Publications by authors named "Aaron D Wrobleski"

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Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.
James R Henry, Michael D Kaufman, Sheng-Bin Peng, Yu Mi Ahn, Timothy M Caldwell, Aaron D Wrobleski

J Med Chem· May 2015

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Total synthesis of the strychnos alkaloid (+)-minfiensine: tandem enantioselective intramolecular Heck-iminium ion cyclization.
Amy B Dounay, Philip G Humphreys, Larry E Overman, Aaron D Wrobleski

J Am Chem Soc· April 2008

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Regioselective single and double conjugate additions to substituted cyclohexa-2,5-dienone monoacetals.
Scott Grecian, Aaron D Wrobleski, Jeffrey Aubé

Org Lett· July 2005

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Sequential catalytic asymmetric Heck-iminium ion cyclization: enantioselective total synthesis of the Strychnos alkaloid minfiensine.
Amy B Dounay, Larry E Overman, Aaron D Wrobleski

J Am Chem Soc· July 2005

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Facile C-N cleavage in a series of bridged lactams.
Yao Lei, Aaron D Wrobleski, Jennifer E Golden, Douglas R Powell, Jeffrey Aubé

J Am Chem Soc· April 2005

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Double diastereoselective intramolecular cyclopropanation to P-chiral [3.1.0]-bicyclic phosphonates.
Joel D Moore, Kevin T Sprott, Aaron D Wrobleski, Paul R Hanson

Org Lett· July 2002

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