Publications by authors named "Aaron Meadows"

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Threshold for Pre-existing Antibody Levels Limiting Transduction Efficiency of Systemic rAAV9 Gene Delivery: Relevance for Translation.
Aaron S Meadows, Ricardo J Pineda, Laurie Goodchild, Tierra A Bobo, Haiyan Fu

Mol Ther Methods Clin Dev· June 2019

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Targeting Root Cause by Systemic scAAV9-h Gene Delivery: Functional Correction and Reversal of Severe MPS II in Mice.
Haiyan Fu, Kim Zaraspe, Naoko Murakami, Aaron S Meadows, Ricardo J Pineda

Mol Ther Methods Clin Dev· September 2018

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Differential Prevalence of Antibodies Against Adeno-Associated Virus in Healthy Children and Patients with Mucopolysaccharidosis III: Perspective for AAV-Mediated Gene Therapy.
Haiyan Fu, Aaron S Meadows, Ricardo J Pineda, Krista L Kunkler, Kristen V Truxal

Hum Gene Ther Clin Dev· December 2017

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Serum global metabolomics profiling reveals profound metabolic impairments in patients with MPS IIIA and MPS IIIB.
Haiyan Fu, Aaron S Meadows, Ricardo J Pineda, Robert P Mohney, Steve Stirdivant

Metab Brain Dis· October 2017

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Near-Complete Correction of Profound Metabolomic Impairments Corresponding to Functional Benefit in MPS IIIB Mice after IV rAAV9-hNAGLU Gene Delivery.
Haiyan Fu, Aaron S Meadows, Tierra Ware, Robert P Mohney, Douglas M McCarty

Mol Ther· March 2017

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Effective Depletion of Pre-existing Anti-AAV Antibodies Requires Broad Immune Targeting.
Victoria M Velazquez, Aaron S Meadows, Ricardo J Pineda, Marybeth Camboni, Douglas M McCarty

Mol Ther Methods Clin Dev· March 2017

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Functional correction of neurological and somatic disorders at later stages of disease in MPS IIIA mice by systemic scAAV9-hSGSH gene delivery.
Haiyan Fu, Marcela P Cataldi, Tierra A Ware, Kimberly Zaraspe, Aaron S Meadows

Mol Ther Methods Clin Dev· June 2016

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Blood genome-wide transcriptional profiles reflect broad molecular impairments and strong blood-brain links in Alzheimer's disease.
Bartholomew J Naughton, F Jason Duncan, Darren A Murrey, Aaron S Meadows, David E Newsom

J Alzheimers Dis· January 2016

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A GLP-Compliant Toxicology and Biodistribution Study: Systemic Delivery of an rAAV9 Vector for the Treatment of Mucopolysaccharidosis IIIB.
Aaron S Meadows, F Jason Duncan, Marybeth Camboni, Kathryn Waligura, Chrystal Montgomery

Hum Gene Ther Clin Dev· December 2015

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Broad functional correction of molecular impairments by systemic delivery of scAAVrh74-hSGSH gene delivery in MPS IIIA mice.
F Jason Duncan, Bartholomew J Naughton, Kimberly Zaraspe, Darren A Murrey, Aaron S Meadows

Mol Ther· April 2015

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Amyloidosis, synucleinopathy, and prion encephalopathy in a neuropathic lysosomal storage disease: the CNS-biomarker potential of peripheral blood.
Bartholomew J Naughton, F Jason Duncan, Darren Murrey, Tierra Ware, Aaron Meadows

PLoS One· September 2014

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Feasibility and safety of systemic rAAV9-hNAGLU delivery for treating mucopolysaccharidosis IIIB: toxicology, biodistribution, and immunological assessments in primates.
Darren A Murrey, Bartholomew J Naughton, F Jason Duncan, Aaron S Meadows, Tierra A Ware

Hum Gene Ther Clin Dev· June 2014

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