Adv Sci (Weinh) September 2025 PMID 40625223

Multi-Region Brain Organoids Integrating Cerebral, Mid-Hindbrain, and Endothelial Systems.

Anannya Kshirsagar, Hayk Mnatsakanyan, Sai Kulkarni, John Guo, Kai Cheng, Luke Daniel Ofria, Oce Bohra, Ram Sagar, Vasiliki Mahairaki, Christian E Badr, Annie Kathuria

Mentions

81
Peak: 25 in Jul 2025
across 5 sources since Jul 2025

Extended reach

2,065,496
potential audience

Total likes

39,526

Video views

744,278

Mentions per month

Jul 2025 – Aug 2025

Where it's discussed

  • News40 articles
  • X / Twitter32 posts
  • Blogs5 articles
  • Bluesky2 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone reveals excitement about the creation of complex, multi-region brain organoids, exemplified by mentions of 'stunningly similar' and descriptions of the models as 'novel' and 'comprehensive.' Diverse comments indicate a strong interest and belief that these developments could significantly influence neurobiological research and treatment approaches, driven by words that highlight innovation and potential applications.

AgreementModerate agreement

Most discussions recognize the significance of the advances described and support the potential of MRBOs for neurodevelopmental studies.

InterestHigh interest

Posts show high enthusiasm and curiosity about the technological breakthrough, with phrases like 'stunningly similar' and 'amazing blob.'

EngagementModerate engagement

Comments reference specific features such as multiple brain regions and blood vessel development, indicating engagement at the method and implications level.

ImpactHigh impact

The discussions emphasize how this research could revolutionize studies of brain development and neuropsychiatric disorders, reflecting high perceived impact.

Abstract in brief

  • Brain organoid technology helps model human brain development in lab settings, but current methods are limited to basic endothelial cell types.
  • Multi-Region Brain Organoids (MRBOs) combine different brain regions with a more diverse range of endothelial cells, enhancing the complexity and realism of these models.
  • Research shows MRBOs share similarities with human fetal brain tissue and reveal new insights into how endothelial cells influence brain development, providing a valuable tool for studying neurodevelopmental disorders.

Top posts

Most liked on X and Bluesky
Medical Xpress
@medical_xpress · X

A novel whole-brain organoid featuring multiple brain regions and rudimentary blood vessels offers a new platform for studying #NeuropsychiatricDisorders and testing experimental therapies. @johnshopkins @advscinews https://t.co/vTIMeLHTlV https://t.co/gYZfBd2kK8

Jul 28, 2025 · 26 likes · 20 shares · 173,158 followers View post →
Pluchino lab - Regenerative Neuroimmunology
@Pluchinolab · X

Multi-Region Brain Organoids Integrating Cerebral, Mid-Hindbrain, and Endothelial Systems https://t.co/o2WagK8Ykz

Jul 28, 2025 · 9 likes · 2 shares · 4,750 followers View post →
Science Advancement and Outreach
@SAOscience · X

Jul 17, 2025 · 8 likes · 1 share · 1,247 followers View post →
Bluntly Put Philosopher (BPP)
@SocraticScribe · X

https://t.co/8gL57mcGC3

Aug 15, 2025 · 2 likes · 1 share · 20,357 followers View post →
Stem Cell Foundation
@AusStemCell · X

‘This Amazing Blob Is Stunningly Similar to The Human Brain’ – interesting read on ‘next generation’ multi-region brain organoids created at Johns Hopkins University [Paper -https://t.co/rMWpjAkBac]: https://t.co/ndboD3hTSx @JohnsHopkins

Aug 12, 2025 · 2 likes · 14,875 followers View post →
DrPaoloMezzana
@DrPaoloMezzana · X

Aug 11, 2025 · 2 likes · 1 share · 9,924 followers View post →

All mentions

サイエンスあれこれ
@sarekore · X

実際の脳(成人の脳の数百億個に対して600万~700万個のニューロン)と比べるとはるかに小さく、脳全体の発達を研究するための独自のプラットフォームを提供します。https://t.co/7Y9ABuQ69b

