Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methylation epigenetic patterns, according to a clinical study that may explain why the condition becomes milder with age. https://t.co/Db0Lbv2dB0 @ScienceTM https://t.co/Cd1Y1KKNUp
Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus.
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Jun 2025 – Aug 2025Where it's discussed
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X / Twitter40 posts
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News17 articles
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Blogs4 articles
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Bluesky3 posts
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What people are saying
The collection of discussions reveals a strong fascination with how aging seems to modify immune responses in lupus patients, particularly through phrases like 'surprising immune reversal' and 'epigenetic attenuation.' Words such as 'breakthrough,' 'important research,' and 'significant' indicate a positive tone and recognition of their potential impact, though some expressions reflect cautious enthusiasm, linking the findings to future therapeutic possibilities.
Most discussions highlight the findings linking aging, epigenetics, and lupus improvement, indicating general support or acceptance of the research conclusions.
Posts demonstrate high curiosity and relevance, with many acknowledging the significance of the findings for lupus treatment and understanding immune aging.
Comments often reference the mechanisms, such as interferon signaling and epigenetic modifications, showing moderate to deep engagement with the scientific content.
While some discussions emphasize the potential for this research to influence future therapies, the perception of immediate high impact appears limited, leaning towards moderate significance.
Abstract in brief
- Aging typically leads to increased inflammation and chronic diseases in the general population, but in systemic lupus erythematosus (SLE), older age is linked to reduced disease activity.
- Researchers analyzed blood immune profiles of 287 SLE patients and 928 healthy controls, finding that aging in SLE patients was associated with lower levels of interferon-stimulated genes (ISGs) and decreased plasma IFN-α2.
- Both groups experienced declines in naïve T cells with age, but SLE patients uniquely showed increased CD56 natural killer cells, alongside evidence of epigenetic changes, indicating a complex relationship between aging and immune function in SLE.
Top posts
Most liked on X and BlueskyEpigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus | Science Translational Medicine https://t.co/fjVVeKtAkE
Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methylation epigenetic patterns, according to a clinical study that may explain why the condition becomes milder with age. https://t.co/Db0Lbv2dB0 @ScienceTM https://t.co/zsHp5FXfyW
Wow, when lower IFN in aging is a good thing! Congratulations Chaz L and team. #ImmuneProfiling #Aging Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/...
Older patients with #lupus display a marked drop in the expression of #interferon stimulated genes and shifts in methylation #epigenetic patterns, according to a clinical study that may explain why the condition becomes milder with age. @UCSF_ID https://t.co/nVlC4829rs https://t.co/l2zimjjSJs
Patients with systemic lupus erythematosus exhibit aging-related epigenetic driven decreases in IFN signaling that correlate with improved disease activity #lupus @ScienceTM @HoangVanPhan2 https://t.co/pDDyYjpcRV https://t.co/pXWKRNrZbr
All mentions
Immune Reversal in Older Adults Suggests New Aging Strategies
New research reveals that immune overactivity in midlife often drops in older adults, reversing the usual age-related rise in inflammation. This breakthrough could lead to new strategies for fighting age-related…
Why Lupus Symptoms Improve with Age Scientific Explanation
Lupus, a severe autoimmune disease, surprisingly tends to improve with age. Recent research shows that aging reduces immune system hyperactivity, especially interferon production, due to epigenetic changes. This…
RT @Kaleidoscope_FL: Lupus News: Researchers at UC San Francisco may have found the antiviral genes that decrease after age 60 ... often i…
RT @Kaleidoscope_FL: Lupus News: Researchers at UC San Francisco may have found the antiviral genes that decrease after age 60 ... often i…
RT @Kaleidoscope_FL: Lupus News: Researchers at UC San Francisco may have found the antiviral genes that decrease after age 60 ... often i…
Lupus News: Researchers at UC San Francisco may have found the antiviral genes that decrease after age 60 ... often improving lupus symptoms. This will be yet another important area of research toward better medications for all ages with lupus! Link; https://t.co/YfMiQr0k6t https://t.co/MXo2J1RN9X
"Scientists Spot Surprising Immune Reversal in Older Age" https://t.co/8TriLz5eFg via @YouTube
RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…
RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…
RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…
RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…
RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…
RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…
RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…
RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…
RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…
RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…
RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…
RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…
Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methylation epigenetic patterns, according to a clinical study that may explain why the condition becomes milder with age. https://t.co/Db0Lbv2dB0 @ScienceTM https://t.co/Cd1Y1KKNUp
Older patients with #lupus display a marked drop in the expression of #interferon stimulated genes and shifts in methylation #epigenetic patterns, according to a clinical study that may explain why the condition becomes milder with age. @UCSF_ID https://t.co/nVlC4829rs https://t.co/l2zimjjSJs
SLEにおいて加齢に伴ってIFNGS、血漿IFNα2が低下する。ただし、他の自然免疫系の活性化は健常人より高い状態を維持する(Sci Transl Med.2025)。 実際の活動性との相関ではなく、現象を見ている。本文にも書いてあるけど、アニフロルマブの有効性との関係が気になる点。 https://t.co/4TBDfrs9qz
RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…
RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…
RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…
RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…
RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…
RT @ScienceMagazine: Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methyla…
Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methylation epigenetic patterns, according to a clinical study that may explain why the condition becomes milder with age. https://t.co/Db0Lbv2dB0 @ScienceTM https://t.co/zsHp5FXfyW
Older patients with #lupus display a marked drop in the expression of #interferon stimulated genes and shifts in methylation #epigenetic patterns, according to a clinical study that may explain why the condition becomes milder with age. @UCSF_ID https://t.co/nVlC4829rs https://t.co/9Ey1ShYcYx
Epigenetics Update - Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus https://t.co/8fTtiQKIcY #Epigenetics #Aging #Lupus #SLE --- Discover the breakthrough at https://t.co/WmSYDGWPJD
Epigenetics Update - Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus bit.ly/4kT2KMV Charles R. Langelier (UCSF) reporting in Sci Trans Med #Epigenetics #Aging #Lupus --- Discover the breakthrough at epigenometech.com
RT @weicao_phd: Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosu…
Wow, when lower IFN in aging is a good thing! Congratulations Chaz L and team. #ImmuneProfiling #Aging Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/...
RT @weicao_phd: Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosu…
RT @weicao_phd: Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosu…
RT @weicao_phd: Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosu…
RT @weicao_phd: Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosu…
RT @weicao_phd: Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosu…
Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus | Science Translational Medicine https://t.co/fjVVeKtAkE
RT @LabWaggoner: Patients with systemic lupus erythematosus exhibit aging-related epigenetic driven decreases in IFN signaling that correla…
RT @LabWaggoner: Patients with systemic lupus erythematosus exhibit aging-related epigenetic driven decreases in IFN signaling that correla…
RT @LabWaggoner: Patients with systemic lupus erythematosus exhibit aging-related epigenetic driven decreases in IFN signaling that correla…
Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/...
Patients with systemic lupus erythematosus exhibit aging-related epigenetic driven decreases in IFN signaling that correlate with improved disease activity #lupus @ScienceTM @HoangVanPhan2 https://t.co/pDDyYjpcRV https://t.co/pXWKRNrZbr