JACC Cardiovasc Interv July 2025 PMID 40669962

Randomized Comparison of Fractional Flow Reserve and Instantaneous Wave Free Ratio in Serial Disease.

Matthew E Li Kam Wa, Saad M Ezad, Bhavik Modi, Ozan M Demir, Jonathan Hinton, Howard Ellis, Kalpa De Silva, Ankur Gulati, Ranil De Silva, Peter O'Kane, Abdel Douiri, Damien Collison, Nick Curzen, Carlos Collet, Divaka Perera

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Mentions

Peak: 48 in Jul 2025

across 2 sources since Jul 2025

Extended reach

352,242

potential audience

Total likes

141

Video views

716

Mentions per month

Jul 2025 – Aug 2025

Where it's discussed

X / Twitter51 posts
YouTube3 videos

AI synopsis

What people are saying

The collective discussions show strong support for the study's findings, with participants emphasizing the need for post-PCI physiology reassessment. The tone varies from professional acclaim, like 'great work' and 'brilliant summary,' to technical analysis of overestimations in hemodynamic benefits, demonstrating both high interest and active engagement in clinical implications.

AgreementModerate agreement

Most discussions support the findings that FFR and iFR may overestimate PCI benefits and emphasize the importance of post-PCI physiology assessment.

InterestHigh interest

Posts demonstrate high interest by highlighting the novelty of the comparison and its implications for clinical practice.

EngagementModerate engagement

Several discussions delve into specific results, such as overestimation of benefits and residual ischemia, indicating active engagement.

ImpactModerate impact

The discussions suggest the study could influence clinical protocols, emphasizing routine post-PCI assessments, which has a moderate yet meaningful impact.

Abstract in brief

The study compares Fractional Flow Reserve (FFR) and instantaneous wave-free ratio (iFR) in predicting the effectiveness of percutaneous coronary intervention (PCI) for patients with complex coronary artery issues.
It found that iFR provided more accurate predictions of post-PCI physiological outcomes than FFR, with less predictive error (4% vs. 12%).
The results suggest that both FFR and iFR can overlook significant residual disease in a notable percentage of cases, highlighting the importance of re-evaluating these metrics after PCI in patients with serial disease.

Read the full abstract

All mentions

Comparing FFR and iFR in Complex Coronary Disease Evaluation

This study assesses the performance of fractional flow reserve and instantaneous wave-free ratio in serial and diffuse coronary disease, highlighting iFR's superior predictive accuracy for post-PCI outcomes and…

UK Heart Research · Jul 14, 2025 456 views

Comparison of FFR and iFR in Serial Coronary Disease Diagnosis

Divaka Perera MD and F Aaysha Cader MBBS MD MSc FACC discuss the SERIAL study, the first randomized comparison of FFR and iFR in serial coronary artery disease, highlighting iFR's superior accuracy in predicting…

American College of Cardiology · Jul 24, 2025 174 views

Comparison of FFR and iFR in Serial Coronary Disease Evaluation

Dr. Divaka Perera discusses the SERIAL study, the first randomized comparison of FFR and iFR in serial coronary artery disease, highlighting the predictive accuracy of iFR over FFR in post-PCI outcomes and the need for…

aayshacader · Jul 14, 2025 86 views

Saad Ezad

@SaadEzad · X

RT @MissouriACC: In serial #cvCAD, both FFR & iFR pullbacks overestimate PCI benefit. Post-PCI physiology should be standard in diffuse/ser…

Aug 8, 2025 · 2 shares · 108 followers View post →

Aish Sinha

@AishSinha1 · X

RT @MissouriACC: In serial #cvCAD, both FFR & iFR pullbacks overestimate PCI benefit. Post-PCI physiology should be standard in diffuse/ser…

Aug 8, 2025 · 2 shares · 489 followers View post →

Kansas ACC

@KansasACC · X

In serial #cvCAD, both FFR & iFR pullbacks overestimate PCI benefit. Post-PCI physiology should be standard in diffuse/serial disease. Read @JACCJournals: https://t.co/xSkA52YswA @divaka_perera @mattlkw #JACCINT #InterventionalCardiology https://t.co/vsvzyOxFkC

