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The collective discussions strongly reflect opposition to the use of vitamin E and beta carotene supplements in smokers, highlighting large clinical trials that revealed harmful or null effects, such as the mention of the 1994 Finnish study that linked beta-carotene to increased lung cancer risk. The tone is serious and evidence-based, with references to scientific studies and calls for caution, which underscore the perceived importance and high impact of the research findings in guiding public health decisions.
Most discussions concur that the reported research shows no benefits from taking vitamin E and beta carotene supplements for smokers, with several explicitly mentioning the trial results indicating potential harm.
The posts demonstrate high curiosity by referencing specific studies, such as the large-scale trials from the 1990s and recent experiments, and emphasize the ongoing relevance of these findings.
Many users deeply analyze the implications, citing detailed trial data, discussing possible biological mechanisms, and contrasting supplement use with dietary intake, indicating a comprehensive engagement with the research.
The discussions suggest a consensus that these findings have major health implications, warning against supplement use among smokers and emphasizing the potential risks, thus underscoring the high perceived impact of the publication.
@DMTomayko @_atanas_ I think that the hypothesis is that cancer cells benefit more from antioxidants compared to healthy cells. Two well known examples (one of them is recent, the other is not): https://t.co/VIVr6Wtbgs https://t.co/TblvQrPbRj
Also, if you're a normal person, don't eat 310g of carrots a day. (Actually the amount you're *not* supposed to eat is somewhere below 310g...) Re: smokers, look up "The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers" https://t.co/okMul0JkJd https://t.co/eZUq5eUc0m
なお、このコホートの元々の研究は、アルファトコフェロールとベータカロチンのがん予防効果には否定的な結果で、むしろ後者は男性の肺がんリスクを増やす可能性が示唆された。 https://t.co/rwT53j2RDW
@Prof_Nick_James stop causing harm by giving Vit E Prostate SELECT trial and NSCLC trial shows detriment https://t.co/g30Q2doKrp https://t.co/KXpeIvuVnk
@EatmeatN @siobhan_huggins @SteakAndIron @LogicalLynx Yeah, that would be based on this: https://t.co/CfpoH83EXc
@CR_ZENZENDEN @samaki_ta 次を見てください。 N Engl J Med. 1994 Apr 14;330(15):1029-35. doi: 10.1056/NEJM199404143301501. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers https://t.co/T8UjrrH5JC
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@AAMortazavi @DrNeilStone see https://t.co/JNjPFyKnq3 and https://t.co/wuw9hSxBtk and https://t.co/zpZKfLqk9M and https://t.co/0jCn1wWNFj
喫煙者におけるβカロテン摂取は肺癌を増やす可能性がある。 https://t.co/OW7g1VZTa6 https://t.co/srh1XsHncA
Fuentes:
RT @RenoHemonc: @Prof_Nick_James stop causing harm by giving Vit E Prostate SELECT trial and NSCLC trial shows detriment https://t.co/g30…
RT @RenoHemonc: @Prof_Nick_James stop causing harm by giving Vit E Prostate SELECT trial and NSCLC trial shows detriment https://t.co/g30…
@Prof_Nick_James stop causing harm by giving Vit E Prostate SELECT trial and NSCLC trial shows detriment https://t.co/g30Q2doKrp https://t.co/KXpeIvuVnk
@igoreckert 2/2 for the RCTs that were done. These were large, some of long duration and ruled out meaningful benefit (indeed hinted at harm) eg https://t.co/cSz0Ijgbx3 https://t.co/MxY9kJmBLk and https://t.co/3SGewDSBTJ (Peto last author)
One thing authors did not consider, especially w/extracted compounds (i.e. supplements): “the possibility that these supplements may actually have harmful as well as beneficial effects…” That’s why BEST to eat a variety of #WFPB foods! https://t.co/WF4if37Oar
