PubHawk
Cephalalgia March 1983 PMID 6342813

Hangover headache and prostaglandins: prophylactic treatment with tolfenamic acid.

S Kaivola, J Parantainen, T Osterman, H Timonen

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Mentions

4
Peak: 1 in Jun 2012
across 3 sources since Jun 2012

Extended reach

6,065,946
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Total likes

32,539

Video views

6,065,757

Mentions per month

Jun 2012 – Oct 2020

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AI synopsis

What people are saying

The discussion echoes prior findings from Igual and Kaivola et al. about the effectiveness of tolfenamic acid in reducing prostaglandins related to hangovers, using terms like 'alivio' (relief) and referencing biochemical markers, which shows a modest level of interest and understanding without deep engagement or perception of high impact.

AgreementModerate agreement

The discussion references historical research supporting the role of prostaglandins in hangover symptoms, indicating general agreement about the biological basis of the article.

InterestModerate interest

The brief comment reflects moderate interest, mainly focusing on the temperature of prior evidence without deep analysis.

EngagementNeutral engagement

The post shows minimal engagement, mentioning findings but not exploring implications or broader context.

ImpactNeutral impact

The discussion hints at biological mechanisms but does not suggest a significant change or impact stemming from the new research.

Abstract in brief

  • Tolfenamic acid (TA) is a drug that inhibits prostaglandin synthesis and was tested to prevent hangover symptoms in a study with 30 volunteers, showing significant improvement, especially in reducing headaches and other symptoms like nausea and dry mouth.
  • Volunteers took TA or a placebo before drinking alcohol and before bed, and the results showed TA was much more effective than the placebo in alleviating hangover symptoms the next morning.
  • A separate study indicated that TA reduced plasma levels of certain prostaglandins (PGE2 and TXB2) during alcohol intake, and the level of TXB2 was linked to blood alcohol levels, suggesting TA's role in modulating inflammatory responses related to alcohol consumption.]
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Top posts

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Alden Haslam
@haslam_med · X

Igual, Kaivola et al. (1983) reporto un alivio de la resaca con ácido tolfenámico, el cual disminuyó los niveles de PGE2 y tromboxano A2, lo cual proporciona evidencia indirecta del rol de estos mediadores en la resaca. https://t.co/qg0I4hEZlr

Oct 28, 2020 · 180 followers View post →

All mentions

Alden Haslam
@haslam_med · X

Igual, Kaivola et al. (1983) reporto un alivio de la resaca con ácido tolfenámico, el cual disminuyó los niveles de PGE2 y tromboxano A2, lo cual proporciona evidencia indirecta del rol de estos mediadores en la resaca. https://t.co/qg0I4hEZlr

Oct 28, 2020 · 180 followers View post →
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... 10.1046/j. 1468-2982.1983.0301031.x/abstract http://www.sciencedirect. com/science/article/pii/0376871683900169 Congeners: http://psycnet.apa.org/psycinfo ...

Dec 16, 2025 View →