Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading.

Source — University of Florida. Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading

@ajmubasher

@BadDataTakes The craziest part? They're working on a generalized version, i.e., not tailored to the genetics of a specific person, and it shows a lot of promise in mice models. Published a month ago in Nature Biomedical Engineering https://t.co/MmCHYGKpvY

Scientists at the University of Florida have developed a breakthrough mRNA vaccine that may be able to fight almost any type of cancer—without needing chemotherapy, surgery, or radiation. It works by reprogramming. Nat. Biomed. Eng (2025). DOI:10.1038/s41551-025-01380-1

『Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading』 Nature Biomedical Engineering 　18 July 2025 初期I型インターフェロン応答が免疫チェックポイント阻害剤効果とエピトープスプレッディングに重要 https://t.co/Rkzlu2PEyI

Research Paper : Qdaisat, S., Wummer, B., Stover, B.D. et al. Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading. Nat. Biomed. Eng (2025). DOI:10.1038/s41551-025-01380-1

Thank you James.

That English secret 'Real estate' agent. He really was a twat wasn't he.

Ja, in Schweden muss man die Pilze teilweise nicht suchen sondern man kann sie regelrecht ernten

actually, don't waste time with a response. You didn't read it. I'm going to bed. Have a good evening friend.

Estoy intentando perfilar una idea, una sensación que a falta de un nombre mejor denomino "subcontratar la euforia".

Ja, da steht ja auch "Kochen".

Keeping my fingers crossed tightly for this little bean. Hugs to you both.

Need myself an appetizer

ひぁ

Ili u 4 različita grada :)

浦畑土康平

154 Curran Hall Regular service has resumed westbound near Midland Ave at Lawrence Ave East South Side.

ぜとぱむ

ドゥリンに限らずだし本当に今更なんだけど、キャラの性能とかスキルや爆発の説明を読んでもなんもわからんっていつも思う　みんな理解できるの？　すごい…

Does having more time make it harder?

薔薇エルフ苦手かも…最後にああいう削り方されるタイプだめだー

Ok, jetzt habt ihr mich so weit. Ich brauch jetzt Dominosteine.

サウンドハウスからBehringerの84HPのユーロラックケースが発送された、と言うメールが届いた。 …が、いつもは佐川急便なのに、今回はヤマト運輸だ。やはり、佐川急便は今、ヤバい状態になっているのかも知れませんね

GetYourGuide is looking for a Senior Product Manager, Communication Platform in Zurich, Switzerland https://weloveproduct.co/jobs/senior-product-manager-communication-platform-getyourguide-cc3v9h #seniorproductmanager #productjobs #jobs #jobsoffer #weloveproduct

Also should give us pause that what was clearly a pretty impressively subsiding basin has somehow ended up an eroding "high" topography across the entire middle of North America in the last few million years with no obvious tectonism.

Guten Morgen Manfred ☕

あとグルーシャ君の記事も今まさにTwitterで暴れ散らかしてるようなアニポケキモオタクが荒らしててキモかったです

Interesting - they're "bribes" when they come from Russia but "donations" if they come from Israel

La cara de un venteañero escuchando por primera vez una canción de los Bee Gees no tiene precio...

Jaaaaa

Anyway, it was a correction so much as a question in wondering whether modern Robert would get £65-85 for his piece?

I don’t play politics. I make my decisions based on right & wrong. I’ll never lie to you. I’ll continue to give out honest information & opinions. As always, as we fight the lies, corruption & incompetence of Donald Trump, thank you for following me. Evil wins when good people stay in the dark.

白人は全員ヨーロッパに帰るべきなのでは

are you watching the westminster dog show rn??

めちゃくちゃ奇跡レベルで良いこと起きた！！！！！しかしwebオンリーの準備は0

Heute um 17 Uhr gibt es die nächste Ausgabe MAUSRITTER

is this the one with inexplicable Henry Rollins?

i didn't expect to experience two stories about how much los angeles sucks in a row this is awesome

I love magsails so much cuz they don't look like anything we percept to be a propulsion system

She is the most perfect slut i have ever seen, one day she will be begging me to fuck her

ねこぱすーさん、おはにゃんぱすー

یہ الگ بات کہ میں چھوڑ چکا کوزہ گری تیرے جیسے تو میں مٹی کے بنا سکتا ہوں عمران عامی

ﾊｧーーーーーｧ

с проснутием

niiiiiiiiiiiice

スパダリのキドも好きだけど★の無防備さとかあれこれにドギマギしてるキドも好きなので…

goddamn, it's so true, also you forget to ask about half of the random ailments that constantly cycle through your poor body

Morning. Thanks, George. I'm glad it's coming across. The caffeine will be hit hard today.

