Several mentions, such as the articles and social discussions, emphasize the significance of the ATTAIN-MAINTAIN trial, highlighting that oral orforglipron can maintain a large portion (75-79%) of weight loss after stopping injectable treatments, with tone and wording expressing optimism. The use of terms like 'game-changer' and references to regulatory approval support the high impact, while phrases like 'promising' and detailed mention of study results reflect strong interest and engagement.
AgreementStrong agreement
Many mentions praise the trial results and the efficacy of orforglipron in maintaining weight loss, with some highlighting its potential to be a game-changer.
InterestHigh interest
The discussions cover key points like weight maintenance after injectable treatments and the drug's oral form, indicating high curiosity and relevance.
EngagementModerate engagement
While many mentions are informative and discuss study results and implications, they tend to be more descriptive than deeply analytical, hence a slightly lower engagement score.
ImpactHigh impact
Mentions frequently cite significant study findings, approval processes, and potential to change obesity treatment, indicating high overall impact on medical practice and public perception.
Abstract in brief
Orforglipron, an oral GLP-1 receptor agonist, was effective in maintaining significant body weight reduction in participants previously treated with tirzepatide or semaglutide, with treatment differences at week 52 of 25.5% and 41.7% of weight loss compared to placebo, respectively, both statistically significant (P < 0.001).
Participants who achieved a weight plateau maintained approximately 74.7% and 79.3% of their weight loss with orforglipron, versus 49.2% and 37.6% with placebo, indicating sustained effectiveness over one year.
The most common adverse events were mild to moderate gastrointestinal effects, supporting orforglipron's safety profile, although the study noted limitations such as the lack of comparison with continued injectable treatments and its 1-year duration.
Two new randomized studies just published
@naturemedicine.bsky.social
for weaning from injectable GLP-1 drugs to maintain weight loss
—Pill, orforglipron nature.com/articles/s41...
—Bacterial supplement for modulating the gut microbiome nature.com/articles/s41...
https://t.co/kAKkIh1WxA Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial #ECO2026 https://t.co/MCxE3lwv8J
May 13, 2026 · 27 likes · 8 shares · 17,797 followersView post →
【注目HL】医学:体重減少後の維持に役立つ可能性のある戦略
https://t.co/i7z8Sc9PWL
Louis Aronneらの@NatureMedicine #OA #論文
Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial
https://t.co/HVTgV7pqnn
#オープンアクセス https://t.co/71WbxjI50J
Jun 29, 2026 · 6 likes · 2 shares · 91,459 followersView post →
NJ
Nature Japan
@NatureJapan · X
【注目HL】医学:体重減少後の維持に役立つ可能性のある戦略
https://t.co/i7z8Sc9PWL
Louis Aronneらの@NatureMedicine #OA #論文
Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial
https://t.co/HVTgV7pqnn
#オープンアクセス https://t.co/QieHUg9D8w https://t.co/PkByRua9YQ
Oct 14, 2026 · 5 likes · 91,459 followersView post →
NJ
Nature Japan
@NatureJapan · X
【注目HL】医学:体重減少後の維持に役立つ可能性のある戦略
https://t.co/i7z8ScanMj
Louis Aronneらの@NatureMedicine #OA #論文
Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial
https://t.co/HVTgV7pYcV
#オープンアクセス https://t.co/nzsBtTtvR8
May 16, 2026 · 4 likes · 91,459 followersView post →
Planning to stop Wegovy or Zepbound? This video outlines a five-step plan based on clinical trial data to help maintain weight loss after discontinuing GLP-1 medications, including dose management, setting regain…
Weissenberg et al. present the first pivotal study on the oral GLP-1 receptor agonist, orforglipron, showing its ability to sustain weight loss after stopping injectable treatments. The 52-week trial highlights its…
Orforglipron, an oral GLP-1 receptor agonist, effectively maintains significant weight loss over one year in participants previously treated with tirzepatide or semaglutide. The trial highlights its potential safety and…
Emagrecer com uma caneta e depois manter o resultado com um comprimido: onde termina a expectativa e começa a evidência? Nesta análise, o orforglipron, um agonista oral do receptor de GLP-1, mostrou eficácia na…
"비만 주사 끊었다고 요요 와서 날 또 부풀리면 어떡해!" Recent scientific breakthroughs reveal two effective methods to prevent weight regain after dieting. These include an oral medication called orforglipron and beneficial gut bacteria to…
Orforglipron, now FDA-approved under the name Foundayo, offers a new oral option for weight loss maintenance. This video reviews how it compares to injectable GLP-1 medications like semaglutide and tirzepatide, and…
