Publications by authors named "Adam Sedgwick"

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Identification of a photoredox-active Pt(IV) complex that induces light-mediated cell death.
Jevon W Marsh, Lina Hacker, Sophie A Twigger, Jake A Vickery, Shitong Huang, Adam C Sedgwick

Chem Sci· October 2025

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Reversible Enzymatic Switching of the Oxidation State of a Eu Complex Controls Relaxivity.
Euan T Sarson, Saul M Cooper, Adam C Sedgwick, Amy-Grace Berger, Sophie A Twigger

J Am Chem Soc· October 2025

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Glycosidase-activated prodrugs of a cytotoxic iron chelator for targeted cancer therapy.
Debashish Tomar, Axel Steinbrueck, Adam C Sedgwick, Matthew S Levine, Jonathan L Sessler

RSC Med Chem· August 2025

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Real-time visualization of epileptic seizures using photoacoustic imaging with a peroxynitrite-responsive manganese(ii) texaphyrin.
Yaguang Ren, Calvin V Chau, Tao Chen, Jingqin Chen, Yu Hu, Adam C Sedgwick

Chem Sci· April 2025

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Specific macrophage RhoA targeting CRISPR-Cas9 for mitigating osteoclastogenesis-induced joint damage in inflammatory arthritis.
Jianhai Chen, Jianwei Tan, Nannan Wang, Hui Li, Wenxiang Cheng, Adam C Sedgwick

Cell Rep Med· April 2025

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Identifying Molecular Probes for Fluorescence-Guided Surgery in Neuroblastoma: A Systematic Review.
Megan Hennessy, Jonathan J Neville, Laura Privitera, Adam Sedgwick, John Anderson

Children (Basel)· April 2025

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The activity of therapeutic molecular cluster Ag5 is dependent on oxygen level and HIF-1 mediated signalling.
Sophie A Twigger, Blanca Dominguez, Vanesa Porto, Lina Hacker, Anthony J Chalmers, Adam C Sedgwick

Redox Biol· October 2024

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Fluorogenic platinum(IV) complexes as potential predictors for the design of hypoxia-activated platinum(IV) prodrugs.
Jevon W Marsh, Lina Hacker, Shitong Huang, Marie H C Boulet, Jhanelle R G White, Adam C Sedgwick

Dalton Trans· September 2024

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Lutetium Texaphyrin-Celecoxib Conjugate as a Potential Immuno-Photodynamic Therapy Agent.
Jusung An, Kong-Peng Lv, Calvin V Chau, Jong Hyeon Lim, Rakesh Parida, Adam C Sedgwick

J Am Chem Soc· July 2024

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A colorimetric approach for monitoring the reduction of platinum(iv) complexes in aqueous solution.
Shitong Huang, Jevon W Marsh, Jhanelle R G White, Tracy Q Ha, Sophie A Twigger, Adam C Sedgwick

New J Chem· April 2024

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Targeted Cyclo[8]pyrrole-Based NIR-II Photoacoustic Tomography Probe for Suppression of Orthotopic Pancreatic Tumor Growth and Intra-abdominal Metastases.
Jingqin Chen, Rui Chen, Calvin V Chau, Adam C Sedgwick, Qiang Xue

J Am Chem Soc· February 2024

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Lutetium texaphyrin: A photocatalyst that triggers pyroptosis via biomolecular photoredox catalysis.
Yunjie Xu, Calvin V Chau, Jieun Lee, Adam C Sedgwick, Le Yu

Proc Natl Acad Sci U S A· February 2024

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Enhancement of sonochemical production of hydroxyl radicals from pulsed cylindrically converging ultrasound waves.
Cherie C Y Wong, Jason L Raymond, Lillian N Usadi, Zhiyuan Zong, Stephanie C Walton, Adam C Sedgwick

Ultrason Sonochem· October 2023

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Deferasirox Derivatives: Ligands for the Lanthanide Series.
Daniel N Mangel, Gabriel J Juarez, Stephanie H Carpenter, Axel Steinbrueck, Vincent M Lynch, Adam C Sedgwick

J Am Chem Soc· October 2023

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Oxali(IV)Fluors: Fluorescence Responsive Oxaliplatin(IV) Complexes Identify a Hypoxia-Dependent Reduction in Cancer Cells.
Marie H C Boulet, Hannah R Bolland, Ester M Hammond, Adam C Sedgwick

J Am Chem Soc· June 2023

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A TCF-based fluorescent probe to determine nitroreductase (NTR) activity for a broad-spectrum of bacterial species.
Kai-Cheng Yan, Jordan E Gardiner, Adam C Sedgwick, Naing Thet, Rachel A Heylen

Chem Commun (Camb)· June 2023

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Fluorescence-based chemical tools for monitoring ultrasound-induced hydroxyl radical production in aqueous solution and in cells.
Cherie Cy Wong, Lu-Lu Sun, Meng-Jiao Liu, Eleanor Stride, Jason L Raymond, Adam C Sedgwick

Chem Commun (Camb)· April 2023

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The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy.
Hai-Hao Han, Han-Min Wang, Paramesh Jangili, Mingle Li, Luling Wu, Adam C Sedgwick

Chem Soc Rev· February 2023

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Fluorescent probes for the detection of chemical warfare agents.
Wen-Qi Meng, Adam C Sedgwick, Nahyun Kwon, Mingxue Sun, Kai Xiao

Chem Soc Rev· January 2023

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TCF-based fluorescent probe for monitoring superoxide anion produced in bacteria under chloramphenicol- and heat-induced stress.
Kai-Cheng Yan, Bethany L Patenall, Jordan E Gardiner, Rachel A Heylen, Naing Thet, Adam C Sedgwick

Chem Commun (Camb)· November 2022

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Photoacoustic image-guided biomimetic nanoparticles targeting rheumatoid arthritis.
Jianhai Chen, Silue Zeng, Qiang Xue, Yuchuan Hong, Liangjian Liu, Adam C Sedgwick

Proc Natl Acad Sci U S A· October 2022

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A fluorescent probe strategy for the detection and discrimination of hydrogen peroxide and peroxynitrite in cells.
Hannah R Bolland, Ester M Hammond, Adam C Sedgwick

Chem Commun (Camb)· September 2022

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2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy.
Yunjie Xu, Yingwei Wang, Jusung An, Adam C Sedgwick, Mingle Li

Bioact Mater· August 2022

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Tuning the Solid- and Solution-State Fluorescence of the Iron-Chelator Deferasirox.
Xi-Le Hu, Adam C Sedgwick, Daniel N Mangel, Ying Shang, Axel Steinbrueck

J Am Chem Soc· April 2022

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Fluorescent probes for the detection of disease-associated biomarkers.
Wei-Tao Dou, Hai-Hao Han, Adam C Sedgwick, Guo-Biao Zhu, Yi Zang

Sci Bull (Beijing)· April 2022

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