Cephalalgia November 2025 PMID 41223010

Abnormal neurovascular coupling in the precuneus associated with migraine chronification: A multimodal magnetic resonance imaging study.

Cunxin Lin, Yuanxiang Li, Zhuang Wang, Chenyang Duan, Geyu Liu, Zhi Guo, Xiaoshuang Li, Zhonghua Xiong, Tong Chen, Mantian Zhang, Tianshuang Gao, Binbin Sui, Yonggang Wang

Mentions

66
Peak: 15 in Dec 2025
across 4 sources since Nov 2025

Extended reach

13,318
potential audience

Total likes

7

Video views

23

Mentions per month

Nov 2025 – Dec 2025

Where it's discussed

  • Instagram50 posts
  • Facebook8 posts
  • X / Twitter6 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions highlight the importance of the abnormal NVC in the precuneus as a key factor in migraine chronification and explore its role as a biomarker, with mentions of depression as a mediating factor. Phrases like 'may serve as a biomarker' and references to the link between NVC and migraine severity reflect a substantive engagement with the research's potential impact and implications.

AgreementModerate agreement

Most comments acknowledge the significance of NVC findings in understanding migraine progression, reflecting general support for the research conclusions.

InterestHigh interest

Discussions show high curiosity, especially regarding NVC as a potential biomarker and its relation to depression, indicating strong engagement with the topic.

EngagementModerate engagement

Comments go beyond mere summary, mentioning implications like biomarkers and depression mediation, demonstrating thoughtful involvement.

ImpactModerate impact

The emphasis on the potential for new diagnostic tools and understanding of migraine mechanisms suggests that users see some influence or importance in the study.

Abstract in brief

  • The study found that both episodic and chronic migraine patients show impaired neurovascular coupling (NVC), indicated by reduced correlation between cerebral blood flow (CBF) and functional activity, compared to healthy controls.
  • Specifically, chronic migraine patients exhibit a decreased NVC ratio in the right precuneus region of the brain, which is linked to migraine severity and psychological factors.
  • The research suggests that NVC measures, especially in the right precuneus, could potentially serve as imaging biomarkers to distinguish between episodic and chronic migraines and help in understanding migraine progression.]

Top posts

Most liked on X and Bluesky
International Headache Society
@ihs_official · X

New in Cephalalgia! Abnormal neurovascular coupling (NVC) in the precuneus was involved in migraine chronification, with depression serving as a mediator in this process. NVC metric may serve as a biomarker for migraine chronification in the future https://t.co/Q3wmIAHwBW https://t.co/ldXk26GKhu

Dec 2, 2025 · 5 likes · 4 shares · 8,483 followers View post →
Cephalalgia
@JCephalalgia · X

New in Cephalalgia! Abnormal neurovascular coupling (NVC) in the precuneus was involved in migraine chronification, with depression serving as a mediator in this process. NVC metric may serve as a biomarker for migraine chronification in the future https://t.co/M3Vw0Ysdm6 https://t.co/NAEkQH98bq

Dec 2, 2025 · 1 like · 3,941 followers View post →
د.مطر أحمد السهيمي
@MatarAlsehemi · X

RT @ihs_official: New in Cephalalgia! Abnormal neurovascular coupling (NVC) in the precuneus was involved in migraine chronification, with…

Dec 2, 2025 · 4 shares · 227 followers View post →
Rosario Corio
@CorioRosario · X

RT @ihs_official: New in Cephalalgia! Abnormal neurovascular coupling (NVC) in the precuneus was involved in migraine chronification, with…

Dec 3, 2025 · 4 shares · 17 followers View post →
MedAprimoramento
@MedAprimora · X

RT @ihs_official: New in Cephalalgia! Abnormal neurovascular coupling (NVC) in the precuneus was involved in migraine chronification, with…

Dec 4, 2025 · 4 shares · 6 followers View post →
Aysha Siddika
@SiddikAysha · X

RT @ihs_official: New in Cephalalgia! Abnormal neurovascular coupling (NVC) in the precuneus was involved in migraine chronification, with…

Dec 2, 2025 · 4 shares · 2 followers View post →

All mentions

MedAprimoramento
@MedAprimora · X

RT @ihs_official: New in Cephalalgia! Abnormal neurovascular coupling (NVC) in the precuneus was involved in migraine chronification, with…

