Publications by authors named "Adam Hurlstone"

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Systemic immunosuppression from ultraviolet radiation exposure inhibits cancer immunotherapy.
Pedro Durao, Timothy Budden, Karthik Mallela, Martha Gutteridge, Isabella Mataloni, Adam Hurlstone

J Immunother Cancer· October 2025

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Transcriptome remodelling and changes in growth and cardiometabolic phenotype result following Grb10a knockdown in the early life of the zebrafish.
Bridget L Evans, Terence Garner, Chiara De Leonibus, Lily Wright, Megan Sharps, Adam F L Hurlstone

Cell Mol Life Sci· July 2025

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Transitory Schwann Cell Precursor and hybrid states underpin melanoma therapy resistance and metastasis.
Vishaka Gopalan, Chun Wai Wong, Rotem Leshem, Luke Owen, Tuulia Vallius, Adam Hurlstone

bioRxiv· July 2025

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Dual effect of targeting LSD1 on the invasiveness and the mechanical response of acute lymphoblastic leukemia cells.
Raquel González-Novo, Marina Armesto, África González-Murillo, Marcel Dreger, Adam F L Hurlstone

Biomed Pharmacother· February 2025

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Combined PARP14 inhibition and PD-1 blockade promotes cytotoxic T cell quiescence and modulates macrophage polarization in relapsed melanoma.
Rotem Leshem, Kieran Neil Sefton, Chun Wai Wong, I-Hsuan Lin, Dervla Tamara Isaac, Adam Hurlstone

J Immunother Cancer· January 2025

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A trafficking regulatory subnetwork governs αβ integrin-HER2 cross-talk to control breast cancer invasion and drug resistance.
Horacio Maldonado, Marcel Dreger, Lara D Bedgood, Theano Kyriakou, Katarzyna I Wolanska, Adam Hurlstone

Sci Adv· December 2024

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A TIAM1-TRIM28 complex mediates epigenetic silencing of protocadherins to promote migration of lung cancer cells.
Lucy Ginn, Joe Maltas, Martin J Baker, Anshuman Chaturvedi, Leah Wilson, Adam Hurlstone

Proc Natl Acad Sci U S A· October 2023

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The role of IFN-γ-signalling in response to immune checkpoint blockade therapy.
Chun Wai Wong, Yang Yu Huang, Adam Hurlstone

Essays Biochem· September 2023

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PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven acquired resistance in preclinical cancer models.
Chun Wai Wong, Christos Evangelou, Kieran N Sefton, Rotem Leshem, Wei Zhang, Adam F L Hurlstone

Nat Commun· September 2023

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Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached.
Daniel J Wilcock, Andrew P Badrock, Chun W Wong, Rhys Owen, Melissa Guerin, Adam F L Hurlstone

Cell Rep· June 2022

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Glucose uptake as an alternative to oxygen uptake for assessing metabolic rate in larvae.
Bridget L Evans, Adam F L Hurlstone, Peter E Clayton, Adam Stevens, Holly A Shiels

Curr Res Physiol· May 2022

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Radiotherapy transiently reduces the sensitivity of cancer cells to lymphocyte cytotoxicity.
Karoliina Tuomela, Debayan Mukherjee, Ashley R Ambrose, Ashish Harikrishnan, Holly Mole, Adam Hurlstone

Proc Natl Acad Sci U S A· January 2022

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Systematic Roadmap for Cancer Drug Screening Using Zebrafish Embryo Xenograft Cancer Models: Melanoma Cell Line as a Case Study.
Patricia Letrado, Holly Mole, María Montoya, Irene Palacios, Jorge Barriuso, Adam Hurlstone

Cancers (Basel)· July 2021

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Dissecting Oncogenic RAS Signaling in Melanoma Development in Genetically Engineered Zebrafish Models.
Andrew P Badrock, Adam Hurlstone

Methods Mol Biol· June 2021

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Zebrafish IL-4-like Cytokines and IL-10 Suppress Inflammation but Only IL-10 Is Essential for Gill Homeostasis.
Federica Bottiglione, Christopher T Dee, Robert Lea, Leo A H Zeef, Andrew P Badrock, Adam F L Hurlstone

J Immunol· August 2020

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Novel contribution of epigenetic changes to nuclear dynamics.
Marcel Dreger, Elena Madrazo, Adam Hurlstone, Javier Redondo-Muñoz

Nucleus· December 2019

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Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck.
Rachel J Carter, Mateus Milani, Michael Butterworth, Ahoud Alotibi, Nicholas Harper, Adam Hurlstone

Cell Death Dis· December 2019

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Enhanced Fatty Acid Scavenging and Glycerophospholipid Metabolism Accompany Melanocyte Neoplasia Progression in Zebrafish.
Fiona Henderson, Hannah R Johnston, Andrew P Badrock, Emrys A Jones, Duncan Forster, Adam Hurlstone

Cancer Res· May 2019

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Using zebrafish larval models to study brain injury, locomotor and neuroinflammatory outcomes following intracerebral haemorrhage.
Siobhan Crilly, Alexandra Njegic, Sarah E Laurie, Elisavet Fotiou, Georgina Hudson, Adam Hurlstone

F1000Res· October 2018

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RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation.
Berta Casar, Andrew P Badrock, Iñaki Jiménez, Imanol Arozarena, Paula Colón-Bolea, Adam Hurlstone

Nat Commun· September 2018

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WDR5 modulates cell motility and morphology and controls nuclear changes induced by a 3D environment.
Pengbo Wang, Marcel Dreger, Elena Madrazo, Craig J Williams, Rafael Samaniego, Adam Hurlstone

Proc Natl Acad Sci U S A· August 2018

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An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition.
Helen L Young, Emily J Rowling, Mattia Bugatti, Emanuele Giurisato, Nadia Luheshi, Adam Hurlstone

J Exp Med· June 2017

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TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells.
Zoi Diamantopoulou, Gavin White, Muhammad Z H Fadlullah, Marcel Dreger, Karen Pickering, Adam F L Hurlstone

Cancer Cell· May 2017

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Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQQ209P-driven uveal melanomas in zebrafish.
Mai Abdel Mouti, Christopher Dee, Sarah E Coupland, Adam F L Hurlstone

Oncotarget· June 2016

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Reprofiling using a zebrafish melanoma model reveals drugs cooperating with targeted therapeutics.
Laura Fernandez Del Ama, Mary Jones, Paul Walker, Anna Chapman, Julia A Braun, Adam F L Hurlstone

Oncotarget· June 2016

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