Publications by authors named "Aaron D Thome"

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Peripheral monocyte transcriptional signatures of inflammation and oxidative stress in Parkinson's disease.
Aaron D Thome, Jinghong Wang, Farah Atassi, Jason R Thonhoff, Alireza Faridar

Front Immunol· August 2025

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Low-dose interleukin-2 in patients with mild to moderate Alzheimer's disease: a randomized clinical trial.
Alireza Faridar, Nazaret Gamez, Daling Li, Yanling Wang, Reena Boradia, Aaron D Thome

Alzheimers Res Ther· July 2025

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A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer's disease.
Alireza Faridar, Abdulmunaim M Eid, Aaron D Thome, Weihua Zhao, David R Beers

Transl Neurodegener· November 2023

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Combined Regulatory T-Lymphocyte and IL-2 Treatment Is Safe, Tolerable, and Biologically Active for 1 Year in Persons With Amyotrophic Lateral Sclerosis.
Jason R Thonhoff, James D Berry, Eric A Macklin, David R Beers, Patricia A Mendoza, Aaron D Thome

Neurol Neuroimmunol Neuroinflamm· November 2022

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Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer's disease.
Alireza Faridar, Matthew Vasquez, Aaron D Thome, Zheng Yin, Hui Xuan

Acta Neuropathol Commun· September 2022

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Tregs Attenuate Peripheral Oxidative Stress and Acute Phase Proteins in ALS.
David R Beers, Jason R Thonhoff, Alireza Faridar, Aaron D Thome, Weihua Zhao

Ann Neurol· August 2022

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Extracellular Vesicles Derived From Expanded Regulatory T Cells Modulate and Inflammation.
Aaron D Thome, Jason R Thonhoff, Weihua Zhao, Alireza Faridar, Jinghong Wang

Front Immunol· July 2022

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Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson's disease.
Aaron D Thome, Farah Atassi, Jinghong Wang, Alireza Faridar, Weihua Zhao

NPJ Parkinsons Dis· May 2021

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Serum programmed cell death proteins in amyotrophic lateral sclerosis.
David R Beers, Weihua Zhao, Jason R Thonhoff, Alireza Faridar, Aaron D Thome

Brain Behav Immun Health· March 2021

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Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis.
David R Beers, Weihua Zhao, Daniel W Neal, Jason R Thonhoff, Aaron D Thome

Sci Rep· September 2020

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Restoring regulatory T-cell dysfunction in Alzheimer's disease through expansion.
Alireza Faridar, Aaron D Thome, Weihua Zhao, Jason R Thonhoff, David R Beers

Brain Commun· July 2020

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Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls.
Weihua Zhao, David R Beers, Jason R Thonhoff, Aaron D Thome, Alireza Faridar

iScience· June 2020

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Functional alterations of myeloid cells during the course of Alzheimer's disease.
Aaron D Thome, Alireza Faridar, David R Beers, Jason R Thonhoff, Weihua Zhao

Mol Neurodegener· November 2018

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Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson's disease.
Gregory P Williams, Aubrey M Schonhoff, Asta Jurkuvenaite, Aaron D Thome, David G Standaert

J Neuroinflammation· August 2018

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Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease.
Ashley S Harms, Aaron D Thome, Zhaoqi Yan, Aubrey M Schonhoff, Gregory P Williams

Exp Neurol· February 2018

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α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration.
Ashley S Harms, Vedad Delic, Aaron D Thome, Nicole Bryant, Zhiyong Liu

Acta Neuropathol Commun· November 2017

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Fractalkine Signaling Regulates the Inflammatory Response in an α-Synuclein Model of Parkinson Disease.
Aaron D Thome, David G Standaert, Ashley S Harms

PLoS One· June 2016

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The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia.
Ranjani Ponnazhagan, Ashley S Harms, Aaron D Thome, Asta Jurkuvenaite, Rocco Gogliotti

J Neuroimmune Pharmacol· June 2016

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microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease.
Aaron D Thome, Ashley S Harms, Laura A Volpicelli-Daley, David G Standaert

J Neurosci· February 2016

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MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration.
Ashley S Harms, Shuwen Cao, Amber L Rowse, Aaron D Thome, Xinru Li

J Neurosci· June 2013

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