August 2025 PMID 40802739

An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo.

Yemsratch T Akalu, Roosheel S Patel, Justin Taft, Rodrigo Canas-Arranz, Rachel Geltman, Ashley Richardson, Sofija Buta, Marta Martin-Fernandez, Christos Sazeides, Rebecca L Pearl, Gayatri Mainkar, Andrew P Kurland, Haylen Rosberger, Diana D Kang, Ann Anu Kurian

Mentions

211
Peak: 137 in Aug 2025
across 6 sources since Aug 2025

Extended reach

9,374,239
potential audience

Total likes

694

Video views

14,850

Mentions per month

Aug 2025 – Sep 2025

Where it's discussed

  • X / Twitter131 posts
  • News51 articles
  • Bluesky15 posts
  • Blogs8 articles
  • YouTube4 videos
  • Facebook2 posts

AI synopsis

What people are saying

The discussions demonstrate widespread enthusiasm, with several posts emphasizing the novelty and promise of the research, such as describing it as a 'universal virus killer' or 'game-changing.' The language used is optimistic and exploratory, reflecting strong interest and belief in the potential impact of this innovative mRNA approach inspired by a genetic deficiency, which could revolutionize how viral diseases are prevented and treated.

AgreementStrong agreement

Most discussions express strong support and excitement for the research findings, viewing the broad-spectrum antiviral as a promising breakthrough.

InterestHigh interest

Participants show high curiosity and enthusiasm, frequently referencing the innovative approach and potential impact on viral infections.

EngagementModerate engagement

Many comments reference specific scientific details and implications, indicating thoughtful engagement, though some lighter reactions show less depth.

ImpactHigh impact

The discussions highlight the potential for significant advances in antiviral therapies, suggesting the research could be transformative for future treatments.

Abstract in brief

  • This research explores how a specific group of 10 interferon-stimulated genes (ISGs), inspired by the natural antiviral state observed in humans with ISG15 deficiency, can provide broad protection against various viral infections, including Zika, VSV, and SARS-CoV-2.
  • The study demonstrates that delivering this 10ISG collection via a lipid nanoparticle-encapsulated mRNA formulation enhances antiviral resistance in cells and animal models, and offers protection when given prophylactically, especially when delivered together.
  • Overall, these findings suggest that this optimized 10ISG-based mRNA approach has strong potential as a broad-spectrum antiviral prophylactic treatment.]

Top posts

Most liked on X and Bluesky
Science Magazine
@ScienceMagazine · X

Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA based antiviral that displays activity against Zika virus, SARS-CoV-2, and influenza virus. https://t.co/Xi0UiQtQpy https://t.co/atDSfCmuhD

Aug 18, 2025 · 152 likes · 64 shares · 4,513,738 followers View post →
Science Magazine
@ScienceMagazine · X

Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA based antiviral that displays activity against Zika virus, SARS-CoV-2, and influenza virus. https://t.co/Xi0UiQtQpy https://t.co/Lk8OcHzW1B

Aug 21, 2025 · 94 likes · 33 shares · 4,513,738 followers View post →
Marc Veldhoen
@marcveld.bsky.social · Bluesky

An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo Fortunately, mRNA-based vaccine developmentd continue. www.science.org/doi/... 1/5

Aug 15, 2025 · 24 likes · 13 shares View post →
Science Translational Medicine
@ScienceTM · X

Inspired by patients with #ISG15 deficiency, researchers have engineered a broad-spectrum, #mRNA based antiviral that displays activity against Zika virus, SARS-CoV-2, and influenza virus. @BogunovicLab https://t.co/9pQiK4FOFm https://t.co/RpecCLgMW7

Aug 15, 2025 · 22 likes · 7 shares · 33,654 followers View post →
ultraviolet
@raurublock · X

https://t.co/p5qYLd6zXC 人体には対ウィルス免疫が強くなりすぎないよう抑える遺伝子というのがあって、それはセーフガードとして必要なのだが、一部の凶悪なウィルス感染の場合は抑えない方が生存率が上がる。mRNA注射によってこのセーフガードを一時的に外せないか?という研究の話

Aug 21, 2025 · 18 likes · 5 shares · 30,168 followers View post →
Cerebro Digital
@cerebrodigital.net · Bluesky

