EMBO Rep September 2025 PMID 40702342

Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes.

Declan Whyte, Sophie L Fisher, Christopher G J McKenzie, David Sumpton, Sandeep Dhayade, Emmanuel Dornier, Madeleine Moore, David Novo, Jasmine Peters, Robert Wiesheu, Michalis D Gounis, Dale M Watt, John B G Mackey, Amanda J McFarlane, Frédéric Fercoq

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Mentions

81
Peak: 14 in Jul 2025
across 4 sources since Jul 2025

Extended reach

24,423
potential audience

Total likes

55

Video views

32

Mentions per month

Jul 2025 – Sep 2025

Where it's discussed

  • News64 articles
  • X / Twitter13 posts
  • Bluesky3 posts
  • YouTube1 videos

AI synopsis

What people are saying

The collective discussions show strong support and enthusiasm, with posts praising the featured work as 'beautiful' and highlighting its importance for understanding metastasis, using words like 'delighted' and 'proud.' The tone and context indicate a positive reception that recognizes both the scientific significance and potential impact of the findings.

AgreementModerate agreement

Most discussions express support and excitement about the significance of the research findings, highlighting the importance of UPP1's role in metastasis.

InterestHigh interest

The tweets reflect high interest through enthusiastic language and interest in the research's implications, such as its potential for future cancer therapies.

EngagementModerate engagement

While some posts mention the publication details and share enthusiasm, there is moderate engagement with scientific content and methodology, suggesting a basic level of thoughtful discussion.

ImpactModerate impact

Posts suggest that the publication is considered impactful, emphasizing the potential for this research to influence cancer treatment strategies and metastasis understanding.

Abstract in brief

  • Understanding how early events in metastatic seeding work is crucial for developing treatments to combat metastasis.
  • Researchers discovered uracil as a key metabolite linked to metastasis in both mouse models and patients with metastatic breast cancer, produced by the enzyme uridine phosphorylase-1 (UPP1) primarily found in neutrophils.
  • Neutrophils influenced by UPP1 express more adhesion molecules, leading to reduced mobility and increased suppression of T-cell activity, contributing to metastasis; inhibiting UPP1 enhances T-cell presence and decrease metastasis in mice.
  • This study suggests that uracil could serve as a metastatic marker and that targeting UPP1 might be an effective strategy to prevent cancer recurrence.

Top posts

Most liked on X and Bluesky
Cassie Clarke
@cassiejclarke.bsky.social · Bluesky

Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....

Jul 23, 2025 · 22 likes · 17 shares View post →
Cassie Clarke
@CassieJClarke · X

Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix landscapes” was published today in @emboreports, describing how #neutrophil #metabolism influences niche priming & #metastasis (1/14) https://t.co/XNy7MUsE8s

Jul 23, 2025 · 16 likes · 9 shares · 603 followers View post →
Cassie Clarke
@CassieJClarke · X

Super proud to see our work featured on the cover of @emboreports today! Many thanks to @pedromics for this beautiful interpretation and depiction of our story. Read the full paper here: https://t.co/XNy7MUtbY0 https://t.co/dhm0wIs46q

Sep 9, 2025 · 12 likes · 1 share · 603 followers View post →
Cassie Clarke
@CassieJClarke · X

Please find the link to our @emboreports publication here: Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports https://t.co/7s2PugchOj

Jul 28, 2025 · 1 like · 603 followers View post →
EMBO Reports
@emboreports.org · Bluesky

Uridine phosphorylase-1 supports #metastasis by altering immune and extracellular matrix landscapes. -> www.embopress.org/doi/full/10....

Jul 24, 2025 · 1 like View post →
Cassie Clarke
@cassiejclarke.bsky.social · Bluesky

And the original publication is here: Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports share.google/JXMzGDRzpl0E...

Jul 28, 2025 · 1 like · 3 shares View post →

All mentions

Muir Lab
@Muir_Lab · X

RT @CassieJClarke: Super proud to see our work featured on the cover of @emboreports today! Many thanks to @pedromics for this beautiful in…

Sep 9, 2025 · 1 share · 2,865 followers View post →
Cassie Clarke
@CassieJClarke · X

Super proud to see our work featured on the cover of @emboreports today! Many thanks to @pedromics for this beautiful interpretation and depiction of our story. Read the full paper here: https://t.co/XNy7MUtbY0 https://t.co/dhm0wIs46q

Sep 9, 2025 · 12 likes · 1 share · 603 followers View post →
UofG Cancer Sciences
@UofGCancerSci · X

RT @CassieJClarke: Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix…

Jul 29, 2025 · 9 shares · 2,221 followers View post →
Cassie Clarke
@cassiejclarke.bsky.social · Bluesky

And the original publication is here: Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports share.google/JXMzGDRzpl0E...

Jul 28, 2025 · 1 like · 3 shares View post →
Cassie Clarke
@CassieJClarke · X

Please find the link to our @emboreports publication here: Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports https://t.co/7s2PugchOj

Jul 28, 2025 · 1 like · 603 followers View post →
Ruhi Deshmukh
@ruhi_deshmukh_ · X

RT @CassieJClarke: Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix…

Jul 25, 2025 · 9 shares · 76 followers View post →
Garry
@GarryRefati · X

RT @CassieJClarke: Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix…

Jul 24, 2025 · 9 shares · 55 followers View post →
Federico Bernuzzi, PhD
@FedericoBernuzz · X

RT @CassieJClarke: Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix…

Jul 24, 2025 · 9 shares · 624 followers View post →
Dylan Ryan
@RyanLab_TCD · X

RT @CassieJClarke: Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix…

Jul 24, 2025 · 9 shares · 2,410 followers View post →
Alexis A. Jourdain
@jourdainlab · X

RT @CassieJClarke: Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix…

Jul 24, 2025 · 9 shares · 1,658 followers View post →
CRUK Scotland Inst
@CRUK_SI · X

RT @CassieJClarke: Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix…

Jul 24, 2025 · 9 shares · 5,170 followers View post →
EMBO Reports
@emboreports.org · Bluesky

Uridine phosphorylase-1 supports #metastasis by altering immune and extracellular matrix landscapes. -> www.embopress.org/doi/full/10....

Jul 24, 2025 · 1 like View post →
Lyssiotis Lab
@LyssiotisLab · X

RT @CassieJClarke: Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix…

Jul 23, 2025 · 9 shares · 7,071 followers View post →
Amecitav
@Amestarfire · X

RT @CassieJClarke: Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix…

Jul 23, 2025 · 9 shares · 209 followers View post →
Cassie Clarke
@cassiejclarke.bsky.social · Bluesky

Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....

Jul 23, 2025 · 22 likes · 17 shares View post →
Cassie Clarke
@CassieJClarke · X

Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix landscapes” was published today in @emboreports, describing how #neutrophil #metabolism influences niche priming & #metastasis (1/14) https://t.co/XNy7MUsE8s

Jul 23, 2025 · 16 likes · 9 shares · 603 followers View post →