Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial.
The group of mentions collectively demonstrates high agreement on the positive findings of the ACHIEVE-3 trial, with tone emphasizing innovations like the oral small-molecule GLP-1 receptor agonist. For example, many mentions describe orforglipron as 'more effective' and highlight its potential to replace injections, reflecting both high interest and perceived impact. The detailed comparison of HbA1c reductions and safety concerns indicates deep engagement and broad recognition of its potential to change treatment paradigms.
AgreementStrong agreement
Many mentions highlight that orforglipron was non-inferior or superior to semaglutide, reflecting strong support for the study results.
InterestHigh interest
Mentions use phrases like 'innovative,' 'breakthrough,' and compare efficacy directly, indicating high engagement and curiosity.
EngagementHigh engagement
Mentions include detailed comparisons of HbA1c reductions and safety profiles, showing deep analysis and aligned discussion of methods and implications.
ImpactHigh impact
Numerous mentions cite the approval and superior results, suggesting significant influence on treatment options and clinical practice.
Abstract in brief
The study found that both doses of orforglipron (12 mg and 36 mg) demonstrated non-inferiority to their respective doses of oral semaglutide (7 mg and 14 mg) in reducing HbA1c levels after 52 weeks in adults with type 2 diabetes, with mean changes from a baseline HbA1c of 8·3% being -1·71% and -1·91% for orforglipron doses compared to -1·23% and -1·47% for semaglutide, respectively.
The primary goal was to see if orforglipron was not worse than semaglutide by more than 0·3% in HbA1c reduction, and the results confirmed this non-inferiority, with estimated treatment differences of about -0·48% favoring semaglutide.
The safety profile of orforglipron was consistent with what is expected for such treatments, using data from all participants who received at least one dose, but specific safety outcomes are not detailed in the provided excerpt.]
Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial https://t.co/MvJPOzDZoM https://t.co/lRLjvgA5v7
Mar 20, 2026 · 24 likes · 8 shares · 8,201 followersView post →
大筋
大坂貴史?糖尿病内科医?筋肉博士
@muscle_penguin_ · X
(626/347) #論文マラソン
オルフォルグリプロン(傾向GLP-1RA) VS 経口セマグルチドと比較することです。
ACHIEVE-3
52週間RCT
HbA1c・体重の平均変化量はオルフォルグリプロンが非劣勢・優勢だった。
有害事象による試験治療はオルフォルグリプロン群の方が多かった。
https://t.co/Yop4xoKWq0
Mar 7, 2026 · 13 likes · 2 shares · 40,572 followersView post →
AM
Ahmed Bennis MD ?
@drbennisahmed · X
Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial
In individuals with type 2 diabetes inadequately controlled with metformin, orforglipron 12 mg and 36 mg was non-inferior and superior to semaglutide 7 mg and 14 mg with respect to the mean change in HbA1c from baseline to 52 weeks.
#Cardiology #MedTwitter #CardioTwitter #HeartHealth #Healthcare
@DLBHATTMD @CMichaelGibson @TheLancetEndo @TheLancet @iamritu @hvanspall @DrMarthaGulati
https://t.co/ah5Q0eEO3e
Feb 27, 2026 · 13 likes · 4 shares · 5,878 followersView post →
RD
redGDPS Diabetes
@redGDPS · X
➡️@PubMedOnline
Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with DM2 (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial
Julio Rosenstock et al. Lancet. 2026.
https://t.co/V3o8itAu44 https://t.co/sQCIkNExF1
"Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial."
Publié ce jour dans @thelancet.com
#medSky #EndoSky
www.thelancet.com/journals/lan...