Sep 2, 2025 · 16 likes · 5 shares View post →

All mentions

Yeshes.Online
@yeshes.online · Bluesky

Found it. pubmed.ncbi.nlm.nih.gov/40802739/

Sep 27, 2025 View post →
Yeshes.Online
@handle.invalid · Bluesky

Found it. pubmed.ncbi.nlm.nih.gov/40802739/

Sep 27, 2025 View post →
Yeshes.Online
@yeshes.online · Bluesky

Found it. Digging in now. #ImmunityGene pubmed.ncbi.nlm.nih.gov/40802739/

Sep 27, 2025 View post →
Yeshes.Online
@handle.invalid · Bluesky

Found it. Digging in now. #ImmunityGene pubmed.ncbi.nlm.nih.gov/40802739/

Sep 27, 2025 View post →
Cheshire Cat ᓚᘏᗢ,
@autismsupsoc.bsky.social · Bluesky

I have a reading disorder so I only get windows of info at a time … I assume this is more details about the “holy shit mRNA!!!” Chatter I was hearing from a few days ago? /rhetorical

Sep 27, 2025 · 8 likes · 3 shares View post →
Eddie e
@chimeraeeee · X

RT @BogunovicLab: Latest from us. Universal antiviral made! How? Transient gene therapy. Which genes? Only 10 suffice, out of thousands of…

Sep 26, 2025 · 57 shares · 6 followers View post →
鈴谷 まひる
@mid0noon · X

RT @tak53381102: 『広域スペクトル抗ウイルス薬』 これは目を疑い読み返してしまった 細菌に対する抗菌薬ならぬ、複数種のウイルスに対する「広域」抗ウイルス薬の開発 https://t.co/LMG1c74zd0…

Sep 23, 2025 · 33 shares · 192 followers View post →
clinimmsoc.bsky.social
@clinimmsoc.bsky.social · Bluesky

New from Akalu et al.: “An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo” (Sci Transl Med). Article link: www.science.org/doi/10.1126/...

Sep 19, 2025 · 1 like View post →
CIS
@ClinImmSoc · X

New from Akalu et al.: “An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo” (Sci Transl Med). Article link: https://t.co/MajpZ1zlpC

Sep 19, 2025 · 1,407 followers View post →
レイテストショット 7/9 MMPNP
@tarashinon · X

RT @CyHusain: An mRNA-based broad-spectrum antiviral inspired by #ISG15 deficiency protects against viral infections in vitro and in vivo.…

Sep 9, 2025 · 1 share · 534 followers View post →
Dr. T
@GertrudRey · X

A recent study out of Columbia University suggests that it might be possible to develop effective broad-spectrum antivirals against known, emerging, and unknown viruses. 3/ https://t.co/D1gJOaIXdZ

Sep 4, 2025 · 2,824 followers View post →
Cy Husain
@CyHusain · X

An mRNA-based broad-spectrum antiviral inspired by #ISG15 deficiency protects against viral infections in vitro and in vivo. #mRNA drugs could protect against a wide range of #viruses by activating key parts of our innate defenses against infection. https://t.co/44Y5Fjmrqj

Sep 3, 2025 · 2 likes · 1 share · 745 followers View post →
Cerebro Digital
@cerebrodigital.net · Bluesky

Sep 2, 2025 · 16 likes · 5 shares View post →
Kohei Shiroshita
@ShiroshitaKohei · X

RT @BogunovicLab: Latest from us. Universal antiviral made! How? Transient gene therapy. Which genes? Only 10 suffice, out of thousands of…

Aug 30, 2025 · 56 shares · 53 followers View post →
@guardian_xcu · X

➡️ Die Publikation von Wissenschaftler/innen der Columbia University, N. Y.,

Aug 29, 2025 · 1 like · 2,298 followers View post →
UltimApe
@ultimape · X

So. We have this miracle cure that seems to stop covid in it's tracks? Sounds promising right? https://t.co/YmquE4Ya6m

Aug 29, 2025 · 2 likes · 6,441 followers View post →
Cerises
@Moooonflash · X

https://t.co/TidQ9LCuMr

Aug 29, 2025 · 3 likes · 748 followers View post →
Fanatic Hermitude (orthostatic.bsky.social)
@hobbyhorrible · X