Dec 4, 2025 · 4 shares · 6 followers View post →
Rosario Corio
@CorioRosario · X

RT @ihs_official: New in Cephalalgia! Abnormal neurovascular coupling (NVC) in the precuneus was involved in migraine chronification, with…

Dec 3, 2025 · 4 shares · 17 followers View post →
د.مطر أحمد السهيمي
@MatarAlsehemi · X

RT @ihs_official: New in Cephalalgia! Abnormal neurovascular coupling (NVC) in the precuneus was involved in migraine chronification, with…

Dec 2, 2025 · 4 shares · 227 followers View post →
Aysha Siddika
@SiddikAysha · X

RT @ihs_official: New in Cephalalgia! Abnormal neurovascular coupling (NVC) in the precuneus was involved in migraine chronification, with…

Dec 2, 2025 · 4 shares · 2 followers View post →
Cephalalgia
@JCephalalgia · X

New in Cephalalgia! Abnormal neurovascular coupling (NVC) in the precuneus was involved in migraine chronification, with depression serving as a mediator in this process. NVC metric may serve as a biomarker for migraine chronification in the future https://t.co/M3Vw0Ysdm6 https://t.co/NAEkQH98bq

Dec 2, 2025 · 1 like · 3,941 followers View post →
International Headache Society
@ihs_official · X

New in Cephalalgia! Abnormal neurovascular coupling (NVC) in the precuneus was involved in migraine chronification, with depression serving as a mediator in this process. NVC metric may serve as a biomarker for migraine chronification in the future https://t.co/Q3wmIAHwBW https://t.co/ldXk26GKhu

Dec 2, 2025 · 5 likes · 4 shares · 8,483 followers View post →
International Headache Society
Facebook

NVC metric may serve as a biomarker for migraine chronification in the future https://journals.sagepub. com/doi/10.1177/03331024251396031 #migraine #headache # ...

Dec 19, 2025 View →
International Headache Society (@IHSheadache) • Facebook
Facebook

NVC metric may serve as a biomarker for migraine chronification in the future https://journals.sagepub. com/doi/10.1177/03331024251396031 #migraine #headache # ...

Dec 19, 2025 View →
Understanding Migraine Chronification through Neurovascular ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2. OCR.

Dec 19, 2025 View →
Congratulations to Dr. Keshet Pardo (Headache Fellow) for her ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Dec 7, 2025 View →
Unlocking Brain Patterns: Altered Networks in Migraines
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Dec 5, 2025 View →
International - New in Cephalalgia! New Austrian Network for ...
Facebook

https://journals.sagepub. com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience · May be a graphic of ...

Dec 4, 2025 View →
Austrian Medical Network Sets Standard for Brain Pressure Care
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Dec 4, 2025 View →
International - New in Cephalalgia! Abnormal neurovascular ...
Facebook

... 10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience | Facebook. Log in. Facebook. May be a graphic of blueprint ...

Dec 2, 2025 View →
New in Cephalalgia! Abnormal neurovascular coupling (NVC) in the ...
Facebook

... 10.1177/03331024251396031 #migraine ... com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience.

Dec 2, 2025 View →
New in Cephalalgia! A substantial variety exists in definitions used ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Dec 1, 2025 View →
Advances in Migraine Care – Anti-CGRP Therapies Prof. Simona ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. 5 days ago.

Nov 28, 2025 View →
Predicting Migraine Attacks with Machine Learning: A Breakthrough ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Nov 27, 2025 View →
New in Cephalalgia! The Committee plans to consider further ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Nov 25, 2025 View →
Revolutionize Migraine Treatment: Long-Term Study Reveals Key ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Nov 24, 2025 View →
New ICOP 2.0 Classification System for Orofacial Pain
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Nov 20, 2025 View →
New in Cephalalgia! Higher Selenium levels are associated with a ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Nov 20, 2025 View →
New in Cephalalgia! This review explores how monogenic disorders ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Nov 19, 2025 View →
@JCephalalgia Editor's @Simona_Sacco_ Recognition #Essential ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Nov 9, 2025 View →
New In Cephalalgia! New migraine associated risk of stroke score ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Nov 3, 2025 View →
New in Cephalalgia! This study showed a pattern of increasing ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Oct 29, 2025 View →
New Study on Migraine Treatment Wins Recognition from ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. 5 days ago.