Weight maintenance is a challenging topic for both clinicians and patients. This episode features insights from Dr. Neil Skolnik and Dr. Jamie Almondoz on toxic narratives in weight loss and the latest strategies for…
Welcome to the latest episode of DOC Updates, reviewing recent research on diabetes, obesity, and cardiometabolic health. Key studies include CagriSema and Retatrutide efficacy, CGM benefits beyond insulin users, and…
Until when I have to use the weight loss pen? This question is common among those considering or using obesity treatments. Obesity is a chronic disease, often requiring prolonged therapy. Stopping treatment can lead to…
Full appraisal: https://youtu.be/t3gFmGmUYkE ATTAIN-MAINTAIN is a phase 3b RCT examining whether oral GLP-1 receptor agonist orforglipron can sustain weight loss post tirzepatide or semaglutide treatment. Over 52 weeks…
ATTAIN-MAINTAIN is a phase 3b trial assessing whether oral GLP-1 receptor agonist orforglipron can preserve weight loss achieved with tirzepatide or semaglutide. After 52 weeks, orforglipron maintained significantly…
Orforglipron, an oral GLP-1 receptor agonist, was effective in maintaining significant body weight reduction over one year. Participants retained around 75-79% of their weight loss, offering a safe and convenient…
This video reviews the first head-to-head randomized trial comparing tirzepatide and semaglutide for weight loss in adults without diabetes. It discusses 72-week results, the significance of findings, and critical study…
Can oral orforglipron preserve weight loss after stopping tirzepatide or semaglutide? The Phase 3b ATTAIN-MAINTAIN trial found that selected adults maintained around 75-79% of their weight reduction over 52 weeks, with…
【注目HL】医学:体重減少後の維持に役立つ可能性のある戦略
https://t.co/i7z8Sc9PWL
Louis Aronneらの@NatureMedicine #OA #論文
Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial
https://t.co/HVTgV7pqnn
#オープンアクセス https://t.co/QieHUg9D8w https://t.co/PkByRua9YQ
Oct 14, 2026 · 5 likes · 91,459 followersView post →
NP
Nature Asia-Pacific
@NatureAsia · X
Medicine: Strategies that may help keep weight off
https://t.co/A6JvD0xnWg
@NatureMedicine #OA #OpenAccess by Louis J. Aronne
Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial
https://t.co/j7trEh56ri
@weillcornell https://t.co/rwQaEkylll https://t.co/Qe6OVM9531
Oct 14, 2026 · 3 likes · 1 share · 3,316 followersView post →
MN
Metabolic Nurse
@metabolicnurse · X
Coming off tirzepatide or semaglutide didn't erase the weight loss. A year later in ATTAIN-MAINTAIN, placebo had kept roughly a third to a half of it; oral orforglipron held 75-79%. No arm continued the shot, a key limit. https://t.co/72fWgZzeTn
【注目HL】医学:体重減少後の維持に役立つ可能性のある戦略
https://t.co/i7z8Sc9PWL
Louis Aronneらの@NatureMedicine #OA #論文
Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial
https://t.co/HVTgV7pqnn
#オープンアクセス https://t.co/71WbxjI50J
Jun 29, 2026 · 6 likes · 2 shares · 91,459 followersView post →
NP
Nature Asia-Pacific
@NatureAsia · X
Medicine: Strategies that may help keep weight off
https://t.co/A6JvD0xVLO
@NatureMedicine #OA #OpenAccess by Louis J. Aronne
Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial
https://t.co/j7trEh5EgQ
@weillcornell https://t.co/KRXGO79kEe
Orforglipron, an oral GLP-1 receptor agonist, shown effective for weight loss during ATTAIN-MAINTAIN trial with phase 3b results. PMID:42120723, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04386-7 #Medsky #Pharmsky #RNA #ASHG #ESHG ?
RT @CristobMorales: https://t.co/kAKkIh1WxA Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b AT…
May 21, 2026 · 8 shares · 888 followersView post →
NJ
Nature Japan
@NatureJapan · X
【注目HL】医学:体重減少後の維持に役立つ可能性のある戦略
https://t.co/i7z8ScanMj
Louis Aronneらの@NatureMedicine #OA #論文
Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial
https://t.co/HVTgV7pYcV
#オープンアクセス https://t.co/nzsBtTtvR8
May 16, 2026 · 4 likes · 91,459 followersView post →
NP
Nature Asia-Pacific
@NatureAsia · X
Medicine: Strategies that may help keep weight off
https://t.co/A6JvD0xnWg
@NatureMedicine #OA #OpenAccess by Louis J. Aronne
Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial
https://t.co/j7trEh56ri
@weillcornell https://t.co/0thvC1lpzs
Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial | Nature Medicine?✅ https://t.co/oiTYVUGRnP
?️ Obesity Treatment · ? peptide, Tirzepatide
? Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial
? Louis J. Aronne, Deborah B. Horn, Carel W. le Roux
? 2026-05-12 · Nature Medicine
? Summary:
Orforglipron, a once-daily oral medication, helped people maintain weight loss over 52 weeks, with 74.7-79.3% of weight reduction maintained compared to 49.2-37.6% with a placebo. This was observed in two cohorts of participants who had previously achieved weight loss with other medications.
