PubHawk
October 2025 PMID 40929630

Associations of Chronic Insomnia, Longitudinal Cognitive Outcomes, Amyloid-PET, and White Matter Changes in Cognitively Normal Older Adults.

Diego Z Carvalho, Bhanu Prakash Kolla, Stuart J McCarter, Erik K St Louis, Mary M Machulda, Scott A Przybelski, Angela J Fought, Val J Lowe, Virend K Somers, Bradley F Boeve, Ronald C Petersen, Clifford R Jack, Jonathan Graff-Radford, Andrew William Varga, Prashanthi Vemuri

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Mentions

224
Peak: 44 in Sep 2025
across 6 sources since Sep 2025

Extended reach

526,449
potential audience

Total likes

204

Video views

1,265

Mentions per month

Sep 2025 – Oct 2025

Where it's discussed

  • News160 articles
  • X / Twitter50 posts
  • Blogs8 articles
  • Bluesky2 posts
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

The discussions show strong recognition of the study's importance, evidenced by posts that mention how insomnia can increase dementia risk and accelerate brain aging, using words like 'warning,' 'associated,' and 'significance.' The tone balances scientific acknowledgment with concerns about public health, making the topic seem both relevant and urgent.

AgreementModerate agreement

Most discussions acknowledge the study’s findings linking insomnia to accelerated brain aging and cognitive decline, showing general agreement.

InterestHigh interest

Posts demonstrate high interest, referencing key findings like increased dementia risk and brain changes, often emphasizing the significance of sleep health.

EngagementModerate engagement

Users actively engage by sharing insights, examples, and implications, such as how improving sleep might protect brain health.

ImpactModerate impact

While the discussions highlight the importance of sleep for brain health, the overall perceived impact appears moderate, with some posts emphasizing practical health implications.

Abstract in brief

  • Chronic insomnia in older adults is linked to faster cognitive decline and a higher risk of developing cognitive impairment over time.
  • The study found that insomnia is associated with increased white matter hyperintensities and amyloid PET burden, which are indicators of brain changes related to aging and Alzheimer’s disease.
  • Participants with insomnia who also experienced reduced sleep showed worse baseline cognitive performance and increased brain pathology markers, suggesting sleep quality impacts brain health in aging.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Gianrico Farrugia
@GFarrugiaMD · X

New Mayo Clinic research shows that improving sleep duration can help protect brain health. Powered by advanced imaging, this work reminds us that modifiable factors like rest can play a key role in healthier futures. https://t.co/NtlmGIEk8I https://t.co/VHSjLm4oEL

Sep 26, 2025 · 27 likes · 6 shares · 8,268 followers View post →
METODOLOGICA_CL
@metodologica_cl · X

Sep 12, 2025 · 27 likes · 10 shares · 3,804 followers View post →
LE COLLECTIF
@tatiann69922625 · X

Pour info ℹ️ L’insomnie chronique pourrait augmenter le risque de déclin cognitif et de démence chez les personnes âgées. Nouvelle étude dans Neurology (2025)

Sep 25, 2025 · 22 likes · 9 shares · 63,529 followers View post →
筋肉博士
@muscle_penguin_ · X

(503/347) #論文マラソン 不眠は認知機能に影響を与えるか？ 認知機能障害のない高齢者のベースラインの不眠症と認知機能を評価。 不眠症は、全般認知スコアの急速な低下と、精神疾患リスクの増加と関連していた。 https://t.co/CbtJlQlzX9

Sep 12, 2025 · 20 likes · 2 shares · 36,392 followers View post →
Neurology Journal
@GreenJournal · X

This study investigated associations between chronic insomnia, longitudinal cognitive outcomes, and brain health in older adults. Read more: https://t.co/2C5ZpS64Sz #NeuroX https://t.co/aEKRgMhTkX

Oct 3, 2025 · 13 likes · 5 shares · 98,137 followers View post →
Brandon Luu, MD
@BrandonLuuMD · X

https://t.co/JLBCmNRUoP

Oct 8, 2025 · 10 likes · 1 share · 20,358 followers View post →

All mentions

お茶柱／心理学のべレスク
@otea_stalk · X

短眠は脳に良くないのか？ 50歳以上の認知的に健康な男女2,750人を調査 慢性不眠症の人は、全般的認知スコアの低下が早い MCI/認知症の発症リスクが増加 不眠症て短眠の人は、白質高信号域の体積が大きい アミロイドレベルも高い https://t.co/LYhWQBwZf8

Oct 14, 2025 · 21 followers View post →
Tom Hsiung
@TomHsiung · X

Associations of Chronic Insomnia, Longitudinal Cognitive Outcomes, Amyloid-PET, and White Matter Changes in Cognitively Normal Older Adults | Neurology https://t.co/RBA2oAHzym

