Many mentions, such as the Bioengineering blog and scientific articles, express strong agreement with the significance of disitamab vedotin's promising trial results. The tone is enthusiastic, with references to reshaping treatment and survival benefits, supporting high interest and impact; the detailed discussion of trial data and implications signifies deep engagement.
AgreementStrong agreement
Most mentions highlight the positive results of the phase 3 trial and the potential of disitamab vedotin, indicating strong overall agreement with the article's findings.
InterestHigh interest
The mentions frequently emphasize new treatment options and clinical trial results, which suggest high public and scientific interest.
EngagementHigh engagement
Discussions include details about trial data, mechanisms, and significance, showing deep engagement.
ImpactHigh impact
Mentions discuss how the drug could reshape treatment for HER2-positive breast cancer with liver metastases, indicating high impact.
Abstract in brief
Disitamab vedotin significantly improved progression-free survival (PFS) in patients with HER2-positive breast cancer with liver metastases, with a median PFS of 9.9 months compared to 4.9 months for lapatinib plus capecitabine, and a hazard ratio of 0.56 (95.48% CI, 0.35-0.91; P = 0.01).
The safety profile was similar between both groups, with grade ≥3 treatment-related adverse events occurring in 37.7% of patients treated with disitamab vedotin and 36.0% with lapatinib plus capecitabine.
These results support disitamab vedotin as a promising treatment option for HER2-positive breast cancer with liver metastases after prior trastuzumab and taxane therapy.
Disitamab Vedotin significantly improved progression-free survival in HER2-positive breast cancer patients with liver metastases, showing a median PFS of 9.9 months compared to 4.9 months with lapatinib plus…
Qingyuan Zhang's research works | Harbin Medical University ...
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Qingyuan Zhang's 475 research items with 14770 citations and 3184 reads, including: Disitamab vedotin for HER2-positive breast cancer with liver metastases: ...
Binghe Xu's research works | Cancer Institute and Hospital, Chinese ...
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Disitamab vedotin for HER2-positive breast cancer with liver metastases: phase 3 results from the RC48-C006 phase 2/3 trial · Article · Full-text available.
Overall survival among patients with breast cancer and liver ...
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Disitamab vedotin for HER2-positive breast cancer with liver metastases: phase 3 results from the RC48-C006 phase 2/3 trial. Article. Full-text available. Aug ...
Lapatinib plus Capecitabine for HER2-Positive Advanced Breast ...
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... y del receptor del factor de crecimiento epidérmico (EGFR), es activo ... https://doi.org/10.1038/s41467-026-75733-y · Crossref. Kathrine Vandraas,; Bjørn ...