Publications by authors named "Aaron Janowsky"

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Specific GPCRs Elicit Unique Extracellular Vesicle MiRNA Array Signatures: An Exploratory Study.
Xiao Shi, Michelle C Palumbo, Sheila Benware, Jack Wiedrick, Sheila Markwardt, Aaron Janowsky

bioRxiv· November 2025

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Combining the alpha-2 adrenergic agonist clonidine with naloxone rescues fentanyl-induced physiologic dysfunction and increases survival.
Alyssa Rivera, William E Schutzer, Alex Sonneborn, Sandra L Shotwell, Aaron Janowsky

bioRxiv· November 2025

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Trace amine-associated receptor 1 agonists differentially regulate dopamine transporter function.
Julia K Huey, Xiao Shi, William E Schutzer, Aaron Janowsky, Atheir I Abbas

Mol Pharmacol· September 2025

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Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia.
Alessandro Bonifazi, Michael Ellenberger, Zachary J Farino, Despoina Aslanoglou, Rana Rais, Aaron Janowsky

Diabetes· September 2024

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Pharmacologic Characterization of Substituted Nitazenes at , , and Opioid Receptors Suggests High Potential for Toxicity.
Laura B Kozell, Amy J Eshleman, Katherine M Wolfrum, Tracy L Swanson, Shelley H Bloom, Aaron Janowsky

J Pharmacol Exp Ther· April 2024

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Development of novel tools for dissection of central versus peripheral dopamine D-like receptor signaling in dysglycemia.
Alessandro Bonifazi, Michael Ellenberger, Zachary J Farino, Despoina Aslanoglou, Rana Rais, Aaron Janowsky

bioRxiv· February 2024

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MicroRNA137-loaded lipid nanoparticles regulate synaptic proteins in the prefrontal cortex.
Michelle C Palumbo, Milan Gautam, Alex Sonneborn, Kilsun Kim, Phillip A Wilmarth, Aaron Janowsky

Mol Ther· October 2023

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Monoacylglycerol Lipase Protects the Presynaptic Cannabinoid 1 Receptor from Desensitization by Endocannabinoids after Persistent Inflammation.
Courtney A Bouchet, Kylie B McPherson, Basile Coutens, Aaron Janowsky, Susan L Ingram

J Neurosci· July 2023

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Enantiomeric Separation, Absolute Configuration by X-ray Crystallographic Analysis, and Functional Evaluation of Enantiomers of the Dual Ligand, SYA0340 at 5-HT and 5-HT Receptors.
Barbara A Bricker, Chandrashekhar Voshavar, Edem K Onyameh, Uma M Gonela, Xinsong Lin, Aaron J Janowsky

ACS Omega· June 2023

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Pharmacologic Activity of Substituted Tryptamines at 5-Hydroxytryptamine (5-HT) Receptor (5-HTR), 5-HTR, 5-HTR, and Serotonin Transporter.
Laura B Kozell, Amy J Eshleman, Tracy L Swanson, Shelley H Bloom, Katherine M Wolfrum, Aaron Janowsky

J Pharmacol Exp Ther· April 2023

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A highly DR-selective and efficacious partial agonist (S)-ABS01-113 compared to its DR-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder.
Ewa Galaj, Guo-Hua Bi, Benjamin Klein, Briana Hempel, Anver Basha Shaik, Aaron Janowsky

Neuropsychopharmacology· December 2022

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Development of a Translational Model to Assess the Impact of Opioid Overdose and Naloxone Dosing on Respiratory Depression and Cardiac Arrest.
John Mann, Mohammadreza Samieegohar, Anik Chaturbedi, Joel Zirkle, Xiaomei Han, Aaron Janowsky

Clin Pharmacol Ther· November 2022

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Fentanyl causes naloxone-resistant vocal cord closure: A platform for testing opioid overdose treatments.
Nicholas B Miner, William E Schutzer, Yalda Zarnegarnia, Aaron Janowsky, Randy Torralva

Drug Alcohol Depend· October 2021

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New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263.
Edward Ofori, Edem K Onyameh, Uma M Gonela, Chandrashekhar Voshavar, Barbara Bricker, Aaron J Janowsky

Eur J Med Chem· March 2021

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Affinity, potency, efficacy, selectivity, and molecular modeling of substituted fentanyls at opioid receptors.
Amy J Eshleman, Shanthi Nagarajan, Katherine M Wolfrum, John F Reed, Aaron Nilsen, Aaron Janowsky

Biochem Pharmacol· December 2020

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Methamphetamine use alters human plasma extracellular vesicles and their microRNA cargo: An exploratory study.
Ursula S Sandau, Erika Duggan, Xiao Shi, Sierra J Smith, Marilyn Huckans, Aaron Janowsky

J Extracell Vesicles· November 2020

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Fentanyl but not Morphine Interacts with Nonopioid Recombinant Human Neurotransmitter Receptors and Transporters.
Randy Torralva, Amy J Eshleman, Tracy L Swanson, Jennifer L Schmachtenberg, William E Schutzer, Aaron Janowsky

J Pharmacol Exp Ther· September 2020

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Trace amine-associated receptor gene polymorphism increases drug craving in individuals with methamphetamine dependence.
Jennifer M Loftis, Michael Lasarev, Xiao Shi, Jodi Lapidus, Aaron Janowsky

PLoS One· March 2020

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Noradrenergic Mechanisms in Fentanyl-Mediated Rapid Death Explain Failure of Naloxone in the Opioid Crisis.
Randy Torralva, Aaron Janowsky

J Pharmacol Exp Ther· November 2019

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The Role of Biogenic Amine Transporters in Trace Amine-Associated Receptor 1 Regulation of Methamphetamine-Induced Neurotoxicity.
Nicholas B Miner, Tamara J Phillips, Aaron Janowsky

J Pharmacol Exp Ther· October 2019

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Activation of Trace Amine-Associated Receptor 1 Stimulates an Antiapoptotic Signal Cascade via Extracellular Signal-Regulated Kinase 1/2.
Xiao Shi, Tracy L Swanson, Nicholas B Miner, Amy J Eshleman, Aaron Janowsky

Mol Pharmacol· October 2019

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gene variants have a causal role in methamphetamine intake and response and interact with .
Alexandra M Stafford, Cheryl Reed, Harue Baba, Nicole Ar Walter, John Rk Mootz, Aaron J Janowsky

Elife· July 2019

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Structure-activity relationships of bath salt components: substituted cathinones and benzofurans at biogenic amine transporters.
Amy J Eshleman, Shanthi Nagarajan, Katherine M Wolfrum, John F Reed, Tracy L Swanson, Aaron Janowsky

Psychopharmacology (Berl)· March 2019

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Neurochemical pharmacology of psychoactive substituted N-benzylphenethylamines: High potency agonists at 5-HT receptors.
Amy J Eshleman, Katherine M Wolfrum, John F Reed, Sunyoung O Kim, Robert A Johnson, Aaron Janowsky

Biochem Pharmacol· December 2018

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Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists.
Dilip K Tosh, Antonella Ciancetta, Philip Mannes, Eugene Warnick, Aaron Janowsky

ACS Omega· October 2018

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