Publications by authors named "Benjamin D Cons"

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Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function.
Swee Y Sharp, Marianna Martella, Sabrina D'Agostino, Christopher I Milton, George Ward, Benjamin D Cons

Nat Commun· November 2024

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Alkene 1,3-Difluorination via Transient Oxonium Intermediates.
Alice C Dean, E Harvey Randle, Andrew J D Lacey, Guilherme A Marczak Giorio, Sayad Doobary, Benjamin D Cons

Angew Chem Int Ed Engl· July 2024

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Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β-Glucocerebrosidase.
Nick Palmer, Christopher Agnew, Caroline Benn, William J Buffham, Joan N Castro, Benjamin D Cons

J Med Chem· July 2024

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Enabling synthesis in fragment-based drug discovery (FBDD): microscale high-throughput optimisation of the medicinal chemist's toolbox reactions.
Chloe Townley, Davide Branduardi, Gianni Chessari, Benjamin D Cons, Charlotte Griffiths-Jones

RSC Med Chem· December 2023

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Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor.
Emiliano Tamanini, Shin Miyamura, Ildiko M Buck, Benjamin D Cons, Lee Dawson

ACS Med Chem Lett· October 2022

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X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor.
Jeffrey D St Denis, Gianni Chessari, Anne Cleasby, Benjamin D Cons, Suzanna Cowan

J Med Chem· September 2022

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Electrostatic Complementarity in Structure-Based Drug Design.
Benjamin D Cons, David G Twigg, Rajendra Kumar, Gianni Chessari

J Med Chem· June 2022

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Fragment-based drug discovery and its application to challenging drug targets.
Amanda J Price, Steven Howard, Benjamin D Cons

Essays Biochem· November 2017

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Total synthesis of (-)-blepharocalyxin D and analogues.
Benjamin D Cons, Adam J Bunt, Christopher D Bailey, Christine L Willis

Org Lett· April 2013

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Bicyclic oxygen heterocycles from γ,δ-unsaturated alcohols: synthetic targets inspired by blepharocalyxin D.
Adam J Bunt, Christopher D Bailey, Benjamin D Cons, Sophie J Edwards, Jon D Elsworth

Angew Chem Int Ed Engl· April 2012

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