Oct 12, 2025 · 465 followers View post →
TheKnightofEvening
@KnightofTh3v3ng · X

RT @BrandonLuuMD: https://t.co/JLBCmNRUoP

Oct 8, 2025 · 1 share · 2,413 followers View post →
Prof. Dr. Sanjeev Bagai
@BagaiDr · X

Associations of Chronic Insomnia, Longitudinal Cognitive Outcomes, Amyloid-PET, White Matter Changes in Cognitively Normal Older Adults; 2,750 participants (mean 70.3 ± 9.7 years old, 49.2% female) with median follow-up of 5.6 years. https://t.co/d4hztTsiMR

Oct 8, 2025 · 34,708 followers View post →
Brandon Luu, MD
@BrandonLuuMD · X

https://t.co/JLBCmNRUoP

Oct 8, 2025 · 10 likes · 1 share · 20,358 followers View post →
Nixa Sedes, MD
@nixassedes.bsky.social · Bluesky

Associations of Chronic Insomnia, Longitudinal Cognitive Outcomes, Amyloid-PET, and White Matter Changes in Cognitively Normal Older Adults

Oct 5, 2025 View post →
Victor Del Bene
@victor_delbene · X

RT @GreenJournal: This study investigated associations between chronic insomnia, longitudinal cognitive outcomes, and brain health in older…

Oct 3, 2025 · 5 shares · 2,069 followers View post →
London Neurology Clinic
@ClinicNeurology · X

RT @GreenJournal: This study investigated associations between chronic insomnia, longitudinal cognitive outcomes, and brain health in older…

Oct 3, 2025 · 5 shares · 471 followers View post →
Neurology Journal
@GreenJournal · X

This study investigated associations between chronic insomnia, longitudinal cognitive outcomes, and brain health in older adults. Read more: https://t.co/2C5ZpS64Sz #NeuroX https://t.co/aEKRgMhTkX

Oct 3, 2025 · 13 likes · 5 shares · 98,137 followers View post →
Professor Erwin Loh
@erwinloh · X

Source: https://t.co/yTeFZIDlZJ

Oct 1, 2025 · 9,414 followers View post →
Dēp Slēpwear
@depslepwear · X

RT @GFarrugiaMD: New Mayo Clinic research shows that improving sleep duration can help protect brain health. Powered by advanced imaging, t…

Sep 29, 2025 · 6 shares · 1,432 followers View post →
Renal Failure
@RenalFailureTF · X

RT @GFarrugiaMD: New Mayo Clinic research shows that improving sleep duration can help protect brain health. Powered by advanced imaging, t…

Sep 28, 2025 · 6 shares · 224 followers View post →
Jose Arriola-Montenegro
@josearriolam · X

RT @GFarrugiaMD: New Mayo Clinic research shows that improving sleep duration can help protect brain health. Powered by advanced imaging, t…

Sep 27, 2025 · 6 shares · 379 followers View post →
fernando fervenza
@fervenzafernan1 · X

RT @GFarrugiaMD: New Mayo Clinic research shows that improving sleep duration can help protect brain health. Powered by advanced imaging, t…

Sep 27, 2025 · 6 shares · 4,185 followers View post →
Amy Oxentenko MD
@AmyOxentenkoMD · X

RT @GFarrugiaMD: New Mayo Clinic research shows that improving sleep duration can help protect brain health. Powered by advanced imaging, t…

Sep 26, 2025 · 6 shares · 24,292 followers View post →
Wisit Cheungpasitporn MD FACP | FASN | FAST
@wisit661 · X

RT @GFarrugiaMD: New Mayo Clinic research shows that improving sleep duration can help protect brain health. Powered by advanced imaging, t…

Sep 26, 2025 · 6 shares · 2,741 followers View post →
Gianrico Farrugia
@GFarrugiaMD · X

New Mayo Clinic research shows that improving sleep duration can help protect brain health. Powered by advanced imaging, this work reminds us that modifiable factors like rest can play a key role in healthier futures. https://t.co/NtlmGIEk8I https://t.co/VHSjLm4oEL

Sep 26, 2025 · 27 likes · 6 shares · 8,268 followers View post →
DouD59
@danieldouet1 · X

RT @tatiann69922625: Pour info ℹ️ L’insomnie chronique pourrait augmenter le risque de déclin cognitif et de démence chez les personnes âgé…

Sep 25, 2025 · 9 shares · 197 followers View post →
ImmortelleXIII
@ImmortelleXIII · X

RT @tatiann69922625: Pour info ℹ️ L’insomnie chronique pourrait augmenter le risque de déclin cognitif et de démence chez les personnes âgé…

