Publications by authors named "Adrian Onu"

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Red Alga Porphyridium Supports High-Yield Production of a Functional Chimeric Hepatitis B Surface Antigen With Strong Cellular and Humoral Immunogenicity.
Ana-Maria Pantazica, Alexander Hammel, Iuliana Caras, Irina Ionescu, Catalin Tucureanu, Adrian Onu

Plant Biotechnol J· November 2025

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Humanized mouse model reveals the immunogenicity of Hepatitis B Virus vaccine candidates produced in CRISPR/Cas9-edited .
Iuliana Caras, Irina-Elena Ionescu, Ana-Maria Pantazica, André van Eerde, Hege Steen, Adrian Onu

Front Immunol· April 2025

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The red alga as a host for molecular farming: Efficient production of immunologically active hepatitis C virus glycoprotein.
Alexander Hammel, Lia-Maria Cucos, Iuliana Caras, Irina Ionescu, Catalin Tucureanu, Adrian Onu

Proc Natl Acad Sci U S A· June 2024

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Generation of a DSF-Guided Refolded Bacterially Expressed Hemagglutinin Ectodomain of Influenza Virus A/Puerto Rico/8/1934 H1N1 as a Model for Influenza Vaccine Antigens.
Vlad-Constantin Tofan, Andreea-Laura Ermeneanu, Iuliana Caraș, Alina Lenghel, Irina-Elena Ionescu, Adrian Onu

Vaccines (Basel)· September 2023

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The "humanized" N-glycosylation pathway in CRISPR/Cas9-edited Nicotiana benthamiana significantly enhances the immunogenicity of a S/preS1 Hepatitis B Virus antigen and the virus-neutralizing antibody response in vaccinated mice.
Ana-Maria Pantazica, André van Eerde, Mihaela-Olivia Dobrica, Iuliana Caras, Irina Ionescu, Adrian Onu

Plant Biotechnol J· June 2023

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Comparison of truncated human angiotensin-converting enzyme 2 (hACE2) expression in pET28a(+) versus pET-SUMO vector and two Escherichia coli strains.
Dora Domnica Baciu, Sorin Dinu, Bianca Palade, Adrian Onu, Adriana Costache

Adv Med Sci· March 2023

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Efficient cellular and humoral immune response and production of virus-neutralizing antibodies by the Hepatitis B Virus S/preS1 antigen.
Ana-Maria Pantazica, Mihaela-Olivia Dobrica, Catalin Lazar, Cristina Scurtu, Catalin Tucureanu, Adrian Onu

Front Immunol· August 2022

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Hepatitis C virus E2 envelope glycoprotein produced in Nicotiana benthamiana triggers humoral response with virus-neutralizing activity in vaccinated mice.
Mihaela-Olivia Dobrica, André van Eerde, Catalin Tucureanu, Adrian Onu, Lisa Paruch

Plant Biotechnol J· October 2021

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Oral administration of a chimeric Hepatitis B Virus S/preS1 antigen produced in lettuce triggers infection neutralizing antibodies in mice.
Mihaela-Olivia Dobrica, Catalin Lazar, Lisa Paruch, André van Eerde, Jihong Liu Clarke, Adrian Onu

Vaccine· September 2018

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Lettuce-produced hepatitis C virus E1E2 heterodimer triggers immune responses in mice and antibody production after oral vaccination.
Jihong Liu Clarke, Lisa Paruch, Mihaela-Olivia Dobrica, Iuliana Caras, Catalin Tucureanu, Adrian Onu

Plant Biotechnol J· December 2017

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A novel chimeric Hepatitis B virus S/preS1 antigen produced in mammalian and plant cells elicits stronger humoral and cellular immune response than the standard vaccine-constituent, S protein.
Mihaela-Olivia Dobrica, Catalin Lazar, Lisa Paruch, Hanne Skomedal, Hege Steen, Adrian Onu

Antiviral Res· August 2017

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Influenza Vaccine Manufacturing: Effect of Inactivation, Splitting and Site of Manufacturing. Comparison of Influenza Vaccine Production Processes.
Theone C Kon, Adrian Onu, Laurentiu Berbecila, Emilia Lupulescu, Alina Ghiorgisor

PLoS One· July 2016

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Technology transfer of oil-in-water emulsion adjuvant manufacturing for pandemic influenza vaccine production in Romania: Preclinical evaluation of split virion inactivated H5N1 vaccine with adjuvant.
Crina Stavaru, Adrian Onu, Emilia Lupulescu, Catalin Tucureanu, Orhan Rasid

Hum Vaccin Immunother· April 2016

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Adenylate cyclases involvement in pathogenicity, a minireview.
Adriana Costache, Nadia Bucurenci, Adrian Onu

Roum Arch Microbiol Immunol· September 2013

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Technology transfer of oil-in-water emulsion adjuvant manufacturing for pandemic influenza vaccine production in Romania.
Christopher B Fox, Chuong Huynh, Michael K O'Hara, Adrian Onu

Vaccine· March 2013

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Survival of H5N1 influenza virus in water and its inactivation by chemical methods.
Maria Elena Mihai, Cristina Tecu, Alina Elena Ivanciuc, Gheorghe Necula, Emilia Lupulescu, Adrian Onu

Roum Arch Microbiol Immunol· December 2011

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Evaluation of the efficacy of a specific hyperimmune serum in experimental influenza infection in mice.
Bogdan Marinescu, Cristin Coman, Adina Daniela Iancu, Crina Stavaru, Emilia Lupulescu, Adrian Onu

Roum Arch Microbiol Immunol· May 2010

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Regulatory mechanisms differ in UMP kinases from gram-negative and gram-positive bacteria.
Cécile Evrin, Monica Straut, Neli Slavova-Azmanova, Nadia Bucurenci, Adrian Onu

J Biol Chem· March 2007

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Matrix metalloproteinase-9 and its natural inhibitor TIMP-1 expressed or secreted by peripheral blood mononuclear cells from patients with systemic lupus erythematosus.
Cristiana Matache, Maria Stefanescu, Cristina Dragomir, Stefanita Tanaseanu, Adrian Onu

J Autoimmun· June 2003

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