? Consider talking to your doctor about orforglipron if you have lost weight and are looking for a medication to help maintain your weight loss.
? AI Analysis:
Breaking news in obesity treatment: a new oral medication called orforglipron has been shown to help people maintain weight loss over time. This could be a game-changer for those strugg
Strategies for maintaining weight lost following injectable treatment or via dieting are described in two unrelated randomised controlled trials published in @natmed.nature.com. spklr.io/63325EzggV and spklr.io/63328Ezggk
#medsky ?⚕️
Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial https://t.co/1VXiYHHdcS The next big thing? And some media: https://t.co/j7FRYGhUQQ "Daily pill to help keep weight off after stopping obesity jabs"
https://t.co/kAKkIh1WxA Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial #ECO2026 https://t.co/MCxE3lwv8J
May 13, 2026 · 27 likes · 8 shares · 17,797 followersView post →
CA
Climate, Ecology, War & More: Dr. Glen Barry BigEarthData.ai
@bigearthdata.ai · Bluesky
Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial
->Nature | More on "Orforglipron weight loss maintenance trial" at BigEarthData.ai
Two new randomized studies just published
@naturemedicine.bsky.social
for weaning from injectable GLP-1 drugs to maintain weight loss
—Pill, orforglipron nature.com/articles/s41...
—Bacterial supplement for modulating the gut microbiome nature.com/articles/s41...
Louis J. Aronne, M.D. at Comprehensive Weight Control Center
News
Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial. May 13, 2026. Tirzepatide for maintenance ...
Foundayo for weight-loss maintenance after GLP injection
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Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial, Nat Med (2026) [PubMed abstract] ...
Louis J. Aronne's research works | Weill Cornell Medicine, New York ...
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Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial · Article · Full-text available. May 2026. ·.
Publications and Events - Weill Center for Metabolic Health
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Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial. Nat Med. (2026) Epub ahead of print ...
Medical treatments for obesity: what does the future have in store?
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, et al. Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial . Nat Med . 2026. ;. 32. (. 7. ):.
Can oral weight-loss medications help you maintain weight loss ...
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Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial. Nature Medicine, 32(7), 2679-2687 ...
Weight Loss Injections UK | Appetite Suppressant Treatment
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... Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial. Nature Medicine. Available from https ...
The following authors, editors, and contributors to the publication were employees of, consultants to, or received compensation from Lilly: Louis J. Aronne, ...
10.1038/s41591-026-04386-7. Contributors: Louis J. Aronne; Deborah B. Horn; Carel W. le Roux; Ariana M. Chao; Wayne Ho; Bruno Halpern; Ryan Griffin; Cathy ...
Tackling obesity as a brain disease - University College Dublin
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NATURE MEDICINE 10.1038/s41591-026-04386-7; Franks, PW; Suliman, SGI; Timpson ... NATURE MEDICINE 10.1038/s41591-026-04363-0; le Roux, CW; Wharton, S ...
Adaptive maintenance after incretin-induced weight loss
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), 10.1038/s41591-026-04386-7 · Google Scholar. [12]. T.A. Wadden, P. Hollander, S. Klein, K. Niswender, V. Woo, P.M. Hale, L. Aronne. Weight maintenance and ...
can oral orforglipron maintain all the weight loss following glucagon ...
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doi:10.1038/s41591-026-04386-7. ATTAIN-MAINTAIN directly examines whether oral orforglipron can preserve weight loss after discontinuation of injectable GLP ...
Full article: Keeping the weight off: can oral orforglipron maintain all ...
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doi:10.1038/s41591-026-04386-7. (Open in a new window)Web of Science ®(Open ... Stevens J, Truesdale KP, McClain JE, Cai J. The definition of weight maintenance.
https: //doi.org/10.1038/s41591-026-04386-7 3. Kansakar, U., Jankauskas, S. S., Pande, S., et al. (2026). Orforglipron: A comprehensive review of an oral ...
How to Switch Between Different GLP-1s for Weight Loss, According ...
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Orforglipron for Maintenance of Body Weight Reduction: The Double-Blind, Randomized Phase 3b ATTAIN-MAINTAIN Trial. Nature Medicine. May 13, 2026. SHARE ...
DOI: 10.1038/s41591-026-04386-7. Study Question Can once-daily oral orforglipron maintain weight-loss benefits in individuals who have achieved a weight ...