Publications by authors named "Adam Helms"

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Prognostic Role of Myocarditis-Like Episodes and Their Treatment in Patients With Pathogenic Desmoplakin Variants.
Alessio Gasperetti, Steven A Muller, Giovanni Peretto, Babken Asatryan, Alexandros Protonotarios, Adam Helms

Circulation· October 2025

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Location of LMNA Variants and Clinical Outcomes in Cardiomyopathy.
Ashwin Bhaskaran, Rabah Ben Yaou, Adam S Helms, Abdallah Fayssoil, Pascale Richard

JAMA Cardiol· September 2025

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Altered cardiac excitability and arrhythmia in models of SCN1B-linked developmental and epileptic encephalopathy.
Roberto Ramos-Mondragon, Shuyun Wang, Nnamdi Edokobi, Qinghua Liu, Xiaotan Qiao, Adam S Helms

JCI Insight· September 2025

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FICD (FIC Domain Protein Adenylyl Transferase) Deficiency Protects Mice From Hypertrophy-Induced Heart Failure and Promotes BiP (Binding Immunoglobulin Protein) -Mediated Activation of the Unfolded Protein Response and Endoplasmic Reticulum-Selective Autophagy in Cardiomyocytes.
Shannon M Lacy, Rebecca J Taubitz, Nicholas D Urban, Samantha N Turowski, Eric N Primack, Adam S Helms

J Am Heart Assoc· August 2025

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Semi-synthetic fibrous fibrin composites promote 3D microvascular assembly, survival, and host integration of endothelial cells without mesenchymal cell support.
Firaol S Midekssa, Christopher D Davidson, Megan E Wieger, Jordan L Kamen, Kaylin M Hanna, Adam S Helms

Bioact Mater· July 2025

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The contribution of truncating variants to human cardiomyopathy.
Brendan J Floyd, Joyce N Njoroge, Vikki A Krysov, Bruna Gomes, Ryan Murtha, Adam Helms

medRxiv· July 2025

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Desmoplakin Haploinsufficiency Underlies Cell-Cell Adhesion Failure in DSP Cardiomyopathy and is Rescued by Transcriptional Activation.
Eric D Smith, Karen Jin, Brianna Ferguson, Yao-Chang Tsan, Samuel J DePalma, Adam S Helms

bioRxiv· June 2025

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Diagnostic Criteria and Disease Staging for Desmoplakin Cardiomyopathy.
Eric Smith, Alessio Gasperetti, Richard T Carrick, Alexandros Protonotarios, Petros Syrris, Adam S Helms

medRxiv· June 2025

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Low Penetrance Sarcomere Variants Contribute to Additive Risk in Hypertrophic Cardiomyopathy.
Joshua K Meisner, Aaron Renberg, Eric D Smith, Yao-Chang Tsan, Brynn Elder, Adam S Helms

Circulation· March 2025

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Correction to: Low Penetrance Sarcomere Variants Contribute to Additive Risk in Hypertrophic Cardiomyopathy.
Joshua K Meisner, Aaron Renberg, Eric D Smith, Yao-Chang Tsan, Brynn Elder, Adam S Helms

Circulation· March 2025

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The Clinical Trajectory of NYHA Functional Class I Patients With Obstructive Hypertrophic Cardiomyopathy.
Monica Ahluwalia, Jiankang Liu, Iacopo Olivotto, Victoria Parikh, Euan A Ashley, Adam S Helms

JACC Heart Fail· February 2025

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Sex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy.
Alexandra Butters, Clare Arnott, Joanna Sweeting, Brian Claggett, Anna Se Cuomo, Adam S Helms

Circ Genom Precis Med· February 2025

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Clinical features and outcomes in carriers of pathogenic desmoplakin variants.
Alessio Gasperetti, Richard T Carrick, Alexandros Protonotarios, Brittney Murray, Mikael Laredo, Adam S Helms

Eur Heart J· January 2025

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Desmoplakin Cardiomyopathy: Role of Inflammation and Potential Role of Disease-Modifying Therapies.
Alessio Gasperetti, Richard T Carrick, Steven Muller, Brittney Murray, Luigi Adamo, Adam Helms

Curr Cardiol Rep· January 2025

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Matrix Architecture and Mechanics Regulate Myofibril Organization, Costamere Assembly, and Contractility in Engineered Myocardial Microtissues.
Samuel J DePalma, Javiera Jilberto, Austin E Stis, Darcy D Huang, Jason Lo, Adam S Helms

Adv Sci (Weinh)· December 2024

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Long-Term Outcomes After Septal Reduction Therapies in Obstructive Hypertrophic Cardiomyopathy: Insights From the SHARE Registry.
Niccolò Maurizi, Panagiotis Antiochos, Anjali Owens, Neal Lakdawala, Sara Saberi, Adam S Helms

Circulation· October 2024

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A novel tool for arrhythmic risk stratification in desmoplakin gene variant carriers.
Richard T Carrick, Alessio Gasperetti, Alexandros Protonotarios, Brittney Murray, Mikael Laredo, Adam S Helms

Eur Heart J· August 2024

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FICD deficiency protects mice from hypertrophy-induced heart failure via BiP-mediated activation of the UPR and ER-phagy.
Shannon M Lacy, Rebecca J Taubitz, Nicholas D Urban, Samantha N Turowski, Eric D Smith, Adam S Helms

bioRxiv· May 2024

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Imaging Features of Arrhythmogenic Cardiomyopathies.
Mauricio S Galizia, Anil K Attili, William R Truesdell, Eric D Smith, Adam S Helms

Radiographics· April 2024

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In Vitro Assessment of Cardiac Fibroblast Activation at Physiologic Stiffness.
Robert S Goldsmith, Yao-Chang Tsan, Rachel E Scissors, Adam S Helms, Matthew J Brody

Curr Protoc· April 2024

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Long-Term Arrhythmic Follow-Up and Risk Stratification of Patients With Desmoplakin-Associated Arrhythmogenic Right Ventricular Cardiomyopathy.
Alessio Gasperetti, Richard Carrick, Alexandros Protonotarios, Mikael Laredo, Iris van der Schaaf, Adam Helms

JACC Adv· March 2024

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A Case of Reverse McConnell's Sign Associated With Acute Respiratory Distress Syndrome and Septic Shock.
Brett Curtis, Albert Ha, Jeffrey Xie, Robert Hyzy, Adam S Helms

Cureus· January 2024

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Integrating mechanical cues with engineered platforms to explore cardiopulmonary development and disease.
Donia W Ahmed, Madeline K Eiken, Samuel J DePalma, Adam S Helms, Rachel L Zemans

iScience· December 2023

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Spatial Single Cell Analysis of Proteins in 2D Human Gastruloids Using Iterative Immunofluorescence.
Emily Freeburne, Seth Teague, Hina Khan, Bolin Li, Siyuan Ding, Adam Helms

Curr Protoc· October 2023

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Matrix architecture and mechanics regulate myofibril organization, costamere assembly, and contractility of engineered myocardial microtissues.
Samuel J DePalma, Javiera Jillberto, Austin E Stis, Darcy D Huang, Jason Lo, Adam S Helms

bioRxiv· October 2023

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