RT @IsabelRamirezRD: An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in…

Aug 28, 2025 · 1 share · 942 followers View post →
Isabel Burnett | Renegade Research
@IsabelRamirezRD · X

https://t.co/idmS5j6DJ2 A simpler explanation https://t.co/X025KsyWmX

Aug 28, 2025 · 1 like · 4,049 followers View post →
Isabel Burnett | Renegade Research
@IsabelRamirezRD · X

An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo Article in comments

Aug 28, 2025 · 8 likes · 1 share · 4,049 followers View post →
(((JReuben1)))
@jreuben1 · X

An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo | Science Translational Medicine https://t.co/bAreyuc6Fh

Aug 24, 2025 · 1 like · 1,952 followers View post →
Sophie Sophie's
@SophieS44606 · X

https://t.co/fyLzTxxBOb

Aug 24, 2025 View post →
Sophie Sophie's
@SophieS44606 · X

https://t.co/276gybUiLC

Aug 24, 2025 View post →
古川 ゆうこ
@vomnYqa0jC71475 · X

RT @BogunovicLab: Latest from us. Universal antiviral made! How? Transient gene therapy. Which genes? Only 10 suffice, out of thousands of…

Aug 22, 2025 · 56 shares · 3 followers View post →
Eder Andrés
@ederandres152 · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 889 followers View post →
Sofi
@CarmenSofi71305 · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 2,743 followers View post →
Dr. Robert Glatter
@DrRobertGlatter · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 5,877 followers View post →
LACont
@LCptbo · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 718 followers View post →
Being chakravarthy
@beingchakravrty · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 329 followers View post →
Dr Jyoti Bala
@DrJyotiBala369 · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 64 shares · 242 followers View post →
Chris Carter
@fintechcyb · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 23 followers View post →
-囈尢蝕
@ichigeitaisyoku · X

RT @raurublock: https://t.co/p5qYLd6zXC 人体には対ウィルス免疫が強くなりすぎないよう抑える遺伝子というのがあって、それはセーフガードとして必要なのだが、一部の凶悪なウィルス感染の場合は抑えない方が生存率が上がる。mRNA注射によってこのセ…

Aug 21, 2025 · 5 shares · 693 followers View post →
ken i + 1
@Scientoufikkk · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 184 followers View post →
ken i + 1
@Scientoufikkk · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 64 shares · 184 followers View post →
Abdulsatar Bochnak
@malksa481 · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 117 followers View post →
Deimar Perea Moreno
@DeimarPerea · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 479 followers View post →
nerolopeajlri
@nerolopeajlri · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 128 followers View post →
nerolopeajlri
@nerolopeajlri · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 64 shares · 128 followers View post →
Research
@Research_Jrnl · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 3,516 followers View post →
cap
@captxxxxxxxxx · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 128 followers View post →
Villagallego
@Villagallego1 · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 400 followers View post →
cap
@captxxxxxxxxx · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 64 shares · 128 followers View post →
nassim_276
@nassim_276 · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 64 shares · 134 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 574 followers View post →
nassim_276
@nassim_276 · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 134 followers View post →
感想おじ
@appwink18 · X

RT @raurublock: https://t.co/p5qYLd6zXC 人体には対ウィルス免疫が強くなりすぎないよう抑える遺伝子というのがあって、それはセーフガードとして必要なのだが、一部の凶悪なウィルス感染の場合は抑えない方が生存率が上がる。mRNA注射によってこのセ…

Aug 21, 2025 · 5 shares · 127 followers View post →
GreenDoc Gwen
@ecogwendoc · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 21 followers View post →
天波 八次浪
@yajirow · X

RT @raurublock: https://t.co/p5qYLd6zXC 人体には対ウィルス免疫が強くなりすぎないよう抑える遺伝子というのがあって、それはセーフガードとして必要なのだが、一部の凶悪なウィルス感染の場合は抑えない方が生存率が上がる。mRNA注射によってこのセ…

Aug 21, 2025 · 5 shares · 906 followers View post →
Daniel S.
@asecretcrow · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 538 followers View post →
mohamed zubair
@zubeyr · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 640 followers View post →
HARMONIAMN
@harmoniaweb_com · X

RT @raurublock: https://t.co/p5qYLd6zXC 人体には対ウィルス免疫が強くなりすぎないよう抑える遺伝子というのがあって、それはセーフガードとして必要なのだが、一部の凶悪なウィルス感染の場合は抑えない方が生存率が上がる。mRNA注射によってこのセ…