Aug 18, 2025 · 922 followers View post →
Lily GraceSABY
@LilyGraceSABY · X

RT @SocraticScribe: https://t.co/8gL57mcGC3

Aug 16, 2025 · 1 share · 4,774 followers View post →
Bluntly Put Philosopher (BPP)
@SocraticScribe · X

https://t.co/8gL57mcGC3

Aug 15, 2025 · 2 likes · 1 share · 20,357 followers View post →
DrPaoloMezzana
@DrPaoloMezzana · X

RT @DrPaoloMezzana:

Aug 12, 2025 · 1 share · 9,924 followers View post →
Stem Cell Foundation
@AusStemCell · X

‘This Amazing Blob Is Stunningly Similar to The Human Brain’ – interesting read on ‘next generation’ multi-region brain organoids created at Johns Hopkins University [Paper -https://t.co/rMWpjAkBac]: https://t.co/ndboD3hTSx @JohnsHopkins

Aug 12, 2025 · 2 likes · 14,875 followers View post →
DrPaoloMezzana
@DrPaoloMezzana · X

Aug 11, 2025 · 2 likes · 1 share · 9,924 followers View post →
Hugo Angulo
@thermotronica · X

Context has never been so gross ! https://t.co/0by5bJcHVd

Aug 10, 2025 · 2,976 followers View post →
Patricia S. Cyrus
@Patricia_Cyrus · X

Multi‐Region Brain Organoids Integrating Cerebral, Mid‐Hindbrain, and Endothelial Systems - Kshirsagar - Advanced Science - Wiley Online Library https://t.co/dg6a0dnsqV

Aug 10, 2025 · 529 followers View post →
Professor Erwin Loh
@erwinloh · X

Source: https://t.co/C2tZmVbtuw

Aug 6, 2025 · 9,415 followers View post →
Javier DN
@javierdn.bsky.social · Bluesky

Multi-Region Brain Organoids Integrating Cerebral, Mid-Hindbrain, and Endothelial Systems advanced.onlinelibrary.wiley.com/doi/10.1002/...

Jul 30, 2025 View post →
Kotobarz
@Kotobarz · X

https://t.co/n5VuZu2zje

Jul 30, 2025 · 2,038 followers View post →
Arthur
@Art2000F · X

RT @neurokinetikz: "Johns Hopkins University researchers have grown a novel whole-brain organoid, complete with neural tissues and rudiment…

Jul 29, 2025 · 1 share · 81 followers View post →
高橋
@Mariaso53513631 · X

RT @medical_xpress: A novel whole-brain organoid featuring multiple brain regions and rudimentary blood vessels offers a new platform for s…

Jul 29, 2025 · 20 shares · 39 followers View post →
Damien Touite
@SwinkAllen · X

RT @medical_xpress: A novel whole-brain organoid featuring multiple brain regions and rudimentary blood vessels offers a new platform for s…

Jul 29, 2025 · 20 shares · 28 followers View post →
Itackle
@Wata1967Meggy · X

RT @medical_xpress: A novel whole-brain organoid featuring multiple brain regions and rudimentary blood vessels offers a new platform for s…

Jul 29, 2025 · 20 shares · 51 followers View post →
MartisCapital
@YouFIKA_nicty · X

RT @medical_xpress: A novel whole-brain organoid featuring multiple brain regions and rudimentary blood vessels offers a new platform for s…

Jul 29, 2025 · 20 shares · 104 followers View post →
gottacop
@ecarolacarrasco · X

RT @medical_xpress: A novel whole-brain organoid featuring multiple brain regions and rudimentary blood vessels offers a new platform for s…

Jul 29, 2025 · 20 shares · 46 followers View post →
NP AGARWAL世界一フォローを目指しますAiming best in world.
@np_grwl · X

RT @medical_xpress: A novel whole-brain organoid featuring multiple brain regions and rudimentary blood vessels offers a new platform for s…

Jul 29, 2025 · 20 shares · 1,793 followers View post →
CopperKettle
@Artyom_Yekat · X

