Science August 2025 PMID 40839725

The gene: An evolutionary history of recurrent introgression and natural selection.

Fernando A Villanea, David Peede, Eli J Kaufman, Valeria Añorve-Garibay, Elizabeth T Chevy, Viridiana Villa-Islas, Kelsey E Witt, Roberta Zeloni, Davide Marnetto, Priya Moorjani, Flora Jay, Paul N Valdmanis, María C Ávila-Arcos, Emilia Huerta-Sánchez

Mentions

113
Peak: 52 in Aug 2025
across 6 sources since Aug 2025

Extended reach

1,361,242
potential audience

Total likes

1,745

Video views

25,991

Mentions per month

Aug 2025 – Nov 2025

Where it's discussed

  • X / Twitter58 posts
  • News42 articles
  • Blogs6 articles
  • Facebook3 posts
  • Bluesky2 posts
  • YouTube2 videos

AI synopsis

What people are saying

Many posts engage with detailed aspects of the article, mentioning the introduction of the Denisovan-like haplotype into modern humans and highlighting its significance in Indigenous American populations. Phrases such as 'super excited' and 'very interesting' illustrate a positive tone and enthusiasm towards the findings, contributing to the identified summary.

AgreementModerate agreement

Most discussions reflect a consensus regarding the article's findings, showing overall support.

InterestHigh interest

Participants express a strong curiosity about the genetic history outlined in the research.

EngagementModerate engagement

While some posts are more informative, others show a basic understanding of the content, indicating moderate engagement.

ImpactHigh impact

The discussions suggest that the publication is perceived as having substantial relevance to current understanding of human genetics.

Abstract in brief

  • The study focuses on a specific gene associated with a Denisovan-like haplotype, particularly in modern humans.
  • It reveals that this haplotype is commonly found in mixed American populations and notably in ancient Indigenous Americans, suggesting it predates European and African admixture.
  • The research shows that the Denisovan-like haplotype has undergone positive selection, potentially due to an increase in the number of certain genetic repeats, and indicates that it may have been introduced into modern humans through Neanderthal ancestry rather than from Denisovans.

Top posts

Most liked on X and Bluesky
Phys.org
@physorg_com · X

#A #Denisovan-derived gene variant, MUC19, is more common in Indigenous American ancestry and may have aided adaptation to new environments during early human migration into the Americas. @sciencemagazine https://t.co/NsqZ61TWrX https://t.co/MYNwfQ7YkI

Aug 21, 2025 · 66 likes · 22 shares · 1,021,592 followers View post →
David Peede
@david_peede · X

Chapter 2 of my PhD is officially out !! https://t.co/xmaygyah7R

Aug 21, 2025 · 26 likes · 7 shares · 384 followers View post →
Roberto Sáez
@robertosaezm · X

Probable herencia genética de una variante del gen MUC19 trasladada a los indígenas de América desde los denisovanos a través de neandertales. The MUC19 gene: An evolutionary history of recurrent introgression and natural selection https://t.co/DjDr5enhPg

Aug 23, 2025 · 18 likes · 8 shares · 12,478 followers View post →
Juhyun Kim
@juhyunk_ · X

The MUC19 gene: An evolutionary history of recurrent introgression and natural selection | Science https://t.co/Si5zkmAXp5 #journals #feedly

Aug 25, 2025 · 17 likes · 2 shares · 1,401 followers View post →
Alex Diaz-Papkovich
@alexandr.bsky.social · Bluesky

@david-peede.bsky.social et al on the convoluted route of a variant of the MUC19 gene: Denisovans (before going extinct) passed the gene to Neanderthals, who (before going extinct) passed it to ancient humans, who then crossed the Bering Strait. Today, 1 in 3 Mexicans carry the genetic variant.