Aug 21, 2025 · 5 shares · 121 followers View post →
_bresom_rfz
@_bresom_rfz · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 64 shares · 211 followers View post →
BT(愚脳)
@mkt_nanama · X

RT @raurublock: https://t.co/p5qYLd6zXC 人体には対ウィルス免疫が強くなりすぎないよう抑える遺伝子というのがあって、それはセーフガードとして必要なのだが、一部の凶悪なウィルス感染の場合は抑えない方が生存率が上がる。mRNA注射によってこのセ…

Aug 21, 2025 · 5 shares · 278 followers View post →
ultraviolet
@raurublock · X

https://t.co/p5qYLd6zXC 人体には対ウィルス免疫が強くなりすぎないよう抑える遺伝子というのがあって、それはセーフガードとして必要なのだが、一部の凶悪なウィルス感染の場合は抑えない方が生存率が上がる。mRNA注射によってこのセーフガードを一時的に外せないか?という研究の話

Aug 21, 2025 · 18 likes · 5 shares · 30,168 followers View post →
_bresom_rfz
@_bresom_rfz · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 211 followers View post →
Tanvir
@jansonsco1 · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 881 followers View post →
Massimiliano Stagi
@MassimilianoS16 · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 109 followers View post →
Katydid46 Standing with Ukraine
@Kathryn10713069 · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 2,935 followers View post →
Cristiano68@bsky.social
@cristiano68 · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 683 followers View post →
lylow
@lylow04awpbf · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 64 shares · 206 followers View post →
HatCat,
@AsclepiasSyrica · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 2,068 followers View post →
㍊%
@momoiro_panther · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 663 followers View post →
Frontiers of Science
@FoSColumbia · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 561 followers View post →
Susan T
@Suz_Todd · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 21, 2025 · 33 shares · 2,064 followers View post →
Science Magazine
@ScienceMagazine · X

Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA based antiviral that displays activity against Zika virus, SARS-CoV-2, and influenza virus. https://t.co/Xi0UiQtQpy https://t.co/Lk8OcHzW1B

Aug 21, 2025 · 94 likes · 33 shares · 4,513,738 followers View post →
Ana Calber
@Ana38425232 · X

RT @manuelmuro5: Muy interesante. Inspirados por pacientes con una rara deficiencia inmunológica, los investigadores han diseñado un antivi…

Aug 20, 2025 · 2 shares · 96 followers View post →
Vicente Malonda
@vicente_malonda · X

Aug 20, 2025 · 497 followers View post →
Ash Paul
@pash22 · X

An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo https://t.co/Ucfvzzy5wm via @BogunovicLab et al

Aug 20, 2025 · 2 likes · 32,252 followers View post →
Ash Paul
@pash22 · X

An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo https://t.co/Ucfvzzy5wm via @BogunovicLab et al

Aug 20, 2025 · 32,252 followers View post →
サイエンスあれこれ
@sarekore · X

最大でも4日間持続しただけです。また、この投与法ではすぐにヒトに投与できるほど高いレベルには達しないと考えられることから、実用化までには時間がかかるが、ウイルスの正体がわからなくても機能するこの万能抗ウイルス薬への期待は高い。https://t.co/dtBpg10OnQ

Aug 19, 2025 · 1 like · 923 followers View post →
M.Patrocinio Chueca
@Pchuecar · X

RT @manuelmuro5: Muy interesante. Inspirados por pacientes con una rara deficiencia inmunológica, los investigadores han diseñado un antivi…

Aug 19, 2025 · 2 shares · 998 followers View post →
Manuel Muro
@manuelmuro5 · X

Muy interesante. Inspirados por pacientes con una rara deficiencia inmunológica, los investigadores han diseñado un antiviral de amplio espectro basado en ARNm que muestra actividad contra el virus del Zika, el SARS-CoV-2 y el virus de la influenza. https://t.co/67x6ATYPab

