Publications by authors named "Jeffrey D St Denis"

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Correction to "Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2)".
James E H Day, Valerio Berdini, Joan Castro, Gianni Chessari, Thomas G Davies, Jeffrey D St Denis

J Med Chem· May 2025

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Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function.
Swee Y Sharp, Marianna Martella, Sabrina D'Agostino, Christopher I Milton, George Ward, Jeffrey D St Denis

Nat Commun· November 2024

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Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β-Glucocerebrosidase.
Nick Palmer, Christopher Agnew, Caroline Benn, William J Buffham, Joan N Castro, Jeffrey D St-Denis

J Med Chem· July 2024

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Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2).
James E H Day, Valerio Berdini, Joan Castro, Gianni Chessari, Thomas G Davies, Jeffrey D St Denis

J Med Chem· March 2024

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X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor.
Jeffrey D St Denis, Gianni Chessari, Anne Cleasby, Benjamin D Cons, Suzanna Cowan

J Med Chem· September 2022

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Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.
Gianni Chessari, Ian R Hardcastle, Jong Sook Ahn, Burcu Anil, Elizabeth Anscombe, Jeffrey D St Denis

J Med Chem· April 2021

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Fragment-based drug discovery: opportunities for organic synthesis.
Jeffrey D St Denis, Richard J Hall, Christopher W Murray, Tom D Heightman, David C Rees

RSC Med Chem· December 2020

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Oxalyl Boronates Enable Modular Synthesis of Bioactive Imidazoles.
C Frank Lee, Aleksandra Holownia, James M Bennett, Jonathan M Elkins, Jeffrey D St Denis

Angew Chem Int Ed Engl· May 2017

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Synthesis of Aminoboronic Acid Derivatives from Amines and Amphoteric Boryl Carbonyl Compounds.
Diego B Diaz, Conor C G Scully, Sean K Liew, Shinya Adachi, Piera Trinchera, Jeffrey D St Denis

Angew Chem Int Ed Engl· October 2016

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Access to Cyclic Amino Boronates via Rhodium-Catalyzed Functionalization of Alkyl MIDA Boronates.
Jeffrey D St Denis, C Frank Lee, Andrei K Yudin

Org Lett· December 2015

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Condensation-Driven Assembly of Boron-Containing Bis(Heteroaryl) Motifs Using a Linchpin Approach.
Shinya Adachi, Sean K Liew, C Frank Lee, Alan Lough, Zhi He, Jeffrey D St Denis

Org Lett· November 2015

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Facile synthesis of borofragments and their evaluation in activity-based protein profiling.
Shinya Adachi, Armand B Cognetta, Micah J Niphakis, Zhi He, Adam Zajdlik, Jeffrey D St Denis

Chem Commun (Camb)· February 2015

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Boron-containing enamine and enamide linchpins in the synthesis of nitrogen heterocycles.
Jeffrey D St Denis, Adam Zajdlik, Joanne Tan, Piera Trinchera, C Frank Lee

J Am Chem Soc· December 2014

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Stereocontrolled disruption of the Ugi reaction toward the production of chiral piperazinones: substrate scope and process development.
Serge Zaretsky, Shinya Adachi, Benjamin H Rotstein, Jennifer L Hickey, Conor C G Scully, Jeffrey D St Denis

J Org Chem· November 2014

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Development of the direct Suzuki-Miyaura cross-coupling of primary B-alkyl MIDA-boronates and aryl bromides.
Jeffrey D St Denis, Conor C G Scully, C Frank Lee, Andrei K Yudin

Org Lett· March 2014

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Stereocontrolled synthesis of 1,2- and 1,3-diamine building blocks from aziridine aldehyde dimers.
Sean K Liew, Zhi He, Jeffrey D St Denis, Andrei K Yudin

J Org Chem· December 2013

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Evaluation of a chiral cubane-based Schiff base ligand in asymmetric catalysis reactions.
Kyle F Biegasiewicz, Michelle L Ingalsbe, Jeffrey D St Denis, James L Gleason, Junming Ho

Beilstein J Org Chem· December 2012

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Chemoselective palladium-catalyzed α-allylation of α-boryl aldehydes.
Jeffrey D St Denis, Zhi He, Andrei K Yudin

Org Biomol Chem· October 2012

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Oxidative geminal functionalization of organoboron compounds.
Zhi He, Piera Trinchera, Shinya Adachi, Jeffrey D St Denis, Andrei K Yudin

Angew Chem Int Ed Engl· October 2012

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Boroalkyl group migration provides a versatile entry into α-aminoboronic acid derivatives.
Zhi He, Adam Zajdlik, Jeffrey D St Denis, Naila Assem, Andrei K Yudin

J Am Chem Soc· June 2012

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Development of a novel expression, ZI MAX/K ZI, for determination of the counter-anion effect on the antimicrobial activity of tetrabutylammonium salts.
Michelle L Ingalsbe, Jeffrey D St Denis, Megan E McGahan, Walter W Steiner, Ronny Priefer

Bioorg Med Chem Lett· September 2009

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