Sci Transl Med June 2025 PMID 40561001

Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus.

Rithwik Narendra, Hoang Van Phan, Sarah L Patterson, Ana Almonte-Loya, Emily C Lydon, Cristina Lanata, Christina Love, Joonsuk Park, Michiko Shimoda, Lisa Barcellos, Honey Mekonen, Angela Detweiler, Padmini Deosthale, Norma Neff, Lindsey A Criswell

Mentions

66
Peak: 25 in Jul 2025
across 5 sources since Jun 2025

Extended reach

9,155,030
potential audience

Total likes

173

Video views

231

Mentions per month

Jun 2025 – Aug 2025

Where it's discussed

  • X / Twitter40 posts
  • News17 articles
  • Blogs4 articles
  • Bluesky3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The collection of discussions reveals a strong fascination with how aging seems to modify immune responses in lupus patients, particularly through phrases like 'surprising immune reversal' and 'epigenetic attenuation.' Words such as 'breakthrough,' 'important research,' and 'significant' indicate a positive tone and recognition of their potential impact, though some expressions reflect cautious enthusiasm, linking the findings to future therapeutic possibilities.

AgreementModerate agreement

Most discussions highlight the findings linking aging, epigenetics, and lupus improvement, indicating general support or acceptance of the research conclusions.

InterestHigh interest

Posts demonstrate high curiosity and relevance, with many acknowledging the significance of the findings for lupus treatment and understanding immune aging.

EngagementModerate engagement

Comments often reference the mechanisms, such as interferon signaling and epigenetic modifications, showing moderate to deep engagement with the scientific content.

ImpactModerate impact

While some discussions emphasize the potential for this research to influence future therapies, the perception of immediate high impact appears limited, leaning towards moderate significance.

Abstract in brief

  • Aging typically leads to increased inflammation and chronic diseases in the general population, but in systemic lupus erythematosus (SLE), older age is linked to reduced disease activity.
  • Researchers analyzed blood immune profiles of 287 SLE patients and 928 healthy controls, finding that aging in SLE patients was associated with lower levels of interferon-stimulated genes (ISGs) and decreased plasma IFN-α2.
  • Both groups experienced declines in naïve T cells with age, but SLE patients uniquely showed increased CD56 natural killer cells, alongside evidence of epigenetic changes, indicating a complex relationship between aging and immune function in SLE.

Top posts

Most liked on X and Bluesky
Science Magazine
@ScienceMagazine · X

Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methylation epigenetic patterns, according to a clinical study that may explain why the condition becomes milder with age. https://t.co/Db0Lbv2dB0 @ScienceTM https://t.co/Cd1Y1KKNUp

Jul 7, 2025 · 69 likes · 15 shares · 4,516,071 followers View post →
Wei Cao
@weicao_phd · X

Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus | Science Translational Medicine https://t.co/fjVVeKtAkE

Jun 26, 2025 · 39 likes · 6 shares · 388 followers View post →
Science Magazine
@ScienceMagazine · X

Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methylation epigenetic patterns, according to a clinical study that may explain why the condition becomes milder with age. https://t.co/Db0Lbv2dB0 @ScienceTM https://t.co/zsHp5FXfyW

Jul 3, 2025 · 26 likes · 7 shares · 4,516,071 followers View post →
Ruth Montgomery
@rrmsky.bsky.social · Bluesky

Wow, when lower IFN in aging is a good thing! Congratulations Chaz L and team. #ImmuneProfiling #Aging Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/...

Jun 27, 2025 · 7 likes · 4 shares View post →
Science Translational Medicine
@ScienceTM · X

Older patients with #lupus display a marked drop in the expression of #interferon stimulated genes and shifts in methylation #epigenetic patterns, according to a clinical study that may explain why the condition becomes milder with age. @UCSF_ID https://t.co/nVlC4829rs https://t.co/l2zimjjSJs

Jul 5, 2025 · 6 likes · 33,688 followers View post →
Waggoner Lab
@LabWaggoner · X

Patients with systemic lupus erythematosus exhibit aging-related epigenetic driven decreases in IFN signaling that correlate with improved disease activity #lupus @ScienceTM @HoangVanPhan2 https://t.co/pDDyYjpcRV https://t.co/pXWKRNrZbr

Jun 25, 2025 · 6 likes · 3 shares · 11,300 followers View post →

All mentions

Ms. Power
@EPower75241250 · X

RT @Kaleidoscope_FL: Lupus News: Researchers at UC San Francisco may have found the antiviral genes that decrease after age 60 ... often i…

