Publications by authors named "Aaron M Leconte"

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Discovery of Red-Shifting Mutations in Firefly Luciferase Using High-Throughput Biochemistry.
Clair M Colee, Nicole M Oberlag, Marcell Simon, Owen S Chapman, Lyndsey C Flanagan, Edison S Reid-McLaughlin, Jordan A Gewing-Mullins, Synaida Maiche, Devi F Patel, Andre R O Cavalcanti

Biochemistry· March 2024

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Publisher Correction: Discovery and biological characterization of geranylated RNA in bacteria.
Christoph E Dumelin, Yiyun Chen, Aaron M Leconte, Y Grace Chen, David R Liu

Nat Chem Biol· December 2025

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Practical Tips for Intentional and Inclusive Recruiting and Hiring for Academic Research Laboratories.
Madison K C Seto, Taiasean Wu, Aaron M Leconte

Chembiochem· December 2025

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Enzymatic Synthesis of Mixed XNA Polymers Containing 2'Fluoro and 2'Azide Modifications.
Hailey E Kang, Ananya Venkatesh, Serena C Liu, Aaron M Leconte

ACS Omega· November 2025

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Biochemical Analysis Leads to Improved Orthogonal Bioluminescent Tools.
Sierra J Williams, Jordan A Gewing-Mullins, Whitney K Lieberman, Bethany Kolbaba-Kartchner, Reema Iqbal, Aaron M Leconte

Chembiochem· March 2023

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Mutant polymerases capable of 2' fluoro-modified nucleic acid synthesis and amplification with improved accuracy.
Trevor A Christensen, Kristi Y Lee, Simone Z P Gottlieb, Mikayla B Carrier, Aaron M Leconte

RSC Chem Biol· August 2022

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Accurate and Efficient One-Pot Reverse Transcription and Amplification of 2'-Fluoro-Modified Nucleic Acids by Commercial DNA Polymerases.
Arianna S Thompson, Susanna E Barrett, Aurora G Weiden, Ananya Venkatesh, Madison K C Seto, Aaron M Leconte

Biochemistry· August 2020

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Statistical Coupling Analysis-Guided Library Design for the Discovery of Mutant Luciferases.
Mira D Liu, Elliot A Warner, Charlotte E Morrissey, Caitlyn W Fick, Taia S Wu, Aaron M Leconte

Biochemistry· February 2018

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DNA Polymerase Activity Assay Using Near-infrared Fluorescent Labeled DNA Visualized by Acrylamide Gel Electrophoresis.
Eliza L Lewis, Aaron M Leconte

J Vis Exp· October 2017

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Design and Discovery of New Combinations of Mutant DNA Polymerases and Modified DNA Substrates.
Sydney L Rosenblum, Aurora G Weiden, Eliza L Lewis, Alexie L Ogonowsky, Hannah E Chia, Aaron M Leconte

Chembiochem· April 2017

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Taq DNA Polymerase Mutants and 2'-Modified Sugar Recognition.
Hayley J Schultz, Andrea M Gochi, Hannah E Chia, Alexie L Ogonowsky, Sharon Chiang, Aaron M Leconte

Biochemistry· September 2015

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Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution.
Bryan C Dickinson, Aaron M Leconte, Benjamin Allen, Kevin M Esvelt, David R Liu

Proc Natl Acad Sci U S A· May 2013

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A population-based experimental model for protein evolution: effects of mutation rate and selection stringency on evolutionary outcomes.
Aaron M Leconte, Bryan C Dickinson, David D Yang, Irene A Chen, Benjamin Allen

Biochemistry· February 2013

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Synthesis and evaluation of substrate analogue inhibitors of trypanothione reductase.
Michael H Duyzend, Christopher T Clark, Shayna L Simmons, Wade B Johnson, Anna M Larson, Aaron M Leconte

J Enzyme Inhib Med Chem· December 2012

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Discovery and biological characterization of geranylated RNA in bacteria.
Christoph E Dumelin, Yiyun Chen, Aaron M Leconte, Y Grace Chen, David R Liu

Nat Chem Biol· November 2012

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Directed evolution of DNA polymerases for next-generation sequencing.
Aaron M Leconte, Maha P Patel, Lauryn E Sass, Peter McInerney, Mirna Jarosz

Angew Chem Int Ed Engl· August 2010

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Optimization of the pyridyl nucleobase scaffold for polymerase recognition and unnatural base pair replication.
Yoshiyuki Hari, Gil Tae Hwang, Aaron M Leconte, Nicolas Joubert, Michal Hocek

Chembiochem· November 2008

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Discovery, characterization, and optimization of an unnatural base pair for expansion of the genetic alphabet.
Aaron M Leconte, Gil Tae Hwang, Shigeo Matsuda, Petr Capek, Yoshiyuki Hari

J Am Chem Soc· February 2008

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Polymerase recognition and stability of fluoro-substituted pyridone nucleobase analogues.
Gil Tae Hwang, Aaron M Leconte, Floyd E Romesberg

Chembiochem· September 2007

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Minor groove hydrogen bonds and the replication of unnatural base pairs.
Shigeo Matsuda, Aaron M Leconte, Floyd E Romesberg

J Am Chem Soc· May 2007

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Stability and polymerase recognition of pyridine nucleobase analogues: role of minor-groove H-bond acceptors.
Yoonkyung Kim, Aaron M Leconte, Yoshiyuki Hari, Floyd E Romesberg

Angew Chem Int Ed Engl· November 2006

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Chemical biology: a broader take on DNA.
Aaron M Leconte, Floyd E Romesberg

Nature· November 2006

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Amplify this! DNA and RNA get a third base pair.
Aaron M Leconte, Floyd E Romesberg

Nat Methods· September 2006

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Efforts towards expansion of the genetic alphabet: pyridone and methyl pyridone nucleobases.
Aaron M Leconte, Shigeo Matsuda, Gil Tae Hwang, Floyd E Romesberg

Angew Chem Int Ed Engl· June 2006

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An efficiently extended class of unnatural base pairs.
Aaron M Leconte, Shigeo Matsuda, Floyd E Romesberg

J Am Chem Soc· May 2006

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