Nat Commun August 2026 PMID 42802176

Disitamab vedotin for HER2-positive breast cancer with liver metastases: phase 3 results from the RC48-C006 phase 2/3 trial.

Jiayu Wang, Quchang Ouyang, Weimin Xie, Zhaofeng Niu, Qingyuan Zhang, Xi Yan, Yue'e Teng, Jianying Chang, Ying Cheng, Airong Wang, Jingfen Wang, Herui Yao, Zhuangqing Yang, Tao Sun, Zhongsheng Tong

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Mentions

10
Peak: 2 in Sep 2026
across 3 sources since Aug 2026

Extended reach

200
potential audience

Total likes

1

Video views

101

Mentions per month

Aug 2026 – Sep 2026

Where it's discussed

  • News8 articles
  • YouTube1 videos
  • Blogs1 articles

AI synopsis

What people are saying

Many mentions, such as the Bioengineering blog and scientific articles, express strong agreement with the significance of disitamab vedotin's promising trial results. The tone is enthusiastic, with references to reshaping treatment and survival benefits, supporting high interest and impact; the detailed discussion of trial data and implications signifies deep engagement.

AgreementStrong agreement

Most mentions highlight the positive results of the phase 3 trial and the potential of disitamab vedotin, indicating strong overall agreement with the article's findings.

InterestHigh interest

The mentions frequently emphasize new treatment options and clinical trial results, which suggest high public and scientific interest.

EngagementHigh engagement

Discussions include details about trial data, mechanisms, and significance, showing deep engagement.

ImpactHigh impact

Mentions discuss how the drug could reshape treatment for HER2-positive breast cancer with liver metastases, indicating high impact.

Abstract in brief

  • Disitamab vedotin significantly improved progression-free survival (PFS) in patients with HER2-positive breast cancer with liver metastases, with a median PFS of 9.9 months compared to 4.9 months for lapatinib plus capecitabine, and a hazard ratio of 0.56 (95.48% CI, 0.35-0.91; P = 0.01).
  • The safety profile was similar between both groups, with grade ≥3 treatment-related adverse events occurring in 37.7% of patients treated with disitamab vedotin and 36.0% with lapatinib plus capecitabine.
  • These results support disitamab vedotin as a promising treatment option for HER2-positive breast cancer with liver metastases after prior trastuzumab and taxane therapy.

All mentions

Qingyuan Zhang's research works | Harbin Medical University ...
News

Qingyuan Zhang's 475 research items with 14770 citations and 3184 reads, including: Disitamab vedotin for HER2-positive breast cancer with liver metastases: ...

Oct 16, 2026 View →
Binghe Xu's research works | Cancer Institute and Hospital, Chinese ...
News

Disitamab vedotin for HER2-positive breast cancer with liver metastases: phase 3 results from the RC48-C006 phase 2/3 trial · Article · Full-text available.

Oct 16, 2026 View →
Overall survival among patients with breast cancer and liver ...
News

Disitamab vedotin for HER2-positive breast cancer with liver metastases: phase 3 results from the RC48-C006 phase 2/3 trial. Article. Full-text available. Aug ...

Oct 16, 2026 View →
Lapatinib plus Capecitabine for HER2-Positive Advanced Breast ...
News

... y del receptor del factor de crecimiento epidérmico (EGFR), es activo ... https://doi.org/10.1038/s41467-026-75733-y · Crossref. Kathrine Vandraas,; Bjørn ...

Oct 16, 2026 View →
HER2-positiver Brustkrebs mit Lebermetastasen: Disitamab Vedotin ...
News

Das berichtet eine chinesische Arbeitsgruppe in der Fachzeitschrift Nature Communications (2026, DOI: 10.1038/s41467-026-75733-y).

Sep 22, 2026 View →
Disitamab vedotin shows phase 3 benefit in HER2-positive breast ...
Blogs

https://doi.org/10.1038/s41467-026-75733-y. Image Credits: AI Generated. DOI: 10.1038/s41467-026-75733-y. Keywords: disitamab vedotin, HER2 ...

Sep 8, 2026 View →
कैंसर के खिलाफ नया हथियार: Disitamab Vedotin के फेज़ 3 ट्रायल का सच
YouTube

... Disitamab vedotin for HER2-positive breast cancer with liver metastases: phase 3 results from the RC48-C006 phase 2/3 trial Journal: Nature ...

Aug 27, 2026 View →
Breast Cancer Symptoms - MedlinePlus
News

Article: Disitamab vedotin for HER2-positive breast cancer with liver metastases: phase 3... Breast Cancer -- see more articles. Reference ...

Aug 3, 2026 View →
Liver Cancer | Hepatocellular Carcinoma - MedlinePlus
News

Article: Disitamab vedotin for HER2-positive breast cancer with liver metastases: phase 3... Article: Comparison of Remimazolam and Propofol ...

Nov 22, 2025 View →
Lapatinib plus Capecitabine for HER2-Positive Advanced Breast ...
News

https://doi.org/10.1038/s41467-026-75733-y · Crossref. Kathrine Vandraas,; Bjørn Naume,; Anna Sætersdal,; Egil Blix,. HER2-positiv brystkreft ...

Dec 28, 2006 View →