Diabetes Care June 2025 PMID 40550011

Inadequately Controlled Type 2 Diabetes and Hypercortisolism: Improved Glycemia With Mifepristone Treatment.

Ralph A DeFronzo, Vivian Fonseca, Vanita R Aroda, Richard J Auchus, Timothy Bailey, Irina Bancos, Robert S Busch, John B Buse, Elena A Christofides, Bradley Eilerman, James W Findling, Yehuda Handelsman, Steven E Kahn, Harold J Miller, Jonathan G Ownby

Mentions

35
Peak: 17 in Jun 2025
across 5 sources since Jun 2025

Extended reach

61,034
potential audience

Total likes

36

Video views

423

Mentions per month

Jun 2025 – Aug 2025

Where it's discussed

  • X / Twitter19 posts
  • News9 articles
  • Facebook3 posts
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

The discussions reflect a generally positive reception to the study, emphasizing the promising effects on glycemic control, weight loss, and management of hypercortisolism, as seen in phrases like 'major step for targeted care' and 'able to lower medications.' The tone is optimistic but balanced, referencing side effects such as hypokalemia, which tempers the overall enthusiasm but indicates recognition of meaningful clinical implications.

AgreementModerate agreement

Most discussions are positive, highlighting the promising results of the study in improving glycemic control using mifepristone.

InterestModerate interest

Participants show moderate interest, with mentions of improved health markers and hope for new treatments, but without deep technical engagement.

EngagementModerate engagement

Comments cite specific findings like lower HbA1c and reduced weight, and some mention side effects, reflecting a medium level of conversation depth.

ImpactModerate impact

The discussions suggest potential for meaningful impact on treatment options for complex diabetes cases, but framing remains cautious.

Abstract in brief

  • The study aimed to see if mifepristone, a glucocorticoid receptor antagonist, could improve glycemic control in individuals with poorly managed type 2 diabetes (T2D) and hypercortisolism.
  • A total of 136 participants were involved, with results showing a significant reduction in HbA1c levels among those treated with mifepristone compared to a placebo, as well as decreases in weight and waist circumference.
  • While mifepristone showed effectiveness, a higher percentage of patients discontinued use due to side effects like fatigue, nausea, and hypokalemia, but overall it had a manageable tolerability profile.

Top posts

Most liked on X and Bluesky
Dr. Alice Cheng
@AliceYYCheng · X

Mifepristone study showed lower A1c, stable norm tension. Able to lower medications. Side effects as expected hypokalemia and mild GI effects. #ADAScisessions https://t.co/Bw1QAwYJGf https://t.co/UPBbFlvgg2

Jun 23, 2025 · 15 likes · 3 shares · 4,384 followers View post →
Diabetes Care, a research journal of the ADA
@DiabetesCareADA · X

CATALYST treatment phase finds that treatment with mifepristone can improve HbA1c in individuals with inadequately controlled diabetes and hypercortisolism and has a manageable tolerability profile. @ADA_Pubs Read Here➡️ https://t.co/ZmKHBxh9fY https://t.co/wuTEbsR11j

Jun 23, 2025 · 8 likes · 4 shares · 3,139 followers View post →
Diana Isaacs, PharmD, BC-ADM, CDCES
@DianaMIsaacs · X

Catalyst 2 trial is published!! #ADA2025 #ADASciSessions https://t.co/QeDItV0Fel

Jun 23, 2025 · 6 likes · 4 shares · 3,137 followers View post →
Cristina Tejera
@cristinatejerap · X

RT @DiabetesCareADA: CATALYST treatment phase finds that treatment with mifepristone can improve HbA1c in individuals with inadequately con…

Jun 23, 2025 · 4 shares · 11,458 followers View post →
ADA Professional Publications
@ADA_Pubs · X

RT @DiabetesCareADA: CATALYST treatment phase finds that treatment with mifepristone can improve HbA1c in individuals with inadequately con…

Jun 23, 2025 · 4 shares · 10,583 followers View post →
ADA Professional Publications
@ADA_Pubs · X

RT @AliceYYCheng: Mifepristone study showed lower A1c, stable norm tension. Able to lower medications. Side effects as expected hypokalemia…

Jun 24, 2025 · 3 shares · 10,583 followers View post →

All mentions

Accellacare
@accellacare · X

Accellacare PI, Dr. John Parker, worked on a newly published study in Diabetes Care. Adults with T2D + hypercortisolism saw improved glycemic control with mifepristone treatment—a major step for targeted care. Read more: https://t.co/JFvA0N10rG https://t.co/aQiWKZjzTQ

Aug 8, 2025 · 50 followers View post →
STITCHES Medicine - the Best of Medical Research
@STITCHESMed · X

Mifepristone significantly improved glycemic control and reduced weight in diabetics with hypercortisolism, despite some participants discontinuing treatment. by DeFronzo RA, Fonseca V (...) Einhorn D et 23 al. in Diabetes Care https://t.co/du5ivPiJ8Y #MedX #MedResearch