Sep 25, 2025 · 9 shares · 1,882 followers View post →
Clément chantal
@CClem64 · X

RT @tatiann69922625: Pour info ℹ️ L’insomnie chronique pourrait augmenter le risque de déclin cognitif et de démence chez les personnes âgé…

Sep 25, 2025 · 9 shares · 726 followers View post →
inihcnarf
@inihcnarf · X

RT @tatiann69922625: Pour info ℹ️ L’insomnie chronique pourrait augmenter le risque de déclin cognitif et de démence chez les personnes âgé…

Sep 25, 2025 · 9 shares · 1,739 followers View post →
Monneret Valérie
@sstellalluna · X

RT @tatiann69922625: Pour info ℹ️ L’insomnie chronique pourrait augmenter le risque de déclin cognitif et de démence chez les personnes âgé…

Sep 25, 2025 · 9 shares · 137 followers View post →
André Jaouen
@Christo04818898 · X

RT @tatiann69922625: Pour info ℹ️ L’insomnie chronique pourrait augmenter le risque de déclin cognitif et de démence chez les personnes âgé…

Sep 25, 2025 · 9 shares · 157 followers View post →
Bruno TIVOLI BARDINI
@BardiniTivoli · X

RT @tatiann69922625: Pour info ℹ️ L’insomnie chronique pourrait augmenter le risque de déclin cognitif et de démence chez les personnes âgé…

Sep 25, 2025 · 9 shares · 1,134 followers View post →
sara.art
@saraart4 · X

RT @tatiann69922625: Pour info ℹ️ L’insomnie chronique pourrait augmenter le risque de déclin cognitif et de démence chez les personnes âgé…

Sep 25, 2025 · 9 shares · 8,503 followers View post →
Ramucho67
@ramucho67 · X

RT @tatiann69922625: Pour info ℹ️ L’insomnie chronique pourrait augmenter le risque de déclin cognitif et de démence chez les personnes âgé…

Sep 25, 2025 · 9 shares · 1,877 followers View post →
LE COLLECTIF
@tatiann69922625 · X

Pour info ℹ️ L’insomnie chronique pourrait augmenter le risque de déclin cognitif et de démence chez les personnes âgées. Nouvelle étude dans Neurology (2025)

Sep 25, 2025 · 22 likes · 9 shares · 63,529 followers View post →
IppeiChiba
@ptIchiba · X

不眠症は認知機能低下を早める 不眠症かつ睡眠時間が短いと白質病変多め、かつAbeta蓄積多め 掘る価値ありそう https://t.co/eOTWTHnsQK

Sep 19, 2025 · 1 like · 239 followers View post →
أ.د. سعد الشريف
@DrSaadAlShareef · X

الأرق يزيد خطر الإصابة بالخرف بنسبة 40%. حسب نتائج دراسة حديثة تابعت المشاركين لأكثر من 5 سنوات. لكن من تحسّن نومهم أو تلقوا علاجًا مناسبًا لم يظهر لديهم هذا الخطر. الشاهد: يساهم علاج الأرق والحصول على نوم كافٍ في الوقاية من الإصابة بالخرف. https://t.co/tPZz6GA49M

Sep 18, 2025 · 2 likes · 14,604 followers View post →
MED
@MEDtriagex · X

Sep 16, 2025 · 709 followers View post →
Domo Futu
@domofutu · X

https://t.co/A20RwgxdBM

Sep 15, 2025 · 1 like · 68 followers View post →
いっちー@バーチャル精神科医
@ichiipsy · X

Associations of Chronic Insomnia, Longitudinal Cognitive Outcomes, Amyloid-PET, and White Matter Changes in Cognitively Normal Older Adults | Neurology https://t.co/rE8G0S80kg

Sep 13, 2025 · 79,162 followers View post →
阿世賀浩一郎@精神科医をめざします
@kasega1960 · X

RT @muscle_penguin_: (503/347) #論文マラソン 不眠は認知機能に影響を与えるか？ 認知機能障害のない高齢者のベースラインの不眠症と認知機能を評価。 不眠症は、全般認知スコアの急速な低下と、精神疾患リスクの増加と関連していた。 https:/…

Sep 13, 2025 · 2 shares · 3,030 followers View post →
@guardian_xcu · X

➡️ Die Publikation von Forschenden der Mayo Clinic in Rochester,

Sep 13, 2025 · 1 like · 2,314 followers View post →
Mario AF
@Mario_A_F_ · X

RT @metodologica_cl:

Sep 13, 2025 · 10 shares · 238 followers View post →
Constanza Rivera
@coniiriverar · X

RT @metodologica_cl:

Sep 13, 2025 · 10 shares · 836 followers View post →
Reiner
@erlangen.bsky.social · Bluesky

Chronic sleep deprivation ages the brain and increases the risk of dementia www.scinexx.de/news/medizin... Associations of Chronic Insomnia, Longitudinal Cognitive Outcomes, Amyloid-PET, and White Matter Changes in Cognitively Normal Older Adults www.neurology.org/doi/10.1212/...