Aug 21, 2025 · 16 likes · 10 shares View post →
Raymond Hames (@rayhames.bsky.social)
@HamesRaymond · X

@highlycited Yes, very interesting but why did you not bother to post the source? https://t.co/PRF0oc1q7B

Oct 6, 2025 · 10 likes · 750 followers View post →

All mentions

Charles Baylor
@Carltaylor15413 · X

RT @ultra_orbs: @J_garcia_cal @highlycited https://t.co/gW1L48Zv3K

Oct 7, 2025 · 1 share · 5 followers View post →
The-Ultra-Normal: The House of Orbs
@ultra_orbs · X

@J_garcia_cal @highlycited https://t.co/gW1L48Zv3K

Oct 6, 2025 · 2 likes · 1 share · 1,289 followers View post →
Raymond Hames (@rayhames.bsky.social)
@HamesRaymond · X

@highlycited Yes, very interesting but why did you not bother to post the source? https://t.co/PRF0oc1q7B

Oct 6, 2025 · 10 likes · 750 followers View post →
Gebnaturalistas geb
@gebnaturalistas · X

RT @robertosaezm: Una interesante historia de herencia genética neandertal y denisovana... The MUC19 gene: An evolutionary history of recur…

Oct 4, 2025 · 1 share · 719 followers View post →
Roberto Sáez
@robertosaezm · X

Una interesante historia de herencia genética neandertal y denisovana... The MUC19 gene: An evolutionary history of recurrent introgression and natural selection https://t.co/DjDr5enhPg

Oct 4, 2025 · 4 likes · 1 share · 12,478 followers View post →
Ben
@Ben17724 · X

Sehr interessant, wir nutzen Denisova-Menschen DNA in unserem Immunsystem. https://t.co/vussG9wRRb

Sep 11, 2025 View post →
Jorge García-Calleja
@J_garcia_cal · X

RT @david_peede: Chapter 2 of my PhD is officially out !! https://t.co/xmaygyah7R

Sep 4, 2025 · 7 shares · 153 followers View post →
Xavier Roca-Rada, PhD
@XavierRocaRada · X

RT @david_peede: Chapter 2 of my PhD is officially out !! https://t.co/xmaygyah7R

Sep 4, 2025 · 7 shares · 692 followers View post →
旅人 tabito
@tabibito250 · X

The MUC19 gene: An evolutionary history of recurrent introgression and natural selection | Science https://t.co/9zYQEQJj9w

Sep 3, 2025 · 1,074 followers View post →
Francis Villatoro
@emulenews · X

#ScienceMag The MUC19 gene: An evolutionary history of recurrent introgression and natural selection https://t.co/9EuZC9DmcB The Denisovan-like haplotype (in orange) was first introgressed from Denisovans into Neanderthals and then introgressed into modern humans. https://t.co/VZE2n2dQq6

Aug 28, 2025 · 45,129 followers View post →
Francisco R. Villatoro
@emulenews.mathstodon.xyz.ap.brid.gy · Bluesky

#ScienceMag The MUC19 gene: An evolutionary history of recurrent introgression and natural selection https://www.science.org/doi/10.1126/science.adl0882 The Denisovan-like haplotype (in orange) was first introgressed from Denisovans into Neanderthals and then introgressed into modern humans.

Aug 28, 2025 View post →
MASALUD Laboratorio Clínico
@masalud1 · X

RT @robertosaezm: Probable herencia genética de una variante del gen MUC19 trasladada a los indígenas de América desde los denisovanos a tr…

Aug 26, 2025 · 8 shares · 364 followers View post →
jono
@Jonnotabot · X

https://t.co/nNlbmYU1mv

Aug 26, 2025 · 96 followers View post →
CRCpaleos
@CRCpaleos · X

ARTÍCULO REFERENCIA (resumen) The MUC19 gene: An evolutionary history of recurrent introgression and natural selection https://t.co/1hhk2VqpcP vía @ScienceMagazine https://t.co/KT5fQa1Ovm

Aug 26, 2025 · 3,149 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @juhyunk_: The MUC19 gene: An evolutionary history of recurrent introgression and natural selection | Science https://t.co/Si5zkmAXp5 #j…