Aug 8, 2025 · 1 like · 722 followers View post →

Missouri ACC

@MissouriACC · X

Aug 8, 2025 · 10 likes · 2 shares · 718 followers View post →

OklahomaACC

@acc_oklahoma · X

In serial #cvCAD, both FFR & iFR pullbacks overestimate PCI benefit. Post-PCI physiology should be standard in diffuse/serial disease. Read @JACCJournals: https://t.co/3bSQoZIPkn @divaka_perera @mattlkw #JACCINT #InterventionalCardiology https://t.co/2Sun2or76v

Aug 8, 2025 · 1 like · 137 followers View post →

IllinoisACC

@IllinoisACC · X

In serial #cvCAD, both FFR & iFR pullbacks overestimate PCI benefit. Post-PCI physiology should be standard in diffuse/serial disease. Read @JACCJournals: https://t.co/nfXuATRXEG @divaka_perera @mattlkw #JACCINT #InterventionalCardiology https://t.co/OilSwUbK7Z

Aug 8, 2025 · 8 likes · 829 followers View post →

Bambang Dwiputra MD

@sapporohunt · X

Pullback gradients (FFRΔ, iFRΔ) significantly overestimate PCI benefit in serial/diffuse CAD, missing residual ischemia in ~1/3 of cases. FFRcalc performed better, but post-PCI FFR/iFR reassessment remains essential.

Jul 28, 2025 · 166 followers View post →

Cardiac Research

@UKheartresearch · X

RT @DrOzanDemir: Great work by the SERIAL Trial investigators

Jul 17, 2025 · 1 share · 1,235 followers View post →

Ozan M. Demir

@DrOzanDemir · X

Great work by the SERIAL Trial investigators

Jul 17, 2025 · 13 likes · 1 share · 985 followers View post →

Emma Mae Fussell

@emmamae_fussell · X

RT @JACCJournals: This first randomized comparison of FFR & iFR in serial #cvCAD shows that both FFR & iFR pullbacks overestimate hemodynam…

Jul 15, 2025 · 15 shares · 105 followers View post →

Hany Ragy

@Hragy · X

RT @JACCJournals: This first randomized comparison of FFR & iFR in serial #cvCAD shows that both FFR & iFR pullbacks overestimate hemodynam…

Jul 15, 2025 · 15 shares · 80,363 followers View post →

Osama Bisht

@Obisht · X

RT @aayshacader: @divaka_perera shares insights from the SERIAL study: 1st randomized comparison of #FFR & #iFR in serial CAD

Jul 15, 2025 · 6 shares · 6,399 followers View post →

Osama Bisht

@Obisht · X

RT @JACCJournals: This first randomized comparison of FFR & iFR in serial #cvCAD shows that both FFR & iFR pullbacks overestimate hemodynam…

Jul 15, 2025 · 15 shares · 6,403 followers View post →

Rajan Rehan

@RajanRehan23 · X

RT @mattlkw:

Jul 15, 2025 · 13 shares · 141 followers View post →

John Mannisi MD

@JMannisi · X

RT @JACCJournals: This first randomized comparison of FFR & iFR in serial #cvCAD shows that both FFR & iFR pullbacks overestimate hemodynam…

Jul 15, 2025 · 15 shares · 1,793 followers View post →

Aish Sinha

@AishSinha1 · X

RT @aayshacader: @divaka_perera shares insights from the SERIAL study: 1st randomized comparison of #FFR & #iFR in serial CAD

Jul 15, 2025 · 6 shares · 489 followers View post →

Aish Sinha

@AishSinha1 · X

RT @UKheartresearch: What better way to launch our @YouTube channel https://t.co/3tBw1ZZCUT than with a brilliant summary of the SERIAL tri…

