October 1996 PMID 8857917

Dietary cholesterol feeding suppresses human cholesterol synthesis measured by deuterium incorporation and urinary mevalonic acid levels.

P J Jones, A S Pappu, L Hatcher, Z C Li, D R Illingworth, W E Connor

Mentions

100
Peak: 53 in Jun 2021
across 5 sources since Mar 2019

Extended reach

530,682
potential audience

Total likes

2,271

Video views

87,609

Mentions per month

Mar 2019 – Jul 2025

Where it's discussed

  • X / Twitter78 posts
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AI synopsis

What people are saying

Across the discussions, commenters explore how dietary cholesterol influences human cholesterol synthesis, with examples like mentions of the body's feedback system balancing intake and production, and debates on dietary myths versus scientific evidence. The tone reveals a mix of curiosity and validation, as participants reference studies, biological processes, and diet considerations, reflecting moderate engagement and potential impact on public understanding.

AgreementModerate agreement

Most contributions acknowledge the findings, emphasizing that dietary cholesterol's effect on internal synthesis is significant or aligns with the study's conclusions.

InterestModerate interest

Posts demonstrate moderate curiosity, with commenters discussing the implications of cholesterol regulation and misinformation about dietary cholesterol.

EngagementModerate engagement

Discussions include references to the biological mechanisms and real-world dietary choices, showing a deeper engagement beyond surface reactions.

ImpactModerate impact

Comments suggest the research might influence dietary guidelines and perceptions about cholesterol, indicating perceived significance.

Abstract in brief

  • The study investigated how different levels of dietary cholesterol (50, 350, and 650 mg per 2800 kcal) affect human cholesterol production, measuring this via deuterium incorporation into erythrocyte cholesterol and urinary mevalonic acid levels.
  • Results showed that cholesterol synthesis significantly decreased when subjects switched from low to medium and high cholesterol diets, with urinary mevalonate excretion also dropping notably, indicating that dietary cholesterol can modestly suppress the body's own cholesterol production.
  • The extent of cholesterol synthesis response was linked to the rate of synthesis during low-cholesterol diets, suggesting that humans regulate cholesterol production in response to dietary intake, regardless of their baseline plasma cholesterol levels.

Top posts

Most liked on X and Bluesky
Dr. Subhasree Ray
@DrSubhasree · X

Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more cholesterol you eat, the less your body produces. Science says up to 3 whole eggs per day is perfectly safe for healthy people.

Jun 29, 2021 · 255 likes · 71 shares · 47,969 followers View post →
CULLINAN
@garvitaryan · X

@bronx_yz Vegan/vegmaxxers, nonvegmaxxers are all stupid, balance is necessary, there is a reason why many leave them. Many examples like this: https://t.co/6LOIEcYUs7 Even resourced celebrities like anne hathaway,mily cyrus,chris/liam Hemsworth,angelina jolie left veganism.  +

Jul 10, 2025 · 2 likes · 202 followers View post →
Michele Spagnuolo (miki.it)
@mikispag · X

@ElenaMattei10 https://t.co/4uAsf8HeuE https://t.co/v8UkX8tVw8 https://t.co/wcrl9JZ2bf https://t.co/r9uFohoDGY

Apr 29, 2023 · 1 like · 7,138 followers View post →
Doc(T)or FDR Hater
@fdr_h8r · X

@econguy123 @SeedOilDsrspctr @Toonga8 Basically, our body’s cholesterol is a highly sensitive feedback system, so dietary intake of cholesterol doesn’t have much effect on blood levels (you eat more->your body produces less, vice-versa) https://t.co/BYwhBdeTJp https://t.co/G4AqvDLzqL

Jan 12, 2022 · 1 like · 4,671 followers View post →
Kurt Lass
@KurtLass1 · X

@DietHeartNews Exogenous cholesterol consumption also reduces endogenous cholesterol production.

Mar 16, 2019 · 1 like · 1,505 followers View post →
Bhavani Shankar Sahu.
@urssahu · X

@abhijit_MLab https://t.co/p1UPKl6ho5

Apr 5, 2023 · 1 like · 1,353 followers View post →

All mentions

CULLINAN
@garvitaryan · X

@bronx_yz Vegan/vegmaxxers, nonvegmaxxers are all stupid, balance is necessary, there is a reason why many leave them. Many examples like this: https://t.co/6LOIEcYUs7 Even resourced celebrities like anne hathaway,mily cyrus,chris/liam Hemsworth,angelina jolie left veganism.  +