@CR_ZENZENDEN @samaki_ta 次を見てください。 N Engl J Med. 1994 Apr 14;330(15):1029-35. doi: 10.1056/NEJM199404143301501. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers https://t.co/T8UjrrH5JC
@nickmmark Don’t forget about the ATBC and SELECT trials. https://t.co/pmuPDTu5WZ
RT @ymori117: なお、このコホートの元々の研究は、アルファトコフェロールとベータカロチンのがん予防効果には否定的な結果で、むしろ後者は男性の肺がんリスクを増やす可能性が示唆された。 https://t.co/rwT53j2RDW
RT @ymori117: なお、このコホートの元々の研究は、アルファトコフェロールとベータカロチンのがん予防効果には否定的な結果で、むしろ後者は男性の肺がんリスクを増やす可能性が示唆された。 https://t.co/rwT53j2RDW
RT @ymori117: なお、このコホートの元々の研究は、アルファトコフェロールとベータカロチンのがん予防効果には否定的な結果で、むしろ後者は男性の肺がんリスクを増やす可能性が示唆された。 https://t.co/rwT53j2RDW
なお、このコホートの元々の研究は、アルファトコフェロールとベータカロチンのがん予防効果には否定的な結果で、むしろ後者は男性の肺がんリスクを増やす可能性が示唆された。 https://t.co/rwT53j2RDW
In 1994, a trial followed 29,133 Finish people in their 50s. All smoked, but only some were given beta-carotene supplements. Within this group, the incidence of lung cancer increased by 16%. https://t.co/bByRRpNGEm
@deevybee Many, many examples with Vitamin E. Also beta carotene associated with reduced risk of lung cancer and heart disease, encouraged consumption of vitamin supplements, but no effect in RCTs eg https://t.co/5yljRLP9Lg and https://t.co/GaRTKjuARq
@ConorKerley @TyRBeal @The_Nutrivore @MattMadore576 @dylanarmbruste3 And several more papers suggesting the ineffectiveness or even increased associative risk of certain cancers with b-carotene supplementation: https://t.co/7JzDohGWVh https://t.co/OquoNOYMeH https://t.co/KpilxNmw1r 2/2
@DanOfAmerica The antioxidant vitamins for smokers. Great in theory. But when you look at the data from this very large RCT, maybe not so wonderful. https://t.co/KNPsQZsYtT
@The_Nutrivore Sure, this is always possible, but what do you think the odds are that it just so happens to be that every RCT that tests this it just so happens to be that the participants had enough baseline antioxidants to counteract the smoking? https://t.co/jfWTLoOXVD
@Rafalovich_ @DMTomayko @bryan_belanger @Mangan150 We shouldn't but high dose antioxidants (Vit E & beta catotene) failed human trials spectacularly too: " this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects." https://t.co/qX4PJyDrAc
Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The New England journal of medicine. 1994;330(15):1029-35. 8127329
@EatmeatN @siobhan_huggins @SteakAndIron @LogicalLynx Yeah, that would be based on this: https://t.co/CfpoH83EXc
RT @Edo_Kon: @DMTomayko @_atanas_ I think that the hypothesis is that cancer cells benefit more from antioxidants compared to healthy cells…
RT @Edo_Kon: @DMTomayko @_atanas_ I think that the hypothesis is that cancer cells benefit more from antioxidants compared to healthy cells…
RT @Edo_Kon: @DMTomayko @_atanas_ I think that the hypothesis is that cancer cells benefit more from antioxidants compared to healthy cells…
RT @Edo_Kon: @DMTomayko @_atanas_ I think that the hypothesis is that cancer cells benefit more from antioxidants compared to healthy cells…
@DMTomayko @_atanas_ I think that the hypothesis is that cancer cells benefit more from antioxidants compared to healthy cells. Two well known examples (one of them is recent, the other is not): https://t.co/VIVr6Wtbgs https://t.co/TblvQrPbRj
RT @JEverettLearned: Also, if you're a normal person, don't eat 310g of carrots a day. (Actually the amount you're *not* supposed to eat is…
Also, if you're a normal person, don't eat 310g of carrots a day. (Actually the amount you're *not* supposed to eat is somewhere below 310g...) Re: smokers, look up "The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers" https://t.co/okMul0JkJd https://t.co/eZUq5eUc0m