Publications by authors named "Aaron Schain"

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OnabotulinumtoxinA alters pro- and anti-inflammatory dural macrophage response to CSD in female mice.
Aaron J Schain, Diego Delgado Fajardo, Andrew M Strassman, Subhash Kulkarni, Ron S Broide

Cephalalgia· September 2025

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Label-free and fluorescence imaging of oligodendrocytes and myelin.
Yasmine Kamen, Megan E Doty, Matthew E Ciolkowski, Xhoela Bame, Alicia N Pietramale, Aaron J Schain

Npj Imaging· July 2025

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OnabotulinumtoxinA affects cortical recovery period but not occurrence or propagation of cortical spreading depression in rats with compromised blood-brain barrier.
Agustin Melo-Carrillo, Andrew M Strassman, Aaron J Schain, Ron S Broide, Brian B Cai

Pain· September 2021

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Combined onabotulinumtoxinA/atogepant treatment blocks activation/sensitization of high-threshold and wide-dynamic range neurons.
Agustin Melo-Carrillo, Andrew M Strassman, Aaron J Schain, Aubrey Manack Adams, Mitchell F Brin

Cephalalgia· January 2021

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Activation of Peripheral and Central Trigeminovascular Neurons by Seizure: Implications for Ictal and Postictal Headache.
Agustin Melo-Carrillo, Aaron J Schain, Andrew M Strassman, Rami Burstein

J Neurosci· July 2020

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Fremanezumab and its isotype slow propagation rate and shorten cortical recovery period but do not prevent occurrence of cortical spreading depression in rats with compromised blood-brain barrier.
Agustin Melo-Carrillo, Aaron J Schain, Jennifer Stratton, Andrew M Strassman, Rami Burstein

Pain· May 2020

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Celecoxib reduces cortical spreading depression-induced macrophage activation and dilatation of dural but not pial arteries in rodents: implications for mechanism of action in terminating migraine attacks.
Aaron J Schain, Agustin Melo-Carrillo, Sait Ashina, Andrew M Strassman, Rami Burstein

Pain· May 2020

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Fluorescently-labeled fremanezumab is distributed to sensory and autonomic ganglia and the dura but not to the brain of rats with uncompromised blood brain barrier.
Rodrigo Noseda, Aaron J Schain, Agustin Melo-Carrillo, Jason Tien, Jennifer Stratton

Cephalalgia· March 2020

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Exploring the effects of extracranial injections of botulinum toxin type A on prolonged intracranial meningeal nociceptors responses to cortical spreading depression in female rats.
Agustin Melo-Carrillo, Andrew M Strassman, Aaron J Schain, Rodrigo Noseda, Sait Ashina

Cephalalgia· October 2019

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CSD-Induced Arterial Dilatation and Plasma Protein Extravasation Are Unaffected by Fremanezumab: Implications for CGRP's Role in Migraine with Aura.
Aaron J Schain, Agustin Melo-Carrillo, Jennifer Stratton, Andrew M Strassman, Rami Burstein

J Neurosci· July 2019

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Activation of pial and dural macrophages and dendritic cells by cortical spreading depression.
Aaron J Schain, Agustin Melo-Carrillo, David Borsook, Jaime Grutzendler, Andrew M Strassman

Ann Neurol· March 2018

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Fremanezumab-A Humanized Monoclonal Anti-CGRP Antibody-Inhibits Thinly Myelinated (Aδ) But Not Unmyelinated (C) Meningeal Nociceptors.
Agustin Melo-Carrillo, Andrew M Strassman, Rony-Reuven Nir, Aaron J Schain, Rodrigo Noseda

J Neurosci· November 2017

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Selective Inhibition of Trigeminovascular Neurons by Fremanezumab: A Humanized Monoclonal Anti-CGRP Antibody.
Agustin Melo-Carrillo, Rodrigo Noseda, Rony-Reuven Nir, Aaron J Schain, Jennifer Stratton

J Neurosci· July 2017

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Extracranial origin of headache.
Rami Burstein, Pamela Blake, Aaron Schain, Carlton Perry

Curr Opin Neurol· June 2017

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Cortical Spreading Depression Closes Paravascular Space and Impairs Glymphatic Flow: Implications for Migraine Headache.
Aaron J Schain, Agustin Melo-Carrillo, Andrew M Strassman, Rami Burstein

J Neurosci· March 2017

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Upregulation of inflammatory gene transcripts in periosteum of chronic migraineurs: Implications for extracranial origin of headache.
Carlton J Perry, Pamela Blake, Catherine Buettner, Efstathios Papavassiliou, Aaron J Schain

Ann Neurol· June 2016

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Simvastatin and vitamin D for migraine prevention: A randomized, controlled trial.
Catherine Buettner, Rony-Reuven Nir, Suzanne M Bertisch, Carolyn Bernstein, Aaron Schain

Ann Neurol· December 2015

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Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques.
Carlo Condello, Peng Yuan, Aaron Schain, Jaime Grutzendler

Nat Commun· January 2015

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Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy.
Aaron J Schain, Robert A Hill, Jaime Grutzendler

Nat Med· April 2014

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Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition.
Carlo Condello, Aaron Schain, Jaime Grutzendler

Sci Rep· August 2013

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CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis.
Zhiqiang Liu, Carlo Condello, Aaron Schain, Roa Harb, Jaime Grutzendler

J Neurosci· December 2010

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