Jul 10, 2025 · 2 likes · 202 followers View post →
AwakeAndAware
@Resist2Exist_ · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Mar 24, 2025 · 71 shares · 250 followers View post →
AwakeAndAware
@Resist2Exist_ · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jan 26, 2025 · 71 shares · 250 followers View post →
Ola-Elu Favour Enterprises
@elu_favour · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jan 15, 2025 · 71 shares View post →
ᛅᛁᚾ ᚢᛚᚠᛦ
@Torquatus13 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Dec 1, 2024 · 71 shares · 239 followers View post →
DR. Martin SABRY (Jr.)
@martinsabry · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 24, 2024 · 71 shares · 1,385 followers View post →
vegymor_fitness
@vegymorfitness · X

Estudio 1 https://t.co/bJvQHPSnbb Estudios 2, 3,4,5 https://t.co/Om9lAtpWAJ https://t.co/52CwKXY0JG https://t.co/TkUU6ACSpF https://t.co/jiB7RJsbvy

Dec 21, 2023 · 1 followers View post →
Michele Spagnuolo (miki.it)
@mikispag · X

@ElenaMattei10 https://t.co/4uAsf8HeuE https://t.co/v8UkX8tVw8 https://t.co/wcrl9JZ2bf https://t.co/r9uFohoDGY

Apr 29, 2023 · 1 like · 7,138 followers View post →
The Ancestral Doc
@j_t_2390 · X

@Asaf1169 @ScepticalDoctor https://t.co/KlcOUsb6V2

Apr 6, 2023 · 207 followers View post →
Bhavani Shankar Sahu.
@urssahu · X

@abhijit_MLab https://t.co/p1UPKl6ho5

Apr 5, 2023 · 1 like · 1,353 followers View post →
Chris Straga
@ChrisStraga · X

@TheNutrivore @MarkoHakk Trivial because suppression of production. https://t.co/7hFEJmXZfE

Mar 25, 2023 · 73 followers View post →
Sinsentido común
@El_Sinsentido · X

@libertad_vegana @mbolo2002 https://t.co/pyaaNneKWb Precisamente de los huevos hay evidencia de sobra. Su relación con el colesterol se considera un mito. Por ejemplo: El cuerpo compensa mayor ingesta de colesterol con menor producción endógena.

Jan 12, 2022 · 76 followers View post →
Doc(T)or FDR Hater
@fdr_h8r · X

@econguy123 @SeedOilDsrspctr @Toonga8 Basically, our body’s cholesterol is a highly sensitive feedback system, so dietary intake of cholesterol doesn’t have much effect on blood levels (you eat more->your body produces less, vice-versa) https://t.co/BYwhBdeTJp https://t.co/G4AqvDLzqL

Jan 12, 2022 · 1 like · 4,671 followers View post →
raman chopra
@rammyy_123 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Aug 20, 2021 · 71 shares · 345 followers View post →
ireaum
@ireaum · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Aug 20, 2021 · 71 shares · 792 followers View post →
Juan Capitani
@AKAMorphined · X

@comino_gomez Depende del tipo de huevo que se coma: A,AA,AA, lo que diga el etiquetado: 0,1,2,3, la edad y sexo de la persona, cómo cocina el huevo y cómo lo almacena, si uno quiere ser muy exacto. La mayoría de la población está bien con 1-3 huevos diarios. Info en: https://t.co/rlgho9UNQA