Aug 26, 2025 · 3 shares · 228 followers View post →
Reverend
@TheIrishPickle · X

RT @Kaleidoscope_FL: Lupus News: Researchers at UC San Francisco may have found the antiviral genes that decrease after age 60 ... often i…

Aug 25, 2025 · 3 shares · 2,018 followers View post →
LESAI_Agent
@LESAI_bot · X

RT @Kaleidoscope_FL: Lupus News: Researchers at UC San Francisco may have found the antiviral genes that decrease after age 60 ... often i…

Aug 25, 2025 · 3 shares · 792 followers View post →
Kaleidoscope Fighting Lupus
@Kaleidoscope_FL · X

Lupus News: Researchers at UC San Francisco may have found the antiviral genes that decrease after age 60 ... often improving lupus symptoms. This will be yet another important area of research toward better medications for all ages with lupus! Link; https://t.co/YfMiQr0k6t https://t.co/MXo2J1RN9X

Aug 25, 2025 · 2 likes · 3 shares · 3,847 followers View post →
jose arcay
@josearcay14 · X

"Scientists Spot Surprising Immune Reversal in Older Age" https://t.co/8TriLz5eFg via @YouTube

Aug 8, 2025 View post →
nike
@wot_mikey · X

RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…

Jul 8, 2025 · 15 shares · 468 followers View post →
Thamarasee Jeewandara
@Jeew333T · X

RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…

Jul 8, 2025 · 15 shares · 1,290 followers View post →
José Luis García-Hernández
@JosLuisGarHer · X

RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…

Jul 8, 2025 · 15 shares · 221 followers View post →
Umar Farooq, PhD
@umarbioc · X

RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…

Jul 8, 2025 · 15 shares · 213 followers View post →
طارق بن سعود بن حمد الجابري
@nomadarab · X

RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…

Jul 8, 2025 · 15 shares · 2,893 followers View post →
Roberto Avelar
@Avelar_Ageing · X

RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…

Jul 8, 2025 · 15 shares · 253 followers View post →
Makate Meshack Tebeila
@MeshackTebeila · X

RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…

Jul 8, 2025 · 15 shares · 1,145 followers View post →
Gin
@ObiBinGinObi · X

RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…

Jul 8, 2025 · 15 shares · 364 followers View post →
Alberto Giraldo
@alb_giraldo · X

RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…

Jul 7, 2025 · 15 shares · 4,362 followers View post →
Dr. Paul Ingwat
@ingwat777 · X

RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…

Jul 7, 2025 · 15 shares · 476 followers View post →
Nitish Kumar Dhingra
@NitishKumarDhi1 · X

RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…

Jul 7, 2025 · 15 shares · 208 followers View post →
David Sipes
@DavidSipes15166 · X

RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…

Jul 7, 2025 · 15 shares · 1,815 followers View post →
Science Magazine
@ScienceMagazine · X

Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methylation epigenetic patterns, according to a clinical study that may explain why the condition becomes milder with age. https://t.co/Db0Lbv2dB0 @ScienceTM https://t.co/Cd1Y1KKNUp

Jul 7, 2025 · 69 likes · 15 shares · 4,516,071 followers View post →
Science Translational Medicine
@ScienceTM · X

Older patients with #lupus display a marked drop in the expression of #interferon stimulated genes and shifts in methylation #epigenetic patterns, according to a clinical study that may explain why the condition becomes milder with age. @UCSF_ID https://t.co/nVlC4829rs https://t.co/l2zimjjSJs

Jul 5, 2025 · 6 likes · 33,688 followers View post →
Hro
@kbhiro0106 · X

SLEにおいて加齢に伴ってIFNGS、血漿IFNα2が低下する。ただし、他の自然免疫系の活性化は健常人より高い状態を維持する(Sci Transl Med.2025)。 実際の活動性との相関ではなく、現象を見ている。本文にも書いてあるけど、アニフロルマブの有効性との関係が気になる点。 https://t.co/4TBDfrs9qz

Jul 4, 2025 · 2 likes · 90 followers View post →
PharmaDecisions LLC
@PharmaDecisions · X

RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…

Jul 3, 2025 · 7 shares · 453 followers View post →
Kristian Larsson
@krislongevity · X

RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…

Jul 3, 2025 · 7 shares · 39 followers View post →
nike
@wot_mikey · X

RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…

Jul 3, 2025 · 7 shares · 468 followers View post →
fernando ferreira
@onfaitavec · X

RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…

Jul 3, 2025 · 7 shares · 3,948 followers View post →
Colm Nestor
@theNestorLab · X

RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…

Jul 3, 2025 · 7 shares · 255 followers View post →
Mohammed Safi
@Mohamme35222784 · X

RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…

Jul 3, 2025 · 7 shares · 17 followers View post →
Science Magazine
@ScienceMagazine · X

Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methylation epigenetic patterns, according to a clinical study that may explain why the condition becomes milder with age. https://t.co/Db0Lbv2dB0 @ScienceTM https://t.co/zsHp5FXfyW

Jul 3, 2025 · 26 likes · 7 shares · 4,516,071 followers View post →
Science Translational Medicine
@ScienceTM · X

Older patients with #lupus display a marked drop in the expression of #interferon stimulated genes and shifts in methylation #epigenetic patterns, according to a clinical study that may explain why the condition becomes milder with age. @UCSF_ID https://t.co/nVlC4829rs https://t.co/9Ey1ShYcYx

Jul 1, 2025 · 4 likes · 33,688 followers View post →
Epigenome Technologies Inc.
@EpigenomeTech · X

Epigenetics Update - Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus https://t.co/8fTtiQKIcY #Epigenetics #Aging #Lupus #SLE --- Discover the breakthrough at https://t.co/WmSYDGWPJD

Jul 1, 2025 · 4 likes · 492 followers View post →
Epigenome Technologies
@epigenometech.bsky.social · Bluesky

Epigenetics Update - Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus bit.ly/4kT2KMV Charles R. Langelier (UCSF) reporting in Sci Trans Med #Epigenetics #Aging #Lupus --- Discover the breakthrough at epigenometech.com

Jul 1, 2025 · 1 like View post →
Johan Van Weyenbergh
@johanvawe · X

RT @weicao_phd: Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosu…

Jun 28, 2025 · 6 shares · 4,739 followers View post →
Ruth Montgomery
@rrmsky.bsky.social · Bluesky

Wow, when lower IFN in aging is a good thing! Congratulations Chaz L and team. #ImmuneProfiling #Aging Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/...

Jun 27, 2025 · 7 likes · 4 shares View post →
priya joseph
@ayirpelle · X

RT @weicao_phd: Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosu…

Jun 27, 2025 · 6 shares · 4,886 followers View post →
Vini Tiwari, PhD
@vinitiwari1 · X

RT @weicao_phd: Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosu…

Jun 27, 2025 · 6 shares · 405 followers View post →
Xiangyue Zhang
@Xiangyue_CA · X

RT @weicao_phd: Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosu…

Jun 26, 2025 · 6 shares · 277 followers View post →
Andrea Salvador
@amsalvador1 · X

RT @weicao_phd: Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosu…

Jun 26, 2025 · 6 shares · 743 followers View post →
Giovanni Di Liberto
@DiLibertoMD · X

RT @weicao_phd: Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosu…

Jun 26, 2025 · 6 shares · 1,208 followers View post →
Wei Cao
@weicao_phd · X

Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus | Science Translational Medicine https://t.co/fjVVeKtAkE

Jun 26, 2025 · 39 likes · 6 shares · 388 followers View post →
Frank Paul Mora
@InTime_49 · X

RT @LabWaggoner: Patients with systemic lupus erythematosus exhibit aging-related epigenetic driven decreases in IFN signaling that correla…

Jun 26, 2025 · 3 shares · 385 followers View post →
Shunsuke Uchiyama
@shunsuke0804 · X

RT @LabWaggoner: Patients with systemic lupus erythematosus exhibit aging-related epigenetic driven decreases in IFN signaling that correla…

Jun 25, 2025 · 3 shares · 16 followers View post →
Rene Sugar
@renesugar · X

RT @LabWaggoner: Patients with systemic lupus erythematosus exhibit aging-related epigenetic driven decreases in IFN signaling that correla…

Jun 25, 2025 · 3 shares · 3,952 followers View post →
Javi Ibarrondo
@jibarrondo.bsky.social · Bluesky

Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/...

Jun 25, 2025 · 2 likes View post →
Waggoner Lab
@LabWaggoner · X

Patients with systemic lupus erythematosus exhibit aging-related epigenetic driven decreases in IFN signaling that correlate with improved disease activity #lupus @ScienceTM @HoangVanPhan2 https://t.co/pDDyYjpcRV https://t.co/pXWKRNrZbr

Jun 25, 2025 · 6 likes · 3 shares · 11,300 followers View post →