Morning Charlotte. Lovely, lovely day off! I'm collecting clothes to drop into the care home today, she's being discharged tomorrow. Hope you get some time foe yourself today. Later, we will both #BeMoreBeans

by / sponsored by @womensmarch.com glad to see media like this

Du hattest die Woche auch genug Spaß, das langt!

寒いからかな…と思ってケツにカイロ貼った

Ex-Brexit Party MEP named in Nathan Gill messages denies taking pro-Russian payments

아 및ㅊ추닌닌ㄴㄴㄴ 버스에서 치킨 냄새를 누가 풍겨어어어어어어

No era uno solo , hasta quince periodistas, con la credibilidad de sus carreras.AHORA le dan a credibilidad a 2 corruptos o son 2 personas honorables a quien darles credibilidad? Torticeros, ustedes que no le dan credibilidad a los familiares de las víctimas cuando fallecen por sus negligencias

吉野家の鍋ラーメンを食べてみたい俺vsケンタッキーのとりの日パックを召し上がりたい俺

Falls euch eine lokale Medienverwaltung lieber ist, als Streamingdienste, so wie mir, dann könnt ihr heute Emby Premiere Lifetime für einen reduzierten Preis ergattern. emby.media/premiere.html

I know the paper... Just because some of the Deccan volcanic rocks (without fossils!) are now dated closer to the end of the Cretaceous doesn't say much about whether the volcanoes played a role in the extinction of actual animals and ecosystems.

oh i just realised that this is the first weekend in a while where i don't have any plans... i can stay in bed all day if i want to? i'm so excited

@patbren.bsky.social I'm sorry for the inconvenience, please help me. We're drowning in tents. Please don't ignore me, we have no one else.

Finn says OOPS!

Das Sie alleine gegen die FPÖ ankämpfen mussten zeigt wie der Staat rechtsextrem geworden ist 25 Jahre FPÖVP hinterlässt eine Ruine ..

Pas besoin de montrer son cul pour appuyer le point quand tu as parfaitement raison, mais que, hélas, trop de monde n'y fait pas attention. Mais ça aurait été dommage de ne pas le voir, donc j'achète la photo pour la révolution.

Es viernes y el cuerpo lo sabe

Moin Mani

Es verdad, ahí llevas razón

¡Ya es casi sábado! Pero ya sabéis que durante unas semanas solo se emitirán en la SER y se publicarán en podcast y vídeo recopilaciones.. Mañana, 29 de noviembre, lo dedicaremos a los mejores momentos solo durante programas publicados en noviembre. Ha quedado curioso. Samanté a borbotones!

nach Europa fließen kann? Kurze Strecken über Spanien sind möglich. Türkei-Griechenland und natürlich Italien sind vergleichbar mit Südamerika einfach zu erschließen. Aber wie gesagt, selbst Afrika ist eher eine Notlösung. Europa hat genug potential für Erneuerbare.

Zeitverschiebung bezüglich Sonneneinstrahlung. Ja Vorteil. Aber nicht zwingend nötig, wenn wir Batteriespeicher haben, die die Leistung Tagsüber speichern können. Was ist günstiger? Ein verlustreiches Seekabel nach Südamerika, oder Batteriespeicher in Afrika, damit der Strom auch Nachts über Kabel⬇️

One of my favorite games too!

Northwest Division, Beat: 538, 6XE - Disturbance Emergency at 32XX BLOCK NORWALK AVE reported on 11/28/2025, 1:45 AM CST, Incident# 25-2106872 #dpdi-div-nw #dpdi-beat-538

its eggnog season

2 dicke Knutscher auf die Spiegeleier und einen aufs leckere Dreieck

Wir haben den 28. November und im Radio läuft "Thank god it's Christmas". Das muss doch nicht sein!

Der soll cringe sein. Und du hast damit mehr media literacy bewiesen als die ganzen coolen kids früher

持っている石すべて使い果たした結果…出ませんでした！！！！！キィーー！！！！

Hoping Tales of Graces f will be better It’d be hard to imagine much worse

I was more thinking one nuke to nuke them all

Okay, define a lot of them then.

Holding her close just to make sure she'd not fall, letting her blood come to him as he tasted each mouthful in passionate delight.

Manny: You’re keeping me here because you need the eggs?