Jul 13, 2021 · 1 like · 402 followers View post →
Sabyasachi
@hi_saby · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jul 9, 2021 · 71 shares · 443 followers View post →
Dr. Ashalatha
@DrDAshalatha · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jul 5, 2021 · 71 shares · 170 followers View post →
ROSHO RAVI
@ROSHORAVI · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jul 4, 2021 · 71 shares · 571 followers View post →
Ragini
@Ragini81118210 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jul 3, 2021 · 71 shares · 19 followers View post →
Ubong David
@DietitianUbongD · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 30, 2021 · 71 shares · 428 followers View post →
Dr Hamed Khan
@drhamedkhan · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 30, 2021 · 71 shares · 5,331 followers View post →
Sunny Lisam
@LisamSunny · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 30, 2021 · 71 shares · 54 followers View post →
Furquan Hussain
@FurquanHussain4 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 30, 2021 · 71 shares · 28 followers View post →
GoldenTrouble
@GoldenTrouble · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 27 followers View post →
Yahiko ❤️‍
@Yahiko_101 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 577 followers View post →
Fermented
@Fermented16 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 702 followers View post →
catoraño
@catorano · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 4,189 followers View post →
David Diamond
@LDLSkeptic · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 45,110 followers View post →
PB
@bothrapawan53 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 3,041 followers View post →
Garfield
@Garfieldzzzzzz · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 31 followers View post →
Sanjay Vohra
@SanjayVohra10 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 329 followers View post →
Eternal Optimist !!
@ShakenAnStirred · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 148 followers View post →
APJ
@apj234 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 9,245 followers View post →
Deepak Anand
@deepakanand · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 563 followers View post →
Ravish Singla
@ravish_singla · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 5,817 followers View post →
Amit Behere
@_amitbehere · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 30,672 followers View post →
Jayesh Shingole
@jayeshshingole · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 74 followers View post →
Sohini M.
@Mittermaniac · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 13,125 followers View post →
Pratik Saha
@Pratik_Saha1999 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 191 followers View post →
Imran Alam
@aalam_imraan · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 217 followers View post →
i@msanju015
@imsanju0151 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 11 followers View post →
kanoon andha hai ...main nahin
@badnamlawyer · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 428 followers View post →
Piyush Singh پیوش سنگھ
@_piyush8693 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 37 followers View post →
Anshul Singhal
@AnshulSinghal66 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 2,019 followers View post →
Niraj Bhatia
@bhatia_niraj23 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 38,692 followers View post →
Baba MaChuvera
@indian_armada · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 84,341 followers View post →
Anil KB -CFP
@anilbatchu · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 13,973 followers View post →
Martin Jones
@beakym · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 83 followers View post →
Partha S Kar
@parthaskar · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 55,798 followers View post →
Sagar Kumar
@sagkumar · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 119 followers View post →
Y
@tryumnaa · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 385 followers View post →
Kanagavel
@krnk02 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 603 followers View post →
DiscoStew
@DiscoStew66 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 10,777 followers View post →
Liver
@DevilsAdvocattt · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 262 followers View post →
DP
@dpbhattaET · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 1,319 followers View post →
IndiaFirst
@IndiaFirst2022 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 249 followers View post →
suryakiran
@suryakiran10 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 101 followers View post →
#JaiBabu
@devd_dhfm · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 2,142 followers View post →
S Sriram
@ssriram19901 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 455 followers View post →
Yagnesh
@yagnesh83 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 697 followers View post →
AB - તોફાની વાદળ
@AakashBharati_ · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 150 followers View post →
madhumitha
@mdv_mitha · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 62 followers View post →
Hpr
@hprpcctr · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 18,321 followers View post →
नाम में क्या रखा है
@RudraanshR · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 2 followers View post →
Guru
@KamathGurudutt · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 10,908 followers View post →
Anoop
@iAnoopSingh23 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 209 followers View post →
Avinash
@i_m_avinash_ · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 24 followers View post →
Martijn
@wal_martijn · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 1,130 followers View post →
ProudIndian
@Gautam24680 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 556 followers View post →
Gunjan / مہوش
@GunjanHassan · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 518 followers View post →
Subha Sundar sastri @subha
@SubhasundarSas1 · X

RT @DrSubhasree: Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more c…

Jun 29, 2021 · 71 shares · 294 followers View post →
Dr. Subhasree Ray
@DrSubhasree · X

Eggs have gotten a bad reputation because the yolks are high in cholesterol. But cholesterol isn’t that simple. The more cholesterol you eat, the less your body produces. Science says up to 3 whole eggs per day is perfectly safe for healthy people.

Jun 29, 2021 · 255 likes · 71 shares · 47,969 followers View post →
ilk insan
@HSapiensIdaltu · X

@Earthling637 31. Dahası diyetle gelen kolesrolden dolayı karaciğerin daha az kolestrol ürettiği ve kandaki değerlerin korunduğu da düşünülmektedir [10]. [10]. https://t.co/3kj4XtvQJR

Dec 11, 2020 · 336 followers View post →
Remarkable Health & Fitness
@RemarkableHandF · X

https://t.co/ONkXjgqFJe

Jul 3, 2020 · 2 followers View post →
Geri Bee
@irishgerrie · X

https://t.co/I9nkuM7BHf

Jun 9, 2020 · 679 followers View post →
RINSE Steeman
@benjans_ · X

@memesnutricion Fuentes: The impact of egg limitations on coronary heart disease risk: do the numbers add up? Dietary Cholesterol Feeding Suppresses Human Cholesterol Synthesis Measured by Deuterium Incorporation and Urinary Mevalonic Acid Levels

Feb 18, 2020 · 343 followers View post →
Kurt Lass
@KurtLass1 · X

@DietHeartNews Exogenous cholesterol consumption also reduces endogenous cholesterol production.

Mar 16, 2019 · 1 like · 1,505 followers View post →