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Cell November 2025 PMID 41005308

Safe immunosuppression-resistant pan-cancer immunotherapeutics by velcro-like density-dependent targeting of tumor-associated carbohydrate antigens.

Raymond W Zhou, Paresh Kumar Purohit, Jai Hyun Kim, Sung-Uk Lee, Nicole Burshteyn, Delia Tifrea, Andres Cordon, Ani Grigorian, Barbara L Newton, Robert A Edwards, Michael Demetriou

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Mentions

237
Peak: 43 in Nov 2025
across 10 sources since Sep 2025

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AI synopsis

What people are saying

The discussions collectively express strong enthusiasm for the new immunotherapeutic approach, with words like 'potent,' 'unique,' and 'game changer' conveying excitement. Participants reference specific details such as 'density-dependent targeting' and 'highly potent class,' demonstrating a focus on the research's innovative aspects and potential clinical impact.

AgreementModerate agreement

Most discussions highlight the innovative nature of the research, suggesting general support or optimism about its potential.

InterestHigh interest

Participants show high interest, frequently mentioning the publication and related research, indicating engagement with cutting-edge science.

EngagementModerate engagement

Comments include references to specific mechanisms like Velcro-like binding and implications for cancer therapy, reflecting active and somewhat in-depth engagement.

ImpactHigh impact

Many posts emphasize the significance of the findings and their potential to revolutionize treatments, implying perceived high impact.

Abstract in brief

  • The study introduces GlyTR pancancer immunotherapeutics, which use a velcro-like lectin binding mechanism to target tumor-associated carbohydrate antigens (TACAs), allowing precise killing of cancer cells with high TACA expression while sparing normal cells with low TACA levels.
  • GlyTR1 and GlyTR2 are designed to bind specific carbohydrate structures on tumor cells, such as Nglycans and TACAs like Tn, sialylTn, LacDiNAc, and GD2, effectively overcoming tumor immune suppression and reducing off-target toxicity.
  • This density-dependent targeting approach results in highly potent, safe cancer immunotherapy options that specifically attack tumor cells without damaging normal tissue, addressing key limitations of traditional antibody-based therapies.]
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『Safe immunosuppression-resistant pan-cancer immunotherapeutics by velcro-like density-dependent targeting of tumor-associated carbohydrate antigens』 Cell 　Sep 25, 2025... GlyTRはがん細胞糖鎖（TACA）に密度依存的に結合する新しい免疫療法。正常細胞を傷つけず複数がんの治療が可能 https://t.co/BmaaospVvE

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"Safe immunosuppression-resistant pan-cancer immunotherapeutics by velcro-like density-dependent targeting of tumor-associated carbohydrate antigens" Zhou RW [..] Demetriou M. Cell 2025-09-25. https://t.co/aohoTjO8v8 GlyT (glycan-dependent T cell recruiter) https://t.co/T8cnyCtLEU

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Araştırmacılar bir sonraki aşama olan insan çalışmalarına hazırlanmak için çalışıyorlar. 4 https://t.co/Hbn5bxe2nc

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Unique pan-cancer immunotherapy destroys tumors without attacking healthy tissue https://www.europesays.com/us/255488/ Credit: Cell (2025). DOI: 10.1016/j.cell.2025.09.001 A new, highly potent class of immunotherapeutics with unique Velcro-like binding properties can…#us #news #usnews

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... 10.1016/j.annonc.2025.09.001 #Oncology #AIinOncology #DigitalHealth ... cell growth), fractures (broken bones), and vascular ...

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... pan-cancer targets. To ... Safe immunosuppression-resistant pan-cancer immunotherapeutics by velcro-like density-dependent targeting of tumor ...

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Saúde intestinal Restrições severas reduzem a diversidade do microbioma (Cell Host & Microbe, 2019). ... 10.1016/j.clnu.2025.09.001 — Efeito do ...

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... 10.1016/j.annonc.2025.09.001 #Oncology #AIinOncology #DigitalHealth ... cell's complex gene expression profile into a simple "Cell ...

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Doi: https://doi.org/10.1016/j.gr.2025.09.001. CSIC Comunicación ... Cell: 633190338. More on this News Release. A 150-million-year-old ...

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... journal, Cell. "With the publication in Cell, GlyTR is entering the ... 10.1016/j.cell.2025.09.001. About GlyTR Therapeutics GlyTR ...

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... cells act in Fragile X. Imagine a busy intersection full of cars with ... DOI: 10.1016/j.ajhg.2025.09.001 https://www.cell.com/ajhg ...

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In a new study published in Cell titled, “Safe immunosuppression-resistant pan-cancer immunotherapeutics by velcro-like density-dependent ...

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Safe immunosuppression-resistant pan-cancer immunotherapeutics by velcro-like density-dependent targeting of tumor-associated carbohydrate ...

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It is not just a Tier 1 journal article but a hope for millions ... cell inflamed tumor only). Further, the GlyTR1 bispecific molecule ...

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... paramount for the prediction of intra-operative speech arrest." https://doi.org/10.1016/j.clinph.2025.2110995".

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Epigenetics is the study of all of the non-DNA sequence alterations that affect how genes are expressed within our cells. These include ...

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It is not just a Tier 1 journal article but a hope for ... ctDNA Dynamics as an Early Indicator in Small Cell Lung Cancer Small cell ...

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Cell Metabolism, 2017. Mostra que a flexibilidade metabólica é a ... 10.1016/j.clnu.2025.09.001 — Efeito do consumo de carne vermelha ...

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Saúde intestinal Restrições severas reduzem a diversidade do microbioma (Cell Host & Microbe, 2019). ... 10.1016/j.clnu.2025.09.001 — Efeito do ...

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A newly published randomized crossover trial (DOI: 10.1016/j.ajcnut.2025.09.001) tested lean vs. high-fat pork (each 20 g protein) after ...

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अड़ियल मंडूसी का एकमात्र समाधान, जोगीरा Pyroxasulfone treatment ...
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Glycosylphosphatidylinositol (GPI) anchoring controls cell ... https://doi.org/10.1016/j.jia.2025.09.001. Upvote 21. Downvote 1 Go to ...

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In oliec acid unsaturation starts at Carbon number a) 9 b) 10 c) 11 d ...
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⚡ Hydrogen , The Fuel of the Future From powering fuel cells ... 10.1016/j.gce.2025.09.001 #Chemical #journal #researchpaper #article.

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Biochemistry Wave Qn 139: Activator of enzyme sulfite oxidase is: a ...
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Biochemistry Wave Q-a-day 26: Which among the following is an ...
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Non nucleated blood cell?* *Answer: RBC* (Erythrocytes) 12. ... j.gce.2025.09.001 #Chemical #journal #researchpaper #article · May be ...

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... 10.1016/j.gce.2025.09.001 #Chemical #journal #researchpaper #article ... cell lines MCF-7 and HeLa. Conclusion The genus Achillea L. is a ...

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