America keeps promising to step up but doesn't.

I was excited about the John Carpenter album until I saw the price. Yikes, he's turning into Gene Simmons.

社会が戦争に近づいていることなんてわかってるし、そのような社会の中で生きていく責任がありますよって言われたってその社会は私たちが作ったものではないんですけどね　勝手に作られてそれに対処する責任だけ押し付けるなんてその傲慢さについて何も思わないんですかね

I need to give up on my young on my phone. I meant I love it

Though our employment based pensions are a shadow of their former selves

This is the old "let's just do a sales tax" but worse. Sales taxes are regressive as the lower and middle incomes spend a higher % of income than the wealthy. So so higher % income is taxed. Tariff is worse bc: 1. hidden tax and 2. distorts costs, leading companies to seek return on tariff costs.

"Laut ihm drangen die Po­li­zis­t*in­nen in der Nacht mit gezogener Waffe in die Wohnung ein, nachdem sie den Strom abgestellt hatten. Für die gehörlose Familie sei die plötzliche Dunkelheit besonders belastend gewesen." taz.de/Bochumer-Pol...

Danke, dir auch einen angenehmen Freitag ☕

I stg Twitch just wants to scuff so much for me this week. If we can get ONE sub before stream tomorrow, I'll give y'all another chance to hit that second sub goal of 30 subs! We're only 17 away, and if we get one sub, it'll be 16! #envtuber | #vtuber | #eldenwood | #subathon | #debut

But what I will always be thankful for most is my family, and the man who makes it all possible. The Love of my life There was once a very long time ago that I almost gave up on this crazy dream. But he was my light and my reason. And now here we are still going making art and friends along the way

Thank you Thursday!!

PSV vernedert Liverpool op Anfield en maakt van Arne Slot 'Arne Lost' https://dgki.nl/979bba0-PSV-Liverpool-Arne-Slot-crisis/

Zero only zero… Babar Azam crossed the limits, became the batsman who got out on 0 the most number of times. This was the second time in this series, when Babar was out on 0. Earlier, his account had not been opened even against Zimbabwe. At the same time, for the third time in the last 30 days…

Planefence ICAO: 43C6F6 Flt: RRR9958 ROYALAIRFORCE First seen: 2025-11-28 09:44:28 IST Min Alt: 8833 m MSL Min Dist: 26.83 km planefence adsb - adsbexchange

Hildur Gudnadóttir, compositrice : «Ce qui me plaît, c’est de fondre la voix humaine dans le son des cordes» www.liberation.fr/culture/musi... (Abonné.e.s)

やア

やまだ@腸活×アンチエイジング

@tarou_ymd_ · X

参考2 前臨床データ Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading | Nature Biomedical Engineering https://t.co/Gfw17lBWuo

DD

Dr. Gennadi Glinsky, MD, Ph.D.

@gglinskii · X

Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading https://t.co/hrbEZ6rqC8

ご

ごちち

@gochichi_nihon · X

RT @sarekore: とほぼ倍増しました。進行性皮膚がん患者では、ワクチン未接種患者の生存期間中央値は26.67ヶ月だったのに対し、ワクチン接種を受けた患者では生存期間中央値が「未達成」となり、多くの患者がはるかに長く生存していることがわかりました。さらに、免疫療法への反…

サ

サイエンスあれこれ

@sarekore · X

とほぼ倍増しました。進行性皮膚がん患者では、ワクチン未接種患者の生存期間中央値は26.67ヶ月だったのに対し、ワクチン接種を受けた患者では生存期間中央値が「未達成」となり、多くの患者がはるかに長く生存していることがわかりました。さらに、免疫療法への反応が低いhttps://t.co/LilRkFHanK

OW

Olga Meiri Chaim #VAX #MaskUp #WashYourHands

@olgachaim · X

Kewl, Qdaisat and cols in July 2025. PD-1'ish. @natBME "I'd like to buy a Anti-Cardiolipina IgG"

Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading | Nature Biomedical Engineering https://t.co/iSHJiulHEv

Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading | Nature Biomedical Engineering https://t.co/kkLrgVxskr

Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading https://t.co/IXL1HFf7LP

@BadDataTakes The craziest part? They're working on a generalized version, i.e., not tailored to the genetics of a specific person, and it shows a lot of promise in mice models. Published a month ago in Nature Biomedical Engineering https://t.co/MmCHYGKpvY