Aug 19, 2025 · 5 likes · 2 shares · 11,199 followers View post →
ลัคกี้ โหมดฤดูงาน
@sr_wiz · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 18, 2025 · 64 shares · 1,612 followers View post →
c6isramf
@C6ISRAMF · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 18, 2025 · 64 shares · 81 followers View post →
PharmaDecisions LLC
@PharmaDecisions · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 18, 2025 · 64 shares · 453 followers View post →
PandaPalooza
@pandapalooza_59 · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 18, 2025 · 64 shares · 142 followers View post →
Henry Muriel
@Bokep_Jav_OWKuV · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 18, 2025 · 64 shares · 2 followers View post →
Achille Zeus
@achille_ze56735 · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 18, 2025 · 64 shares · 28 followers View post →
Henry Sossa 
@hsossa · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 18, 2025 · 64 shares · 500 followers View post →
Villagallego
@Villagallego1 · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 18, 2025 · 64 shares · 400 followers View post →
Azouria
@Azouria1 · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 18, 2025 · 64 shares · 687 followers View post →
Luis Fdez Pereira
@lfdezpereira · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 18, 2025 · 64 shares · 45 followers View post →
CrowdedHead
@CrowdedHead · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 18, 2025 · 64 shares · 3,529 followers View post →
Quod scripsi, scripsi
@2lcrs6 · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 18, 2025 · 64 shares · 185 followers View post →
Bill Wang
@iu22ie33 · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 18, 2025 · 64 shares · 10,707 followers View post →
Nelson1777
@Nelson1777768 · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 18, 2025 · 64 shares · 182 followers View post →
Nina M. Hill, Ph.D.
@NinaMHillPhD1 · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 18, 2025 · 64 shares · 185 followers View post →
Khushboo
@Khushbo57096490 · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 18, 2025 · 64 shares · 58 followers View post →
Jose A. Olmeda
@Jaolmedagm · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 18, 2025 · 64 shares · 1,273 followers View post →
Jerry4BofEd
@Jerry4BOfEd · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 18, 2025 · 64 shares · 489 followers View post →
Global Conundrums
@tefl_on · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 18, 2025 · 64 shares · 770 followers View post →
grnbee
@grnbee · X

RT @ScienceMagazine: Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA…

Aug 18, 2025 · 64 shares · 483 followers View post →
Science Magazine
@ScienceMagazine · X

Inspired by patients with a rare immune deficiency, researchers in @ScienceTM have engineered a broad-spectrum, #mRNA based antiviral that displays activity against Zika virus, SARS-CoV-2, and influenza virus. https://t.co/Xi0UiQtQpy https://t.co/atDSfCmuhD

Aug 18, 2025 · 152 likes · 64 shares · 4,513,738 followers View post →
Nikola
@nikolacupic · X

The therapy isn't ready for humans yet because delivery into the lungs needs optimization. But the breakthrough was just published in Science Translational Medicine on August 13, 2025: https://t.co/uKdwzbgs6x

Aug 18, 2025 · 6 likes · 4,458 followers View post →
fdzaraf
@fdzaraf · X

ISG15欠損症では、IFN-I応答が持続的・低レベルに活性化しており、ISG(IFN誘導遺伝子)の発現と軽度の自己炎症が広範な抗ウイルス作用を与えます。 Published 2025/8/13 ISG15欠損に着想を得たmRNAベースの広域抗ウイルス療法が、in vitroおよびin vivoでウイルス感染を防御 https://t.co/bGTkZuBohs

Aug 17, 2025 · 2 likes · 13,045 followers View post →
Lucky Sarkar, PhD
@LuckySarkar94 · X

RT @BogunovicLab: Latest from us. Universal antiviral made! How? Transient gene therapy. Which genes? Only 10 suffice, out of thousands of…

Aug 16, 2025 · 56 shares · 99 followers View post →
Ajjj
@Ajjj318267622 · X

抗ウイルス薬 https://t.co/VFfgT3l3tZ

Aug 16, 2025 · 612 followers View post →
nobnak
@nobuyuki_nakata · X

RT @tak53381102: 『広域スペクトル抗ウイルス薬』 これは目を疑い読み返してしまった 細菌に対する抗菌薬ならぬ、複数種のウイルスに対する「広域」抗ウイルス薬の開発 https://t.co/LMG1c74zd0…

Aug 16, 2025 · 33 shares · 96 followers View post →
みつき
@901228Mitsuki · X

IFN-I刺激遺伝子15(ISG15)を欠く個体の細胞は,低levelのIFN-I応答を維持し,自然に治癒する軽度の自己炎症によりウイルス感染を抑制 ISG15を欠く個体の細胞で観察されるものを模倣する10個のISG setを特定し,これらの10個のISGのmRNA薬が広域スペクトルの抗ウイルス剤として機能https://t.co/JzdhP3U6i9