The study found that both doses of orforglipron demonstrated non-inferiority to oral semaglutide in reducing HbA1c levels after 52 weeks in adults with type 2 diabetes. The safety profile was consistent with…
The oral GLP-1 pill orforglipron (Foundayo) outperformed oral semaglutide in blood sugar control and weight reduction during the ACHIEVE-3 trial. However, tolerability issues and lack of cardiovascular data are…
The FDA approved the oral GLP-1 medication orforglipron (Foundayo) on April 1, 2026. This first oral GLP-1 tablet requires no food, water, or timing restrictions. Clinical trials show it is as effective as semaglutide…
Orforglipron is now FDA-approved as Foundayo, making it one of the first serious oral small-molecule GLP-1 weight loss medications. In this video, we analyze how it functions, compare it to injectable GLP-1 agonists…
This study evaluates the efficacy and safety of once-daily oral orforglipron compared to oral semaglutide. Both doses of orforglipron demonstrated non-inferiority in reducing HbA1c levels over 52 weeks, supporting its…
Orforglipron (Foundayo), an oral GLP-1 agonist, has now been approved, marking a significant advancement in weight loss therapies. Unlike other formulations, it is a non-peptide small-molecule drug that offers potential…
Both doses of orforglipron demonstrated non-inferiority to oral semaglutide in reducing HbA1c levels over 52 weeks, with similar safety profiles. This study highlights the efficacy, tolerability, and potential clinical…
Orforglipron, a small molecule oral GLP-1 receptor agonist, offers advantages over peptide-based semaglutide, including better absorption and production. The ACHIEVE-3 trial shows non-inferiority in HbA1c reduction…
➡️@PubMedOnline
Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with DM2 (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial
Julio Rosenstock et al. Lancet. 2026.
https://t.co/V3o8itAu44 https://t.co/sQCIkNExF1
Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial - The Lancet https://t.co/Gnwi4OVmlH - amazing and I think it's soon
Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial - The Lancet www.thelancet.com/journals/lan...
RT @DiegoBellido2: Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIE…
Mar 22, 2026 · 8 shares · 871 followersView post →
JE
Juan Carlos Elizalde:.?????⚕️??
@JuanElizalde777 · X
RT @DiegoBellido2: Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIE…
Mar 21, 2026 · 8 shares · 2,436 followersView post →
DV
Dr. Ashwin Pachaatt Vinod
@pachaatt · X
RT @DiegoBellido2: Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIE…
Mar 21, 2026 · 8 shares · 974 followersView post →
BM
BaladoCritique : club de lecture médical
@baladocritique.bsky.social · Bluesky
"Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial."
Publié ce jour dans @thelancet.com
#medSky #EndoSky
www.thelancet.com/journals/lan...
RT @DiegoBellido2: Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIE…
Mar 21, 2026 · 8 shares · 4,943 followersView post →
MT
Martín López de la Torre
@elendocrino · X
RT @DiegoBellido2: Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIE…
Mar 21, 2026 · 8 shares · 2,967 followersView post →
DB
Diego Bellido
@DiegoBellido2 · X
Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial https://t.co/MvJPOzDZoM https://t.co/lRLjvgA5v7
Mar 20, 2026 · 24 likes · 8 shares · 8,201 followersView post →
CT
Camilo J. Llamoza-Torres
@CamiloJT · X
Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial - The Lancet https://t.co/qysmWVGMtz
[Articles] Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial https://t.co/wdP4FiFa6I
RT @drbennisahmed: Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIE…
Feb 28, 2026 · 4 shares · 33,355 followersView post →
RM
Ritu Thamman MD
@iamritu · X
RT @drbennisahmed: Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIE…
Feb 27, 2026 · 4 shares · 32,438 followersView post →
AM
Ahmed Bennis MD ?
@drbennisahmed · X
Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial
In individuals with type 2 diabetes inadequately controlled with metformin, orforglipron 12 mg and 36 mg was non-inferior and superior to semaglutide 7 mg and 14 mg with respect to the mean change in HbA1c from baseline to 52 weeks.
#Cardiology #MedTwitter #CardioTwitter #HeartHealth #Healthcare
@DLBHATTMD @CMichaelGibson @TheLancetEndo @TheLancet @iamritu @hvanspall @DrMarthaGulati
https://t.co/ah5Q0eEO3e
Feb 27, 2026 · 13 likes · 4 shares · 5,878 followersView post →
expert reaction to ACHIEVE-3 trial results about efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes
www.sciencemediacentre.org/expert-react...
expert reaction to ACHIEVE-3 trial results about efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes
https://t.co/3IxXlMkRVg
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