Aug 26, 2025 · 2 shares · 202 followers View post →
Frank Paul Mora
@InTime_49 · X

RT @juhyunk_: The MUC19 gene: An evolutionary history of recurrent introgression and natural selection | Science https://t.co/Si5zkmAXp5 #j…

Aug 25, 2025 · 2 shares · 413 followers View post →
Mauricio Cerisola
@Desiertoafuera · X

Aquí está el artículo: https://t.co/ZLBAMQfbhJ

Aug 25, 2025 · 1 like · 208 followers View post →
Joel López Parés
@jovepaleontoleg · X

RT @robertosaezm: Probable herencia genética de una variante del gen MUC19 trasladada a los indígenas de América desde los denisovanos a tr…

Aug 25, 2025 · 8 shares · 1,460 followers View post →
Juhyun Kim
@juhyunk_ · X

The MUC19 gene: An evolutionary history of recurrent introgression and natural selection | Science https://t.co/Si5zkmAXp5 #journals #feedly

Aug 25, 2025 · 17 likes · 2 shares · 1,401 followers View post →
Andraos Al-Sulh
@AndrewV691 · X

RT @Biorealism: "The Denisovan-like haplotype (in orange) was first introgressed from Denisovans into Neanderthals and then introgressed in…

Aug 24, 2025 · 1 share · 193 followers View post →
Bàrbara Mas
@BarbaraMas5 · X

RT @robertosaezm: Probable herencia genética de una variante del gen MUC19 trasladada a los indígenas de América desde los denisovanos a tr…

Aug 24, 2025 · 8 shares · 177 followers View post →
Professor Erwin Loh
@erwinloh · X

Source: https://t.co/HYdumvbMub

Aug 24, 2025 · 8,219 followers View post →
Holtz
@Biorealism · X

"The Denisovan-like haplotype (in orange) was first introgressed from Denisovans into Neanderthals and then introgressed into modern humans. The introgressed haplotype later experienced positive selection in populations from the Americas" https://t.co/3VpW9N4yPw

Aug 24, 2025 · 5 likes · 1 share · 8,928 followers View post →
Diego Ortega-Del Vecchyo
@dortega_delv · X

RT @david_peede: Chapter 2 of my PhD is officially out !! https://t.co/xmaygyah7R

Aug 23, 2025 · 7 shares · 1,402 followers View post →
Marques de Carabas
@nguerral · X

RT @robertosaezm: Probable herencia genética de una variante del gen MUC19 trasladada a los indígenas de América desde los denisovanos a tr…

Aug 23, 2025 · 8 shares · 198 followers View post →
Demografía (CSIC)
@Demografia_CSIC · X

RT @robertosaezm: Probable herencia genética de una variante del gen MUC19 trasladada a los indígenas de América desde los denisovanos a tr…

Aug 23, 2025 · 8 shares · 9,178 followers View post →
Mirada Antropologica
@AntropologiaGC · X

RT @robertosaezm: Probable herencia genética de una variante del gen MUC19 trasladada a los indígenas de América desde los denisovanos a tr…

Aug 23, 2025 · 8 shares · 2,893 followers View post →
Catherine P M
@CatherinePM3 · X

RT @robertosaezm: Probable herencia genética de una variante del gen MUC19 trasladada a los indígenas de América desde los denisovanos a tr…

Aug 23, 2025 · 8 shares · 64 followers View post →
Juan Pablo Huerta Coso
@jphuertacoso · X

RT @robertosaezm: Probable herencia genética de una variante del gen MUC19 trasladada a los indígenas de América desde los denisovanos a tr…

Aug 23, 2025 · 8 shares · 245 followers View post →
Roberto Sáez
@robertosaezm · X

Probable herencia genética de una variante del gen MUC19 trasladada a los indígenas de América desde los denisovanos a través de neandertales. The MUC19 gene: An evolutionary history of recurrent introgression and natural selection https://t.co/DjDr5enhPg

