Publications by authors named "Simon Ward"

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High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1.
Judith Reeks, Pravin Mahajan, Mellissa Clark, Suzanna R Cowan, Elena Di Daniel, Simon E Ward

Structure· August 2025

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Tetrahydropyrazolopyridinones as a Novel Class of Potent and Highly Selective LIMK Inhibitors.
Alex G Baldwin, David W Foley, D Heulyn Jones, Hyunah Lee, Ross Collins, Simon E Ward

J Med Chem· August 2025

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The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells.
Róbert Zach, Michael Annis, Sandra M Martin-Guerrero, Abdulrahman Alatawi, Kim Hou Chia, Simon E Ward

Nat Commun· August 2025

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Fingerprints of supersymmetric spin and charge dynamics observed by inelastic neutron scattering.
Björn Wehinger, Franco T Lisandrini, Noam Kestin, Pierre Bouillot, Simon Ward

Nat Commun· April 2025

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Discovery of MDI-114215: A Potent and Selective LIMK Inhibitor To Treat Fragile X Syndrome.
Alex G Baldwin, David W Foley, Ross Collins, Hyunah Lee, D Heulyn Jones, Simon E Ward

J Med Chem· January 2025

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Porous Silicon on Paper: A Platform for Quantitative Rapid Diagnostic Tests.
Huijin An, Simon J Ward, Rabeb Layouni, Paul E Laibinis, Andrea K Locke

ACS Appl Mater Interfaces· January 2025

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How Do Gepotidacin and Zoliflodacin Stabilize DNA-Cleavage Complexes with Bacterial Type IIA Topoisomerases? 2. A Single Moving Metal Mechanism.
Robert A Nicholls, Harry Morgan, Anna J Warren, Simon E Ward, Fei Long

Int J Mol Sci· December 2024

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Collection: Drug Discovery in the UK.
Simon E Ward, Emmanuel H Demont

J Med Chem· November 2024

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How Do Gepotidacin and Zoliflodacin Stabilize DNA Cleavage Complexes with Bacterial Type IIA Topoisomerases? 1. Experimental Definition of Metal Binding Sites.
Harry Morgan, Robert A Nicholls, Anna J Warren, Simon E Ward, Gwyndaf Evans

Int J Mol Sci· October 2024

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Beware of -Benzoyloxybenzamides.
Jonathan Cubitt, Mari Davies, Ross Riseley, Gabrielle Evans, Sian E Gardiner, Simon E Ward

Molecules· October 2024

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Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases.
Scott H Henderson, Fiona J Sorrell, James M Bennett, Oleg Fedorov, Marcus T Hanley, Simon E Ward

Eur J Med Chem· April 2024

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Cancer-specific glycosylation of CD13 impacts its detection and activity in preclinical cancer tissues.
Francis M Barnieh, Sebastian P Galuska, Paul M Loadman, Simon Ward, Robert A Falconer

iScience· November 2023

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Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis.
Jingying Zhou, Huanyu Wang, Ting Shu, Jing Wang, Weiqin Yang, Simon E Ward

iScience· October 2023

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Charge and lipophilicity are required for effective block of the hair-cell mechano-electrical transducer channel by FM1-43 and its derivatives.
Marco Derudas, Molly O'Reilly, Nerissa K Kirkwood, Emma J Kenyon, Sybil Grimsey, Simon E Ward

Front Cell Dev Biol· October 2023

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Protein Identification and Quantification Using Porous Silicon Arrays, Optical Measurements, and Machine Learning.
Simon J Ward, Tengfei Cao, Xiang Zhou, Catie Chang, Sharon M Weiss

Biosensors (Basel)· September 2023

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Central Nervous System Targeted Protein Degraders.
Bedwyr Ab Ion Thomas, H Lois Lewis, D Heulyn Jones, Simon E Ward

Biomolecules· July 2023

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A pilot study investigating feasibility of mainstreaming germline BRCA1 and BRCA2 testing in high-risk patients with breast and/or ovarian cancer in three tertiary Cancer Centres in Ireland.
Terri Patricia McVeigh, Karl J Sweeney, Donal J Brennan, Una M McVeigh, Simon Ward

Fam Cancer· April 2023

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Grand challenges in entomology: Priorities for action in the coming decades.
Sarah H Luke, Helen E Roy, Chris D Thomas, Luke A N Tilley, Simon Ward

Insect Conserv Divers· March 2023

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Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity.
Ross Collins, Hyunah Lee, D Heulyn Jones, Jonathan M Elkins, Jason A Gillespie, Simon E Ward

J Med Chem· October 2022

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Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase.
Chloe R Koulouris, Sian E Gardiner, Tessa K Harris, Karen T Elvers, S Mark Roe, Simon E Ward

Commun Biol· April 2022

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Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery.
Fiona Scott, Angela M Fala, Jessica E Takarada, Mihaela P Ficu, Lewis E Pennicott, Simon E Ward

Bioorg Med Chem Lett· March 2022

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Porous Silicon-Based Aptasensors: Toward Cancer Protein Biomarker Detection.
Sofia Arshavsky-Graham, Simon J Ward, Naama Massad-Ivanir, Thomas Scheper, Sharon M Weiss

ACS Meas Sci Au· October 2021

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Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors.
Scott H Henderson, Fiona Sorrell, James Bennett, Oleg Fedorov, Marcus T Hanley, Simon E Ward

J Med Chem· August 2021

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Morlet Wavelet Filtering and Phase Analysis to Reduce the Limit of Detection for Thin Film Optical Biosensors.
Simon J Ward, Rabeb Layouni, Sofia Arshavsky-Graham, Ester Segal, Sharon M Weiss

ACS Sens· August 2021

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Liver Immune Microenvironment and Metastasis from Colorectal Cancer-Pathogenesis and Therapeutic Perspectives.
Xuezhen Zeng, Simon E Ward, Jingying Zhou, Alfred S L Cheng

Cancers (Basel)· May 2021

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