Publications by authors named "Adam D Hughes"

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Reproductive gene expression in female broodstock European flat oyster, Ostrea edulis, under ambient and constant temperature and photoperiod regimes.
Mairi E Cowan, Eduardo Jimenez-Fernandez, Aaliyah Malla, Adam D Hughes

Comp Biochem Physiol A Mol Integr Physiol· December 2025

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Sexual dimorphism in the gonad lipidome of blue mussels (Mytilus sp.): New insights from a global lipidomics approach.
Vincenzo Alessandro Laudicella, Stefano Carboni, Phillip D Whitfield, Mary K Doherty, Adam D Hughes

Comp Biochem Physiol Part D Genomics Proteomics· December 2023

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Lung-restricted ALK5 inhibition avoids systemic toxicities associated with TGFβ pathway inhibition.
Jonathan M Maher, Rui Zhang, Gopinath Palanisamy, Kimberly Perkins, Lynda Liu, Adam D Hughes

Toxicol Appl Pharmacol· March 2022

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Lipidomics analysis of juveniles' blue mussels (Mytilus edulis L. 1758), a key economic and ecological species.
Vincenzo Alessandro Laudicella, Christine Beveridge, Stefano Carboni, Sofia C Franco, Mary K Doherty, Adam D Hughes

PLoS One· April 2020

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Comparing the effectiveness of twine- and binder-seeding in the Laminariales species and .
Philip D Kerrison, Mairi Innes, Adrian Macleod, Emily McCormick, Peter D Elbourne, Adam D Hughes

J Appl Phycol· March 2020

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Early development and substrate twine selection for the cultivation of (Yendo) Fensholt under laboratory conditions.
Hau Nhu Le, Adam D Hughes, Philip D Kerrison

J Appl Phycol· April 2018

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Decontamination treatments to eliminate problem biota from macroalgal tank cultures of , and .
Philip D Kerrison, Hau Nhu Le, Gail C Twigg, Duncan R Smallman, Rory MacPhee, Adam D Hughes

J Appl Phycol· July 2016

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Heterotrophic compensation: a possible mechanism for resilience of coral reefs to global warming or a sign of prolonged stress?
Adam D Hughes, Andréa G Grottoli

PLoS One· May 2015

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Discovery of (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate (TD-5959, GSK961081, batefenterol): first-in-class dual pharmacology multivalent muscarinic antagonist and β₂ agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD).
Adam D Hughes, Yan Chen, Sharath S Hegde, Jeffrey R Jasper, Sarah Jaw-Tsai

J Med Chem· March 2015

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Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties.
Sharath S Hegde, Adam D Hughes, Yan Chen, Tod Steinfeld, Jeffrey R Jasper

J Pharmacol Exp Ther· October 2014

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Fucosylated chondroitin sulfates from the body wall of the sea cucumber Holothuria forskali: conformation, selectin binding, and biological activity.
Charalampos G Panagos, Derek S Thomson, Claire Moss, Adam D Hughes, Maeve S Kelly

J Biol Chem· October 2014

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Echinoderms display morphological and behavioural phenotypic plasticity in response to their trophic environment.
Adam D Hughes, Lars Brunner, Elizabeth J Cook, Maeve S Kelly, Ben Wilson

PLoS One· February 2013

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Fatty acid profiles during gametogenesis in sea urchin (Paracentrotus lividus): effects of dietary inputs on gonad, egg and embryo profiles.
Stefano Carboni, Adam D Hughes, Tim Atack, Douglas R Tocher, Herve Migaud

Comp Biochem Physiol A Mol Integr Physiol· February 2013

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Biogas from Macroalgae: is it time to revisit the idea?
Adam D Hughes, Maeve S Kelly, Kenneth D Black, Michele S Stanley

Biotechnol Biofuels· November 2012

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Multivalent dual pharmacology muscarinic antagonist and β₂ agonist (MABA) molecules for the treatment of COPD.
Adam D Hughes, Alexander McNamara, Tod Steinfeld

Prog Med Chem· August 2012

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Inhalation by design.
Lyn H Jones, Adam D Hughes

Future Med Chem· October 2011

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Dual-pharmacology muscarinic antagonist and β₂ agonist molecules for the treatment of chronic obstructive pulmonary disease.
Adam D Hughes, Lyn H Jones

Future Med Chem· October 2011

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THRX-198321 is a bifunctional muscarinic receptor antagonist and beta2-adrenoceptor agonist (MABA) that binds in a bimodal and multivalent manner.
Tod Steinfeld, Adam D Hughes, Uwe Klein, Jacqueline A M Smith, Mathai Mammen

Mol Pharmacol· March 2011

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Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules.
Adam D Hughes, Kay H Chin, Sarah L Dunham, Jeffrey R Jasper, Kristin E King

Bioorg Med Chem Lett· March 2011

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Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonist.
Alexander McNamara, Maria Teresa Pulido-Rios, Shelley Sweazey, Glenmar P Obedencio, Harold Thibodeaux, Adam D Hughes

Eur J Pharmacol· March 2009

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