Publications by authors named "Adam Throup"

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Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.
Nicholas C K Valerie, Kumar Sanjiv, Oliver Mortusewicz, Si Min Zhang, Seher Alam, Adam Throup

Nat Commun· December 2024

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Sidechain structure-activity relationships of cyclobutane-based small molecule αvβ3 antagonists.
Adam Throup, Manar Saleh Zraikat, Andrew Gordon, Shohreh Jafarinejad Soumehsaraei, Kathrin D Haase

RSC Med Chem· September 2024

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Synthesis and Biological Evaluation of Cyclobutane-Based β3 Integrin Antagonists: A Novel Approach to Targeting Integrins for Cancer Therapy.
Mark Sutherland, Andrew Gordon, Fatemah O F O Al-Shammari, Adam Throup, Amy Cilia La Corte

Cancers (Basel)· August 2023

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NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir.
Si Min Zhang, Daniel Rehling, Ann-Sofie Jemth, Adam Throup, Natalia Landázuri

Cell Chem Biol· December 2021

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Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
Daniel Rehling, Si Min Zhang, Ann-Sofie Jemth, Tobias Koolmeister, Adam Throup

J Biol Chem· August 2021

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Development of a chemical probe against NUDT15.
Si Min Zhang, Matthieu Desroses, Anna Hagenkort, Nicholas C K Valerie, Daniel Rehling, Adam Throup

Nat Chem Biol· October 2020

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Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold.
Megan Carter, Ann-Sofie Jemth, Jordi Carreras-Puigvert, Patrick Herr, Markel Martínez Carranza, Adam Throup

Structure· February 2018

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Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction.
Sabin Llona-Minguez, Adam Throup, Emilie Steiner, Molly Lightowler, Sandra Van der Haegen

Org Biomol Chem· September 2017

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Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines.
Sabin Llona-Minguez, Maria Häggblad, Ulf Martens, Adam Throup, Olga Loseva

Bioorg Med Chem Lett· August 2017

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Intramolecular thermal stepwise [2 + 2] cycloadditions: investigation of a stereoselective synthesis of [n.2.0]-bicyclolactones.
Adam Throup, Laurence H Patterson, Helen M Sheldrake

Org Biomol Chem· October 2016

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