J Am Coll Cardiol August 2025 PMID 40769671

Outcomes in Older Patients After Switching to a Newer Anticoagulant or Remaining on Warfarin: The COMBINE-AF Substudy.

Andre M Nicolau, Robert P Giugliano, Andre Zimerman, Jonathan Afilalo, Baris Gencer, Jan Steffel, Michael G Palazzolo, John W Eikelboom, Christopher B Granger, Manesh R Patel, Renato D Lopes, Bernard J Gersh, Belal Suleiman, Joris R de Groot, Mauricio I Scanavacca

Mentions

59
Peak: 53 in Aug 2025
across 4 sources since Aug 2025

Extended reach

182,701
potential audience

Total likes

156

Video views

594

Mentions per month

Aug 2025 – Sep 2025

Where it's discussed

  • X / Twitter52 posts
  • News3 articles
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

Evaluations reveal a consensus that switching to newer anticoagulants may improve outcomes for frail elderly patients, with phrases like 'confidence that such a switch may be beneficial' and references to 'reduction in stroke and bleeding' illustrate both agreement and perceived high impact. The tone and choice of words indicate a moderate level of curiosity and recognition of clinical importance, reflecting ongoing debates on best practices for anticoagulation in elder care.

AgreementModerate agreement

Most discussions support the positive findings of the study, indicating a general consensus that switching anticoagulants can be beneficial for frail, elderly patients.

InterestModerate interest

Participants show moderate interest, often referencing the study and its implications but without deep technical analysis, reflecting curiosity about aging, stroke prevention, and medication switching.

EngagementModerate engagement

The social discussions include some mentions of specific outcomes, such as reduced stroke risk and bleeding complications, showing a decent level of engagement.

ImpactModerate impact

The discussions suggest that this research could influence clinical practices in anticoagulation management for older patients, highlighting its practical significance.

Top posts

Most liked on X and Bluesky
JACC Journals
@JACCJournals · X

In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anticoagulant reduced stroke, fatal/intracranial bleeding, and death, despite more GI bleeding. https://t.co/VueCCDedLL #JACC #DOAC https://t.co/GptlGKAtqw

Aug 8, 2025 · 111 likes · 40 shares · 114,740 followers View post →
Gunnar Henrik Heine
@gunnar_heine · X

FRAIL-AF questioned our standard approach to switch frail people with A Fib from VKA to DOAC. However this new COMBINE-AF Substudy gives confidence that such a switch may be beneficial in the majority of our frail pat. https://t.co/UrymJiQYzw https://t.co/oqNInwqnAo

Aug 5, 2025 · 20 likes · 5 shares · 2,404 followers View post →
Francesc Formiga
@FormigaFrancesc · X

Outcomes in Older Patients After Switching to a Newer Anticoagulant or... https://t.co/uawwxK4SxL @IcyfaSemi @chemachir @SABOURETCardio @markinho_gc @JuliaSellerm @ResidentesSEMI INTERESANTE

Aug 4, 2025 · 5 likes · 1,947 followers View post →
pinacol
@pinacol · X

【観察研究】心房細動患者のうち3つの基準(VKA服用歴、75歳以上、フレイル)に合致する患者において、DOACは、ワルファリンと比較して、大出血リスクは同様であった一方、基準に合致しない患者ではリスク減少が見られた。正味の臨床転帰も同様の結果であった。 #ペ読 https://t.co/0PzzX1mMA0

Aug 10, 2025 · 2 likes · 1 share · 1,616 followers View post →
Raviele Antonio
@drraviele · X

https://t.co/4tIHJqefII

Aug 10, 2025 · 23,426 followers View post →
Prof Derek Connolly
@DrDerekConnolly · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 10, 2025 · 40 shares · 3,933 followers View post →

All mentions

Weekly Review of Cardiology Developments and Studies

This week in cardiology, we discuss listener feedback on SURPASS CVOT ablation limits and recent FDA alerts regarding the Watchman device. Join Dr. John Mandola as he covers oral anticoagulation options for elderly…