Jul 15, 2025 · 6 shares · 489 followers View post →

Biljana Parapid, MD, PhD, FESC

@biljana_parapid · X

RT @mattlkw:

Jul 15, 2025 · 13 shares · 8,497 followers View post →

Hany Ragy

@Hragy · X

RT @mattlkw:

Jul 15, 2025 · 13 shares · 80,363 followers View post →

Natsir Ramadhan

@natsiradhan · X

RT @JACCJournals: This first randomized comparison of FFR & iFR in serial #cvCAD shows that both FFR & iFR pullbacks overestimate hemodynam…

Jul 15, 2025 · 15 shares · 557 followers View post →

Damien Collison

@DamienCollison · X

RT @JACCJournals: This first randomized comparison of FFR & iFR in serial #cvCAD shows that both FFR & iFR pullbacks overestimate hemodynam…

Jul 15, 2025 · 15 shares · 510 followers View post →

Damien Collison

@DamienCollison · X

RT @mattlkw:

Jul 15, 2025 · 13 shares · 510 followers View post →

Mona Tirén

@monaltiren · X

RT @UKheartresearch: What better way to launch our @YouTube channel https://t.co/3tBw1ZZCUT than with a brilliant summary of the SERIAL tri…

Jul 15, 2025 · 6 shares · 1,093 followers View post →

Mona Tirén

@monaltiren · X

RT @aayshacader: @divaka_perera shares insights from the SERIAL study: 1st randomized comparison of #FFR & #iFR in serial CAD

Jul 15, 2025 · 6 shares · 1,093 followers View post →

Kuchal Agadi

@AgadiKuchal · X

RT @JACCJournals: This first randomized comparison of FFR & iFR in serial #cvCAD shows that both FFR & iFR pullbacks overestimate hemodynam…

Jul 14, 2025 · 15 shares · 120 followers View post →

ranil de silva

@ranildesilva2 · X

RT @JACCJournals: This first randomized comparison of FFR & iFR in serial #cvCAD shows that both FFR & iFR pullbacks overestimate hemodynam…

Jul 14, 2025 · 15 shares · 77 followers View post →

trauma&vascular, sometimes cardiac

@VascularTrauma · X

RT @JACCJournals: This first randomized comparison of FFR & iFR in serial #cvCAD shows that both FFR & iFR pullbacks overestimate hemodynam…

Jul 14, 2025 · 15 shares · 63 followers View post →

Richard Bogle

@richardbogle · X

RT @mattlkw:

Jul 14, 2025 · 13 shares · 5,163 followers View post →

Cardiac Research

@UKheartresearch · X

RT @aayshacader: @divaka_perera shares insights from the SERIAL study: 1st randomized comparison of #FFR & #iFR in serial CAD

Jul 14, 2025 · 6 shares · 1,234 followers View post →

Divaka Perera

@divaka_perera · X

RT @aayshacader: @divaka_perera shares insights from the SERIAL study: 1st randomized comparison of #FFR & #iFR in serial CAD

Jul 14, 2025 · 6 shares · 1,081 followers View post →

Solveig Grimstad

@ViaDelSol · X

RT @JACCJournals: This first randomized comparison of FFR & iFR in serial #cvCAD shows that both FFR & iFR pullbacks overestimate hemodynam…

Jul 14, 2025 · 15 shares · 213 followers View post →

Kalpa De Silva

@K_DeSilva · X

RT @mattlkw:

Jul 14, 2025 · 13 shares · 1,518 followers View post →

Becker Al-Khayatt

@beckeralkhayatt · X

RT @UKheartresearch: What better way to launch our @YouTube channel https://t.co/3tBw1ZZCUT than with a brilliant summary of the SERIAL tri…

Jul 14, 2025 · 6 shares · 83 followers View post →

Antonio de Marvao

@AdeMarvao · X

RT @JACCJournals: This first randomized comparison of FFR & iFR in serial #cvCAD shows that both FFR & iFR pullbacks overestimate hemodynam…