Aug 23, 2025 · 18 likes · 8 shares · 12,478 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

The MUC19 gene: An evolutionary history of recurrent introgression and natural selection | Science https://t.co/L21kVuoqlA

Aug 23, 2025 · 1 like · 2,064 followers View post →
MOIZ ESUFALLY
@moizesufally · X

The MUC19 gene: An evolutionary history of recurrent introgression and natural selection | Scie - https://t.co/bJ9gNuF1CL #GoogleAlerts

Aug 22, 2025 · 328 followers View post →
Xinjun Zhang
@Xinjun90 · X

RT @david_peede: Chapter 2 of my PhD is officially out !! https://t.co/xmaygyah7R

Aug 22, 2025 · 7 shares · 1,421 followers View post →
matiere*
@matiere · X

The MUC19 gene: An evolutionary history of recurrent introgression and natural selection | Science https://t.co/YxdvbKZRzv

Aug 22, 2025 · 2,853 followers View post →
David Peede
@david_peede · X

RT @pvaldmanis: Super excited to be a part of this project! Most tandem repeats expansions lead to disease but we found one in MUC19 underg…

Aug 22, 2025 · 2 shares · 384 followers View post →
Yadira Peña-García
@Yadirapga · X

RT @david_peede: Chapter 2 of my PhD is officially out !! https://t.co/xmaygyah7R

Aug 22, 2025 · 7 shares · 142 followers View post →
Chris Stringer
@ChrisStringer65 · X

RT @ChrisStringer65: The MUC19 gene: An evolutionary history of recurrent introgression and natural selection | Science https://t.co/oPX8iT…

Aug 22, 2025 · 3 shares · 29,801 followers View post →
Valeria Añorve-Garibay
@valenomics · X

RT @david_peede: Chapter 2 of my PhD is officially out !! https://t.co/xmaygyah7R

Aug 22, 2025 · 7 shares · 176 followers View post →
Eli
@kaufmanelij · X

RT @pvaldmanis: Super excited to be a part of this project! Most tandem repeats expansions lead to disease but we found one in MUC19 underg…

Aug 22, 2025 · 2 shares · 21 followers View post →
Jun Yasuda
@jyasuda1 · X

こちらが元論文。 https://t.co/soUYBvSEbs

Aug 21, 2025 · 5,471 followers View post →
Paul Valdmanis
@pvaldmanis · X

Super excited to be a part of this project! Most tandem repeats expansions lead to disease but we found one in MUC19 undergoing positive selection. The repeat adds >12,000bp to a coding exon and is present on a haplotype inherited from Denisovans. https://t.co/qG2hrG4y6E

Aug 21, 2025 · 6 likes · 2 shares · 108 followers View post →
Stetson
@stetson_thacker · X

RT @ChrisStringer65: The MUC19 gene: An evolutionary history of recurrent introgression and natural selection | Science https://t.co/oPX8iT…

Aug 21, 2025 · 3 shares · 876 followers View post →
Jake Marglous
@jmarglous · X

RT @david_peede: Chapter 2 of my PhD is officially out !! https://t.co/xmaygyah7R

Aug 21, 2025 · 7 shares · 34 followers View post →
Miguel Angel Contreras Sieck
@MiguelSieck · X

https://t.co/mhofsuwPAz

Aug 21, 2025 · 1 like · 1,574 followers View post →
Shapley Fürskyn
@shiva137 · X

RT @physorg_com: #A #Denisovan-derived gene variant, MUC19, is more common in Indigenous American ancestry and may have aided adaptation to…

Aug 21, 2025 · 22 shares · 220 followers View post →
Tukang Kebun
@forestbiologist · X

"multiple introgression events, from Denisovans to Neanderthals and Neanderthals to modern humans" https://t.co/U6IokQ4UYw

Aug 21, 2025 · 338 followers View post →
Odyssey to the Far East
@motherlander · X

