Publications by authors named "Adrian Manea"

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Therapeutic S100A8/A9 inhibition reduces NADPH oxidase expression, reactive oxygen species production and NLRP3 inflammasome priming in the ischemic myocardium.
Mihaela-Loredana Vlad, Razvan Gheorghita Mares, Gabriel Jakobsson, Simona-Adriana Manea, Alexandra-Gela Lazar, Adrian Manea

Eur J Pharmacol· June 2025

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SET7 lysine methyltransferase mediates the up-regulation of NADPH oxidase expression, oxidative stress, and NLRP3 inflammasome priming in atherosclerosis.
Simona-Adriana Manea, Mihaela-Loredana Vlad, Alexandra-Gela Lazar, Horia Muresian, Maya Simionescu, Adrian Manea

J Transl Med· March 2025

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Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction.
Gabriel Jakobsson, Praveen Papareddy, Henrik Andersson, Megan Mulholland, Ravi Bhongir, Adrian Manea

Crit Care· September 2023

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Pharmacological Inhibition of Lysine-Specific Demethylase 1A Reduces Atherosclerotic Lesion Formation in Apolipoprotein E-Deficient Mice by a Mechanism Involving Decreased Oxidative Stress and Inflammation; Potential Implications in Human Atherosclerosis.
Simona-Adriana Manea, Mihaela-Loredana Vlad, Alexandra-Gela Lazar, Horia Muresian, Maya Simionescu, Adrian Manea

Antioxidants (Basel)· December 2022

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Activated Histone Acetyltransferase p300/CBP-Related Signalling Pathways Mediate Up-Regulation of NADPH Oxidase, Inflammation, and Fibrosis in Diabetic Kidney.
Alexandra-Gela Lazar, Mihaela-Loredana Vlad, Adrian Manea, Maya Simionescu, Simona-Adriana Manea

Antioxidants (Basel)· August 2021

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Detection of Vascular Reactive Oxygen Species in Experimental Atherosclerosis by High-Resolution Near-Infrared Fluorescence Imaging Using VCAM-1-Targeted Liposomes Entrapping a Fluorogenic Redox-Sensitive Probe.
Simona-Adriana Manea, Mihaela-Loredana Vlad, Daniela Rebleanu, Alexandra-Gela Lazar, Ioana Madalina Fenyo, Adrian Manea

Oxid Med Cell Longev· May 2021

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Histone Acetyltransferase-Dependent Pathways Mediate Upregulation of NADPH Oxidase 5 in Human Macrophages under Inflammatory Conditions: A Potential Mechanism of Reactive Oxygen Species Overproduction in Atherosclerosis.
Mihaela-Loredana Vlad, Simona-Adriana Manea, Alexandra-Gela Lazar, Monica Raicu, Horia Muresian, Adrian Manea

Oxid Med Cell Longev· March 2020

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Pharmacological inhibition of histone deacetylase reduces NADPH oxidase expression, oxidative stress and the progression of atherosclerotic lesions in hypercholesterolemic apolipoprotein E-deficient mice; potential implications for human atherosclerosis.
Simona-Adriana Manea, Mihaela-Loredana Vlad, Ioana Madalina Fenyo, Alexandra-Gela Lazar, Monica Raicu, Adrian Manea

Redox Biol· January 2020

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The anti-cancer drug doxorubicin induces substantial epigenetic changes in cultured cardiomyocytes.
Alina Hanf, Matthias Oelze, Adrian Manea, Huige Li, Thomas Münzel

Chem Biol Interact· November 2019

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Epigenetic regulation of vascular NADPH oxidase expression and reactive oxygen species production by histone deacetylase-dependent mechanisms in experimental diabetes.
Simona-Adriana Manea, Mihaela-Loredana Antonescu, Ioana Madalina Fenyo, Monica Raicu, Maya Simionescu, Adrian Manea

Redox Biol· June 2018

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c-Src tyrosine kinase mediates high glucose-induced endothelin-1 expression.
Simona-Adriana Manea, Ioana Madalina Fenyo, Adrian Manea

Int J Biochem Cell Biol· June 2016

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Hu antigen R is required for NOX-1 but not NOX-4 regulation by inflammatory stimuli in vascular smooth muscle cells.
Andrea Aguado, Thierry Fischer, Cristina Rodríguez, Adrian Manea, José Martínez-González

J Hypertens· February 2016

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High-glucose-increased expression and activation of NADPH oxidase in human vascular smooth muscle cells is mediated by 4-hydroxynonenal-activated PPARα and PPARβ/δ.
Adrian Manea, Simona-Adriana Manea, Andra Todirita, Irina Cristina Albulescu, Monica Raicu

Cell Tissue Res· August 2015

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The redox biology network in cancer pathophysiology and therapeutics.
Gina Manda, Gheorghita Isvoranu, Maria Victoria Comanescu, Adrian Manea, Bilge Debelec Butuner

Redox Biol· August 2015

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Regulation of Nox enzymes expression in vascular pathophysiology: Focusing on transcription factors and epigenetic mechanisms.
Simona-Adriana Manea, Alina Constantin, Gina Manda, Shlomo Sasson, Adrian Manea

Redox Biol· August 2015

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Human monocytes and macrophages express NADPH oxidase 5; a potential source of reactive oxygen species in atherosclerosis.
Adrian Manea, Simona-Adriana Manea, Ana Maria Gan, Alina Constantin, Ioana Madalina Fenyo

Biochem Biophys Res Commun· May 2015

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High glucose-induced increased expression of endothelin-1 in human endothelial cells is mediated by activated CCAAT/enhancer-binding proteins.
Simona-Adriana Manea, Andra Todirita, Adrian Manea

PLoS One· March 2015

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Functional analysis of the fractalkine gene promoter in human aortic smooth muscle cells exposed to proinflammatory conditions.
Ana-Maria Gan, Elena Butoi, Adrian Manea, Monica Madalina Pirvulescu, Daniela Stan

FEBS J· September 2014

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C/EBP transcription factors regulate NADPH oxidase in human aortic smooth muscle cells.
Simona-Adriana Manea, Andra Todirita, Monica Raicu, Adrian Manea

J Cell Mol Med· July 2014

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Oxidative stress in cardiovascular pathologies: genetics, cellular, and molecular mechanisms and future antioxidant therapies.
Adrian Manea, Ana Fortuno, Jose Luis Martin-Ventura

Oxid Med Cell Longev· July 2013

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Inflammatory effects of resistin on human smooth muscle cells: up-regulation of fractalkine and its receptor, CX3CR1 expression by TLR4 and Gi-protein pathways.
Ana-Maria Gan, Elena Dragomir Butoi, Adrian Manea, Viorel Simion, Daniela Stan

Cell Tissue Res· January 2013

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Positive regulation of NADPH oxidase 5 by proinflammatory-related mechanisms in human aortic smooth muscle cells.
Adrian Manea, Simona A Manea, Irina C Florea, Catalina M Luca, Monica Raicu

Free Radic Biol Med· May 2012

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Nox enzymes and oxidative stress in atherosclerosis.
Adrian Manea, Maya Simionescu

Front Biosci (Schol Ed)· January 2012

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Tyrphostin AG490 reduces NAPDH oxidase activity and expression in the aorta of hypercholesterolemic apolipoprotein E-deficient mice.
Ioana M Fenyo, Irina C Florea, Monica Raicu, Adrian Manea

Vascul Pharmacol· September 2011

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NADPH oxidase-derived reactive oxygen species: involvement in vascular physiology and pathology.
Adrian Manea

Cell Tissue Res· December 2010

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