Jul 1, 2025 · 83 followers View post →
Farmacia Madrid AP
@FarmaMadridAP · X

(Diabetes Care) DM2 mal controlada e hipercortisolismo: mejora de la glucemia con el tratamiento con mifepristona. https://t.co/0U5Xdy55ud https://t.co/MG0PPKJnRH

Jun 26, 2025 · 8,354 followers View post →
luis Rodriguez
@luisRod60597844 · X

RT @AliceYYCheng: Mifepristone study showed lower A1c, stable norm tension. Able to lower medications. Side effects as expected hypokalemia…

Jun 25, 2025 · 3 shares · 23 followers View post →
INTERNAL MEDICINE
@medicinterna · X

RT @DiabetesCareADA: CATALYST treatment phase finds that treatment with mifepristone can improve HbA1c in individuals with inadequately con…

Jun 25, 2025 · 4 shares · 2,458 followers View post →
Starlin H-Greatting,MS-MPH,BPharm,CDM,FAPhA,FADCES
@StarlinRPh · X

RT @DianaMIsaacs: Catalyst 2 trial is published!! #ADA2025 #ADASciSessions https://t.co/QeDItV0Fel

Jun 24, 2025 · 4 shares · 920 followers View post →
Wasita W. Parksook
@WParksook · X

RT @DianaMIsaacs: Catalyst 2 trial is published!! #ADA2025 #ADASciSessions https://t.co/QeDItV0Fel

Jun 24, 2025 · 4 shares · 289 followers View post →
ADA Professional Publications
@ADA_Pubs · X

RT @AliceYYCheng: Mifepristone study showed lower A1c, stable norm tension. Able to lower medications. Side effects as expected hypokalemia…

Jun 24, 2025 · 3 shares · 10,583 followers View post →
猫被り医(PhD, MD, 中の人は獰猛かなぁ)
@shh_toyama · X

Inadequately Controlled Type 2 Diabetes and Hypercortisolism: Improved Glycemia With Mifepristone Treatment | Diabetes Care | American Diabetes Association https://t.co/wIwedMdSkI

Jun 24, 2025 · 284 followers View post →
Aaisha
@aaishasaqib · X

RT @AliceYYCheng: Mifepristone study showed lower A1c, stable norm tension. Able to lower medications. Side effects as expected hypokalemia…

Jun 24, 2025 · 3 shares · 174 followers View post →
Natalie Bellini
@natalie_bellini · X

RT @DianaMIsaacs: Catalyst 2 trial is published!! #ADA2025 #ADASciSessions https://t.co/QeDItV0Fel

Jun 24, 2025 · 4 shares · 333 followers View post →
ADA Professional Publications
@ADA_Pubs · X

RT @DiabetesCareADA: CATALYST treatment phase finds that treatment with mifepristone can improve HbA1c in individuals with inadequately con…

Jun 23, 2025 · 4 shares · 10,583 followers View post →
Edith WK Chow
@EWKChow · X

RT @DiabetesCareADA: CATALYST treatment phase finds that treatment with mifepristone can improve HbA1c in individuals with inadequately con…

Jun 23, 2025 · 4 shares · 19 followers View post →
Rodolfo J. Galindo MD
@RodolfoJGalindo · X

RT @DianaMIsaacs: Catalyst 2 trial is published!! #ADA2025 #ADASciSessions https://t.co/QeDItV0Fel

Jun 23, 2025 · 4 shares · 1,099 followers View post →
Dr. Alice Cheng
@AliceYYCheng · X

Mifepristone study showed lower A1c, stable norm tension. Able to lower medications. Side effects as expected hypokalemia and mild GI effects. #ADAScisessions https://t.co/Bw1QAwYJGf https://t.co/UPBbFlvgg2

Jun 23, 2025 · 15 likes · 3 shares · 4,384 followers View post →
Diana Isaacs, PharmD, BC-ADM, CDCES
@DianaMIsaacs · X

Catalyst 2 trial is published!! #ADA2025 #ADASciSessions https://t.co/QeDItV0Fel

Jun 23, 2025 · 6 likes · 4 shares · 3,137 followers View post →
Diana Isaacs, PharmD, BC-ADM, CDCES
@DianaMIsaacs · X

Catalyst 2 trial is published!! https://t.co/QeDItV1d3T

Jun 23, 2025 · 3,137 followers View post →
Cristina Tejera
@cristinatejerap · X

RT @DiabetesCareADA: CATALYST treatment phase finds that treatment with mifepristone can improve HbA1c in individuals with inadequately con…

Jun 23, 2025 · 4 shares · 11,458 followers View post →
Diabetes Care, a research journal of the ADA
@DiabetesCareADA · X

CATALYST treatment phase finds that treatment with mifepristone can improve HbA1c in individuals with inadequately controlled diabetes and hypercortisolism and has a manageable tolerability profile. @ADA_Pubs Read Here➡️ https://t.co/ZmKHBxh9fY https://t.co/wuTEbsR11j

Jun 23, 2025 · 8 likes · 4 shares · 3,139 followers View post →