Publications by authors named "Abraham Scaria"

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Subretinal Gene Therapy Drug AGTC-501 for XLRP Phase 1/2 Multicenter Study (HORIZON): 24-Month Safety and Efficacy Results.
Paul Yang, David Birch, Andreas Lauer, Robert Sisk, Rajiv Anand, Abraham Scaria

Am J Ophthalmol· March 2025

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AAV Gene Augmentation of Truncated Complement Factor H Differentially Rescues Ocular Complement Dysregulation in a Mouse Model.
Daniel Grigsby, Mikael Klingeborn, Una Kelly, Lindsey A Chew, Aravind Asokan, Abraham Scaria

Invest Ophthalmol Vis Sci· July 2023

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Addendum to: Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases.
Moritz J Schmidt, Ashish Gupta, Christien Bednarski, Stefanie Gehrig-Giannini, Florian Richter, Abraham Scaria

Nat Commun· June 2023

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Preclinical studies in support of phase I/II clinical trials to treat -associated Leber congenital amaurosis.
Sanford L Boye, Catherine O'Riordan, James Morris, Michael Lukason, David Compton, Abraham Scaria

Mol Ther Methods Clin Dev· March 2023

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BEST Disease and Gene Therapy.
Abraham Scaria

Int Ophthalmol Clin· October 2021

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Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases.
Moritz J Schmidt, Ashish Gupta, Christien Bednarski, Stefanie Gehrig-Giannini, Florian Richter, Abraham Scaria

Nat Commun· July 2021

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Universal Method for the Purification of Recombinant AAV Vectors of Differing Serotypes.
Shelley A Nass, Maryellen A Mattingly, Denise A Woodcock, Brenda L Burnham, Jeffrey A Ardinger, Abraham Scaria

Mol Ther Methods Clin Dev· June 2018

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Rationally designed AAV2 and AAVrh8R capsids provide improved transduction in the retina and brain.
Jennifer A Sullivan, Lisa M Stanek, Michael J Lukason, Jie Bu, Shayla R Osmond, Abraham Scaria

Gene Ther· June 2018

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Ocular gene therapy for neovascular AMD: a new era? - Authors' reply.
Peter A Campochiaro, Jeffrey S Heier, Saleema Kherani, Annaig Le-Halpere, Abraham Scaria

Lancet· November 2017

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Intravitreous injection of AAV2-sFLT01 in patients with advanced neovascular age-related macular degeneration: a phase 1, open-label trial.
Jeffrey S Heier, Saleema Kherani, Shilpa Desai, Pravin Dugel, Shalesh Kaushal, Abraham Scaria

Lancet· July 2017

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AAVS1-Targeted Plasmid Integration in AAV Producer Cell Lines.
Yuxia Luo, Amy Frederick, John M Martin, Abraham Scaria, Seng H Cheng

Hum Gene Ther Methods· June 2017

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Soluble FLT1 Gene Therapy Alleviates Brain Arteriovenous Malformation Severity.
Wan Zhu, Fanxia Shen, Lei Mao, Lei Zhan, Shuai Kang, Abraham Scaria

Stroke· May 2017

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CRISPR/Cas9-Mediated Genome Editing as a Therapeutic Approach for Leber Congenital Amaurosis 10.
Guo-Xiang Ruan, Elizabeth Barry, Dan Yu, Michael Lukason, Seng H Cheng, Abraham Scaria

Mol Ther· February 2017

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Analytical Ultracentrifugation as an Approach to Characterize Recombinant Adeno-Associated Viral Vectors.
Brenda Burnham, Shelley Nass, Elton Kong, MaryEllen Mattingly, Denise Woodcock, Abraham Scaria

Hum Gene Ther Methods· December 2015

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Aurintricarboxylic acid increases yield of HSV-1 vectors.
Peter Pechan, Jeffery Ardinger, Jyothi Ketavarapu, Hillard Rubin, Samuel C Wadsworth, Abraham Scaria

Mol Ther Methods Clin Dev· May 2015

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Interleukin-17 retinotoxicity is prevented by gene transfer of a soluble interleukin-17 receptor acting as a cytokine blocker: implications for age-related macular degeneration.
Daniel Ardeljan, Yujuan Wang, Stanley Park, Defen Shen, Xi Kathy Chu, Abraham Scaria

PLoS One· January 2015

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Gene Therapies for Neovascular Age-Related Macular Degeneration.
Peter Pechan, Samuel Wadsworth, Abraham Scaria

Cold Spring Harb Perspect Med· December 2014

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Translational fidelity of intrathecal delivery of self-complementary AAV9-survival motor neuron 1 for spinal muscular atrophy.
Marco A Passini, Jie Bu, Amy M Richards, Christopher M Treleaven, Jennifer A Sullivan, Abraham Scaria

Hum Gene Ther· July 2014

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Prevalence of neutralizing factors against adeno-associated virus types 2 in age-related macular degeneration and polypoidal choroidal vasculopathy.
Yong Cheng, Lvzhen Huang, Xiaoxin Li, Huijun Qi, Peng Zhou, Abraham Scaria

Curr Gene Ther· June 2013

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Development of a cellular model of rod opsin retinitis pigmentosa.
Matthew Adamowicz, Antonius Song, Samuel Wadsworth, Abraham Scaria, Catherine O'Riordan

Adv Exp Med Biol· April 2012

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AAV5-mediated sFLT01 gene therapy arrests retinal lesions in Ccl2(-/-)/Cx3cr1(-/-) mice.
Jingsheng Tuo, Ji-Jing Pang, Xiaoguang Cao, Defen Shen, Jun Zhang, Abraham Scaria

Neurobiol Aging· February 2012

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sFLT01: a novel fusion protein with antiangiogenic activity.
Rebecca G Bagley, Leslie Kurtzberg, William Weber, Tri-Hung Nguyen, Stephanie Roth, Abraham Scaria

Mol Cancer Ther· March 2011

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Inhibition of choroidal neovascularization in a nonhuman primate model by intravitreal administration of an AAV2 vector expressing a novel anti-VEGF molecule.
Michael Lukason, Elizabeth DuFresne, Hillard Rubin, Peter Pechan, Qiuhong Li, Abraham Scaria

Mol Ther· February 2011

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Preclinical safety evaluation of AAV2-sFLT01- a gene therapy for age-related macular degeneration.
Timothy K Maclachlan, Michael Lukason, Margaret Collins, Robert Munger, Elisabete Isenberger, Abraham Scaria

Mol Ther· February 2011

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Probing the vibrational dynamics of high-lying electronic states using pump-degenerate four-wave mixing.
Jörg Liebers, Abraham Scaria, Arnulf Materny, Ulrich Kleinekathöfer

Phys Chem Chem Phys· February 2010

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