptor GLP-1 oral en desarrollo clínico para la diabetes tipo 2 y el control del peso.
?Resultados tras 40 semanas:
• Reducción de HbA1c de hasta –1.48%
• Pérdida de peso de hasta –7.6%
• Sin hipoglucemias graves
• Perfil de seguridad favorable
DOI: 10.1056/NEJMoa2505669
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes. The New England journal of medicine, 10.1056/NEJMoa2505669.
https://t.co/hNLokpG2gU
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes
Orforglipron is a small-molecule, nonpeptide glucagon-like peptide-1 (GLP-1) receptor agonist in clinical development for type 2 diabetes and weight management. Additional data on the efficacy and safety of orforglipron are needed.
In adults with early type 2 diabetes, orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks
https://t.co/nM7ohohS28
Jun 30, 2025 · 16 likes · 4 shares · 5,878 followersView post →
A clinical trial found that orforglipron, a new medication for type 2 diabetes, significantly lowered blood sugar levels and helped participants lose weight over 40 weeks, with mild digestive side effects being common. - Read more: https://t.co/IbxS28KsJy
Jun 25, 2025 · 1 like · 1,067 followersView post →
RB
Research Bites
@Research_Bites · X
A 40-week study found that orforglipron, a new medication for type 2 diabetes, significantly lowered blood sugar levels and aided weight loss in participants compared to a placebo, with manageable side effects. - Read more: https://t.co/IbxS28KsJy
Jun 25, 2025 · 1 like · 1,067 followersView post →
EG
Esteban Jódar Gimeno
@estebanjodar · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…
Jun 25, 2025 · 22 shares · 4,538 followersView post →
RD
redGDPS Diabetes
@redGDPS · X
Acceso artículo en @PubMedOnline
https://t.co/RmgV8bfdJv
Jun 24, 2025 · 1 like · 16,014 followersView post →
R
RedGDPS
@redgdps.bsky.social · Bluesky
Acceso en #pubmed
pubmed.ncbi.nlm.nih.gov/40544435/
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…
Jun 24, 2025 · 22 shares · 15 followersView post →
BD
Basem Mishriky, MD, FACP, ABOM Diplomate
@BasemMishriky · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…
Jun 24, 2025 · 22 shares · 269 followersView post →
PN
Pancreatic Cell News
@PancreaticCell · X
Introducing Orforglipron, an oral small-molecule GLP-1 receptor agonist, in early #T2D! ?
ACHIEVE-1 trial investigators report that in adults with early T2D, orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks.
@NEJM | https://t.co/dBfeGZ97c8
This could mark a major step forward in oral GLP-1 therapies for type 2 diabetes.
manuscript: www.nejm.org/doi/full/10....
#Diabetes #GLP1 #Orforglipron #WeightManagement #Endocrinology #ClinicalTrials
? Latest in Type 2 Diabetes & Weight Management ?
New data from the phase 3 ACHIEVE-1 trial shows promising results for Orforglipron, a once-daily, oral, nonpeptide GLP-1 receptor agonist.
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…
Jun 23, 2025 · 22 shares · 4,169 followersView post →
JA
JoseM Garcia Almeida
@jgarciaalmeida · X
RT @CristobMorales: https://t.co/YwCnsjilp4 Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New Eng…
Jun 23, 2025 · 3 shares · 3,948 followersView post →
JG
Joe Gordon
@josephwgordon · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…
Jun 23, 2025 · 22 shares · 2,091 followersView post →
A
Abstream
@abstreamme · X
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes
#science #publication #research #publications
https://t.co/XWlEm6VyMP
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…
Jun 23, 2025 · 22 shares · 253 followersView post →
MA
Mohammad Aleidi
@aleidimed · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes
In adults with early type 2 diabe…
Jun 23, 2025 · 2 shares · 699 followersView post →
AM
Ahmed Bennis MD ?
@drbennisahmed · X
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes
In adults with early type 2 diabetes, orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks
https://t.co/EjiiorKHAX https://t.co/2qDK3nulnZ
Jun 23, 2025 · 16 likes · 2 shares · 5,878 followersView post →
AM
Ahmed Bennis MD ?
