Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes.
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Jul 2025 – Sep 2025Where it's discussed
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News64 articles
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X / Twitter13 posts
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Bluesky3 posts
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YouTube1 videos
AI synopsis
What people are saying
The collective discussions show strong support and enthusiasm, with posts praising the featured work as 'beautiful' and highlighting its importance for understanding metastasis, using words like 'delighted' and 'proud.' The tone and context indicate a positive reception that recognizes both the scientific significance and potential impact of the findings.
Most discussions express support and excitement about the significance of the research findings, highlighting the importance of UPP1's role in metastasis.
The tweets reflect high interest through enthusiastic language and interest in the research's implications, such as its potential for future cancer therapies.
While some posts mention the publication details and share enthusiasm, there is moderate engagement with scientific content and methodology, suggesting a basic level of thoughtful discussion.
Posts suggest that the publication is considered impactful, emphasizing the potential for this research to influence cancer treatment strategies and metastasis understanding.
Abstract in brief
- Understanding how early events in metastatic seeding work is crucial for developing treatments to combat metastasis.
- Researchers discovered uracil as a key metabolite linked to metastasis in both mouse models and patients with metastatic breast cancer, produced by the enzyme uridine phosphorylase-1 (UPP1) primarily found in neutrophils.
- Neutrophils influenced by UPP1 express more adhesion molecules, leading to reduced mobility and increased suppression of T-cell activity, contributing to metastasis; inhibiting UPP1 enhances T-cell presence and decrease metastasis in mice.
- This study suggests that uracil could serve as a metastatic marker and that targeting UPP1 might be an effective strategy to prevent cancer recurrence.
Top posts
Most liked on X and BlueskyDelighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix landscapes” was published today in @emboreports, describing how #neutrophil #metabolism influences niche priming & #metastasis (1/14) https://t.co/XNy7MUsE8s
Super proud to see our work featured on the cover of @emboreports today! Many thanks to @pedromics for this beautiful interpretation and depiction of our story. Read the full paper here: https://t.co/XNy7MUtbY0 https://t.co/dhm0wIs46q
Please find the link to our @emboreports publication here: Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports https://t.co/7s2PugchOj
Uridine phosphorylase-1 supports #metastasis by altering immune and extracellular matrix landscapes. -> www.embopress.org/doi/full/10....
And the original publication is here: Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports share.google/JXMzGDRzpl0E...
All mentions
Uridine Phosphorylase-1's Role in Cancer Metastasis and Immune Modulation
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes. This study reveals how UPP1 influences neutrophil function and T-cell suppression, suggesting targeting UPP1 as a…
RT @CassieJClarke: Super proud to see our work featured on the cover of @emboreports today! Many thanks to @pedromics for this beautiful in…
Super proud to see our work featured on the cover of @emboreports today! Many thanks to @pedromics for this beautiful interpretation and depiction of our story. Read the full paper here: https://t.co/XNy7MUtbY0 https://t.co/dhm0wIs46q
RT @CassieJClarke: Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix…
And the original publication is here: Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports share.google/JXMzGDRzpl0E...
Please find the link to our @emboreports publication here: Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports https://t.co/7s2PugchOj
RT @CassieJClarke: Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix…
RT @CassieJClarke: Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix…
RT @CassieJClarke: Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix…
RT @CassieJClarke: Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix…
RT @CassieJClarke: Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix…
RT @CassieJClarke: Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix…
Uridine phosphorylase-1 supports #metastasis by altering immune and extracellular matrix landscapes. -> www.embopress.org/doi/full/10....
RT @CassieJClarke: Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix…
RT @CassieJClarke: Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix…
Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....
Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune & extracellular matrix landscapes” was published today in @emboreports, describing how #neutrophil #metabolism influences niche priming & #metastasis (1/14) https://t.co/XNy7MUsE8s