Oct 27, 2025 View →
Migraine Treatment Breakthrough: Rimegepant's Safety and ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Oct 24, 2025 View →
Understanding Migraine Pathophysiology and Treatment Options
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. 5 days ago.

Oct 21, 2025 View →
New Research Uncovers Unique Brain Patterns in Visual Snow ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Oct 20, 2025 View →
New in Cephalalgia! Atogepant treatment demonstrated statistically ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Oct 20, 2025 View →
New in Cephalalgia! Letter to the Editor Complementary, but not ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Oct 17, 2025 View →
Switching CGRP-mAbs May Pose Rare Allergic Risks for Migraine ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Oct 8, 2025 View →
Understanding the Link Between Migraines and Sensory Sensitivity
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Oct 7, 2025 View →
New in Cephalalgia! Non-invasive stimulation of the vagus nerve is ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Oct 5, 2025 View →
Unlock the Safety and Effectiveness of Atogepant for Migraine ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Oct 3, 2025 View →
New in Cephalalgia! Preclinical and clinical evaluation of ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Oct 2, 2025 View →
Opning af ATP-sensitve potassium kanaler aktiverer meningeale ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Sep 30, 2025 View →
Understanding Adrenomedullin Levels in Migraine: A Study Update
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Sep 29, 2025 View →
Visual Snow Syndrome vs. Migraine Aura: Latest Research Insights
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Sep 13, 2025 View →
New perspectives on migraine and the brain Deciphering the ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Sep 12, 2025 View →
PACAP versus CGRP in migraine: Bridging basic science and ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. 6 days ago.

Sep 11, 2025 View →
Predicting Outcomes After MVD: Understanding Diffusion Tensor ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Aug 27, 2025 View →
Comparing Migraine Treatments: Rimegepant vs Oral Triptans
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Aug 15, 2025 View →
New in Cephalalgia ADGRL3 gene was associated with both ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Aug 4, 2025 View →
New in Cephalalgia A post-hoc analysis of a phase 2/3, open-label ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2 · Sign up ...

Jul 31, 2025 View →
New in Cephalalgia! How does migraine with aura (MA) alter brain ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2.

Jul 22, 2025 View →
Throwback Thursday! Do you remember iHEAD 2023 in Seoul? We ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. 6 days ago.

Jul 10, 2025 View →
If you missed the incredibly informative webinar held by Dr. Atif Zafar ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2 · air106 ...

Jul 4, 2025 View →
This letter is presented as a thought experiment—grounded in ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. 5 days ago.

Apr 22, 2025 View →
International - Is Migraine an Evolutionary Mismatch? A new article ...
Facebook

https://journals.sagepub. com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience · May be a graphic of ...

Apr 18, 2025 View →
Fremanezumab treatment was effective and safe for patients with ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. 5 days ago.

Apr 11, 2025 View →
Migraine aura is one of the most fascinating subjects. @michele ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. 6 days ago.

Mar 23, 2025 View →
Using three mouse models, this study examined the impact of ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. 5 days ago.

Mar 11, 2025 View →
February's Editor's Choice We are pleased to announce and ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. 2 days ago.

Mar 3, 2025 View →
International - "The prevalence of IIH is high (27%) in the chronic ...
Facebook

https://journals.sagepub. com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience · May be a graphic of ...

Oct 22, 2024 View →
Two cases of female patients with chronic migraine who both ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. December 2. baap.uk.

Jun 27, 2024 View →
Special Topical Collection is now open for submission "Advancing ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. 17 hours ago.

May 6, 2024 View →
Efficacy of CGRP receptor antagonists (i.e., gepants) for treatment of ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. 7 days ago.

Apr 8, 2024 View →
The traditional IHS football (soccer?) match between Europe vs Rest ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. 3 days ago.

Feb 22, 2024 View →
How many people have migraine in the world? Based on the Global ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. 5 days ago.

Dec 2, 2021 View →
The answer to the #Sundayquiz is C. According to ICHD-3 criteria ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. 6 days ago.

Nov 15, 2021 View →
Frequency and intensity predictors of COVID-19 related headache ...
Instagram

https://journals.sagepub.com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience. more. 4 days ago.

Nov 28, 2020 View →
International Headache Society - Do you know ICHD-3 also include ...
Facebook

https://journals.sagepub. com/doi/10.1177/03331024251396031 #migraine #headache #brain #pain #neurology #neuroscience · May be a graphic of ...

Oct 13, 2020 View →