Jul 14, 2025 · 15 shares · 2,630 followers View post →

Aaysha Cader

@aayshacader · X

@divaka_perera shares insights from the SERIAL study: 1st randomized comparison of #FFR & #iFR in serial CAD

Jul 14, 2025 · 11 likes · 6 shares · 9,048 followers View post →

Dr Peter O'Kane

@DrPeterOKane · X

RT @JACCJournals: This first randomized comparison of FFR & iFR in serial #cvCAD shows that both FFR & iFR pullbacks overestimate hemodynam…

Jul 14, 2025 · 15 shares · 3,696 followers View post →

Dr Peter O'Kane

@DrPeterOKane · X

RT @mattlkw:

Jul 14, 2025 · 13 shares · 3,696 followers View post →

Dr Peter O'Kane

@DrPeterOKane · X

RT @UKheartresearch: What better way to launch our @YouTube channel https://t.co/3tBw1ZZCUT than with a brilliant summary of the SERIAL tri…

Jul 14, 2025 · 6 shares · 3,692 followers View post →

Sandeep Jalli

@sandeep_jalli · X

RT @mattlkw:

Jul 14, 2025 · 13 shares · 97 followers View post →

REVIVED

@REVIVED_BCIS2 · X

RT @UKheartresearch: What better way to launch our @YouTube channel https://t.co/3tBw1ZZCUT than with a brilliant summary of the SERIAL tri…

Jul 14, 2025 · 6 shares · 978 followers View post →

Divaka Perera

@divaka_perera · X

RT @UKheartresearch: What better way to launch our @YouTube channel https://t.co/3tBw1ZZCUT than with a brilliant summary of the SERIAL tri…

Jul 14, 2025 · 6 shares · 1,081 followers View post →

Cardiac Research

@UKheartresearch · X

What better way to launch our @YouTube channel https://t.co/3tBw1ZZCUT than with a brilliant summary of the SERIAL trial by @mattlkw! https://t.co/aDbUGDfnOd https://t.co/A5pnZxVv45

Jul 14, 2025 · 10 likes · 6 shares · 1,234 followers View post →

Matthew Li Kam Wa

@mattlkw · X

RT @JACCJournals: This first randomized comparison of FFR & iFR in serial #cvCAD shows that both FFR & iFR pullbacks overestimate hemodynam…

Jul 14, 2025 · 15 shares · 124 followers View post →

Divaka Perera

@divaka_perera · X

RT @JACCJournals: This first randomized comparison of FFR & iFR in serial #cvCAD shows that both FFR & iFR pullbacks overestimate hemodynam…

Jul 14, 2025 · 15 shares · 1,080 followers View post →

JACC Journals

@JACCJournals · X

Jul 14, 2025 · 54 likes · 15 shares · 114,422 followers View post →

Saad Ezad

@SaadEzad · X

RT @mattlkw:

Jul 14, 2025 · 13 shares · 108 followers View post →

Clwb Calon

@CalonClwb · X

RT @mattlkw:

Jul 14, 2025 · 13 shares · 220 followers View post →

Holly

@hollymorgs · X

RT @mattlkw:

Jul 14, 2025 · 13 shares · 3,993 followers View post →

Becker Al-Khayatt

@beckeralkhayatt · X

RT @mattlkw:

Jul 14, 2025 · 13 shares · 83 followers View post →

Aish Sinha

@AishSinha1 · X

RT @mattlkw:

Jul 14, 2025 · 13 shares · 489 followers View post →

Matthew Li Kam Wa

@mattlkw · X

Jul 14, 2025 · 32 likes · 13 shares · 124 followers View post →

Randomized Comparison of Fractional Flow Reserve and Instantaneous Wave Free Ratio in Serial Disease.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Comparing FFR and iFR in Complex Coronary Disease Evaluation

Comparison of FFR and iFR in Serial Coronary Disease Diagnosis

Comparison of FFR and iFR in Serial Coronary Disease Evaluation