@drbennisahmed · X
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes
In adults with early type 2 diabetes, orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks
https://t.co/EjiiorLfqv https://t.co/5zitcyAKOj
Jun 23, 2025 · 6 likes · 5,878 followersView post →
NH
Naeem ul Hassan
@naeemulhassan_ · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…
Jun 23, 2025 · 22 shares · 320 followersView post →
AR
Arshad Rashid
@arshadkema · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…
Jun 23, 2025 · 22 shares · 997 followersView post →
M
mocchi
@mocchi_ym · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…
Jun 22, 2025 · 22 shares · 195 followersView post →
ED
Erol Demir
@eroldemir83 · X
RT @KSusztak: The oral GLP !! Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | @NEJM https://t.co…
Jun 22, 2025 · 4 shares · 279 followersView post →
X
xxy
@xxy07255392 · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…
Jun 22, 2025 · 22 shares · 202 followersView post →
SI
Servicio de Geriatría del INCMNSZ
@INCMNSZ_Geria · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…
Jun 22, 2025 · 22 shares · 16,941 followersView post →
FM
Frank Paul Mora
@InTime_49 · X
RT @KSusztak: The oral GLP !! Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | @NEJM https://t.co…
Jun 22, 2025 · 4 shares · 493 followersView post →
LO
Layla Omar
@hlaylaomar · X
RT @KSusztak: The oral GLP !! Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | @NEJM https://t.co…
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…
Jun 22, 2025 · 22 shares · 4,919 followersView post →
GB
Gibran Bello
@gibranbello · X
RT @CristobMorales: https://t.co/YwCnsjilp4 Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New Eng…
Jun 22, 2025 · 3 shares · 135 followersView post →
JA
Juan Luis Alonso
@jalojer · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…
Jun 22, 2025 · 22 shares · 1,418 followersView post →
LP
Laura Pérez ??⚕️
@tatana2007 · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…
Jun 22, 2025 · 22 shares · 240 followersView post →
AA
Alexis A.
@Alexis_arbra · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…
Jun 22, 2025 · 22 shares · 223 followersView post →
DD
Dr Ashok Dalal
@DrAshokGastro · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…
Jun 22, 2025 · 22 shares · 1,685 followersView post →
AE
Alexia Espiño
@Alexia_EAlvarez · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…
Jun 22, 2025 · 22 shares · 49 followersView post →
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José Mª Gª Quintana
@jose_g_quintana · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…
Jun 22, 2025 · 22 shares · 860 followersView post →
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Cristobal Morales
@CristobMorales · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial)…
Jun 22, 2025 · 22 shares · 17,797 followersView post →
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NEJM
@NEJM · X
Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (ACHIEVE-1 phase 3 trial) https://t.co/qKRfQon3fN
@ADA_DiabetesPro | #ADASciSessions https://t.co/TlSPkixnBI
Jun 22, 2025 · 69 likes · 22 shares · 1,041,724 followersView post →
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Katalin Susztak
@KSusztak · X
The oral GLP !! Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | @NEJM https://t.co/9XuyCeT6ew
Jun 22, 2025 · 27 likes · 4 shares · 7,610 followersView post →
RT @CMEINDIA1: Key clinical pearls from the ACHIEVE-1 trial on Orforglipron (NEJM 2025; DOI:10.1056/NEJMoa2505669):
? ORFORGLIPRON – Oral…
Jun 22, 2025 · 2 shares · 261 followersView post →
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Dr. Shashank Joshi
@AskDrShashank · X
RT @CMEINDIA1: Key clinical pearls from the ACHIEVE-1 trial on Orforglipron (NEJM 2025; DOI:10.1056/NEJMoa2505669):
? ORFORGLIPRON – Oral…
Jun 22, 2025 · 2 shares · 33,355 followersView post →
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CME INDIA
@CMEINDIA1 · X
Key clinical pearls from the ACHIEVE-1 trial on Orforglipron (NEJM 2025; DOI:10.1056/NEJMoa2505669):
? ORFORGLIPRON – Oral Nonpeptide GLP-1 RA
? Once-daily oral GLP-1 agonist (non-peptide)
? First-in-class, no fasting or water restrictions
? ACHIEVE-1 Trial Highlights (40 Weeks)
? 559 adults with early T2DM (HbA1c 7–9.5%, BMI ≥23)
? Orforglipron 3/12/36 mg vs placebo
✅ HbA1c Reduction
• −1.24% (3 mg)
• −1.47% (12 mg)
• −1.48% (36 mg)
• Placebo: −0.41%
✅ Weight Loss
• −4.5% (3 mg)
• −5.8% (12 mg)
• −7.6% (36 mg)
• Placebo: −1.7%
⚠️ Safety Profile
? GI AEs (mild-moderate): nausea, diarrhea
? No severe hypoglycemia
? Discontinuation: 4–8% (vs 1.4% placebo)
? CME INDIA Pearls
? Oral GLP-1RA = injectable-like efficacy with better convenience
? HbA1c <6.5% achieved in majority at 36 mg
? Excellent weight loss (~7–8%) without plateau at 40 weeks
? Ideal for early T2DM, obese, needle-a
Jun 22, 2025 · 8 likes · 2 shares · 7,460 followersView post →
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Dr. Karl Nadolsky
@drkarlnadolsky.bsky.social · Bluesky
Orforglipron, small molecule GLP-1ra in type 2 #diabetes.
