Publications by authors named "Judith Reeks"

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High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1.
Judith Reeks, Pravin Mahajan, Mellissa Clark, Suzanna R Cowan, Elena Di Daniel

Structure· August 2025

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Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β-Glucocerebrosidase.
Nick Palmer, Christopher Agnew, Caroline Benn, William J Buffham, Joan N Castro, Judith Reeks

J Med Chem· July 2024

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Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor.
Emiliano Tamanini, Shin Miyamura, Ildiko M Buck, Benjamin D Cons, Lee Dawson, Judith Reeks

ACS Med Chem Lett· October 2022

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Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.
Gianni Chessari, Ian R Hardcastle, Jong Sook Ahn, Burcu Anil, Elizabeth Anscombe, Judith Reeks

J Med Chem· April 2021

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Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation.
Marco Salamina, Bailey C Montefiore, Mengxi Liu, Daniel J Wood, Richard Heath, Judith Reeks

J Mol Biol· March 2021

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Fragment-based drug discovery using cryo-EM.
Michael Saur, Michael J Hartshorn, Jing Dong, Judith Reeks, Gabor Bunkoczi

Drug Discov Today· March 2020

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Tuning the Binding Affinity and Selectivity of Perfluoroaryl-Stapled Peptides by Cysteine-Editing.
Sanne J M Verhoork, Claire E Jennings, Neshat Rozatian, Judith Reeks, Jieman Meng

Chemistry· January 2019

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Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design.
Yaw Sing Tan, Judith Reeks, Christopher J Brown, Dawn Thean, Fernando Jose Ferrer Gago

J Phys Chem Lett· September 2016

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CRISPR interference: a structural perspective.
Judith Reeks, James H Naismith, Malcolm F White

Biochem J· July 2013

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Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing.
Judith Reeks, Richard D Sokolowski, Shirley Graham, Huanting Liu, James H Naismith

Biochem J· June 2013

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Structure of the archaeal Cascade subunit Csa5: relating the small subunits of CRISPR effector complexes.
Judith Reeks, Shirley Graham, Linzi Anderson, Huanting Liu, Malcolm F White

RNA Biol· May 2013

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Structure and mechanism of the CMR complex for CRISPR-mediated antiviral immunity.
Jing Zhang, Christophe Rouillon, Melina Kerou, Judith Reeks, Kim Brugger

Mol Cell· February 2012

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