PubHawk
Pharmacol Toxicol February 1995 PMID 7746802

Astra Award Lecture. Adenosine, adenosine receptors and the actions of caffeine.

B B Fredholm

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Mentions

76
Peak: 2 in May 2022
across 5 sources since Jul 2017

Extended reach

2,816,527
potential audience

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67,433

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Jul 2017 – Sep 2024

Where it's discussed

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AI synopsis

What people are saying

Posts display a balanced curiosity about caffeine's neurobiological effects, with some posts explaining how caffeine blocks adenosine, increasing neuronal activity, while others question its broader effects on different neural systems, demonstrating moderate interest and engagement through detailed explanations.

AgreementNeither agree nor disagree

The discussions show varied reactions, with some posts interpreting caffeine's role in neuroactivation, but no strong consensus is evident.

InterestModerate interest

Participants demonstrate moderate interest, especially with posts explaining caffeine's effects on neurotransmitters like dopamine and norepinephrine.

EngagementModerate engagement

Comments include explanations of neural interactions and references to biological mechanisms, indicating a moderate level of engagement.

ImpactNeutral impact

The overall discussions are informative but do not seem to influence or change opinions significantly; impact appears limited.

Abstract in brief

  • Caffeine primarily works by blocking adenosine receptors, specifically A1 and A2a, which are normally activated by adenosine to regulate neuronal activity.
  • Activation of A1 receptors by adenosine reduces neuron firing and neurotransmitter release, while A2a receptors influence dopamine-related pathways, impacting mood and alertness.
  • Caffeine can cause quick changes in gene expression and longer-term adaptive effects, such as neuroprotection and seizure prevention, making it a promising target for drug development.]
Read the full abstract

Top posts

Most liked on X and Bluesky
سعود الشهري
@saud_alshehry_ · X

للاستزادة

May 6, 2022 · 5 likes · 1 share · 175,649 followers View post →
Honey Singh
@honeytech · X

Caffeine help the brain in blocking effects of an inhibitory neurotransmitter called Adenosine. This increases neuronal firing in the brain and the release of other neurotransmitters like dopamine and norepinephrine. https://t.co/78AQIltWH2

May 19, 2020 · 1 like · 15,894 followers View post →
James Pickett
@jamesrpickett · X

@NeckDok @SBakerMD https://t.co/faq5L5BbWe

Jan 27, 2024 · 1 like · 3,127 followers View post →
James M O’Reilly ⚡️
@realjimoreilly · X

@Scott_Spain21 @SBakerMD https://t.co/8r8gcXzx8l

Nov 28, 2023 · 1 like · 894 followers View post →
أبو عبدالعزيز الحربي
@omar1400131 · X

RT @saud_alshehry_: للاستزادة

May 6, 2022 · 1 share · 4,391 followers View post →
Arya Su
@hira__lena · X

https://t.co/bxq2LQukxb 6 https://t.co/werPBAJLEa 7  https://t.co/huwjeIEUYj 8  https://t.co/5LdyWiTV9V 9  https://t.co/k9QYorjOLX

Jul 23, 2023 · 3,135 followers View post →

All mentions

Kevin Corl
@ketovorekevin · X

Is Coffee HARMING Your Carnivore Diet? https://t.co/FGO6ADV3HF via @YouTube

Sep 4, 2024 · 843 followers View post →
James Pickett
@jamesrpickett · X

@NeckDok @SBakerMD https://t.co/faq5L5BbWe

Jan 27, 2024 · 1 like · 3,127 followers View post →
James M O’Reilly ⚡️
@realjimoreilly · X

@Scott_Spain21 @SBakerMD https://t.co/8r8gcXzx8l

Nov 28, 2023 · 1 like · 894 followers View post →
Tomasz M. Gondek
@GondekTM · X

@ParolDamian @cosmicfavoreq Wpływ substancji na jeden układ neuroprzekaźnikowy nie wyklucza jej pośrednich efektów dla innych układów w mózgu. Interakcje między modulowaniem receptorów adenozyny a aktywnością układu dopaminergicznego są znane od dawna, np.: https://t.co/kMDbYdY1oP

Sep 14, 2023 · 652 followers View post →
Arya Su
@hira__lena · X

https://t.co/bxq2LQukxb 6 https://t.co/werPBAJLEa 7  https://t.co/huwjeIEUYj 8  https://t.co/5LdyWiTV9V 9  https://t.co/k9QYorjOLX

Jul 23, 2023 · 3,135 followers View post →
American Carnivore
@2StpsFromHell · X

Is Coffee HARMING Your Carnivore Diet? https://t.co/q37jBVJjz7 via @YouTube

May 19, 2023 · 1,899 followers View post →
أبو عبدالعزيز الحربي
@omar1400131 · X

RT @saud_alshehry_: للاستزادة

May 6, 2022 · 1 share · 4,391 followers View post →
سعود الشهري
@saud_alshehry_ · X

للاستزادة

May 6, 2022 · 5 likes · 1 share · 175,649 followers View post →
Mama Mambo
@mamamamb0 · X

@ValeskaK Hier

Oct 5, 2021 · 462 followers View post →
Honey Singh
@honeytech · X

Caffeine help the brain in blocking effects of an inhibitory neurotransmitter called Adenosine. This increases neuronal firing in the brain and the release of other neurotransmitters like dopamine and norepinephrine. https://t.co/78AQIltWH2

May 19, 2020 · 1 like · 15,894 followers View post →