Publications by authors named "Adam B Weinglass"

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A
A non-canonical mechanism of GPCR activation.
Alexander S Powers, Aasma Khan, Joseph M Paggi, Naomi R Latorraca, Sarah Souza, Adam B Weinglass

Nat Commun· November 2024

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A non-canonical mechanism of GPCR activation.
Alexander S Powers, Aasma Khan, Joseph M Paggi, Naomi R Latorraca, Sarah Souza, Adam B Weinglass

bioRxiv· August 2023

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Design, synthesis and biological evaluation of indane derived GPR40 agoPAMs.
Barbara Pio, Harry R Chobanian, Yan Guo, Hubert Josien, William K Hagmann, Adam B Weinglass

Bioorg Med Chem Lett· July 2019

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Structure-Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs.
Helen Y Chen, Christopher W Plummer, Dong Xiao, Harry R Chobanian, Duane DeMong, Adam B Weinglass

ACS Med Chem Lett· July 2018

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GPR40 partial agonists and AgoPAMs: Differentiating effects on glucose and hormonal secretions in the rodent.
Michele J Pachanski, Melissa E Kirkland, Daniel T Kosinski, Joel Mane, Boonlert Cheewatrakoolpong, Adam B Weinglass

PLoS One· November 2017

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GPR40 partial agonist MK-2305 lower fasting glucose in the Goto Kakizaki rat via suppression of endogenous glucose production.
Corin Miller, Michele J Pachanski, Melissa E Kirkland, Daniel T Kosinski, Joel Mane, Adam B Weinglass

PLoS One· September 2017

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GPR40 reduces food intake and body weight through GLP-1.
Judith N Gorski, Michele J Pachanski, Joel Mane, Christopher W Plummer, Sarah Souza, Adam B Weinglass

Am J Physiol Endocrinol Metab· July 2017

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Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.
Jun Lu, Noel Byrne, John Wang, Gerard Bricogne, Frank K Brown, Adam B Weinglass

Nat Struct Mol Biol· July 2017

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Design and Synthesis of Novel, Selective GPR40 AgoPAMs.
Christopher W Plummer, Matthew J Clements, Helen Chen, Murali Rajagopalan, Hubert Josien, Adam B Weinglass

ACS Med Chem Lett· February 2017

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GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo.
Maria Hauge, Marie A Vestmar, Anna S Husted, Jeppe P Ekberg, Michael J Wright, Adam B Weinglass

Mol Metab· January 2015

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Technologies for transporter drug discovery.
Adam B Weinglass, Maria L Garcia, Gregory L Kaczorowski

Channels (Austin)· July 2011

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ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors.
William A Schmalhofer, Jeffrey Calhoun, Rachel Burrows, Timothy Bailey, Martin G Kohler, Adam B Weinglass

Mol Pharmacol· November 2008

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Extracellular loop C of NPC1L1 is important for binding to ezetimibe.
Adam B Weinglass, Martin Kohler, Uwe Schulte, Jessica Liu, Emmanuel O Nketiah

Proc Natl Acad Sci U S A· August 2008

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Madin-Darby canine kidney II cells: a pharmacologically validated system for NPC1L1-mediated cholesterol uptake.
Adam B Weinglass, Martin G Köhler, Emmanuel O Nketiah, Jessica Liu, William Schmalhofer

Mol Pharmacol· April 2008

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A high-capacity membrane potential FRET-based assay for the sodium-coupled glucose co-transporter SGLT1.
Adam B Weinglass, Andrew M Swensen, Jessica Liu, William Schmalhofer, Anu Thomas

Assay Drug Dev Technol· April 2008

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Characterization of Kir1.1 channels with the use of a radiolabeled derivative of tertiapin.
John P Felix, Jessica Liu, William A Schmalhofer, Timothy Bailey, Maria A Bednarek, Adam B Weinglass

Biochemistry· August 2006

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Exploring the role of a unique carboxyl residue in EmrE by mass spectrometry.
Adam B Weinglass, Misha Soskine, Jose-Luis Vazquez-Ibar, Julian P Whitelegge, Kym F Faull

J Biol Chem· March 2005

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Sugar recognition by the lactose permease of Escherichia coli.
José Luis Vázquez-Ibar, Lan Guan, Adam B Weinglass, Gill Verner, Ruth Gordillo

J Biol Chem· November 2004

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Integrating mass spectrometry into membrane protein drug discovery.
Adam B Weinglass, Julian P Whitelegge, H Ronald Kaback

Curr Opin Drug Discov Devel· September 2004

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In vitro synthesis of lactose permease to probe the mechanism of membrane insertion and folding.
Shushi Nagamori, José Luis Vázquez-Ibar, Adam B Weinglass, H Ronald Kaback

J Biol Chem· April 2003

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Elucidation of substrate binding interactions in a membrane transport protein by mass spectrometry.
Adam B Weinglass, Julian P Whitelegge, Yonglin Hu, Gillian E Verner, Kym F Faull

EMBO J· April 2003

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Binding of enzyme IIAGlc, a component of the phosphoenolpyruvate:sugar phosphotransferase system, to the Escherichia coli lactose permease.
Melissa Sondej, Adam B Weinglass, Alan Peterkofsky, H Ronald Kaback

Biochemistry· April 2002

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Engineering a terbium-binding site into an integral membrane protein for luminescence energy transfer.
José Luis Vázquez-Ibar, Adam B Weinglass, H Ronald Kaback

Proc Natl Acad Sci U S A· March 2002

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Manipulating conformational equilibria in the lactose permease of Escherichia coli.
Adam B Weinglass, Melissa Sondej, H Ronald Kaback

J Mol Biol· January 2002

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