Fantastiskt. (https://t.co/RjvP5zx65L) https://t.co/AKaVSEVDfG

すげー。 父ちゃんも死なずにすんだのかな？ がん治療に革命！特定のがんを狙わない汎用ワクチンがついに誕生 https://t.co/xPsCGuf3uM @YouTubeより

RT @basemstat: @ajmubasher

RT @basemstat: @ajmubasher

RT @basemstat: @ajmubasher

@ajmubasher

https://t.co/HLnGMlluHf

This is FUCKED UP. This is literally defunding a possible universal cancer cure: Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading. Nat Biomed Eng. 2025 Jul 18. doi: 10.1038/s41551-025-01380-1. PMID: 40681861. https://t.co/pJJhkaMbId

@Forbes https://t.co/HLnGMlluHf

@Forbes This is FUCKED UP. This is literally defunding a possible universal cancer cure: Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading. Nat Biomed Eng. 2025 Jul 18. doi: 10.1038/s41551-025-01380-1. PMID: 40681861. https://t.co/KDXd9vaHgN

Research Paper : Qdaisat, S., Wummer, B., Stover, B.D. et al. Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading. Nat. Biomed. Eng (2025). DOI:10.1038/s41551-025-01380-1

Scientists at the University of Florida: Qdaisat, S., Wummer, B., Stover, B.D. et al. Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading. Nat. Biomed. Eng (2025). DOI:10.1038/s41551-025-01380-1 https://t.co/gImOax3vFu

Revolutionary and transformative, Solutions Research Paper : Qdaisat, S., Wummer, B., Stover, B.D. et al. Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading. Nat. Biomed. Eng (2025). DOI:10.1038/s41551-025-01380-1 https://t.co/bV3isXfXrW

Research Paper : Qdaisat, S., Wummer, B., Stover, B.D. et al. Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading. Nat. Biomed. Eng (2025). DOI:10.1038/s41551-025-01380-1

(Research Paper : Qdaisat, S., Wummer, B., Stover, B.D. et al. Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading. Nat. Biomed. Eng (2025). DOI:10.1038/s41551-025-01380-1)

by boosting early type-I interferon responses enables epitope spreading. Nat. Biomed. Eng (2025). DOI:10.1038/s41551-025-01380-1 Çok uzun bi yazı Evre ama seninle paylaşmasam olmazdı. Doktorlarına göster, umarım aşı piyasaya çıkmıştır ve seni de hemencecik iyileştirir. Sevgiler

Scientists at the University of Florida have developed a breakthrough mRNA vaccine that may be able to fight almost any type of cancer—without needing chemotherapy, surgery, or radiation. It works by reprogramming. Nat. Biomed. Eng (2025). DOI:10.1038/s41551-025-01380-1

Someone's really close, or has, figured a large part out. "loaded with RNA coding for tumour-unspecific antigens" Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading https://t.co/aHvfuyX6XO

A new hope to people with difficult-to-treat cases… Research Paper : Qdaisat, S., Wummer, B., Stover, B.D. et al. Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading. Nat. Biomed. Eng (2025). DOI:10.1038/s41551-025-01380-1

Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading | Nature Biomedical Engineering https://t.co/bDDA41sjOU

RT @RT_com: Source — University of Florida. Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables…

RT @RT_com: Source — University of Florida. Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables…

Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading | Nature Biomedical Engineering https://t.co/upiz08MTq0

RT @RT_com: Source — University of Florida. Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables…

RT @RT_com: Source — University of Florida. Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables…

RT @RT_com: Source — University of Florida. Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables…

RT @RT_com: Source — University of Florida. Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables…

RT @RT_com: Source — University of Florida. Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables…

Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading | Nature Biomedical Engineering https://www.nature.com/articles/s41551-025-01380-1 #PostSapiens

RT @RT_com: Source — University of Florida. Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables…

Source — University of Florida. Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading

Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading | Nature Biomedical Engineering @Nigelj08223326 https://t.co/SrRrYZmnwC

で、免疫系を活性化させます。さらに、皮膚がん、骨がん、脳腫瘍のマウスモデルにおいて、異なるmRNA製剤を、免疫チェックポイント阻害剤を一緒に投与しない単独治療として試験したところ、有益な効果が得られました。一部のモデルでは、腫瘍が完全に消失しました。https://t.co/LilRkFHanK

『Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading』 Nature Biomedical Engineering 　18 July 2025 初期I型インターフェロン応答が免疫チェックポイント阻害剤効果とエピトープスプレッディングに重要 https://t.co/Rkzlu2PEyI

Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading ->Nature | More info from EcoSearch