RT @medical_xpress: A novel whole-brain organoid featuring multiple brain regions and rudimentary blood vessels offers a new platform for s…

Jul 29, 2025 · 20 shares · 384 followers View post →
Weisse Rose
@Z0KPiyAPUz8Mt4c · X

RT @medical_xpress: A novel whole-brain organoid featuring multiple brain regions and rudimentary blood vessels offers a new platform for s…

Jul 29, 2025 · 20 shares · 657 followers View post →
camilo rodriguez
@camilintri19 · X

RT @medical_xpress: A novel whole-brain organoid featuring multiple brain regions and rudimentary blood vessels offers a new platform for s…

Jul 29, 2025 · 20 shares · 19 followers View post →
TulipsTechAI
@Devisri_24_ · X

RT @medical_xpress: A novel whole-brain organoid featuring multiple brain regions and rudimentary blood vessels offers a new platform for s…

Jul 29, 2025 · 20 shares · 611 followers View post →
Luis Alberto Luengo
@luengo1958 · X

RT @medical_xpress: A novel whole-brain organoid featuring multiple brain regions and rudimentary blood vessels offers a new platform for s…

Jul 29, 2025 · 20 shares · 17,889 followers View post →
Patrick Wayte
@PatrickWayte · X

RT @medical_xpress: A novel whole-brain organoid featuring multiple brain regions and rudimentary blood vessels offers a new platform for s…

Jul 28, 2025 · 20 shares · 807 followers View post →
Robbie tronick
@bovitronick · X

RT @medical_xpress: A novel whole-brain organoid featuring multiple brain regions and rudimentary blood vessels offers a new platform for s…

Jul 28, 2025 · 20 shares · 797 followers View post →
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@insurrealist · X

RT @medical_xpress: A novel whole-brain organoid featuring multiple brain regions and rudimentary blood vessels offers a new platform for s…

Jul 28, 2025 · 20 shares · 4,568 followers View post →
Phys.org
@physorg_com · X

RT @medical_xpress: A novel whole-brain organoid featuring multiple brain regions and rudimentary blood vessels offers a new platform for s…

Jul 28, 2025 · 20 shares · 1,024,242 followers View post →
Medical Xpress
@medical_xpress · X

A novel whole-brain organoid featuring multiple brain regions and rudimentary blood vessels offers a new platform for studying #NeuropsychiatricDisorders and testing experimental therapies. @johnshopkins @advscinews https://t.co/vTIMeLHTlV https://t.co/gYZfBd2kK8

Jul 28, 2025 · 26 likes · 20 shares · 173,158 followers View post →
neurokinetikz
@neurokinetikz · X

"Johns Hopkins University researchers have grown a novel whole-brain organoid, complete with neural tissues and rudimentary blood vessels." https://t.co/iG0fdwxccc

Jul 28, 2025 · 1 like · 1 share · 457 followers View post →
Daniel Foster
@innofoster · X

RT @Pluchinolab: Multi-Region Brain Organoids Integrating Cerebral, Mid-Hindbrain, and Endothelial Systems https://t.co/o2WagK8Ykz

Jul 28, 2025 · 2 shares · 12 followers View post →
Pluchino lab - Regenerative Neuroimmunology
@pluchinolab.bsky.social · Bluesky

Multi-Region Brain Organoids Integrating Cerebral, Mid-Hindbrain, and Endothelial Systems advanced.onlinelibrary.wiley.com/doi/10.1002/...

Jul 28, 2025 · 1 like View post →
Pluchino lab - Regenerative Neuroimmunology
@Pluchinolab · X

Multi-Region Brain Organoids Integrating Cerebral, Mid-Hindbrain, and Endothelial Systems https://t.co/o2WagK8Ykz

Jul 28, 2025 · 9 likes · 2 shares · 4,750 followers View post →
Marta Tafalla
@TafallaMarta · X

RT @SAOscience:

Jul 17, 2025 · 1 share · 13,081 followers View post →
Science Advancement and Outreach
@SAOscience · X

Jul 17, 2025 · 8 likes · 1 share · 1,247 followers View post →