Aug 15, 2025 · 230 followers View post →
Bill Wang
@iu22ie33 · X

RT @ScienceTM: Inspired by patients with #ISG15 deficiency, researchers have engineered a broad-spectrum, #mRNA based antiviral that displa…

Aug 15, 2025 · 7 shares · 10,707 followers View post →
Dorothea Sachsen-Anhalt
@DorotheaHoffm15 · X

RT @WolfmannotJack: If my understanding of this paper is correct, there is a chance of developing a broad-spectrum (or, near as dammit, uni…

Aug 15, 2025 · 1 share · 1,037 followers View post →
Grayson Bell
@ai_healthgeeks · X

RT @ScienceTM: Inspired by patients with #ISG15 deficiency, researchers have engineered a broad-spectrum, #mRNA based antiviral that displa…

Aug 15, 2025 · 7 shares · 24 followers View post →
Dr. rer. nat. W. Meier-Augenstein, FRSC
@WolfmannotJack · X

@jsm2334 Wonder if Bhattacharya has seen this paper, which, oh the irony, sees mRNA vaccine technology as a chance of developing a broad-spectrum antiviral. https://t.co/VhPfPrDGrK

Aug 15, 2025 · 3 likes · 3,809 followers View post →
Dr. rer. nat. W. Meier-Augenstein, FRSC
@WolfmannotJack · X

➡️ Link: https://t.co/VhPfPrD8Cc @IntegralAnswers @jakescottMD @AlastairMcA30 @DrNeilStone @thereal_truther @BrandyZadrozny @jsm2334

Aug 15, 2025 · 1 like · 3,809 followers View post →
Dr. rer. nat. W. Meier-Augenstein, FRSC
@WolfmannotJack · X

If my understanding of this paper is correct, there is a chance of developing a broad-spectrum (or, near as dammit, universal) antiviral vaccine. However, it would be based on mRNA vaccine technology which would be rather ironic, wouldn’t it @HHSGov ? https://t.co/VhPfPrD8Cc

Aug 15, 2025 · 5 likes · 1 share · 3,809 followers View post →
Science Translational Medicine
@ScienceTM · X

Inspired by patients with #ISG15 deficiency, researchers have engineered a broad-spectrum, #mRNA based antiviral that displays activity against Zika virus, SARS-CoV-2, and influenza virus. @BogunovicLab https://t.co/9pQiK4FOFm https://t.co/RpecCLgMW7

Aug 15, 2025 · 22 likes · 7 shares · 33,654 followers View post →
ゔんゔくのちゃがま
@XZibPNn8MzJRxoG · X

RT @tak53381102: 『広域スペクトル抗ウイルス薬』 これは目を疑い読み返してしまった 細菌に対する抗菌薬ならぬ、複数種のウイルスに対する「広域」抗ウイルス薬の開発 https://t.co/LMG1c74zd0…

Aug 15, 2025 · 33 shares · 84 followers View post →
Marc Veldhoen
@marcveld.bsky.social · Bluesky

An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo Fortunately, mRNA-based vaccine developmentd continue. www.science.org/doi/... 1/5

Aug 15, 2025 · 24 likes · 13 shares View post →
Marc Veldhoen
@marc-veld.mastodon.online.ap.brid.gy · Bluesky

An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo Fortunately, mRNA-based vaccine developmentd continue. https://www.science.org/doi/10.1126/scitranslmed.adx5758 1/5

Aug 15, 2025 · 1 share View post →
Dee
@winthrop317 · X

RT @vipintukur: Here is the link to the study

Aug 15, 2025 · 10 shares · 995 followers View post →
Reveal
@Reveal_ac · X

RT @BogunovicLab: Latest from us. Universal antiviral made! How? Transient gene therapy. Which genes? Only 10 suffice, out of thousands of…

Aug 15, 2025 · 56 shares · 5 followers View post →
CD BioSciences
@CDBioSciences · X

Harnessing a unique set of 10 IFN-stimulated genes inspired by ISG15 deficiency, researchers developed an mRNA platform that is effective against Zika, influenza, and SARS-CoV-2 in vitro and in animal models. #mRNA #Antivirals #PandemicPreparedness https://t.co/oMBBfJhvxv

Aug 15, 2025 · 32 followers View post →
Thelonevirologist
@thelonevirologist.bsky.social · Bluesky

An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo www.science.org/doi/10.1126/...

