Publications by authors named "Adam R Root"

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Illuminating protein space with a programmable generative model.
John B Ingraham, Max Baranov, Zak Costello, Karl W Barber, Wujie Wang, Adam R Root

Nature· November 2023

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Molecular insights into recognition of GUCY2C by T-cell engaging bispecific antibody anti-GUCY2CxCD3.
Pragya Rampuria, Lidia Mosyak, Adam R Root, Kristine Svenson, Michael J Agostino

Sci Rep· August 2023

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Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors.
Adam R Root, Gurkan Guntas, Madan Katragadda, James R Apgar, Jatin Narula

MAbs· October 2021

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A Novel GUCY2C-CD3 T-Cell Engaging Bispecific Construct (PF-07062119) for the Treatment of Gastrointestinal Cancers.
Divya Mathur, Adam R Root, Bozena Bugaj-Gaweda, Stephanie Bisulco, Xingzhi Tan

Clin Cancer Res· May 2020

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A CD3-bispecific molecule targeting P-cadherin demonstrates T cell-mediated regression of established solid tumors in mice.
Timothy S Fisher, Andrea T Hooper, Justin Lucas, Tracey H Clark, Allison K Rohner, Adam R Root

Cancer Immunol Immunother· February 2018

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Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer.
Adam R Root, Wei Cao, Bilian Li, Peter LaPan, Caryl Meade

Antibodies (Basel)· March 2016

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Cloning and characterization of a functional type II gonadotropin-releasing hormone receptor with a lengthy carboxy-terminal tail from an ancestral vertebrate, the sea lamprey.
Matthew R Silver, Nathaniel V Nucci, Adam R Root, Karen L Reed, Stacia A Sower

Endocrinology· August 2005

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In situ characterization of gonadotropin- releasing hormone-I, -III, and glutamic acid decarboxylase expression in the brain of the sea lamprey, Petromyzon marinus.
Adam R Root, Nathaniel V Nucci, Jocelyn D Sanford, Beverly S Rubin, Vance L Trudeau

Brain Behav Evol· March 2005

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Distribution of gonadotropin-releasing hormone (GnRH) by in situ hybridization in the tunicate Ciona intestinalis.
Scott I Kavanaugh, Adam R Root, Stacia A Sower

Gen Comp Endocrinol· March 2005

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In vitro and in vivo effects of GABA, muscimol, and bicuculline on lamprey GnRH concentration in the brain of the sea lamprey (Petromyzon marinus).
Adam R Root, Jocelyn D Sanford, Scott I Kavanaugh, Stacia A Sower

Comp Biochem Physiol A Mol Integr Physiol· August 2004

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