Medscape · Aug 8, 2025 588 views
Satoru Mitsuboshi
@3stars67664378 · X

RT @pinacol: 【観察研究】心房細動患者のうち3つの基準(VKA服用歴、75歳以上、フレイル)に合致する患者において、DOACは、ワルファリンと比較して、大出血リスクは同様であった一方、基準に合致しない患者ではリスク減少が見られた。正味の臨床転帰も同様の結果であった。…

Aug 13, 2025 · 1 share · 1,783 followers View post →
Smooth257
@HdR259 · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 11, 2025 · 40 shares · 192 followers View post →
Juan Carlos Obaya
@jcobaya69 · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 11, 2025 · 40 shares · 858 followers View post →
ゆめみるネコ
@Bsdhnfjn · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 11, 2025 · 40 shares · 291 followers View post →
pinacol
@pinacol · X

【観察研究】心房細動患者のうち3つの基準(VKA服用歴、75歳以上、フレイル)に合致する患者において、DOACは、ワルファリンと比較して、大出血リスクは同様であった一方、基準に合致しない患者ではリスク減少が見られた。正味の臨床転帰も同様の結果であった。 #ペ読 https://t.co/0PzzX1mMA0

Aug 10, 2025 · 2 likes · 1 share · 1,616 followers View post →
Raviele Antonio
@drraviele · X

https://t.co/4tIHJqefII

Aug 10, 2025 · 23,426 followers View post →
Prof Derek Connolly
@DrDerekConnolly · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 10, 2025 · 40 shares · 3,933 followers View post →
Department of Civilization Diseases
@CivilizationDis · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 10, 2025 · 40 shares · 19 followers View post →
PTChC
@PTChCpl · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 10, 2025 · 40 shares · 94 followers View post →
Jibril Mohamed
@jtmohamed · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 143 followers View post →
Tomohiro Fujisaki
@TomohiroFujisa2 · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 652 followers View post →
Bassam Atallah, PharmD
@batallah08 · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 481 followers View post →
Nidhi Rohatgi, MD, MS, SFHM
@nrohatgi2 · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 366 followers View post →
Gabriel Paredes, MD, FACC, FSSC
@gnparedes · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 363 followers View post →
Fabricio Vassallo, MD, PhD
@fvassallomd · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 1,183 followers View post →
Lo-Chieh Ling, MD
@lochieh19798 · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 65 followers View post →
k.h3q
@090_0655 · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 365 followers View post →
Nurten Sayar, MD
@nsayar3 · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 854 followers View post →
Cardio-Primària
@catcardiocamfic · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 1,871 followers View post →
Omar Mobarak
@Omobarak123 · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 121 followers View post →
Dr Jainer Mendez
@JainerDr · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 317 followers View post →
Kiruba Nagaratnam
@kiru_nagaratnam · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 365 followers View post →
David de las Cuevas
@DaviddlCuevas · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 1,400 followers View post →
Tabeer Taseer Ahmed
@TabeerTaseerMD · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 1,846 followers View post →
だらくびと
@blaugraner8 · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 302 followers View post →
Yohei Turi Ohno
@OhnoTuri · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 626 followers View post →
Hiroyuki Takahashi / 高橋 宏幸
@37_hr · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 266 followers View post →
Tulio Peñuela
@Tenuela · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 565 followers View post →
Percy Durand
@PercyDurand30 · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 81 followers View post →
Rodrigo Aquino
@DrRaav · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 9, 2025 · 40 shares · 72 followers View post →
Kingston
@kianboy · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 8, 2025 · 40 shares · 460 followers View post →
BiigNaJaa
@BiigNaJaa · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 8, 2025 · 40 shares · 530 followers View post →
maldinilin
@maldinilin · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 8, 2025 · 40 shares · 97 followers View post →
Fabio E. Parada
@QuiqueParada · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 8, 2025 · 40 shares · 616 followers View post →
PharmaDecisions LLC
@PharmaDecisions · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 8, 2025 · 40 shares · 453 followers View post →
Rami Kafa
@RamiKafa · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 8, 2025 · 40 shares · 1,182 followers View post →
Andrés Ochoa
@andres8adiaz · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 8, 2025 · 40 shares · 512 followers View post →
キャスバルレムダイクン@learning medicine student.
@in6b85t4 · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 8, 2025 · 40 shares · 46 followers View post →
Matthew J. Chung
@MatthewChungMD · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 8, 2025 · 40 shares · 835 followers View post →
lal0155
@lal0155 · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 8, 2025 · 40 shares · 12 followers View post →
trauma&vascular, sometimes cardiac
@VascularTrauma · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 8, 2025 · 40 shares · 68 followers View post →
Rodrigo Nunes Cal
@CalZole · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 8, 2025 · 40 shares · 3,796 followers View post →
Lisa Alderson
@LisaAlderson2 · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 8, 2025 · 40 shares · 361 followers View post →
Usha Tedrow
@utedrow · X