Sep 12, 2025 · 6 likes · 3 shares View post →
Reiner 
@erlesen · X

Chronic sleep deprivation ages the brain and increases the risk of dementia https://t.co/XEYWuR3uYw Associations of Chronic Insomnia, Longitudinal Cognitive Outcomes, Amyloid-PET, and White Matter Changes in Cognitively Normal Older Adults https://t.co/fTjLPCaxhO

Sep 12, 2025 · 2 likes · 7,863 followers View post →
Súper Dinámico Marsupial del Futuro
@rockmeza · X

RT @metodologica_cl:

Sep 12, 2025 · 10 shares · 892 followers View post →
Arturo Trostel
@XxTurok · X

RT @metodologica_cl:

Sep 12, 2025 · 10 shares · 200 followers View post →
Fender 2.0
@Ffender1312 · X

RT @metodologica_cl:

Sep 12, 2025 · 10 shares · 3,257 followers View post →
METODOLOGICA_CL
@metodologica_cl · X

Sep 12, 2025 · 27 likes · 10 shares · 3,804 followers View post →
Hmmm...
@HmmmNiceee · X

Insomnia associated with accelerated brain aging | Associations of Chronic Insomnia, Longitudinal Cognitive Outcomes, Amyloid-PET, and White Matter Changes in Cognitively Normal Older Adults https://t.co/EPaC3aeRLj

Sep 12, 2025 · 341 followers View post →
Joel "Heart Prevention" Kahn MD, FACC
@drjkahn · X

Associations of Chronic Insomnia, Longitudinal Cognitive Outcomes, Amyloid-PET, and White Matter Changes in Cognitively Normal Older Adults | Neurology https://t.co/Uy9ZqfCPmF

Sep 12, 2025 · 32,258 followers View post →
user_ittk
@user_ittk · X

RT @muscle_penguin_: (503/347) #論文マラソン 不眠は認知機能に影響を与えるか？ 認知機能障害のない高齢者のベースラインの不眠症と認知機能を評価。 不眠症は、全般認知スコアの急速な低下と、精神疾患リスクの増加と関連していた。 https:/…

Sep 12, 2025 · 2 shares · 48 followers View post →
筋肉博士
@muscle_penguin_ · X

(503/347) #論文マラソン 不眠は認知機能に影響を与えるか？ 認知機能障害のない高齢者のベースラインの不眠症と認知機能を評価。 不眠症は、全般認知スコアの急速な低下と、精神疾患リスクの増加と関連していた。 https://t.co/CbtJlQlzX9

Sep 12, 2025 · 20 likes · 2 shares · 36,392 followers View post →
筋肉博士
@muscle_penguin_ · X

(502/347) #論文マラソン 不眠は認知機能に影響を与えるか？ 認知機能障害のない高齢者のベースラインの不眠症と認知機能を評価。 不眠症は、全般認知スコアの急速な低下と、精神疾患リスクの増加と関連していた。 https://t.co/CbtJlQlzX9

Sep 12, 2025 · 36,392 followers View post →
Tommy Jaxon
@HealthyAI_TJ · X

RT @TimePieChina: Can’t sleep? Scientists warn: #Insomnia might associated with accelerated brain #aging. People with chronic insomnia wer…

Sep 12, 2025 · 1 share · 32 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Associations of Chronic Insomnia, Longitudinal Cognitive Outcomes, Amyloid-PET, and White Matter Changes in Cognitively Normal Older Adults https://t.co/eXysv0Vyp0

Sep 11, 2025 · 2 likes · 2,239 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

Can’t sleep? Scientists warn: #Insomnia might associated with accelerated brain #aging. People with chronic insomnia were 40% more likely to develop dementia or mild cognitive issues than those without insomnia--equivalent of 3.5 additional years of aging https://t.co/YlqEkNeb8W https://t.co/QC7OOON6hx

Sep 11, 2025 · 2 likes · 1 share · 700 followers View post →
Edtreo
@EdisonTanEdtreo · X

Insomnia Increases the Risk of Dementia in Cognitively Healthy Older Adults https://t.co/UW0sa4xYeW

Sep 11, 2025 · 255 followers View post →
Professor Erwin Loh
@erwinloh · X

Source: https://t.co/yTeFZIDlZJ

Sep 11, 2025 · 9,414 followers View post →