➡️mean HbA1c at baseline was 8.0%. At week 40, it dropped −1.24% with 3-mg, −1.47 % with 12-mg, −1.48 % with 36-mg dose, and −0.41 % with placebo.
www.nejm.org/doi/full/10....
#ADA2025
¿Un GLP-1 oral, sin restricciones ni aguja, con eficacia comparable a inyectables?
Orforglipron es el primer agonista del receptor GLP-1 no peptídico aprobado en estudios fase 3 para la diabetes tipo 2. Su principal ventaja: se administra en cápsula diaria, sin restricciones de comida, agua o ayuno. Publicado en NEJM el 21 de junio de 2025 (DOI: 10.1056/NEJMoa2505669), el estudio ACHIEVE-1 evaluó su eficacia y seguridad en 559 adultos con diabetes tipo 2 temprana manejada solo con dieta y ejercicio.
– Diseño doble ciego, controlado con placebo
– Tres dosis (3, 12 y 36 mg/día) por 40 semanas
– Sin uso previo de fármacos antidiabéticos
Resultados clave:
– Reducción de HbA1c hasta –1.48 %
– Reducción de peso corporal de hasta –7.9 %
– HbA1c < 7 % en 76.2 %
– HbA1c ≤ 6.5 % en 66.0 %
– HbA1c < 5.7 % (valor normal) en 25.8 %
– Efecto sostenido desde semana 4
Ventajas farmacológicas:
– Vida
Jun 21, 2025 · 2 likes · 1 share · 24,380 followersView post →
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Melina Manolas, MD, MPH
@melina_manolas · X
? New in @NEJM : Orforglipron, a once-daily oral GLP‑1, led to ~2% A1c drop & ~16 lb weight loss in T2D (ACHIEVE-1 trial). A non-peptide, no-injection option with classic GLP-1 GI profile.
Big step for access & adherence!
?https://t.co/aIb2CShopY
Jun 21, 2025 · 72 likes · 10 shares · 10,684 followersView post →
PB
Prof. Dr. Sanjeev Bagai
@BagaiDr · X
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early T2DM | New England Journal of Medicine. phase 3, double-blind, placebo-controlled trial, randomly assigned in a 1:1:1:1 ratio to receive orforglipron at 1 of 3 doses (3 mg, 12 mg, 36 mg) https://t.co/yXChehuZpu
https://t.co/YwCnsjilp4 Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New England Journal of Medicine @NEJM #ADA2025
Jun 21, 2025 · 14 likes · 3 shares · 17,797 followersView post →
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Daniel Drucker
@danieljdrucker.bsky.social · Bluesky
A detailed P3 look at the leading small molecule oral GLP-1 RA orforglipron studied at a range of doses for moderate #T2D Good tolerability, solid efficacy on glucose and #weightloss no serious off target SAEs www.nejm.org/doi/full/10....
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https://doi.org/10.1056/NEJMoa2505669 #Metabolife #Orforglipron #Obesidad #DiabetesTipo2 #SaludMetabólica #GLP1 · May be an image of medicine and text.
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