RT @JACCJournals: In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anti…

Aug 8, 2025 · 40 shares · 2,749 followers View post →
JACC Journals
@JACCJournals · X

In frail, elderly #AFib patients previously on a vitamin K antagonist, switching to standard-dose direct-acting oral anticoagulant reduced stroke, fatal/intracranial bleeding, and death, despite more GI bleeding. https://t.co/VueCCDedLL #JACC #DOAC https://t.co/GptlGKAtqw

Aug 8, 2025 · 111 likes · 40 shares · 114,740 followers View post →
lal0155
@lal0155 · X

RT @gunnar_heine: FRAIL-AF questioned our standard approach to switch frail people with A Fib from VKA to DOAC. However this new COMBINE-AF…

Aug 5, 2025 · 5 shares · 12 followers View post →
soda_troubles,https://med-mastodon.com/@haysam
@set_fortess · X

RT @gunnar_heine: FRAIL-AF questioned our standard approach to switch frail people with A Fib from VKA to DOAC. However this new COMBINE-AF…

Aug 5, 2025 · 5 shares · 2,548 followers View post →
ong beng hooi
@ongbenghooi1 · X

RT @gunnar_heine: FRAIL-AF questioned our standard approach to switch frail people with A Fib from VKA to DOAC. However this new COMBINE-AF…

Aug 5, 2025 · 5 shares · 541 followers View post →
Cristian Llano
@CLlanoC · X

RT @gunnar_heine: FRAIL-AF questioned our standard approach to switch frail people with A Fib from VKA to DOAC. However this new COMBINE-AF…

Aug 5, 2025 · 5 shares · 118 followers View post →
Garnet
@GarnetGG · X

RT @gunnar_heine: FRAIL-AF questioned our standard approach to switch frail people with A Fib from VKA to DOAC. However this new COMBINE-AF…

Aug 5, 2025 · 5 shares · 140 followers View post →
Gunnar Henrik Heine
@gunnar_heine · X

FRAIL-AF questioned our standard approach to switch frail people with A Fib from VKA to DOAC. However this new COMBINE-AF Substudy gives confidence that such a switch may be beneficial in the majority of our frail pat. https://t.co/UrymJiQYzw https://t.co/oqNInwqnAo

Aug 5, 2025 · 20 likes · 5 shares · 2,404 followers View post →
Francesc Formiga
@FormigaFrancesc · X

Outcomes in Older Patients After Switching to a Newer Anticoagulant or... https://t.co/uawwxK4SxL @IcyfaSemi @chemachir @SABOURETCardio @markinho_gc @JuliaSellerm @ResidentesSEMI INTERESANTE

Aug 4, 2025 · 5 likes · 1,947 followers View post →