Aug 15, 2025 · 1 like · 2 shares View post →
Leo Liu
@leonardliu88 · X

RT @BogunovicLab: Latest from us. Universal antiviral made! How? Transient gene therapy. Which genes? Only 10 suffice, out of thousands of…

Aug 15, 2025 · 56 shares · 233 followers View post →
Reiner 
@erlesen · X

RT @erlesen: An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo htt…

Aug 15, 2025 · 1 share · 7,848 followers View post →
AdMOSC-Research
@AdMOSC_Research · X

RT @Biomimetics_abe: An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in…

Aug 15, 2025 · 1 share · 98 followers View post →
Arda
@Ardabalci01 · X

RT @BogunovicLab: Latest from us. Universal antiviral made! How? Transient gene therapy. Which genes? Only 10 suffice, out of thousands of…

Aug 15, 2025 · 57 shares · 346 followers View post →
REBLOG to give her your liver
@letmygaysmarry · X

RT @vipintukur: Here is the link to the study

Aug 15, 2025 · 10 shares · 722 followers View post →
TK
@KOBA1556 · X

https://t.co/Bp9P0TtbfS

Aug 15, 2025 · 1,928 followers View post →
Endangered Hawaii @endangered808.bsky.social
@EndangeredHI · X

RT @vipintukur: Here is the link to the study

Aug 15, 2025 · 10 shares · 1,751 followers View post →
AMG
@amg19842000 · X

RT @vipintukur: Here is the link to the study

Aug 15, 2025 · 10 shares · 244 followers View post →
mitsu
@mitsuVo · X

RT @tak53381102: 『広域スペクトル抗ウイルス薬』 これは目を疑い読み返してしまった 細菌に対する抗菌薬ならぬ、複数種のウイルスに対する「広域」抗ウイルス薬の開発 https://t.co/LMG1c74zd0…

Aug 15, 2025 · 33 shares · 371 followers View post →
Dylan Ryan
@RyanLab_TCD · X

RT @vipintukur: Here is the link to the study

Aug 15, 2025 · 10 shares · 2,373 followers View post →
Jerri Proctor
@jjp117 · X

RT @vipintukur: Here is the link to the study

Aug 14, 2025 · 10 shares · 922 followers View post →
Locomotion
@Megaminano · X

이건 좀 신기하달까... 재밌는 연구네... 면역기능(인터페론 호출)을 상시 활성화시켜서 자가면역질환을 유발하는 대신 대부분의 바이러스에 저항할 수 있는 능력을 가지는 증상을 인위적으로 발생시킨다니 https://t.co/4xg592aAJE

Aug 14, 2025 · 316 followers View post →
Kathleen Lanzer
@lanzerkat · X

RT @BogunovicLab: Latest from us. Universal antiviral made! How? Transient gene therapy. Which genes? Only 10 suffice, out of thousands of…

Aug 14, 2025 · 57 shares · 68 followers View post →
Norio Nakatsuji
@norionakatsuji.bsky.social · Bluesky

元論文→ Reference: Akalu YT, Patel RS, Taft J, et al. An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo. Sci Transl Med. 17(811):eadx5758. doi: 10.1126/scitranslmed.adx5758 www.science.org/doi/10.1126/...

Aug 14, 2025 · 1 like View post →
Norio Nakatsuji
@norionakatsuji · X

元論文→ Reference: Akalu YT, Patel RS, Taft J, et al. An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo. Sci Transl Med. 17(811):eadx5758. doi: 10.1126/scitranslmed.adx5758 https://t.co/nzfvk69Wep

Aug 14, 2025 · 15,706 followers View post →
キ之國屋紊左ヱ門
@kinobun · X

RT @tak53381102: 『広域スペクトル抗ウイルス薬』 これは目を疑い読み返してしまった 細菌に対する抗菌薬ならぬ、複数種のウイルスに対する「広域」抗ウイルス薬の開発 https://t.co/LMG1c74zd0…

