Publications by authors named "Adam B Edwards"

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Assessment of the safety of the cationic arginine-rich peptides (CARPs) poly-arginine-18 (R18 and R18D) in models of mast cell degranulation and red blood cell hemolysis.
Adam B Edwards, Frank L Mastaglia, Neville W Knuckey, Kwok-Ho Yip, Bruno Meloni

Biochem Biophys Rep· September 2022

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Impact of poly-arginine peptides R18D and R18 on alteplase and tenecteplase thrombolysis in vitro, and neuroprotective stability to proteolysis.
Bruno P Meloni, David J Blacker, Adam B Edwards, Neville W Knuckey

J Thromb Thrombolysis· July 2022

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Comparative Assessment of the Proteolytic Stability and Impact of Poly-Arginine Peptides R18 and R18D on Infarct Growth and Penumbral Tissue Preservation Following Middle Cerebral Artery Occlusion in the Sprague Dawley Rat.
Diego Milani, Vince W Clark, Kirk W Feindel, David J Blacker, Michael Bynevelt, Adam B Edwards

Neurochem Res· May 2021

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Neuroprotective Cationic Arginine-Rich Peptides (CARPs): An Assessment of Their Clinical Safety.
Adam B Edwards, Frank L Mastaglia, Neville W Knuckey, Bruno P Meloni

Drug Saf· October 2020

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Assessment of therapeutic window for poly-arginine-18D (R18D) in a P7 rat model of perinatal hypoxic-ischaemic encephalopathy.
Adam B Edwards, Ryan S Anderton, Neville W Knuckey, Bruno P Meloni

J Neurosci Res· November 2018

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Perinatal Hypoxic-Ischemic Encephalopathy and Neuroprotective Peptide Therapies: A Case for Cationic Arginine-Rich Peptides (CARPs).
Adam B Edwards, Ryan S Anderton, Neville W Knuckey, Bruno P Meloni

Brain Sci· August 2018

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Poly-arginine R18 and R18D (D-enantiomer) peptides reduce infarct volume and improves behavioural outcomes following perinatal hypoxic-ischaemic encephalopathy in the P7 rat.
Adam B Edwards, Jane L Cross, Ryan S Anderton, Neville W Knuckey, Bruno P Meloni

Mol Brain· February 2018

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Assessment of R18, COG1410, and APP96-110 in Excitotoxicity and Traumatic Brain Injury.
Li Shan Chiu, Ryan S Anderton, Jane L Cross, Vince W Clark, Adam B Edwards

Transl Neurosci· November 2017

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Assessment of the Neuroprotective Effects of Arginine-Rich Protamine Peptides, Poly-Arginine Peptides (R12-Cyclic, R22) and Arginine-Tryptophan-Containing Peptides Following In Vitro Excitotoxicity and/or Permanent Middle Cerebral Artery Occlusion in Rats.
Bruno P Meloni, Diego Milani, Jane L Cross, Vince W Clark, Adam B Edwards

Neuromolecular Med· September 2017

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Modification to the Rice-Vannucci perinatal hypoxic-ischaemic encephalopathy model in the P7 rat improves the reliability of cerebral infarct development after 48hours.
Adam B Edwards, Kirk W Feindel, Jane L Cross, Ryan S Anderton, Vincent W Clark

J Neurosci Methods· August 2017

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Characterisation of neuroprotective efficacy of modified poly-arginine-9 (R9) peptides using a neuronal glutamic acid excitotoxicity model.
Adam B Edwards, Ryan S Anderton, Neville W Knuckey, Bruno P Meloni

Mol Cell Biochem· February 2017

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The Neuroprotective Peptide Poly-Arginine-12 (R12) Reduces Cell Surface Levels of NMDA NR2B Receptor Subunit in Cortical Neurons; Investigation into the Involvement of Endocytic Mechanisms.
Gabriella MacDougall, Ryan S Anderton, Adam B Edwards, Neville W Knuckey, Bruno P Meloni

J Mol Neurosci· February 2017

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Neuroprotective peptides fused to arginine-rich cell penetrating peptides: Neuroprotective mechanism likely mediated by peptide endocytic properties.
Bruno P Meloni, Diego Milani, Adam B Edwards, Ryan S Anderton, Ryan L O'Hare Doig

Pharmacol Ther· September 2015

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Poly-arginine and arginine-rich peptides are neuroprotective in stroke models.
Bruno P Meloni, Laura M Brookes, Vince W Clark, Jane L Cross, Adam B Edwards

J Cereb Blood Flow Metab· June 2015

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Initial experience with upfront arterial and perfusion imaging among ischemic stroke patients presenting within the 4.5-hour time window.
Ali Reza Noorian, Katja Bryant, Ashley Aiken, Andrew D Nicholson, Adam B Edwards

J Stroke Cerebrovasc Dis· February 2014

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