RT @physorg_com: #A #Denisovan-derived gene variant, MUC19, is more common in Indigenous American ancestry and may have aided adaptation to…

Aug 21, 2025 · 22 shares · 22,757 followers View post →
John Greene
@Greene_Thoughts · X

RT @physorg_com: #A #Denisovan-derived gene variant, MUC19, is more common in Indigenous American ancestry and may have aided adaptation to…

Aug 21, 2025 · 22 shares · 1,709 followers View post →
Alexander
@Monro1766 · X

RT @physorg_com: #A #Denisovan-derived gene variant, MUC19, is more common in Indigenous American ancestry and may have aided adaptation to…

Aug 21, 2025 · 22 shares · 121 followers View post →
Dr Cynthia Larbey
@CynthiaLarbey · X

RT @ChrisStringer65: The MUC19 gene: An evolutionary history of recurrent introgression and natural selection | Science https://t.co/oPX8iT…

Aug 21, 2025 · 3 shares · 1,126 followers View post →
Daniela Adorno Mascarenhas
@DanielaAdornoM1 · X

RT @physorg_com: #A #Denisovan-derived gene variant, MUC19, is more common in Indigenous American ancestry and may have aided adaptation to…

Aug 21, 2025 · 22 shares · 2,153 followers View post →
Mika Ainasoja
@MikaAinasoja · X

RT @physorg_com: #A #Denisovan-derived gene variant, MUC19, is more common in Indigenous American ancestry and may have aided adaptation to…

Aug 21, 2025 · 22 shares · 2,180 followers View post →
Michelle Malatesta
@green1mickey · X

RT @physorg_com: #A #Denisovan-derived gene variant, MUC19, is more common in Indigenous American ancestry and may have aided adaptation to…

Aug 21, 2025 · 22 shares · 590 followers View post →
Nrken19
@nrken19 · X

RT @physorg_com: #A #Denisovan-derived gene variant, MUC19, is more common in Indigenous American ancestry and may have aided adaptation to…

Aug 21, 2025 · 22 shares · 75,848 followers View post →
Chris Stringer
@ChrisStringer65 · X

The MUC19 gene: An evolutionary history of recurrent introgression and natural selection | Science https://t.co/oPX8iTjxQc

Aug 21, 2025 · 8 likes · 3 shares · 29,801 followers View post →
sherman osborn
@nascar_oz · X

RT @physorg_com: #A #Denisovan-derived gene variant, MUC19, is more common in Indigenous American ancestry and may have aided adaptation to…

Aug 21, 2025 · 22 shares · 5,226 followers View post →
Phys.org
@physorg_com · X

#A #Denisovan-derived gene variant, MUC19, is more common in Indigenous American ancestry and may have aided adaptation to new environments during early human migration into the Americas. @sciencemagazine https://t.co/NsqZ61TWrX https://t.co/MYNwfQ7YkI

Aug 21, 2025 · 66 likes · 22 shares · 1,021,592 followers View post →
David Peede
@david_peede · X

Chapter 2 of my PhD is officially out !! https://t.co/xmaygyah7R

Aug 21, 2025 · 26 likes · 7 shares · 384 followers View post →
Waggoner Lab
@LabWaggoner · X

The MUC19 gene: An evolutionary history of recurrent introgression and natural selection @ScienceMagazine https://t.co/gDD7mdPcA6 @david_peede @emiliahsc https://t.co/1nO1Moh0Jl

Aug 21, 2025 · 2 likes · 11,621 followers View post →
Alex Diaz-Papkovich
@alexandr.bsky.social · Bluesky

@david-peede.bsky.social et al on the convoluted route of a variant of the MUC19 gene: Denisovans (before going extinct) passed the gene to Neanderthals, who (before going extinct) passed it to ancient humans, who then crossed the Bering Strait. Today, 1 in 3 Mexicans carry the genetic variant.

Aug 21, 2025 · 16 likes · 10 shares View post →