Aug 14, 2025 · 32 shares · 520 followers View post →
佐倉はるか
@beauprintemps27 · X

RT @tak53381102: 『広域スペクトル抗ウイルス薬』 これは目を疑い読み返してしまった 細菌に対する抗菌薬ならぬ、複数種のウイルスに対する「広域」抗ウイルス薬の開発 https://t.co/LMG1c74zd0…

Aug 14, 2025 · 32 shares · 36 followers View post →
THEE Gregory Stewart
@gstewtwo · X

RT @vipintukur: Here is the link to the study

Aug 14, 2025 · 10 shares · 2,638 followers View post →
Paul B |
@Paul_Briley · X

RT @vipintukur: Here is the link to the study

Aug 14, 2025 · 10 shares · 6,213 followers View post →
conegoneco
@conegoneco · X

RT @tak53381102: 『広域スペクトル抗ウイルス薬』 これは目を疑い読み返してしまった 細菌に対する抗菌薬ならぬ、複数種のウイルスに対する「広域」抗ウイルス薬の開発 https://t.co/LMG1c74zd0…

Aug 14, 2025 · 32 shares · 122 followers View post →
チュラパンタカ
@5U4yz8vFlRv9VTm · X

RT @tak53381102: 『広域スペクトル抗ウイルス薬』 これは目を疑い読み返してしまった 細菌に対する抗菌薬ならぬ、複数種のウイルスに対する「広域」抗ウイルス薬の開発 https://t.co/LMG1c74zd0…

Aug 14, 2025 · 32 shares · 73 followers View post →
Nnankya
@Nnankya · X

An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo | Science Translational Medicine https://t.co/QFxTQ7BScq @BioteClinica , #Covid , #sars-cov2

Aug 14, 2025 · 140 followers View post →
わきまえないナニカのぴっち 삧치 ∀
@zpitschi · X

RT @tak53381102: 『広域スペクトル抗ウイルス薬』 これは目を疑い読み返してしまった 細菌に対する抗菌薬ならぬ、複数種のウイルスに対する「広域」抗ウイルス薬の開発 https://t.co/LMG1c74zd0…

Aug 14, 2025 · 32 shares · 3,727 followers View post →
Susa
@SusanneAydinlik · X

@Rainmaker1973 Too good to be true/to replicate in clinical studies on humans. Here is the publication that this is probably about: https://t.co/A2QjxrrJJH

Aug 14, 2025 · 1 like · 443 followers View post →
SZ, CEO & Founder @ X3EM
@x3em.bsky.social · Bluesky

Inspired by a Rare Genetic Condition, Researchers Uncover a Universal Virus Killer: An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo www.biorxiv.org/content/10.1...

Aug 14, 2025 · 1 share View post →
Reiner
@erlangen.bsky.social · Bluesky

An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo www.science.org/doi/10.1126/... An experimental therapy could lead to one universal antiviral to rule them all medicalxpress.com/news/2025-08...

Aug 13, 2025 · 1 like · 1 share View post →
Reiner 
@erlesen · X

An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo https://t.co/5aqJxWbPT7 An experimental therapy could lead to one universal antiviral to rule them all https://t.co/rsnqFU57Fb

Aug 13, 2025 · 4 likes · 1 share · 7,848 followers View post →
Dr Anthony Martin
@AMAinsight · X

An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo | Science Translational Medicine https://t.co/tP1Yw4xOIK

Aug 13, 2025 · 915 followers View post →
Biomimetics
@Biomimetics_abe · X

An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo | https://t.co/2N2c5kL7KV

Aug 13, 2025 · 1 like · 1 share · 391 followers View post →
Bogunovic Lab
@bogunoviclab.bsky.social · Bluesky

Latest by us! An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo | Science Translational Medicine www.science.org/doi/10.1126/...

Aug 13, 2025 · 15 likes · 10 shares View post →
D'Ombre et de Lumière
@louvetou · X

RT @greg_folkers: Sci Transl Med: An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in…

Aug 13, 2025 · 1 share · 132 followers View post →
Greg Folkers
@greg_folkers · X

Sci Transl Med: An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo Yemsratch T. Akalu et al https://t.co/NAuGFHO8es https://t.co/cYns0DoEHS

Aug 13, 2025 · 1 share · 4,587 followers View post →
Greg Folkers
@gregfolkers.bsky.social · Bluesky

Sci Transl Med: An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo Yemsratch T. Akalu et al bit.ly/3HAWafs

Aug 13, 2025 · 1 like View post →