In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anticoagulant reduced stroke, fatal/intracranial bleeding, and death, despite more GI bleeding. https://t.co/VueCCDedLL #JACC #DOAC https://t.co/GptlGKAtqw
Outcomes in Older Patients After Switching to a Newer Anticoagulant or Remaining on Warfarin: The COMBINE-AF Substudy.
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Aug 2025 – Sep 2025Where it's discussed
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X / Twitter52 posts
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News3 articles
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YouTube2 videos
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Facebook2 posts
AI synopsis
What people are saying
Evaluations reveal a consensus that switching to newer anticoagulants may improve outcomes for frail elderly patients, with phrases like 'confidence that such a switch may be beneficial' and references to 'reduction in stroke and bleeding' illustrate both agreement and perceived high impact. The tone and choice of words indicate a moderate level of curiosity and recognition of clinical importance, reflecting ongoing debates on best practices for anticoagulation in elder care.
Most discussions support the positive findings of the study, indicating a general consensus that switching anticoagulants can be beneficial for frail, elderly patients.
Participants show moderate interest, often referencing the study and its implications but without deep technical analysis, reflecting curiosity about aging, stroke prevention, and medication switching.
The social discussions include some mentions of specific outcomes, such as reduced stroke risk and bleeding complications, showing a decent level of engagement.
The discussions suggest that this research could influence clinical practices in anticoagulation management for older patients, highlighting its practical significance.
Top posts
Most liked on X and BlueskyFRAIL-AF questioned our standard approach to switch frail people with A Fib from VKA to DOAC. However this new COMBINE-AF Substudy gives confidence that such a switch may be beneficial in the majority of our frail pat. https://t.co/UrymJiQYzw https://t.co/oqNInwqnAo
Outcomes in Older Patients After Switching to a Newer Anticoagulant or... https://t.co/uawwxK4SxL @IcyfaSemi @chemachir @SABOURETCardio @markinho_gc @JuliaSellerm @ResidentesSEMI INTERESANTE
【観察研究】心房細動患者のうち3つの基準(VKA服用歴、75歳以上、フレイル)に合致する患者において、DOACは、ワルファリンと比較して、大出血リスクは同様であった一方、基準に合致しない患者ではリスク減少が見られた。正味の臨床転帰も同様の結果であった。 #ペ読 https://t.co/0PzzX1mMA0
https://t.co/4tIHJqefII
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
All mentions
Weekly Review of Cardiology Developments and Studies
This week in cardiology, we discuss listener feedback on SURPASS CVOT ablation limits and recent FDA alerts regarding the Watchman device. Join Dr. John Mandola as he covers oral anticoagulation options for elderly…
Outcomes in Older Patients on New Anticoagulants vs Warfarin
In this week's Friday Mace Club, Dr. Henrique Marcos discusses the OAT TRIAL on coronary interventions and the COMBINE-AF study outcomes in older patients switching to newer anticoagulants compared to those staying on…
RT @pinacol: 【観察研究】心房細動患者のうち3つの基準(VKA服用歴、75歳以上、フレイル)に合致する患者において、DOACは、ワルファリンと比較して、大出血リスクは同様であった一方、基準に合致しない患者ではリスク減少が見られた。正味の臨床転帰も同様の結果であった。…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
【観察研究】心房細動患者のうち3つの基準(VKA服用歴、75歳以上、フレイル)に合致する患者において、DOACは、ワルファリンと比較して、大出血リスクは同様であった一方、基準に合致しない患者ではリスク減少が見られた。正味の臨床転帰も同様の結果であった。 #ペ読 https://t.co/0PzzX1mMA0
https://t.co/4tIHJqefII
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…
In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anticoagulant reduced stroke, fatal/intracranial bleeding, and death, despite more GI bleeding. https://t.co/VueCCDedLL #JACC #DOAC https://t.co/GptlGKAtqw
RT @gunnar_heine: FRAIL-AF questioned our standard approach to switch frail people with A Fib from VKA to DOAC. However this new COMBINE-AF…
RT @gunnar_heine: FRAIL-AF questioned our standard approach to switch frail people with A Fib from VKA to DOAC. However this new COMBINE-AF…
RT @gunnar_heine: FRAIL-AF questioned our standard approach to switch frail people with A Fib from VKA to DOAC. However this new COMBINE-AF…
RT @gunnar_heine: FRAIL-AF questioned our standard approach to switch frail people with A Fib from VKA to DOAC. However this new COMBINE-AF…
RT @gunnar_heine: FRAIL-AF questioned our standard approach to switch frail people with A Fib from VKA to DOAC. However this new COMBINE-AF…
FRAIL-AF questioned our standard approach to switch frail people with A Fib from VKA to DOAC. However this new COMBINE-AF Substudy gives confidence that such a switch may be beneficial in the majority of our frail pat. https://t.co/UrymJiQYzw https://t.co/oqNInwqnAo
Outcomes in Older Patients After Switching to a Newer Anticoagulant or... https://t.co/uawwxK4SxL @IcyfaSemi @chemachir @SABOURETCardio @markinho_gc @JuliaSellerm @ResidentesSEMI INTERESANTE