Publications by authors named "Adam P Silverman"

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Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA.
Michelle E Pizzo, Edward D Plowey, Nathalie Khoury, Wanda Kwan, Jordan Abettan, Adam P Silverman

Science· August 2025

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Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines.
Spencer C Wei, Aaron J Cantor, Jack Walleshauser, Rina Mepani, Kory Melton, Adam P Silverman

PLoS One· June 2025

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Identification of a Guide RNA Targeting an Ultraconserved Element for Evaluation of Cas9 Genome Editors Across Mammalian Species.
Benjamin G Gowen, Prachi Khekare, Shannon R McCawley, Kory Melton, Craig Soares, Adam P Silverman

CRISPR J· December 2024

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Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines.
Spencer C Wei, Aaron J Cantor, Jack Walleshauser, Rina Mepani, Kory Melton, Adam P Silverman

bioRxiv· December 2024

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Identification of bacterial protease domains that cleave human IgM.
Tricia Windgassen, Nikki Kruse, Brian Ferrer, Faye Du, Hirdesh Kumar, Adam P Silverman

Enzyme Microb Technol· February 2024

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Oral enzyme therapy for maple syrup urine disease (MSUD) suppresses plasma leucine levels in intermediate MSUD mice and healthy nonhuman primates.
Kristen Skvorak, Joyce Liu, Nikki Kruse, Roasa Mehmood, Subhamoy Das, Adam P Silverman

J Inherit Metab Dis· November 2023

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An orally administered enzyme therapeutic for homocystinuria that suppresses homocysteine by metabolizing methionine in the gastrointestinal tract.
Kristen Skvorak, Vesna Mitchell, Leann Teadt, Kierra A Franklin, Hyung-Ok Lee, Adam P Silverman

Mol Genet Metab· August 2023

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Optimizing human α-galactosidase for treatment of Fabry disease.
William C Hallows, Kristen Skvorak, Nick Agard, Nikki Kruse, Xiyun Zhang, Adam P Silverman

Sci Rep· March 2023

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APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function.
Monica Xiong, Hong Jiang, Javier Remolina Serrano, Ernesto R Gonzales, Chao Wang, Adam P Silverman

Sci Transl Med· February 2021

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Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice.
Julie C Ullman, Annie Arguello, Jennifer A Getz, Akhil Bhalla, Cathal S Mahon, Adam P Silverman

Sci Transl Med· May 2020

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Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys.
Mihalis S Kariolis, Robert C Wells, Jennifer A Getz, Wanda Kwan, Cathal S Mahon, Adam P Silverman

Sci Transl Med· May 2020

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Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.
Fan Liao, Aimin Li, Monica Xiong, Nga Bien-Ly, Hong Jiang, Adam P Silverman

J Clin Invest· May 2018

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Engineered ligand-based VEGFR antagonists with increased receptor binding affinity more effectively inhibit angiogenesis.
Shiven Kapur, Adam P Silverman, Anne Z Ye, Niv Papo, Darren Jindal

Bioeng Transl Med· March 2017

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111In-labeled cystine-knot peptides based on the Agouti-related protein for targeting tumor angiogenesis.
Lei Jiang, Zheng Miao, Richard H Kimura, Adam P Silverman, Gang Ren

J Biomed Biotechnol· October 2012

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Antagonistic VEGF variants engineered to simultaneously bind to and inhibit VEGFR2 and alphavbeta3 integrin.
Niv Papo, Adam P Silverman, Jennifer L Lahti, Jennifer R Cochran

Proc Natl Acad Sci U S A· August 2011

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Cystine-knot peptides engineered with specificities for α(IIb)β(3) or α(IIb)β(3) and α(v)β(3) integrins are potent inhibitors of platelet aggregation.
Adam P Silverman, Mihalis S Kariolis, Jennifer R Cochran

J Mol Recognit· July 2011

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Evaluation of a (64)Cu-labeled cystine-knot peptide based on agouti-related protein for PET of tumors expressing alphavbeta3 integrin.
Lei Jiang, Richard H Kimura, Zheng Miao, Adam P Silverman, Gang Ren

J Nucl Med· February 2010

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Interrogating and predicting tolerated sequence diversity in protein folds: application to E. elaterium trypsin inhibitor-II cystine-knot miniprotein.
Jennifer L Lahti, Adam P Silverman, Jennifer R Cochran

PLoS Comput Biol· September 2009

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Engineered cystine-knot peptides that bind alpha(v)beta(3) integrin with antibody-like affinities.
Adam P Silverman, Aron M Levin, Jennifer L Lahti, Jennifer R Cochran

J Mol Biol· January 2009

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Steric effects in RNA interference: probing the influence of nucleobase size and shape.
Alvaro Somoza, Adam P Silverman, Rand M Miller, Jijumon Chelliserrykattil, Eric T Kool

Chemistry· October 2008

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Developing therapeutic proteins by engineering ligand-receptor interactions.
Douglas S Jones, Adam P Silverman, Jennifer R Cochran

Trends Biotechnol· September 2008

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Quenched autoligation probes.
Adam P Silverman, Hiroshi Abe, Eric T Kool

Methods Mol Biol· September 2008

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Probing the active site steric flexibility of HIV-1 reverse transcriptase: different constraints for DNA- versus RNA-templated synthesis.
Adam P Silverman, Scott J Garforth, Vinayaka R Prasad, Eric T Kool

Biochemistry· April 2008

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Steric and electrostatic effects in DNA synthesis by the SOS-induced DNA polymerases II and IV of Escherichia coli.
Adam P Silverman, Qingfei Jiang, Myron F Goodman, Eric T Kool

Biochemistry· December 2007

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RNA probes of steric effects in active sites: high flexibility of HIV-1 reverse transcriptase.
Adam P Silverman, Eric T Kool

J Am Chem Soc· September 2007

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